Revisiting the Relative Contribution of Common and Rare Genetic Variants to Attention-Deficit/Hyperactivity Disorder Among Diverse Populations

Polygenic risk score (PRS) represents a groundbreaking advancement in personalized medicine, offering a nuanced and predictive tool for assessing an individual ’s susceptibility to polygenic diseases based on their genetic makeup by aggregating the small effects of many common variants. However, the application of PRS in neuropsychiatric disorders is limited due to the challenges in achieving clinical utility in general medical settings (1). Copy number variants (CNVs) are deletions or duplications of sections of DNA that often result in changes in gene dosage.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research