Longitudinal transcriptomic analysis of human cortical spheroids identifies axonal dysregulation in the prenatal brain as a mediator of genetic risk for schizophrenia
Schizophrenia (SCZ) has a known neurodevelopmental etiology, but limited access to human prenatal brain tissue hampers the investigation of basic disease mechanisms in early brain development. Here, we elucidate the molecular mechanisms contributing to SCZ risk in a disease-relevant model of the prenatal human brain. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 1, 2023 Category: Psychiatry Authors: Ibrahim A. Akkouh, Thor Ueland, Attila Szabo, Timothy Hughes, Olav B. Smeland, Ole A. Andreassen, Jordi Requena Osete, Srdjan Djurovic Tags: Archival Report Source Type: research
Developmental disruptions of the dorsal striatum in autism spectrum disorder
Autism spectrum disorder (ASD) is an increasingly prevalent neurodevelopmental condition that is characterized by social and communication deficits as well as patterns of restricted, repetitive behavior. Abnormal brain development has long been postulated to underlie ASD, but longitudinal studies aimed at understanding the developmental course of the disorder have been limited. More recently, abnormal development of the striatum in ASD has become an area of interest in research, partially due to overlap of striatal functions and deficit areas in ASD, as well as the critical role of striatum in early development when ASD is...
Source: Biological Psychiatry - August 28, 2023 Category: Psychiatry Authors: Maya M. Evans, Jaekyoon Kim, Ted Abel, Thomas Nickl-Jockschat, Hanna E. Stevens Tags: Review Source Type: research
Low-Intensity Focused Ultrasound Targeting the Bilateral Nucleus Accumbens as a Potential Treatment for Substance Use Disorder: A First-in-Human Report
Over 110,000 drug overdose deaths occurred in the U.S. in 2022, the most in recorded history, with>75% involving opioids (1). Moreover, there are 46.3 million people in the United States with a substance use disorder (SUD), with only ∼7% receiving specialty treatment (2). There have been significant efforts to improve treatment outcomes; for example, the combination of behavioral treatment with medication for opioid use disorder (MOUD) has been associated with increased treatment retention and reduced opioid craving and use (3 ,4). (Source: Biological Psychiatry)
Source: Biological Psychiatry - August 22, 2023 Category: Psychiatry Authors: James J. Mahoney, Daisy G.Y. Thompson-Lake, Manish Ranjan, Jennifer L. Marton, Jeffrey S. Carpenter, Wanhong Zheng, James H. Berry, Daniel L. Farmer, Pierre D ’Haese, Victor S. Finomore, Padma Tirumalai, Ashley S. Mears, Jacob Suffridge, Ashley Ames, Sa Tags: Correspondence Source Type: research
Objective Measure of a Subjective Experience: A Real-Time Biomarker of Mood Status?
If only my anguish could be weighed and all my misery be placed on the scales! —Job 6:2 (Source: Biological Psychiatry)
Source: Biological Psychiatry - August 21, 2023 Category: Psychiatry Authors: Miklos Argyelan, Albert J. Fenoy Tags: Commentary Source Type: research
Neurophysiological Biomarkers as a Springboard for the Refinement of Transcranial Magnetic Stimulation Therapy: Stratification, Mechanisms of Action, and Next Steps
In the current issue of Biological Psychiatry, Strafella et al. (1) take an important step forward in the study of transcranial magnetic stimulation (TMS) therapy for major depressive disorder (MDD). The authors evaluate TMS–electroencephalography (TMS-EEG)-evoked potential components as putative biomarkers of intermittent theta burst stimulation (iTBS) clinical outcome within the context of a larger triple-blind randomized controlled clinical trial. The highest-powered study of its kind to date (N = 114 patients), this study carefully examines the interaction between clinical predictors (baseline) and clinical target...
Source: Biological Psychiatry - August 21, 2023 Category: Psychiatry Authors: Nicholas Murphy Tags: Commentary Source Type: research
