Guide for Authors
Biological Psychiatry, founded in 1969, is an official journal of the Society of Biological Psychiatry and the first in the Biological Psychiatry family of journals. Companion titles include Biological Psychiatry: Cognitive Neuroscience and Neuroimaging and Biological Psychiatry: Global Open Science. The Society ’s purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, and behavior. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 30, 2023 Category: Psychiatry Source Type: research
Hippocampal circAnk3 Deficiency Causes Anxiety-like Behaviors and Social Deficits by Regulating the miR-7080-3p/IQGAP1 Pathway in Mice
In this study, we investigated the function of circAnk3 and its downstream regulatory network for target genes in the hippocampus of mice. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 30, 2023 Category: Psychiatry Authors: Yuman He, Linhong Jiang, Haxiaoyu Liu, Qian Bu, Weihong Kuang, Ying Zhao, Yaxing Chen, Ni Zhang, Yuzhou Xiao, Shu Li, Rong Chen, Shuang Han, Yuanyi Zhou, Jiamei Zhang, Xuemei Wan, Rui Xu, Shaomin Wang, Haoluo Zhang, Hui Gu, Qingfan Wei, Feng Qin, Yue Zhao Tags: Archival Report Source Type: research
Stressed to the Core: Inflammation and Intestinal Permeability Link Stress-Related Gut Microbiota Shifts to Mental Health Outcomes
Stress levels are surging, alongside the incidence of stress-related psychiatric disorders. Perhaps a related phenomenon, especially in urban areas, the human gut contains fewer bacterial species than ever before. Although the functional implications of this absence is unclear, one consequence may be reduced stress resilience. Preclinical and clinical evidence has shown how stress exposure can alter the gut microbiota and their metabolites, affecting host physiology. Also, stress-related shifts in the gut microbiota jeopardize tight junctions of the gut barrier. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 28, 2023 Category: Psychiatry Authors: Annelise A. Madison, Michael T. Bailey Tags: Review Source Type: research
Link Stress-Related Gut Microbiota Shifts to Mental Health Outcomes
Stress levels are surging, alongside the incidence of stress-related psychiatric disorders. Perhaps a related phenomenon, especially in urban areas, the human gut contains fewer bacterial species than ever before. Although the functional implications of this absence is unclear, one consequence may be reduced stress resilience. Preclinical and clinical evidence has shown how stress exposure can alter the gut microbiota and their metabolites, affecting host physiology. Also, stress-related shifts in the gut microbiota jeopardize tight junctions of the gut barrier. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 28, 2023 Category: Psychiatry Authors: Annelise A. Madison, Michael T. Bailey Tags: Review Source Type: research
Disengagement of somatostatin neurons from lateral septum circuitry by oxytocin and vasopressin restores social-fear extinction and suppresses aggression outbursts in Prader-Willi syndrome model
Responding to social signals by expressing the correct behavior is not only challenged in autism, but also in diseases with high prevalence of autism, like Prader-Willi Syndrome (PWS). Clinical evidence suggests aberrant pro-social behavior in patients can be regulated by intranasal oxytocin (OXT) or vasopressin (AVP). However, what neuronal mechanisms underlie impaired behavioral responses in a socially-aversive context, and how can they be corrected, remains largely unknown. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 27, 2023 Category: Psychiatry Authors: Yann Dromard, Am élie M. Borie, Prabahan Chakraborty, Françoise Muscatelli, Gilles Guillon, Michel G. Desarménien, Freddy Jeanneteau Tags: Archival Report Source Type: research
Brain Circuits Involved in Transcranial Magnetic Stimulation Response in Adults Are Connected to a Similar Prefrontal Target in Children
Functional magnetic resonance imaging connectivity measures have been used to identify and optimize brain circuit targets for neuromodulation treatments such as transcranial magnetic stimulation (TMS) and deep brain stimulation (1,2). This approach leverages interconnected brain networks to assess convergence across treatment modalities and datasets (3). For example, brain lesions causing depression and neuromodulation sites relieving depression functionally connect to a similar brain network across 14 independent datasets (4). (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 24, 2023 Category: Psychiatry Authors: Joseph J. Taylor, Stephan T. Palm, Alexander Li Cohen, Paul E. Croarkin, William Drew, Michael D. Fox, Shan Siddiqi Tags: Correspondence Source Type: research
A Protective Role of Low Polygenic Risk Score in Healthy Individuals Carrying Attention-Deficit/Hyperactivity Disorder –Associated Copy Number Variations
Previous studies have implicated both rare copy number variations (CNVs) and common variants in liability for attention-deficit/hyperactivity disorder (ADHD). However, how common and rare genetic variants jointly contribute to individual liability requires further investigation in larger cohorts. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 19, 2023 Category: Psychiatry Authors: Xiao Chang, Huiqi Qu, Yichuan Liu, Joseph Glessner, Hakon Hakonarson Tags: Archival Report Source Type: research
Depression in Alzheimer ’s disease: epidemiology, mechanisms, and treatment
Depression and Alzheimer's disease (AD) are substantial public health concerns. In the past decades, a link between two disease entities has received extensive acknowledgment, yet the complex nature of this relationship has demanded further clarification. Some evidence indicates that mid-life depression may be an AD risk factor, while a chronic course of depression in late life may be a precursor to or symptom of dementia. Recently, multiple pathophysiological mechanisms have been proposed to underlie the bidirectional relationship between depression and AD, including genetic predisposition, immune dysregulation, the accum...
Source: Biological Psychiatry - October 19, 2023 Category: Psychiatry Authors: Yu-Yuan Huang, Yi-Han Gan, Liu Yang, Wei Cheng, Jin-Tai Yu Tags: Review Source Type: research
A protective role of low polygenic risk score in healthy individuals carrying ADHD-associated CNVs
Previous studies have implicated both rare copy number variations (CNVs) and common variants in liability for Attention deficit hyperactivity disorder (ADHD). However, how common and rare genetic variants jointly contribute to individual liability requires further investigation in larger cohorts. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 19, 2023 Category: Psychiatry Authors: Xiao Chang, Huiqi Qu, Yichuan Liu, Joseph Glessner, Hakon Hakonarson Tags: Archival Report Source Type: research
5-HT1A Receptors on Dentate Gyrus Granule Cells Confer Stress Resilience
Hyperactivity of granule cells in the ventral dentate gyrus (vDG) promotes vulnerability to chronic stress. However, which receptors in the vDG could be targeted to inhibit this hyperactivity and confer stress resilience is not known. The serotonin 1A receptor (5-HT1AR) is a Gi protein –coupled inhibitory receptor that has been implicated in stress adaptation, anxiety, depression, and antidepressant responses. 5-HT1ARs are highly expressed in the DG, but their potential to promote stress resilience by regulating granule cell activity has never been examined. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 18, 2023 Category: Psychiatry Authors: John Gregory Bickle, Yifei Li, Amira Millette, Rushell Dixon, Serena Wu, Elena Carazo Arias, Victor Mari Luna, Christoph Anacker Tags: Archival Report Source Type: research
5HT1A receptors on dentate gyrus granule cells confer stress resilience
Hyperactivity of granule cells in the ventral dentate gyrus (vDG) promotes vulnerability to chronic stress. However, which receptors in the vDG could be targeted to inhibit this hyperactivity and confer stress resilience is not known. The serotonin 1A receptor (5HT1AR) is a Gi protein coupled inhibitory receptor that has been implicated in stress adaptation, anxiety, depression, and antidepressant responses. 5HT1ARs are highly expressed in the DG, but their potential to promote stress resilience by regulating granule cell activity has never been examined. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 18, 2023 Category: Psychiatry Authors: John Gregory Bickle, Yifei Li, Amira Millette, Rushell Dixon, Serena Wu, Elena Carazo Arias, Victor Mari Luna, Christoph Anacker Tags: Archival Report Source Type: research
Frontal Theta Helps to Explain Etiological Variability
Central tendency is overrated. Stereotyped, even. What are we missing when we neglect the breadth of data we collect? Like the adage of trash and treasure, sometimes noise is the signal. In a preregistered report in the current issue of Biological Psychiatry, Aydin et al. (1) describe a heritable noisiness in brain-behavior relationships involved in the etiology of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 16, 2023 Category: Psychiatry Authors: James F. Cavanagh Tags: Commentary Source Type: research
Linking Neurogenetics and Functional Connectivity in Autism
The large neurobiological heterogeneity of autism spectrum disorder (ASD) and its genetic diversity have challenged our ability to identify how genetic risk translates into changes of brain structure and function and, finally, into behavioral symptoms. Various lines of evidence, stemming from genetics (1,2), neuroimaging [reviewed in (3)], and behavioral phenotyping (4), have highlighted the subtle and multifactorial mechanisms underlying the disease, which have resulted in limited success developing novel therapeutics. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 16, 2023 Category: Psychiatry Authors: Michael Hawrylycz, Thomas Nickl-Jockschat Tags: Commentary Source Type: research
The East Asian –Specific Risk Genes in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a heterogeneous developmental disorder defined by deficits in social interaction or communication with restricted patterns of behaviors or interests. Previous reports have suggested that ASD has a strong genetic component, as shown by a higher concordance rate in monozygotic than dizygotic twins. Whole-genome sequencing or whole-exome sequencing (WES) has identified numerous rare inherited or de novo variants in ASD. Subsequent analyses, such as molecular pathway analysis, have uncovered that genes linked to synaptic function are important in the pathophysiology of ASD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 16, 2023 Category: Psychiatry Authors: Kota Tamada, Toru Takumi Tags: Commentary Source Type: research
In This Issue
Volume 94, Number 10, November 15, 2023 (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 16, 2023 Category: Psychiatry Tags: In This Issue Source Type: research
