NGF/TrkA promotes the vitality, migration and adhesion of bone marrow stromal cells in hypoxia by regulating the Nrf2 pathway
ConclusionsNGF/TrkA promoted the viability, migration and adhesion of BMSCs in IS via activating Nrf2 pathway. (Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - May 17, 2022 Category: Neurology Source Type: research

Alcohol binge drinking decreases brain glucose metabolism and functional connectivity in adolescent rats
This study utilized a binge drinking model in adolescent rats to examine effects on brain function as measured by brain glucose metabolism (BGluM). Following an injection of [18 FDG] fluro-2-deoxy-D-glucose, rats had voluntary access to either water or various concentrations of ethanol to obtain the following targeted doses: water (no ethanol), low dose ethanol (0.29  ± 0.03 g/kg), moderate dose ethanol (0.98 ± 0.05), and high dose ethanol (2.19 ± 0.23 g/kg). Rats were subsequently scanned using positron emission tomography. All three doses of ethanol were found to decrease BGluM in the restrosplenial cort...
Source: Metabolic Brain Disease - May 14, 2022 Category: Neurology Source Type: research

Neuroinflammatory responses following zinc or branched-chain amino acids supplementation in obese rats
AbstractThe excessive production of pro-inflammatory mediators, characteristic of obesity, leads to neuroinflammation. Zinc (Zn) and the branched-chain amino acids (BCAA) are supplements known for their immunomodulatory properties. Our goal was to evaluate if Zn or BCAA supplementation can affect long-term recognition memory and neuroinflammatory parameters of obese rats after a high-fat diet (HFD). Three-month-old Wistar rats were divided into six groups: Standard diet (SD)  + vehicle; SD + Zn; SD + BCAA; High-fat diet (HFD) + vehicle; HFD + Zn; and HFD + BCAA. Diets were administrated for 19 week...
Source: Metabolic Brain Disease - May 13, 2022 Category: Neurology Source Type: research

Asiatic acid attenuates aluminium chloride-induced behavioral changes, neuronal loss and astrocyte activation in rats
In conclusion, the study suggests that AA protects rat brain from Al neurotoxicity by inhibiting oxidative stress, neuronal loss and reactive astrogliosis. (Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - May 13, 2022 Category: Neurology Source Type: research

Neuroinflammatory responses following zinc or branched-chain amino acids supplementation in obese rats
AbstractThe excessive production of pro-inflammatory mediators, characteristic of obesity, leads to neuroinflammation. Zinc (Zn) and the branched-chain amino acids (BCAA) are supplements known for their immunomodulatory properties. Our goal was to evaluate if Zn or BCAA supplementation can affect long-term recognition memory and neuroinflammatory parameters of obese rats after a high-fat diet (HFD). Three-month-old Wistar rats were divided into six groups: Standard diet (SD)  + vehicle; SD + Zn; SD + BCAA; High-fat diet (HFD) + vehicle; HFD + Zn; and HFD + BCAA. Diets were administrated for 19 week...
Source: Metabolic Brain Disease - May 13, 2022 Category: Neurology Source Type: research

Asiatic acid attenuates aluminium chloride-induced behavioral changes, neuronal loss and astrocyte activation in rats
In conclusion, the study suggests that AA protects rat brain from Al neurotoxicity by inhibiting oxidative stress, neuronal loss and reactive astrogliosis. (Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - May 13, 2022 Category: Neurology Source Type: research

Putative involvement of sirtuin modulators in LPS-induced sickness behaviour in mice
This study investigates the inflammomodulatory pot ential of resveratrol (RES), a sirtuin activator and sirtinol (SIR), a sirtuin inhibitor in lipopolysaccharide (LPS)-induced model of sickness behaviour in mice. Male Swiss albino mice were divided into five groups (n = 6) consisting of saline (SAL), LPS, RES, SIR, and fluoxetine (FLU) respectiv ely, each group except LPS was prepared by intraperitoneally (i.p.) administration of SAL (10 mL/kg), RES (50 mg/kg), SIR (2 mg/kg) and FLU (10 mg/kg). Thirty minutes after the treatments, all the groups, except SAL were administered LPS (2 mg/kg, i.p.). The behavioural as...
Source: Metabolic Brain Disease - May 12, 2022 Category: Neurology Source Type: research

Basal metabolic rate and risk of multiple sclerosis: a Mendelian randomization study
AbstractTo determine the relationship between basal metabolic rate (BMR) and multiple sclerosis (MS) susceptibility, we analyzed genome-wide association study (GWAS) summary statistics data from the International Multiple Sclerosis Genetics Consortium on a total of 115,803 participants of European descent, including 47,429 patients with MS and 68,374 controls. We selected 378 independent genetic variants strongly associated with BMR in a GWAS involving 454,874 participants as instrumental variables to examine a potential causal relationship between BMR and MS. A genetically predicted higher BMR was associated with a greate...
Source: Metabolic Brain Disease - May 11, 2022 Category: Neurology Source Type: research

Emerging targets signaling for inflammation in Parkinson ’s disease drug discovery
AbstractParkinson ’s disease (PD) patients not only show motor features such as bradykinesia, tremor, and rigidity but also non-motor features such as anxiety, depression, psychosis, memory loss, attention deficits, fatigue, sexual dysfunction, gastrointestinal issues, and pain. Many pharmacological treatments are available for PD patients; however, these treatments are partially or transiently effective since they only decrease the symptoms. As these therapies are unable to restore dopaminergic neurons and stop the development of Parkinson's disease, therefore, the need for an effective therapeutic approach is required....
Source: Metabolic Brain Disease - May 10, 2022 Category: Neurology Source Type: research

Retraction Note to: Long non-coding RNA SNHG7 upregulates FGF9 to alleviate oxygen and glucose deprivation-induced neuron cell injury in a miR-134-5p-dependent manner
(Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - May 10, 2022 Category: Neurology Source Type: research

Emerging targets signaling for inflammation in Parkinson ’s disease drug discovery
AbstractParkinson ’s disease (PD) patients not only show motor features such as bradykinesia, tremor, and rigidity but also non-motor features such as anxiety, depression, psychosis, memory loss, attention deficits, fatigue, sexual dysfunction, gastrointestinal issues, and pain. Many pharmacological treatments are available for PD patients; however, these treatments are partially or transiently effective since they only decrease the symptoms. As these therapies are unable to restore dopaminergic neurons and stop the development of Parkinson's disease, therefore, the need for an effective therapeutic approach is required....
Source: Metabolic Brain Disease - May 10, 2022 Category: Neurology Source Type: research

Retraction Note to: Long non-coding RNA SNHG7 upregulates FGF9 to alleviate oxygen and glucose deprivation-induced neuron cell injury in a miR-134-5p-dependent manner
(Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - May 10, 2022 Category: Neurology Source Type: research