Hesperetin attenuates cognitive dysfunction via SIRT6/NLRP3 pathway in scopolamine-induced mice
In this study, the scopolamine (SCOP)-induced cognitive dysfunction in mice model was used to evaluate the neuroprotective effects of hesperetin. Behavioral tests (Morris water maze, open field, and novel object recognition tests) were conducted to evaluate the effect of hesperetin on cognitive dysfunction behaviors. Nissl staining and Immunofluorescence were used to evaluate hippocampal neuronal damage and microglial activation in mice. The levels of proinflammatory factors, oxidant stres s, and the cholinergic neurotransmitter were detected by real-time quantitative fluorescence PCR (RT-qPCR) or biochemical reagent kits....
Source: Metabolic Brain Disease - June 29, 2023 Category: Neurology Source Type: research
Transient neonatal hyperglycemia induces metabolic shifts in the rat hippocampus: a 1H NMR-based metabolomics analysis
AbstractDiabetes has been reported to induce brain metabolic disturbance, but the effect of transient neonatal hyperglycemia (TNH) on brain metabolism remains unclear. Herein the rats were treated with a single intraperitoneal injection of 100 µg/g body weight of streptozotocin within 12 h after birth and displayed a typical clinical characteristic of TNH. Then we used NMR-based metabolomics to examine the metabolic changes in the hippocampus between TNH and normal control (Ctrl) rats at postnatal 7 days (P7) and 21 days (P21). The re sults show that TNH rats had significantly increased levels of N-acetyl aspartate, gl...
Source: Metabolic Brain Disease - June 26, 2023 Category: Neurology Source Type: research
Jobelyn ® improves motor dysfunctions induced by haloperidol in mice via neuroprotective mechanisms relating to modulation of cAMP response-element binding protein and mitogen-activated protein kinase
This study was therefore designed to evaluate the effect of Jobelyn ® (JB), an antioxidant supplement, on haloperidol-induced motor dysfunctions and underlying molecular mechanisms in male Swiss mice. The animals were distributed into 5 groups (n = 8), and treated orally with distilled water (control), haloperidol (1 mg/kg) alone or in combination with each do se of JB (10, 20 and 40 mg/kg), daily for 14 days. Thereafter, changes in motor functions were evaluated on day 14. Brain biomarkers of oxidative stress, proinflammatory cytokines (tumor necrosis factor-alpha and interleukin-6), cAMP response-element binding p...
Source: Metabolic Brain Disease - June 22, 2023 Category: Neurology Source Type: research
Pharmacological targeting of coagulation factor XI attenuates experimental autoimmune encephalomyelitis in mice
AbstractMultiple sclerosis (MS) is the most common causes of non-traumatic disability in young adults worldwide. MS pathophysiologies include the formation of inflammatory lesions, axonal damage and demyelination, and blood brain barrier (BBB) disruption. Coagulation proteins, including factor (F)XII, can serve as important mediators of the adaptive immune response during neuroinflammation. Indeed, plasma FXII levels are increased during relapse in relapsing-remitting MS patients, and previous studies showed that reducing FXII levels was protective in a murine model of MS, experimental autoimmune encephalomyelitis (EAE). O...
Source: Metabolic Brain Disease - June 21, 2023 Category: Neurology Source Type: research
New insights on the potential effect of vinpocetine in Parkinson ’s disease: one of the neglected warden and baffling topics
In conclusion, this review indicated that VPN could be effective in the management of PD. (Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - June 19, 2023 Category: Neurology Source Type: research
Crosstalk between Alzheimer ’s disease and diabetes: a focus on anti-diabetic drugs
AbstractAlzheimer ’s disease (AD) and Type 2 diabetes mellitus (T2DM) are two of the most common age-related diseases. There is accumulating evidence of an overlap in the pathophysiological mechanisms of these two diseases. Studies have demonstrated insulin pathway alternation may interact with amyloid-β protein d eposition and tau protein phosphorylation, two essential factors in AD. So attention to the use of anti-diabetic drugs in AD treatment has increased in recent years. In vitro, in vivo, and clinical studies have evaluated possible neuroprotective effects of anti-diabetic different medicines in AD, wi th some pr...
Source: Metabolic Brain Disease - June 19, 2023 Category: Neurology Source Type: research
New insights on the potential effect of vinpocetine in Parkinson ’s disease: one of the neglected warden and baffling topics
In conclusion, this review indicated that VPN could be effective in the management of PD. (Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - June 19, 2023 Category: Neurology Source Type: research
Crosstalk between Alzheimer ’s disease and diabetes: a focus on anti-diabetic drugs
AbstractAlzheimer ’s disease (AD) and Type 2 diabetes mellitus (T2DM) are two of the most common age-related diseases. There is accumulating evidence of an overlap in the pathophysiological mechanisms of these two diseases. Studies have demonstrated insulin pathway alternation may interact with amyloid-β protein d eposition and tau protein phosphorylation, two essential factors in AD. So attention to the use of anti-diabetic drugs in AD treatment has increased in recent years. In vitro, in vivo, and clinical studies have evaluated possible neuroprotective effects of anti-diabetic different medicines in AD, wi th some pr...
Source: Metabolic Brain Disease - June 19, 2023 Category: Neurology Source Type: research
Neuroprotective effects of vitamin B1 on memory impairment and suppression of pro-inflammatory cytokines in traumatic brain injury
AbstractTraumatic Brain Injury (TBI) remains one of the prevailing disorders that affect millions of people around the globe. There is a cascade of secondary attributes attached to TBI including excitotoxicity, axonal degeneration, neuroinflammation, oxidative stress, and apoptosis. Neuroinflammation is caused due to the activation of microglia along with pro-inflammatory cytokines. The activation of microglia triggers TNF- α which sequentially results in the triggering and upregulation of NF-kB. The aim of the current research was to investigate vitamin B1’s potential as neuroprotective agent against TBI-induced neuroi...
Source: Metabolic Brain Disease - June 14, 2023 Category: Neurology Source Type: research
Correction to: Astrocyte ablation induced by La-aminoadipate (L-AAA) potentiates remyelination in a cuprizone demyelinating mouse model
(Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - June 13, 2023 Category: Neurology Source Type: research
