Integrated bioinformatics and network pharmacology identifying the mechanisms and molecular targets of Guipi Decoction for treatment of comorbidity with depression and gastrointestinal disorders
ConclusionWe found that GPD may regulate inflammatory and oxidative stress responses through EGF, PPARG, IL10 and CRP targets, and then be involved in the treatment of both depression and GI disorders. (Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - October 17, 2023 Category: Neurology Source Type: research
Potential neuroprotective effect of nanomicellar curcumin on learning and memory functions following subacute exposure to bisphenol A in adult male rats
AbstractBisphenol A (BPA) is an endocrine-disrupting chemical commonly utilized in the manufacture of plastics, which may cause damage to brain tissue. Curcumin is a phytochemical with protective effects against neurological and mental diseases. The purpose of this research was to evaluate whether nanomicellar curcumin (NmCur) might protect rats against BPA-induced learning and memory deficits. After determining the proper dose of BPA, the animals were randomly divided into 8 groups (8 rats in each group) receiving dextrose 5% (as vehicle of NmCur) (Dex), sesame oil (as vehicle of BPA) (Sea), Sea plus Dex, NmCur (50 mg/k...
Source: Metabolic Brain Disease - October 16, 2023 Category: Neurology Source Type: research
Regulation of oxygen –glucose deprivation/reperfusion-induced inflammatory responses and M1-M2 phenotype switch of BV2 microglia by lobetyolin
Abstract To elucidate the protective mechanism of lobetyolin on oxygen –glucose deprivation/reperfusion (OGD/R)-induced damage in BV2 microglial cells. The OGD/R model was established using a chemical modeling method to simulate in vivo brain ischemia in lobetyolin-pretreated BV2 cells. The optimum lobetyolin dosage, chemical concentration, and OGD/R modeling duratio n were screened. The changes in cell morphology were observed, and the levels of immune response-related factors, including tumor necrosis factor-α (TNF-α), interleukin-6, inducible nitric oxide synthase (iNOS), and cluster of differentiation (CD)206, ...
Source: Metabolic Brain Disease - October 14, 2023 Category: Neurology Source Type: research
Tramadol induces apoptosis, inflammation, and oxidative stress in rat choroid plexus
ConclusionsOur findings indicate that tramadol induces neurotoxicity in the CP via apoptosis, inflammation, and oxidative stress. (Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - October 13, 2023 Category: Neurology Source Type: research
The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction
AbstractDiabetes-associated cognitive dysfunction is linked to chronic hyperglycemia, oxidative stress, inflammation, cholinergic dysfunction, and neuronal degeneration. We investigated the antidiabetic and neuroprotective activity of a mixture ofSclerocarya birrea, Nauclea latifolia, andPiper longum (SNP) in type 2 diabetic (T2D) rat model-induced memory impairment. Fructose (10%) and streptozotocin (35 mg/kg) were used to induce T2D in male Wistar rats. Diabetic animals received distilled water, metformin (200 mg/kg), or SNP mixture (75, 150, or 300 mg/kg). HPLC–MS profiling of the mixture was performed. Behavioral...
Source: Metabolic Brain Disease - October 12, 2023 Category: Neurology Source Type: research
Intermittent fasting and Alzheimer's disease —Targeting ketone bodies as a potential strategy for brain energy rescue
AbstractAlzheimer's disease (AD) lacks effective clinical treatments. As the disease progresses, the cerebral glucose hypometabolism that appears in the preclinical phase of AD gradually worsens, leading to increasingly severe brain energy disorders. This review analyzes the brain energy deficit in AD and its etiology, brain energy rescue strategies based on ketone intervention, the effects and mechanisms of IF, the differences in efficacy between IF and ketogenic diet and the duality of IF. The evidence suggests that brain energy deficits lead to the development and progression of AD pathology. IF, which improves brain en...
Source: Metabolic Brain Disease - October 12, 2023 Category: Neurology Source Type: research
The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction
AbstractDiabetes-associated cognitive dysfunction is linked to chronic hyperglycemia, oxidative stress, inflammation, cholinergic dysfunction, and neuronal degeneration. We investigated the antidiabetic and neuroprotective activity of a mixture ofSclerocarya birrea, Nauclea latifolia, andPiper longum (SNP) in type 2 diabetic (T2D) rat model-induced memory impairment. Fructose (10%) and streptozotocin (35 mg/kg) were used to induce T2D in male Wistar rats. Diabetic animals received distilled water, metformin (200 mg/kg), or SNP mixture (75, 150, or 300 mg/kg). HPLC–MS profiling of the mixture was performed. Behavioral...
Source: Metabolic Brain Disease - October 12, 2023 Category: Neurology Source Type: research
Intermittent fasting and Alzheimer's disease —Targeting ketone bodies as a potential strategy for brain energy rescue
AbstractAlzheimer's disease (AD) lacks effective clinical treatments. As the disease progresses, the cerebral glucose hypometabolism that appears in the preclinical phase of AD gradually worsens, leading to increasingly severe brain energy disorders. This review analyzes the brain energy deficit in AD and its etiology, brain energy rescue strategies based on ketone intervention, the effects and mechanisms of IF, the differences in efficacy between IF and ketogenic diet and the duality of IF. The evidence suggests that brain energy deficits lead to the development and progression of AD pathology. IF, which improves brain en...
Source: Metabolic Brain Disease - October 12, 2023 Category: Neurology Source Type: research
Correction to: Rolipram and pentoxifylline combination ameliorates experimental diabetic neuropathy through inhibition of oxidative stress and inflammatory pathways in the dorsal root ganglion neurons
(Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - October 11, 2023 Category: Neurology Source Type: research
Correction to: Paeoniforin ameliorates cognitive impairment in Parkinson ’s disease via JNK/p53 signaling
(Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - October 7, 2023 Category: Neurology Source Type: research
