Crosstalk between Alzheimer ’s disease and diabetes: a focus on anti-diabetic drugs
AbstractAlzheimer ’s disease (AD) and Type 2 diabetes mellitus (T2DM) are two of the most common age-related diseases. There is accumulating evidence of an overlap in the pathophysiological mechanisms of these two diseases. Studies have demonstrated insulin pathway alternation may interact with amyloid-β protein d eposition and tau protein phosphorylation, two essential factors in AD. So attention to the use of anti-diabetic drugs in AD treatment has increased in recent years. In vitro, in vivo, and clinical studies have evaluated possible neuroprotective effects of anti-diabetic different medicines in AD, wi th some pr...
Source: Metabolic Brain Disease - June 19, 2023 Category: Neurology Source Type: research
New insights on the potential effect of vinpocetine in Parkinson ’s disease: one of the neglected warden and baffling topics
In conclusion, this review indicated that VPN could be effective in the management of PD. (Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - June 19, 2023 Category: Neurology Source Type: research
Crosstalk between Alzheimer ’s disease and diabetes: a focus on anti-diabetic drugs
AbstractAlzheimer ’s disease (AD) and Type 2 diabetes mellitus (T2DM) are two of the most common age-related diseases. There is accumulating evidence of an overlap in the pathophysiological mechanisms of these two diseases. Studies have demonstrated insulin pathway alternation may interact with amyloid-β protein d eposition and tau protein phosphorylation, two essential factors in AD. So attention to the use of anti-diabetic drugs in AD treatment has increased in recent years. In vitro, in vivo, and clinical studies have evaluated possible neuroprotective effects of anti-diabetic different medicines in AD, wi th some pr...
Source: Metabolic Brain Disease - June 19, 2023 Category: Neurology Source Type: research
Neuroprotective effects of vitamin B1 on memory impairment and suppression of pro-inflammatory cytokines in traumatic brain injury
AbstractTraumatic Brain Injury (TBI) remains one of the prevailing disorders that affect millions of people around the globe. There is a cascade of secondary attributes attached to TBI including excitotoxicity, axonal degeneration, neuroinflammation, oxidative stress, and apoptosis. Neuroinflammation is caused due to the activation of microglia along with pro-inflammatory cytokines. The activation of microglia triggers TNF- α which sequentially results in the triggering and upregulation of NF-kB. The aim of the current research was to investigate vitamin B1’s potential as neuroprotective agent against TBI-induced neuroi...
Source: Metabolic Brain Disease - June 14, 2023 Category: Neurology Source Type: research
Correction to: Astrocyte ablation induced by La-aminoadipate (L-AAA) potentiates remyelination in a cuprizone demyelinating mouse model
(Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - June 13, 2023 Category: Neurology Source Type: research
Integrated pathway and network analyses of metabolomic alterations in peripheral blood of patients with depression
The objective of this study was to integrate metabolomic changes to reveal the underlying molecular alternations of depression. We retrieved altered metabolites in the blood of patients with depression from the MENDA database. Pathway analysis was conducted to explore enriched pathways based on candidate metabolites. Pathway crosstalk analysis was performed to explore potential correlations of these enriched pathways, base d on their shared candidate metabolites. Moreover, potential interactions of candidate metabolites with other biomolecules such as proteins were assessed by network analysis. A total of 854 differenti...
Source: Metabolic Brain Disease - June 10, 2023 Category: Neurology Source Type: research
Therapeutic potential of endoplasmic reticulum stress inhibitors in the treatment of diabetic peripheral neuropathy
AbstractEndoplasmic stress response, the unfolded protein response (UPR), is a homeostatic signaling pathway comprising transmembrane sensors that get activated upon alterations in ER luminal environment. Studies suggest a relation between activated UPR pathways and several disease states such as Parkinson, Alzheimer, inflammatory bowel disease, tumor growth, and metabolic syndrome. Diabetic peripheral neuropathy (DPN), a common microvascular complication of diabetes-related chronic hyperglycemia, causes chronic pain, loss of sensation, foot ulcers, amputations, allodynia, hyperalgesia, paresthesia, and spontaneous pain. F...
Source: Metabolic Brain Disease - June 8, 2023 Category: Neurology Source Type: research
Repurposing Niclosamide as a plausible neurotherapeutic in autism spectrum disorders, targeting mitochondrial dysfunction: a strong hypothesis
AbstractAutism Spectrum Disorders (ASD) are a complex set of neurodevelopmental manifestations which present in the form of social and communication deficits. Affecting a growing proportion of children worldwide, the exact pathogenesis of this disorder is not very well understood, and multiple signaling pathways have been implicated. Among them, the ERK/MAPK pathway is critical in a number of cellular processes, and the normal functioning of neuronal cells also depends on this cascade. As such, recent studies have increasingly focused on the impact this pathway has on the development of autistic symptoms. Improper ERK sign...
Source: Metabolic Brain Disease - June 7, 2023 Category: Neurology Source Type: research
Deregulation of NF- κB associated long non-coding RNAs in bipolar disorder
AbstractLong non-coding RNAs (lncRNAs) are major genetic factors whose disruption lead to many diseases, including nervous system diseases. Bipolar disorder (BD) is a neuro-psychiatric disease with no definitive diagnosis and incomplete treatment. Regarding the role of NF- κB-associated lncRNAs in the neuro-psychiatric disorders, we examined the expression of three lncRNAs, DICER1-AS1, DILC, and CHAST, in BD patients. To assess lncRNA expression in peripheral blood mononuclear cells (PBMCs) of 50 BD patients and 50 healthy individuals, Real-time PCR was used. Additio nally, some clinical characteristics of BD patients wer...
Source: Metabolic Brain Disease - June 6, 2023 Category: Neurology Source Type: research
