Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain metastasis in NSCLC via synergistically promoting microglia M1 polarization
CONCLUSIONS: Our study revealed that targeting the MIF-CD74 axis promoted microglia M1 polarization and synergized with radiotherapy for brain metastasis in NSCLC.PMID:38685050 | DOI:10.1186/s13046-024-03024-9 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Lichao Liu Jian Wang Ying Wang Lingjuan Chen Ling Peng Yawen Bin Peng Ding Ruiguang Zhang Fan Tong Xiaorong Dong Source Type: research
Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain metastasis in NSCLC via synergistically promoting microglia M1 polarization
CONCLUSIONS: Our study revealed that targeting the MIF-CD74 axis promoted microglia M1 polarization and synergized with radiotherapy for brain metastasis in NSCLC.PMID:38685050 | DOI:10.1186/s13046-024-03024-9 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Lichao Liu Jian Wang Ying Wang Lingjuan Chen Ling Peng Yawen Bin Peng Ding Ruiguang Zhang Fan Tong Xiaorong Dong Source Type: research
The multifaceted functions of long non-coding RNA < em > HOTAIR < /em > in neuropathologies and its potential as a prognostic marker and therapeutic biotarget
The objective of this review is to recapitulate all the relevant data pertaining to the regulatory roles of HOTAIR in neuronal (patho)physiology. To this end, we discuss the pathogenic mechanisms of HOTAIR in multiple neuronal diseases, such as neurodegeneration, traumatic brain injury and neuropsychiatric disorders. Finally, we also summarize the results from the studies incriminating HOTAIR in the pathogeneses of gliomas and other brain cancers. Implications of HOTAIR serving as a suitable therapeutic target in neuropathologies are also discussed.PMID:38682637 | DOI:10.1017/erm.2024.11 (Source: Molecular Medicine)
Source: Molecular Medicine - April 29, 2024 Category: Molecular Biology Authors: Faraz Ahmad Ravi Sudesh Atheeq Toufeeq Ahmed Mohanapriya Arumugam Darin Mansor Mathkor Shafiul Haque Source Type: research
How Does the Number of Brain Metastases Correlate With Normal Brain Exposure in Single-Isocenter Multitarget Multifraction Stereotactic Radiosurgery
CONCLUSIONS: Based on clinical SRT plans, our study provides information on correlations between normal brain exposure and the number and total volume of targets. As SRT becomes more greatly used for patients with increasingly extensive brain metastases, more clinical data on outcomes and toxicities is necessary to better define the normal brain dose constraints for high-exposure cases and to optimize the SRT management for those patients.PMID:38681891 | PMC:PMC11047183 | DOI:10.1016/j.adro.2024.101499 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Dandan Zheng Jihyung Yoon Hyunuk Jung Olga Maria Dona Lemus Lang Gou Yuwei Zhou Kenneth Y Usuki Sara Hardy Michael T Milano Source Type: research
Unique genomic alterations in the circulating tumor DNA of patients with solid tumors brain metastases
CONCLUSIONS: This study illustrates the feasibility of detecting alterations from ctDNA among patients with BrMs. A higher frequency of actionable mutations was observed in ctDNA in patients with BrMs. Additional studies comparing ctDNA and alterations in BrMs tissue are needed to determine if ctDNA can be considered a surrogate to support treatment decisions.PMID:38680992 | PMC:PMC11046982 | DOI:10.1093/noajnl/vdae052 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Laura Alder Gloria Broadwater Michelle Green Amanda E D Van Swearingen Eric S Lipp Jeffrey Melson Clarke Carey K Anders Sarah Sammons Source Type: research
A phase I dose-escalation study of pulsatile afatinib in patients with recurrent or progressive brain cancer
CONCLUSIONS: Afatinib taken orally was safe and well-tolerated up to 280 mg every 7 days in brain cancer patients.PMID:38680990 | PMC:PMC11046985 | DOI:10.1093/noajnl/vdae049 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Tiffany M Juarez Jaya M Gill Annie Heng Jose A Carrillo Naveed Wagle Natsuko Nomura Minhdan Nguyen Judy Truong Lucia Dobrawa Walavan Sivakumar Garni Barkhoudarian Daniel F Kelly Santosh Kesari Source Type: research
[11C]-methionine positron emission tomography in the evaluation of pediatric low-grade gliomas
CONCLUSIONS: Our study shows that [11C]-MET-PET reliably characterizes new and previously treated pLGGs. Our study also shows that quantitative parameters tend to decrease with treatment, and differences may exist between various pLGG types.PMID:38680989 | PMC:PMC11055465 | DOI:10.1093/noajnl/vdae056 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Emily Y Kim Amy L Vavere Scott E Snyder Jason Chiang Yimei Li Tushar Patni Ibrahim Qaddoumi Thomas E Merchant Giles W Robinson Joseph L Holtrop Barry L Shulkin Asim K Bag Source Type: research
Enhanced therapeutic efficacy for glioblastoma immunotherapy with an oncolytic herpes simplex virus armed with anti-PD-1 antibody and IL-12
In this study, we developed a new generation of oncolytic herpes simplex virus C5252 by deletion of a 15-kb internal repeat region and both copies of γ34.5 genes. Additionally, C5252 was armed with anti-programmed cell death protein 1 antibody and interleukin-12 to enhance its therapeutic efficacy for glioblastoma immune-virotherapy. In vitro and in vivo experiments demonstrate that C5252 has a remarkable safety profile and potent anti-tumor activity against glioblastoma. Mechanistic studies demonstrated that C5252 specifically induces cell apoptosis by caspase-3/7 activation via downregulating ciliary neurotrophic factor...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Lei Wang Xusha Zhou Xiaoqing Chen Yuanyuan Liu Yue Huang Yuan Cheng Peigen Ren Jing Zhao Grace Guoying Zhou Source Type: research
Roles of TRPM channels in glioma
Cancer Biol Ther. 2024 Dec 31;25(1):2338955. doi: 10.1080/15384047.2024.2338955. Epub 2024 Apr 29.ABSTRACTGliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central nervous system (CNS). Gliomas are characterized by high malignancy, heterogeneity, invasiveness, and high resistance to radiotherapy and chemotherapy. It is urgent to find potential new molecular targets for glioma. The TRPM channels consist of TRPM1-TPRM8 and play a role in many cellular functions, including proliferation, migration, invasion, angiogenesis, etc. ...
Source: Cancer Biology and Therapy - April 29, 2024 Category: Cancer & Oncology Authors: Zhigang Chen Han Xie Jun Liu JiaJia Zhao Ruixiang Huang Yufei Xiang Haoyuan Wu Dasheng Tian Erbao Bian Zhang Xiong Source Type: research
A review of natural products and small-molecule therapeutics acting on central nervous system malignancies: Approaches for drug development, targeting pathways, clinical trials, and challenges
Drug Dev Res. 2024 May;85(3):e22180. doi: 10.1002/ddr.22180.ABSTRACTIn 2021, the World Health Organization released the fifth edition of the central nervous system (CNS) tumor classification. This classification uses histopathology and molecular pathogenesis to group tumors into more biologically and molecularly defined entities. The prognosis of brain cancer, particularly malignant tumors, has remained poor worldwide, approximately 308,102 new cases of brain and other CNS tumors were diagnosed in the year 2020, with an estimated 251,329 deaths. The cost and time-consuming nature of studies to find new anticancer agents ma...
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Ardalan Pasdaran Irwin Darren Grice Azadeh Hamedi Source Type: research
Methyl jasmonate ameliorates pain ‐induced learning and memory impairments through regulating the expression of genes involved in neuroinflammation
ConclusionsThese findings highlight the notable antinociceptive potential of MeJA and its ability to inhibit pain-induced learning and memory dysfunction through its anti-inflammatory effect. (Source: Brain and Behavior)
Source: Brain and Behavior - April 29, 2024 Category: Neurology Authors: Fatemeh Mohammadinia,
Saeed Esmaeili ‐Mahani,
Mehdi Abbasnejad,
Manijeh Dogani,
Ali Mohammad Poorrahimi Tags: ORIGINAL ARTICLE Source Type: research
Two-headed UNetEfficientNets for parallel execution of segmentation and classification of brain tumors: incorporating postprocessing techniques with connected component labelling
ConclusionOur study demonstrates the high efficiency and accuracy of the proposed UNetEfficientNet-B4 model in the automatic and parallel detection and segmentation of brain tumors from MRI images. This approach holds promise for improving diagnosis and treatment planning for patients with brain tumors, potentially leading to better outcomes and prognosis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 29, 2024 Category: Cancer & Oncology Source Type: research
Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors
While the excessive inflammation in cancer cachexia is well-known to be induced by the overproduction of inflammatory mediators in the periphery, microflora disruption and brain dysfunction are also considered... (Source: Molecular Brain)
Source: Molecular Brain - April 29, 2024 Category: Neuroscience Authors: Yukari Suda, Keiko Nakamura, Fukiko Matsuyama, Yusuke Hamada, Hitoshi Makabe, Michiko Narita, Yasuyuki Nagumo, Tomohisa Mori, Naoko Kuzumaki and Minoru Narita Tags: Research Source Type: research
Clinico –pathologic factors and survival of patients with breast cancer diagnosed with de novo brain metastasis: a national cancer database analysis
ConclusionsThis analysis suggests that treatment of systemic disease is the major factor influencing survival in patients with BCBM. Moreover, targeted therapy with anti –HER2 increased survival when added to systemic therapy explaining the highest median OS noted in the Triple Positive subgroup. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 29, 2024 Category: Cancer & Oncology Source Type: research
Advanced diffusion MRI provides evidence for altered axonal microstructure and gradual peritumoral infiltration in GBM in comparison to brain metastases
ConclusionOur findings provide evidence of gradual alterations within the peritumoral zone of brain tumors. These are compatible with predominant (vasogenic) edema formation in metastases, whereas our findings in GBM are in line with an axonal destructive component in the immediate peritumoral area and evidence of tumor cell infiltration with accentuation in the tumor ’s vicinity. (Source: Clinical Neuroradiology)
Source: Clinical Neuroradiology - April 29, 2024 Category: Neurology Source Type: research
