Neural circuit analysis using a novel intersectional split intein-mediated split-Cre recombinase system
The defining features of a neuron are its functional and anatomical connections with thousands of other neurons in the brain. Together, these neurons form functional networks that direct animal behavior. Curre... (Source: Molecular Brain)
Source: Molecular Brain - July 2, 2020 Category: Neuroscience Authors: Audrey Tze Ting Khoo, Paul Jong Kim, Ho Min Kim and H. Shawn Je Tags: Methodology Source Type: research

Peripheral nerve injury reduces the excitation-inhibition balance of basolateral amygdala inputs to prelimbic pyramidal neurons projecting to the periaqueductal gray
Cellular and synaptic mechanisms underlying how chronic pain induces maladaptive alterations to local circuits in the medial prefrontal cortex (mPFC), while emerging, remain unresolved. Consistent evidence sho... (Source: Molecular Brain)
Source: Molecular Brain - June 29, 2020 Category: Neuroscience Authors: John Cheriyan and Patrick L. Sheets Tags: Micro report Source Type: research

Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex
The serotonin (5-HT) system is the target of multiple anxiolytics, including Buspirone, which is a partial agonist of the serotonin 1A receptor (5-HT1A). Similarly, ligands of the serotonin 2A receptor (5-HT2A... (Source: Molecular Brain)
Source: Molecular Brain - June 29, 2020 Category: Neuroscience Authors: Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, D ébora Jacky and Anna Beyeler Tags: Research Source Type: research

Effects of interferon-alpha on hippocampal neurogenesis and behavior in common marmosets
In many mammalian species, the production of new neurons in the hippocampal dentate gyrus continues throughout life. Previous studies using rodents suggest that adult-born neurons are involved in memory and co... (Source: Molecular Brain)
Source: Molecular Brain - June 26, 2020 Category: Neuroscience Authors: Naoko Kaneko, Sayuri Nakamura and Kazunobu Sawamoto Tags: Micro report Source Type: research

Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury
Effective treatment of high-impact pain patients is one of the major stated goals of the National Pain Strategy in the United States. Identification of new targets and mechanisms underlying neuropathic pain wi... (Source: Molecular Brain)
Source: Molecular Brain - June 22, 2020 Category: Neuroscience Authors: Aubin Moutal, Yingshi Ji, Shreya Sai Bellampalli and Rajesh Khanna Tags: Research Source Type: research

Genetic associations between voltage-gated calcium channels and autism spectrum disorder: a systematic review
The present review systematically summarized existing publications regarding the genetic associations between voltage-gated calcium channels (VGCCs) and autism spectrum disorder (ASD). (Source: Molecular Brain)
Source: Molecular Brain - June 22, 2020 Category: Neuroscience Authors: Xiaoli Liao and Yamin Li Tags: Review Source Type: research

Selective inhibition of neuronal Cav3.3 T-type calcium channels by TAT-based channel peptide
Low-voltage-activated Cav3 calcium channels (T-type) play an essential role in the functioning of the nervous system where they support oscillatory activities that relie on several channel molecular determinants ... (Source: Molecular Brain)
Source: Molecular Brain - June 19, 2020 Category: Neuroscience Authors: Leos Cmarko and Norbert Weiss Tags: Micro report Source Type: research

Receptor protein tyrosine phosphatase delta is not essential for synapse maintenance or transmission at hippocampal synapses
Members of the leukocyte common antigen-related receptor protein tyrosine phosphatase (LAR-RPTP) family, comprising PTP σ, PTPδ and LAR, are key hubs for presynaptic assembly and differentiation in vertebrate n... (Source: Molecular Brain)
Source: Molecular Brain - June 17, 2020 Category: Neuroscience Authors: Kyung Ah Han, Hee-Yoon Lee, Dongseok Lim, Jungsu Shin, Taek Han Yoon, Xinran Liu, Ji Won Um, Se-Young Choi and Jaewon Ko Tags: Research Source Type: research

Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression
Accumulating evidence implicates dysregulation of hippocampal synaptic plasticity in the pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and their contribution to its mec... (Source: Molecular Brain)
Source: Molecular Brain - June 16, 2020 Category: Neuroscience Authors: Lily R. Aleksandrova, Yu Tian Wang and Anthony G. Phillips Tags: Research Source Type: research

Intraventricular IL-17A administration activates microglia and alters their localization in the mouse embryo cerebral cortex
Viral infection during pregnancy has been suggested to increase the probability of autism spectrum disorder (ASD) in offspring via the phenomenon of maternal immune activation (MIA). This has been modeled in r... (Source: Molecular Brain)
Source: Molecular Brain - June 16, 2020 Category: Neuroscience Authors: Tetsuya Sasaki, Saki Tome and Yosuke Takei Tags: Short report Source Type: research

The BDNF-FoxO1 Axis in the medial prefrontal cortex modulates depressive-like behaviors induced by chronic unpredictable stress in postpartum female mice
Postpartum depression (PPD) is a serious psychiatric disorder, affecting not only the childbearing women but also the health of their offsprings. The brain-derived neurotrophic factor (Bdnf) gene is an important ... (Source: Molecular Brain)
Source: Molecular Brain - June 12, 2020 Category: Neuroscience Authors: Jing Liu, Fantao Meng, Juanjuan Dai, Min Wu, Wentao Wang, Cuilan Liu, Di Zhao, Hongcai Wang, Jingyan Zhang and Chen Li Tags: Research Source Type: research

Drp1 is widely, yet heterogeneously, distributed in the mouse central nervous system
Drp1 is widely expressed in the mouse central nervous system and plays a role in inducing the mitochondrial fission process. Many diseases are associated with Drp1 and mitochondria. However, since the exact di... (Source: Molecular Brain)
Source: Molecular Brain - June 10, 2020 Category: Neuroscience Authors: Ting-Ting Luo, Chun-Qiu Dai, Jia-Qi Wang, Zheng-Mei Wang, Yi Yang, Kun-Long Zhang, Fei-Fei Wu, Yan-Ling Yang and Ya-Yun Wang Tags: Research Source Type: research

Cx3cr1CreERT2-driven Atg7 deletion in adult mice induces intestinal adhesion
Microglia are macrophages resident in the central nervous system. C-X3-C motif chemokine receptor 1 (CX3CR1) is a G αi-coupled seven-transmembrane protein exclusively expressed in the mononuclear phagocyte system ... (Source: Molecular Brain)
Source: Molecular Brain - June 8, 2020 Category: Neuroscience Authors: Younghwan Lee, Ji-Won Lee, Hyeri Nam and Seong-Woon Yu Tags: Micro report Source Type: research

Reduced free ubiquitin levels and proteasome activity in cultured neurons and brain tissues treated with amyloid beta aggregates
Neurodegenerative diseases are characterized by progressive cognitive decline and the loss of neurons in the central nervous system; many are also characterized by abnormal aggregation of misfolded proteins. U... (Source: Molecular Brain)
Source: Molecular Brain - June 8, 2020 Category: Neuroscience Authors: Chul-Woo Park, Byung-Kwon Jung and Kwon-Yul Ryu Tags: Micro report Source Type: research

The DISC1 R264Q variant increases affinity for the dopamine D2 receptor and increases GSK3 activity
The Disrupted in schizophrenia 1 (DISC1) gene encodes a scaffolding protein that is involved in many neural functions such as neurogenesis, neural differentiation, embryonic neuron migration and neurotransmitter ... (Source: Molecular Brain)
Source: Molecular Brain - June 3, 2020 Category: Neuroscience Authors: Ping Su, Hailong Zhang, Albert H. C. Wong and Fang Liu Tags: Research Source Type: research

Propionic acid induces dendritic spine loss by MAPK/ERK signaling and dysregulation of autophagic flux
Propionic acid (PPA) is a short-chain fatty acid that is an important mediator of cellular metabolism. It is also a by-product of human gut enterobacteria and a common food preservative. A recent study found t... (Source: Molecular Brain)
Source: Molecular Brain - June 2, 2020 Category: Neuroscience Authors: Hyosun Choi, In Sik Kim and Ji Young Mun Tags: Research Source Type: research

Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression
Genetic and epigenetic factors contribute to the development of the spinal cord. Failure in correct exertion of the developmental programs, including neurulation, neural tube closure and neurogenesis of the di... (Source: Molecular Brain)
Source: Molecular Brain - May 29, 2020 Category: Neuroscience Authors: Angelica Gray de Cristoforis, Francesco Ferrari, Fr édéric Clotman and Tanja Vogel Tags: Research Source Type: research

Clozapine generates obsessive compulsive disorder-like behavior in mice
Clozapine is thought to induce obsessive compulsive symptoms (OCS) in schizophrenic patients. However, because OCS are often comorbid with schizophrenia regardless of clozapine treatment, it remains unclear wh... (Source: Molecular Brain)
Source: Molecular Brain - May 29, 2020 Category: Neuroscience Authors: Shinwon Kang, Hyun Jong Noh, Soo Hyeon Bae, Yong-Seok Kim, Hogun Lew, Jisoo Lim, Se Joo Kim, Kyung Sue Hong, Jong-Cheol Rah and Chul Hoon Kim Tags: Micro report Source Type: research

Pathological alterations in striatal compartments in the human brain of autism spectrum disorder
The striatum comprises a mosaic structure of striosomal and matrix compartments. Imbalanced neuronal activity between striosomes and matrix is implicated in neurological deficits in psychomotor and limbic func... (Source: Molecular Brain)
Source: Molecular Brain - May 27, 2020 Category: Neuroscience Authors: Hsiao-Ying Kuo and Fu-Chin Liu Tags: Micro report Source Type: research

Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2  J mice
Glaucoma is the leading cause of irreversible vision loss. Ocular hypertension is a major risk factor for glaucoma and recent work has demonstrated critical early neuroinflammatory insults occur in the optic n... (Source: Molecular Brain)
Source: Molecular Brain - May 25, 2020 Category: Neuroscience Authors: James R. Tribble, Jeffrey M. Harder, Pete A. Williams and Simon W. M. John Tags: Research Source Type: research

Exome sequencing study revealed novel susceptibility loci in subarachnoid hemorrhage (SAH)
To expand our current understanding of the genetic basis of subarachnoid hemorrhage (SAH), and reveal the susceptibility genes in SAH risk. (Source: Molecular Brain)
Source: Molecular Brain - May 25, 2020 Category: Neuroscience Authors: Xiwa Hao, Jiangxia Pang, Ruiming Li, Lin Lv, Guorong Liu, Yuechun Li, Guojuan Cheng and Jingfen Zhang Tags: Research Source Type: research

Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities
Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome, a rare congenital anomaly syndrome characterized by intellectual disability, brain malformation, facial dysmorphism, musculoskeletal abnormalities, and some visceral ... (Source: Molecular Brain)
Source: Molecular Brain - May 24, 2020 Category: Neuroscience Authors: Masashi Ueda, Tohru Matsuki, Masahide Fukada, Shima Eda, Akie Toya, Akio Iio, Hidenori Tabata and Atsuo Nakayama Tags: Research Source Type: research

A two-compartment model of synaptic computation and plasticity
The synapse is typically viewed as a single compartment, which acts as a linear gain controller on incoming input. Traditional plasticity rules enable this gain control to be dynamically optimized by Hebbian a... (Source: Molecular Brain)
Source: Molecular Brain - May 20, 2020 Category: Neuroscience Authors: Rudi Tong, Nigel J. Emptage and Zahid Padamsey Tags: Review Source Type: research

Foetal neural progenitors contribute to postnatal circuits formation ex vivo: an electrophysiological investigation
Neuronal progenitor cells (NPC) play an essential role in homeostasis of the central nervous system (CNS). Considering their ability to differentiate into specific lineages, their manipulation and control coul... (Source: Molecular Brain)
Source: Molecular Brain - May 19, 2020 Category: Neuroscience Authors: Matteo Manzati, Teresa Sorbo, Michele Giugliano and Laura Ballerini Tags: Micro report Source Type: research

Frameshift peptides alter the properties of truncated FUS proteins in ALS-FUS
Mutations in the FUS gene cause a subset of ALS cases (ALS-FUS). The majority of FUS mutations are missense mutations affecting the nuclear localisation signal (NLS) of FUS. In addition, a number of frameshift mu... (Source: Molecular Brain)
Source: Molecular Brain - May 13, 2020 Category: Neuroscience Authors: Haiyan An, Camille Rabesahala de Meritens, Vladimir L. Buchman and Tatyana A. Shelkovnikova Tags: Micro report Source Type: research

Endoplasmic reticulum retention and degradation of a mutation in SLC6A1 associated with epilepsy and autism
Mutations in SLC6A1, encoding γ-aminobutyric acid (GABA) transporter 1 (GAT-1), have been recently associated with a spectrum of epilepsy syndromes, intellectual disability and autism in clinic. However, the path... (Source: Molecular Brain)
Source: Molecular Brain - May 12, 2020 Category: Neuroscience Authors: Jie Wang, Sarah Poliquin, Felicia Mermer, Jaclyn Eissman, Eric Delpire, Juexin Wang, Wangzhen Shen, Kefu Cai, Bing-Mei Li, Zong-Yan Li, Dong Xu, Gerald Nwosu, Carson Flamm, Wei-Ping Liao, Yi-Wu Shi and Jing-Qiong Kang Tags: Research Source Type: research

1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain
Chronic pain can be the result of an underlying disease or condition, medical treatment, inflammation, or injury. The number of persons experiencing this type of pain is substantial, affecting upwards of 50 mi... (Source: Molecular Brain)
Source: Molecular Brain - May 11, 2020 Category: Neuroscience Authors: Yuan Zhou, Song Cai, Kimberly Gomez, E. M. Kithsiri Wijeratne, Yingshi Ji, Shreya S. Bellampalli, Shizhen Luo, Aubin Moutal, A. A. Leslie Gunatilaka and Rajesh Khanna Tags: Research Source Type: research

Altered behavior in mice overexpressing soluble ST2
Psychoneuroimmunological studies have clearly demonstrated that both cellular and humoral immunity are related to major depression. Soluble ST2 is regarded as a key molecule regulating immune system as well as... (Source: Molecular Brain)
Source: Molecular Brain - May 11, 2020 Category: Neuroscience Authors: Motoshi Kikuchi, Kenkichi Takase, Morisada Hayakawa, Hiroko Hayakawa, Shin-ichi Tominaga and Tsukasa Ohmori Tags: Research Source Type: research

Reduced complement of dopaminergic neurons in the substantia nigra pars compacta of mice with a constitutive “low footprint” genetic knockout of alpha-synuclein
Previous studies of the alpha-synuclein null mutant mice on the C57Bl6 genetic background have revealed reduced number of dopaminergic neurons in their substantia nigra pars compacta (SNpc). However, the prese... (Source: Molecular Brain)
Source: Molecular Brain - May 11, 2020 Category: Neuroscience Authors: Valeria V. Goloborshcheva, Kirill D. Chaprov, Ekaterina V. Teterina, Ruslan Ovchinnikov and Vladimir L. Buchman Tags: Micro report Source Type: research

RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection
Prion diseases and prion-like disorders, including Alzheimer ’s disease and Parkinson’s disease, are characterized by gliosis and accumulation of misfolded aggregated host proteins. Ablating microglia in prion-... (Source: Molecular Brain)
Source: Molecular Brain - May 7, 2020 Category: Neuroscience Authors: James A. Carroll, Brent Race, Katie Williams, James Striebel and Bruce Chesebro Tags: Research Source Type: research

Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory
Inositol phosphate metabolism has emerged as one of the key players in synaptic transmission. Previous studies have shown that the deletion of inositol hexakisphosphate kinase 1 (IP6K1), which is responsible f... (Source: Molecular Brain)
Source: Molecular Brain - May 7, 2020 Category: Neuroscience Authors: Min-Gyu Kim, Seungjae Zhang, Hoyong Park, Seung Ju Park, Seyun Kim and ChiHye Chung Tags: Micro report Source Type: research

Frequency-dependent gating of feedforward inhibition in thalamofrontal synapses
Thalamic recruitment of feedforward inhibition is known to enhance the fidelity of the receptive field by limiting the temporal window during which cortical neurons integrate excitatory inputs. Feedforward inh... (Source: Molecular Brain)
Source: Molecular Brain - May 6, 2020 Category: Neuroscience Authors: Jungmin Lee, Joon Ho Choi and Jong-Cheol Rah Tags: Research Source Type: research

Autophagy pathway upregulation in a human iPSC-derived neuronal model of Cohen syndrome with VPS13B missense mutations
Significant clinical symptoms of Cohen syndrome (CS), a rare autosomal recessive disorder, include intellectual disability, facial dysmorphism, postnatal microcephaly, retinal dystrophy, and intermittent neutr... (Source: Molecular Brain)
Source: Molecular Brain - May 6, 2020 Category: Neuroscience Authors: You-Kyung Lee, Soo-Kyeong Lee, Suin Choi, Yang Hoon Huh, Ji-Hye Kwak, Yong-Seok Lee, Deok-Jin Jang, Jae-Hyung Lee, Kyungmin Lee, Bong-Kiun Kaang, Chae-Seok Lim and Jin-A Lee Tags: Micro report Source Type: research

Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish
Attention deficit-hyperactivity disorder (ADHD) is a prevalent neuropsychiatric disorder found in children. It is characterized by inattention, hyperactivity, and impulsivity. Methylphenidate (MPH) and atomoxe... (Source: Molecular Brain)
Source: Molecular Brain - May 6, 2020 Category: Neuroscience Authors: Shiho Suzuki, Ryo Kimura, Shingo Maegawa, Masatoshi Nakata and Masatoshi Hagiwara Tags: Micro report Source Type: research

Afferents of the mouse linear nucleus
The linear nucleus (Li) was identified in 1978 from its projections to the cerebellum. However, there is no systematic study of its connections with other areas of the central nervous system possibly due to th... (Source: Molecular Brain)
Source: Molecular Brain - May 5, 2020 Category: Neuroscience Authors: Huazheng Liang and George Paxinos Tags: Research Source Type: research

PDK1 regulates the survival of the developing cortical interneurons
Inhibitory interneurons are critical for maintaining the excitatory/inhibitory balance. During the development cortical interneurons originate from the ganglionic eminence and arrive at the dorsal cortex throu... (Source: Molecular Brain)
Source: Molecular Brain - May 4, 2020 Category: Neuroscience Authors: Yongjie Wei, Xiaoning Han and Chunjie Zhao Tags: Research Source Type: research

Axl receptor tyrosine kinase is a regulator of apolipoprotein E
Alzheimer ’s disease (AD), the leading cause of dementia, is a chronic neurodegenerative disease. Apolipoprotein E (apoE), which carries lipids in the brain in the form of lipoproteins, plays an undisputed role... (Source: Molecular Brain)
Source: Molecular Brain - May 4, 2020 Category: Neuroscience Authors: Wenchen Zhao, Jianjia Fan, Iva Kulic, Cheryl Koh, Amanda Clark, Johan Meuller, Ola Engkvist, Samantha Barichievy, Carina Raynoschek, Ryan Hicks, Marcello Maresca, Qi Wang, Dean G. Brown, Alvin Lok, Cameron Parro, Jerome Robert & hellip; Tags: Research Source Type: research

CCR2 is localized in microglia and neurons, as well as infiltrating monocytes, in the lumbar spinal cord of ALS mice
It remains controversial whether circulating monocytes expressing CCR2 infiltrate the central nervous system (CNS) and contribute to pathogenicity of amyotrophic lateral sclerosis (ALS). A previous report used... (Source: Molecular Brain)
Source: Molecular Brain - April 29, 2020 Category: Neuroscience Authors: Hiroyasu Komiya, Hideyuki Takeuchi, Yuki Ogawa, Yuki Hatooka, Keita Takahashi, Atsuko Katsumoto, Shun Kubota, Haruko Nakamura, Misako Kunii, Mikiko Tada, Hiroshi Doi and Fumiaki Tanaka Tags: Micro report Source Type: research

Arginine is neuroprotective through suppressing HIF-1 α/LDHA-mediated inflammatory response after cerebral ischemia/reperfusion injury
In this study we show that arginine treat... (Source: Molecular Brain)
Source: Molecular Brain - April 22, 2020 Category: Neuroscience Authors: Song-Feng Chen, Meng-Xian Pan, Jun-Chun Tang, Jing Cheng, Dan Zhao, Ya Zhang, Hua-Bao Liao, Rui Liu, Yang Zhuang, Zhi-Feng Zhang, Juan Chen, Rui-Xue Lei, Shi-Fang Li, Huan-Ting Li, Ze-Fen Wang and Qi Wan Tags: Research Source Type: research

Physical activity reduces anxiety and regulates brain fatty acid synthesis
Physical activity impacts brain functions, but the direct mechanisms of this effect are not fully recognized or understood. Among multidimensional changes induced by physical activity, brain fatty acids (FA) a... (Source: Molecular Brain)
Source: Molecular Brain - April 17, 2020 Category: Neuroscience Authors: Arkadiusz Li śkiewicz, Marta Przybyła, Anna Wojakowska, Łukasz Marczak, Katarzyna Bogus, Marta Nowacka-Chmielewska, Daniela Liśkiewicz, Andrzej Małecki, Jarosław Barski, Joanna Lewin-Kowalik and Michal Toborek Tags: Research Source Type: research

Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior
Sentrin/SUMO-specific protease 2 (SENP2) is a member of SENPs family involved in maturation of SUMO precursors and deSUMOylation of specific target, and is highly expressed in the central nervous system (CNS).... (Source: Molecular Brain)
Source: Molecular Brain - April 14, 2020 Category: Neuroscience Authors: Dehua Huang, Huiqing Liu, Aoxue Zhu, Yi Zhou and Yong Li Tags: Research Source Type: research

Involvement of A13 dopaminergic neurons located in the zona incerta in nociceptive processing: a fiber photometry study
The roles of serotonergic and noradrenergic signaling in nociceptive processing in the central nervous system are well known. However, dopaminergic signaling is also relevant to various physical functions, inc... (Source: Molecular Brain)
Source: Molecular Brain - April 14, 2020 Category: Neuroscience Authors: Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Honami Setoyama, Yunsu Hwang, Akihiro Yamanaka and Tomoyuki Kuwaki Tags: Micro report Source Type: research

Chronic morphine regulates TRPM8 channels via MOR-PKC β signaling
Postoperative shivering and cold hypersensitivity are major side effects of acute and chronic opioid treatments respectively. TRPM8 is a cold and menthol-sensitive channel found in a subset of dorsal root gang... (Source: Molecular Brain)
Source: Molecular Brain - April 14, 2020 Category: Neuroscience Authors: Mircea Iftinca, Lilian Basso, Robyn Flynn, Charlie Kwok, Corinne Roland, Ahmed Hassan, Manon Defaye, Rithwik Ramachandran, Tuan Trang and Christophe Altier Tags: Research Source Type: research

Nasal delivery of a CRMP2-derived CBD3 adenovirus improves cognitive function and pathology in APP/PS1 transgenic mice
Calcium dysregulation is a key pathological event in Alzheimer ’s disease (AD). In studying approaches to mitigate this calcium overload, we identified the collapsin response mediator protein 2 (CRMP2), an axon... (Source: Molecular Brain)
Source: Molecular Brain - April 9, 2020 Category: Neuroscience Authors: Baochang Qi, Yu Yang, Yingying Cheng, Di Sun, Xu Wang, Rajesh Khanna and Weina Ju Tags: Research Source Type: research

Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus
The receptor deleted in colorectal cancer (DCC) and its ligand netrin-1 are essential for axon guidance during development and are expressed by neurons in the mature brain. Netrin-1 recruits GluA1-containing α... (Source: Molecular Brain)
Source: Molecular Brain - April 7, 2020 Category: Neuroscience Authors: Stephen D. Glasgow, Edwin W. Wong, Greta Thompson-Steckel, Nathalie Marcal, Philippe S éguéla, Edward S. Ruthazer and Timothy E. Kennedy Tags: Research Source Type: research

Temporal expression profiling of DAMPs-related genes revealed the biphasic post-ischemic inflammation in the experimental stroke model
The neuroinflammation in the ischemic brain could occur as sterile inflammation in response to damage-associated molecular patterns (DAMPs). However, its long-term dynamic transcriptional changes remain poorly... (Source: Molecular Brain)
Source: Molecular Brain - April 7, 2020 Category: Neuroscience Authors: Atsushi Yamaguchi, Tatsuya Jitsuishi, Takashi Hozumi, Jun Iwanami, Keiko Kitajo, Hiroo Yamaguchi, Yasutake Mori, Masaki Mogi and Setsu Sawai Tags: Research Source Type: research

Identification of a novel Shank2 transcriptional variant in Shank2 knockout mouse model of autism spectrum disorder
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders that are highly heterogeneous in clinical symptoms as well as etiologies. Mutations in SHANK2 are associated with ASD and accordingly, Sha... (Source: Molecular Brain)
Source: Molecular Brain - April 6, 2020 Category: Neuroscience Authors: Yong-Seok Lee, Nam-Kyung Yu, Jeewan Chun, Jung-eun Yang, Chae-Seok Lim, Hyopil Kim, Gaeun Park, Jin-A Lee, Kyungmin Lee, Bong-Kiun Kaang and Jae-Hyung Lee Tags: Short report Source Type: research

Donald O. Hebb and the Organization of Behavior: 17  years in the writing
The Organization of Behavior has played a significant part in the development of behavioural neuroscience for the last 70  years. This book introduced the concepts of the “Hebb synapse”, the “Hebbian cell assembly... (Source: Molecular Brain)
Source: Molecular Brain - April 6, 2020 Category: Neuroscience Authors: Richard E. Brown Tags: Review Source Type: research

Activity-dependent redistribution of CaMKII in the postsynaptic compartment of hippocampal neurons
Calcium/calmodulin-dependent protein kinase II (CaMKII), an abundant protein in neurons, is involved in synaptic plasticity and learning. CaMKII associates with multiple proteins located at or near the postsyn... (Source: Molecular Brain)
Source: Molecular Brain - April 1, 2020 Category: Neuroscience Authors: Jung-Hwa Tao-Cheng Tags: Research Source Type: research

Role of miR-326 in neonatal hypoxic-ischemic brain damage pathogenesis through targeting of the δ-opioid receptor
In this study, we focused on the role of miR-326 and i... (Source: Molecular Brain)
Source: Molecular Brain - March 30, 2020 Category: Neuroscience Authors: Xuan Wang, Han Zhou, Rui Cheng, Xiaoguang Zhou, Xuewen Hou, Jun Chen and Jie Qiu Tags: Research Source Type: research