Synaptopodin is required for long-term depression at Schaffer collateral-CA1 synapses
Synaptopodin (SP), an actin-associated protein found in telencephalic neurons, affects activity-dependant synaptic plasticity and dynamic changes of dendritic spines. While being required for long-term depress... (Source: Molecular Brain)
Source: Molecular Brain - April 2, 2024 Category: Neuroscience Authors: Yanis Inglebert, Pei You Wu, Julia Tourbina-Kolomiets, Cong Loc Dang and R. Anne McKinney Tags: Research Source Type: research
Differential contribution of canonical and noncanonical NLGN3 pathways to early social development and memory performance
Neuroligin (NLGN) 3 is a postsynaptic cell adhesion protein organizing synapse formation through two different types of transsynaptic interactions, canonical interaction with neurexins (NRXNs) and a recently i... (Source: Molecular Brain)
Source: Molecular Brain - March 12, 2024 Category: Neuroscience Authors: Lin-Yu Li, Ayako Imai, Hironori Izumi, Ran Inoue, Yumie Koshidaka, Keizo Takao, Hisashi Mori and Tomoyuki Yoshida Tags: Research Source Type: research
Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
Synucleinopathies refer to a group of disorders characterized by SNCA/ α-synuclein (α-Syn)-containing cytoplasmic inclusions and neuronal cell loss in the nervous system including the cortex, a common feature b... (Source: Molecular Brain)
Source: Molecular Brain - March 5, 2024 Category: Neuroscience Authors: Hidefumi Suzuki, Naohiro Egawa, Keiko Imamura, Takayuki Kondo, Takako Enami, Kayoko Tsukita, Mika Suga, Yuichiro Yada, Ran Shibukawa, Ryosuke Takahashi and Haruhisa Inoue Tags: Research Source Type: research
Spermidine treatment: induction of autophagy but also apoptosis?
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a fatal neurodegenerative disease that causes loss of balance and motor co-ordination, eventually leading to paralysis. It is cause... (Source: Molecular Brain)
Source: Molecular Brain - March 5, 2024 Category: Neuroscience Authors: Maxinne Watchon, Amanda L. Wright, Holly I. Ahel, Katherine J. Robinson, Stuart K. Plenderleith, Andrea Kuriakose, Kristy C. Yuan and Angela S. Laird Tags: Research Source Type: research
Crucial role of TFAP2B in the nervous system for regulating NREM sleep
The AP-2 transcription factors are crucial for regulating sleep in both vertebrate and invertebrate animals. In mice, loss of function of the transcription factor AP-2 β (TFAP2B) reduces non-rapid eye movement ... (Source: Molecular Brain)
Source: Molecular Brain - February 27, 2024 Category: Neuroscience Authors: Ayaka Nakai, Mitsuaki Kashiwagi, Tomoyuki Fujiyama, Kanako Iwasaki, Arisa Hirano, Hiromasa Funato, Masashi Yanagisawa, Takeshi Sakurai and Yu Hayashi Tags: Short report Source Type: research
TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway
This study aim to explore the potential mechanism of TREM2 i... (Source: Molecular Brain)
Source: Molecular Brain - February 26, 2024 Category: Neuroscience Authors: Yi Tian, Xiao Xiao, Weiliang Liu, Shanqing Cheng, Na Qian, Ling Wang, Yang Liu, Rong Ai and Xiaoping Zhu Tags: Research Source Type: research
Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice
Adenylyl cyclase 1 (AC1) is a selective subtype of ACs, which is selectively expressed in neurons. The activation of AC1 is activity-dependent, and AC1 plays an important role in cortical excitation that contr... (Source: Molecular Brain)
Source: Molecular Brain - February 22, 2024 Category: Neuroscience Authors: Wantong Shi, Qi-Yu Chen, Yujie Ma, Jinjin Wan, Xu-Hui Li and Min Zhuo Tags: Research Source Type: research
A simple and reliable method for claustrum localization across age in mice
The anatomical organization of the rodent claustrum remains obscure due to lack of clear borders that distinguish it from neighboring forebrain structures. Defining what constitutes the claustrum is imperative... (Source: Molecular Brain)
Source: Molecular Brain - February 17, 2024 Category: Neuroscience Authors: Tarek Shaker, Gwyneth J. Dagpa, Vanessa Cattaud, Brian A. Marriott, Mariam Sultan, Mohammed Almokdad and Jesse Jackson Tags: Methodology Source Type: research
In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation
One of the main hallmarks of Parkinson ’s disease (PD) is abnormal alpha-synuclein (α-syn) aggregation which forms the main component of intracellular Lewy body inclusions. This short report used preformed α-sy... (Source: Molecular Brain)
Source: Molecular Brain - February 15, 2024 Category: Neuroscience Authors: Viktoria Xing, Kyle Biggar, Stephen S. G. Ferguson and Shawn Hayley Tags: Short report Source Type: research
Deleting IP6K1 stabilizes neuronal sodium –potassium pumps and suppresses excitability
Inositol pyrophosphates are key signaling molecules that regulate diverse neurobiological processes. We previously reported that the inositol pyrophosphate 5-InsP7, generated by inositol hexakisphosphate kinase 1... (Source: Molecular Brain)
Source: Molecular Brain - February 13, 2024 Category: Neuroscience Authors: Hongfu Jin, Aili Liu, Alfred C. Chin, Chenglai Fu, Hui Shen and Weiwei Cheng Tags: Micro report Source Type: research
Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells
Tau is a microtubule-associated protein that is regulated by post-translational modifications. The most studied of these modifications is phosphorylation, which affects Tau ’s aggregation and loss- and gain-of-... (Source: Molecular Brain)
Source: Molecular Brain - February 12, 2024 Category: Neuroscience Authors: Pranesh Padmanabhan, Andrew Kneynsberg, Esteban Cruz, Adam Briner and J ürgen Götz Tags: Micro report Source Type: research
Correction: The deficiency of Maged1 attenuates Parkinson ’s disease progression in mice
(Source: Molecular Brain)
Source: Molecular Brain - February 9, 2024 Category: Neuroscience Authors: Jie Wang, Sheng ‑Ye Xu, Zhi‑Yuan Ye, Zhou‑Na Sun, Jia‑Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Chuan He, Wei‑Yan You and Jun Gao Tags: Correction Source Type: research
Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice
Entorhinal cortical (EC)-hippocampal (HPC) circuits are crucial for learning and memory. Although it was traditionally believed that superficial layers (II/III) of the EC mainly project to the HPC and deep lay... (Source: Molecular Brain)
Source: Molecular Brain - February 5, 2024 Category: Neuroscience Authors: Naoki Yamamoto, Jun Yokose, Kritika Ramesh, Takashi Kitamura and Sachie K. Ogawa Tags: Micro report Source Type: research
The brain cytokine orchestra in multiple sclerosis: from neuroinflammation to synaptopathology
The central nervous system (CNS) is finely protected by the blood –brain barrier (BBB). Immune soluble factors such as cytokines (CKs) are normally produced in the CNS, contributing to physiological immunosurve... (Source: Molecular Brain)
Source: Molecular Brain - January 23, 2024 Category: Neuroscience Authors: Roberta Amoriello, Christian Memo, Laura Ballerini and Clara Ballerini Tags: Review Source Type: research
Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state
Alzheimer ’s disease (AD) is characterized by the loss of memory due to aggregation of misphosphorylated tau and amyloid beta (Aβ) plaques in the brain, elevated release of inhibitory neurotransmitter gamma-ami... (Source: Molecular Brain)
Source: Molecular Brain - January 12, 2024 Category: Neuroscience Authors: Mridula Bhalla and C. Justin Lee Tags: Short report Source Type: research
