Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development
Schizophrenia (SZ) is a devastating brain disease that affects about 1% of world population. Among the top genetic associations, zinc finger protein 804A (ZNF804A) gene encodes a zinc finger protein, associated w... (Source: Molecular Brain)
Source: Molecular Brain - January 14, 2021 Category: Neuroscience Authors: Fengping Dong, Joseph Mao, Miranda Chen, Joy Yoon and Yingwei Mao Tags: Research Source Type: research

Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice
The number of young adult patients with major depression, one of the most common mental disorders, is gradually increasing in modern society. Stressful experiences in early life are considered one of the risk ... (Source: Molecular Brain)
Source: Molecular Brain - January 13, 2021 Category: Neuroscience Authors: Jinho Kim, Yoo-Hun Suh and Keun-A Chang Tags: Research Source Type: research

Distinct role of 5 ′UTR sequences in dendritic trafficking of BDNF mRNA: additional mechanisms for the BDNF splice variants spatial code
The neurotrophin Brain-derived neurotrophic factor (BDNF) is encoded by multiple bipartite transcripts. Each BDNF transcript is composed by one out of 11 alternatively spliced exons containing the 5 ′untranslat... (Source: Molecular Brain)
Source: Molecular Brain - January 12, 2021 Category: Neuroscience Authors: Andrea Colliva and Enrico Tongiorgi Tags: Short report Source Type: research

The nuclear lamina is a hub for the nuclear function of Jacob
In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to ... (Source: Molecular Brain)
Source: Molecular Brain - January 12, 2021 Category: Neuroscience Authors: Sebastian Samer, Rajeev Raman, Gregor Laube, Michael R. Kreutz and Anna Karpova Tags: Short report Source Type: research

Roles of palmitoylation in structural long-term synaptic plasticity
Long-term potentiation (LTP) and long-term depression (LTD) are important cellular mechanisms underlying learning and memory processes. N-Methyl-d-aspartate receptor (NMDAR)-dependent LTP and LTD play especially ... (Source: Molecular Brain)
Source: Molecular Brain - January 11, 2021 Category: Neuroscience Authors: Benjun Ji and Ma łgorzata Skup Tags: Review Source Type: research

Increased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells
As a dynamic organelle, mitochondria continuously fuse and divide with adjacent mitochondria. Imbalance in mitochondria dynamics leads to their dysfunction, which implicated in neurodegenerative diseases. Howe... (Source: Molecular Brain)
Source: Molecular Brain - January 9, 2021 Category: Neuroscience Authors: So Jung Park, Ji-Eun Bae, Doo Sin Jo, Joon Bum Kim, Na Yeon Park, Jianguo Fang, Yong-Keun Jung, Dong Gyu Jo and Dong-Hyung Cho Tags: Micro report Source Type: research

Regulation of behavioral response to stress by microRNA-690
Psychiatric disorders are affected by genetic susceptibility and environmental adversities. Therefore, the regulation of gene expression under certain environments, such as stress, is a key issue in psychiatri... (Source: Molecular Brain)
Source: Molecular Brain - January 9, 2021 Category: Neuroscience Authors: Jungyoung Park, Joonhee Lee, Koeul Choi and Hyo Jung Kang Tags: Micro report Source Type: research

A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels
A novel missense mutation in the CACNA1A gene that encodes the pore forming α1 subunit of the CaV2.1 voltage-gated calcium channel was identified in a patient with trigeminal neuralgia. This mutation leads to a s... (Source: Molecular Brain)
Source: Molecular Brain - January 7, 2021 Category: Neuroscience Authors: Eder Gambeta, Maria A. Gandini, Ivana A. Souza, Laurent Ferron and Gerald W. Zamponi Tags: Short report Source Type: research

Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice
Reduced expression of glutamate decarboxylase 67 (GAD67), encoded by the Gad1 gene, is a consistent finding in postmortem brains of patients with several psychiatric disorders, including schizophrenia, bipolar di... (Source: Molecular Brain)
Source: Molecular Brain - January 7, 2021 Category: Neuroscience Authors: Shigeo Miyata, Toshikazu Kakizaki, Kazuyuki Fujihara, Hideru Obinata, Touko Hirano, Junichi Nakai, Mika Tanaka, Shigeyoshi Itohara, Masahiko Watanabe, Kenji F. Tanaka, Manabu Abe, Kenji Sakimura and Yuchio Yanagawa Tags: Research Source Type: research

Optogenetic inhibition of medial entorhinal cortex inputs to the hippocampus during a short period of time right after learning disrupts contextual fear memory formation
Formation of temporal association memory and context-specific fear memory is thought to require medial entorhinal cortex (MEC) inputs to the hippocampus during learning events. However, whether the MEC inputs ... (Source: Molecular Brain)
Source: Molecular Brain - January 6, 2021 Category: Neuroscience Authors: Min Soo Kang and Jin-Hee Han Tags: Micro report Source Type: research

Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort
To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults. (Source: Molecular Brain)
Source: Molecular Brain - January 6, 2021 Category: Neuroscience Authors: Xiao Liang, ShiQiang Cheng, Jing Ye, XiaoMeng Chu, Yan Wen, Li Liu, Xin Qi, YuMeng Jia and Feng Zhang Tags: Research Source Type: research

Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency
CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional... (Source: Molecular Brain)
Source: Molecular Brain - January 5, 2021 Category: Neuroscience Authors: Dong Il Choi, Myeongwon Kim, Somi Kim, Nam-Kyung Yu, Chuljung Kwak, Hyunhyo Seo, Kyungmin Lee and Bong-Kiun Kaang Tags: Micro report Source Type: research

Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/ β-catenin, and mTOR signaling during corticogenesis
Corticogenesis is one of the most critical and complicated processes during embryonic brain development. Any slight impairment in corticogenesis could cause neurodevelopmental disorders such as Fragile X syndr... (Source: Molecular Brain)
Source: Molecular Brain - December 16, 2020 Category: Neuroscience Authors: Cristine R. Casingal, Takako Kikkawa, Hitoshi Inada, Yukio Sasaki and Noriko Osumi Tags: Research Source Type: research

Prefrontal cortex, dorsomedial striatum, and dentate gyrus are necessary in the object-based attention test in mice
Disturbances of attention are a common behavioral feature associated with neuropsychiatric disorders with largely unknown underlying causes. We previously developed an object-based attention test (OBAT) as a s... (Source: Molecular Brain)
Source: Molecular Brain - December 14, 2020 Category: Neuroscience Authors: Bolati Wulaer, Kazuo Kunisawa, Hisayoshi Kubota, Willy Jaya Suento, Kuniaki Saito, Akihiro Mouri and Toshitaka Nabeshima Tags: Micro report Source Type: research

Integrin β3 organizes dendritic complexity of cerebral cortical pyramidal neurons along a tangential gradient
Dysfunctional dendritic arborization is a key feature of many developmental neurological disorders. Across various human brain regions, basal dendritic complexity is known to increase along a caudal-to-rostral... (Source: Molecular Brain)
Source: Molecular Brain - December 14, 2020 Category: Neuroscience Authors: Brian D. Swinehart, Katherine M. Bland, Z. Logan Holley, Andrew J. Lopuch, Zachary O. Casey, Christopher J. Handwerk and George S. Vidal Tags: Short report Source Type: research

Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells
The brain is composed of cells having distinct genomic DNA sequences that arise post-zygotically, known as somatic genomic mosaicism (SGM). One form of SGM is aneuploidy —the gain and/or loss of chromosomes—whi... (Source: Molecular Brain)
Source: Molecular Brain - December 14, 2020 Category: Neuroscience Authors: Whitney S. McDonald, Kyoko Miyamoto, Richard Rivera, Grace Kennedy, Beatriz S. V. Almeida, Marcy A. Kingsbury and Jerold Chun Tags: Research Source Type: research

Overexpression of astroglial major histocompatibility complex class I in the medial prefrontal cortex impairs visual discrimination learning in mice
Immune molecules, such as cytokines, complement, and major histocompatibility complex (MHC) proteins, in the central nervous system are often associated with neuropsychiatric disorders. Neuronal MHC class I (M... (Source: Molecular Brain)
Source: Molecular Brain - December 14, 2020 Category: Neuroscience Authors: Bolati Wulaer, Kazuhiro Hada, Akira Sobue, Norimichi Itoh, Toshitaka Nabeshima, Taku Nagai and Kiyofumi Yamada Tags: Research Source Type: research

LRP4 LDL α repeats of astrocyte enhance dendrite arborization of the neuron
The low-density lipoprotein receptor-related protein 4 (LRP4) is essential for inducing the neuromuscular junction (NMJ) formation in muscle fibers, and LRP4 plays a critical role in dendritic development and ... (Source: Molecular Brain)
Source: Molecular Brain - December 10, 2020 Category: Neuroscience Authors: Min Yan, Amin Guo, Peng Chen, Hongyang Jing, Dongyan Ren, Yanzi Zhong, Yongqiang Wu, Erkang Fei, Xinsheng Lai, Suqi Zou and Shunqi Wang Tags: Research Source Type: research

Translational changes induced by acute sleep deprivation uncovered by TRAP-Seq
Sleep deprivation is a global health problem adversely affecting health as well as causing decrements in learning and performance. Sleep deprivation induces significant changes in gene transcription in many br... (Source: Molecular Brain)
Source: Molecular Brain - December 3, 2020 Category: Neuroscience Authors: Lisa C. Lyons, Snehajyoti Chatterjee, Yann Vanrobaeys, Marie E. Gaine and Ted Abel Tags: Research Source Type: research

Altered striatal dopamine levels in Parkinson ’s disease VPS35 D620N mutant transgenic aged mice
Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network. Mutations such as D620N in t... (Source: Molecular Brain)
Source: Molecular Brain - December 1, 2020 Category: Neuroscience Authors: Sarivin Vanan, Xiaoxia Zeng, Sook Yoong Chia, Katarina Varn äs, Mei Jiang, Ke Zhang, Wuan Ting Saw, Parasuraman Padmanabhan, Wei-Ping Yu, Zhi-Dong Zhou, Christer Halldin, Balázs Gulyás, Eng-King Tan and Li Zeng Tags: Research Source Type: research

Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel CaV3.1 caused by a mutation responsible for spinocerebellar ataxia
Spinocerebellar ataxia (SCA) 42 is caused by a mutation in CACNA1G, which encodes the low voltage-gated calcium channel CaV3.1 (T-type). Patients with SCA42 exhibit a pure form of cerebellar ataxia. We encountere... (Source: Molecular Brain)
Source: Molecular Brain - November 26, 2020 Category: Neuroscience Authors: Naoyuki Hara, Hiroyuki Morino, Yukiko Matsuda, Kenichi Satoh, Kouichi Hashimoto, Hirofumi Maruyama and Hideshi Kawakami Tags: Research Source Type: research

Manganese-enhanced MRI depicts a reduction in brain responses to nociception upon mTOR inhibition in chronic pain rats
Neuropathic pain induced by a nerve injury can lead to chronic pain. Recent studies have reported hyperactive neural activities in the nociceptive-related area of the brain as a result of chronic pain. Althoug... (Source: Molecular Brain)
Source: Molecular Brain - November 23, 2020 Category: Neuroscience Authors: Myeounghoon Cha, Songyeon Choi, Kyeongmin Kim and Bae Hwan Lee Tags: Research Source Type: research

Enhanced bodily states of fear facilitates bias perception of fearful faces
We investigated whether enhanced interoceptive bodily states of fear would facilitate recognition of the fearful faces. Participants performed an emotional judgment task after a bodily imagery task inside a fu... (Source: Molecular Brain)
Source: Molecular Brain - November 23, 2020 Category: Neuroscience Authors: Won-Mo Jung, Ye-Seul Lee, In-Seon Lee, Christian Wallraven, Yeonhee Ryu and Younbyoung Chae Tags: Research Source Type: research

Focal loss of the paranodal domain protein Neurofascin155 in the internal capsule impairs cortically induced muscle activity in vivo
Paranodal axoglial junctions are essential for rapid nerve conduction and the organization of axonal domains in myelinated axons. Neurofascin155 (Nfasc155) is a glial cell adhesion molecule that is also requir... (Source: Molecular Brain)
Source: Molecular Brain - November 23, 2020 Category: Neuroscience Authors: Kazuo Kunisawa, Nobuhiko Hatanaka, Takeshi Shimizu, Kenta Kobayashi, Yasuyuki Osanai, Akihiro Mouri, Qian Shi, Manzoor A. Bhat, Atsushi Nambu and Kazuhiro Ikenaka Tags: Short report Source Type: research

Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain
CHD8 encodes a chromatin-remodeling factor and is one of the most recurrently mutated genes in individuals with autism spectrum disorder (ASD). Although we have recently shown that mice heterozygous for Chd8 muta... (Source: Molecular Brain)
Source: Molecular Brain - November 23, 2020 Category: Neuroscience Authors: Atsuki Kawamura, Yoshifumi Abe, Fumiko Seki, Yuta Katayama, Masaaki Nishiyama, Norio Takata, Kenji F. Tanaka, Hideyuki Okano and Keiichi I. Nakayama Tags: Research Source Type: research

CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals
Previous studies have shown that CCL2 may cause chronic pain, but the exact mechanism of central sensitization is unclear. In this article, we further explore the presynaptic role of CCL2. Behavioral experimen... (Source: Molecular Brain)
Source: Molecular Brain - November 23, 2020 Category: Neuroscience Authors: Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo and Rou-Gang Xie Tags: Research Source Type: research

Nicotinamide, a vitamin B3 ameliorates depressive behaviors independent of SIRT1 activity in mice
Sirtuin 1 (SIRT1), is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase and a candidate gene for depression. Nicotinamide (NAM), a form of vitamin B3, is reported as a potential inhibitor o... (Source: Molecular Brain)
Source: Molecular Brain - November 23, 2020 Category: Neuroscience Authors: Zhuxi Liu, Caiqin Li, Xuelian Fan, Yifang Kuang, Xu Zhang, Lei Chen, Jinjing Song, Ying Zhou, Eiki Takahashi, Guang He and Weidong Li Tags: Short report Source Type: research

MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus
Long-term memory formation is supported by functional and structural changes of neuronal networks, which rely on de novo gene transcription and protein synthesis. The modulation of the neuronal transcriptome i... (Source: Molecular Brain)
Source: Molecular Brain - November 17, 2020 Category: Neuroscience Authors: David V. C. Brito, Kubra Gulmez Karaca, Janina Kupke, Lukas Frank and Ana M. M. Oliveira Tags: Research Source Type: research

Correction to: Ascending noradrenergic excitation from the locus coeruleus to the anterior cingulate cortex
An amendment to this paper has been published and can be accessed via the original article. (Source: Molecular Brain)
Source: Molecular Brain - November 13, 2020 Category: Neuroscience Authors: Kohei Koga, Akihiro Yamada, Qian Song, Xu-Hui Li, Qi-Yu Chen, Ren-Hao Liu, Jun Ge, Cheng Zhan, Hidemasa Furue, Min Zhuo and Tao Chen Tags: Correction Source Type: research

Neuregulin-1 inhibits CoCl2-induced upregulation of excitatory amino acid carrier 1 expression and oxidative stress in SH-SY5Y cells and the hippocampus of mice
Excitatory amino acid carrier 1 (EAAC1) is an important subtype of excitatory amino acid transporters (EAATs) and is the route for neuronal cysteine uptake. CoCl2 is not only a hypoxia-mimetic reagent but also an... (Source: Molecular Brain)
Source: Molecular Brain - November 13, 2020 Category: Neuroscience Authors: Han-Byeol Kim, Ji-Young Yoo, Seung-Yeon Yoo, Jun-Ho Lee, Wonseok Chang, Hye-Sun Kim, Tai-Kyoung Baik and Ran-Sook Woo Tags: Research Source Type: research

Frequency and methylation status of selected retrotransposition competent L1 loci in amyotrophic lateral sclerosis
Long interspersed element-1 (LINE-1/L1) is the only autonomous transposable element in the human genome that currently mobilises in both germline and somatic tissues. Recent studies have identified correlation... (Source: Molecular Brain)
Source: Molecular Brain - November 13, 2020 Category: Neuroscience Authors: Abigail L. Savage, Ana Illera Lopez, Alfredo Iacoangeli, Vivien J. Bubb, Bradley Smith, Claire Troakes, Nada Alahmady, Sulev Koks, Gerald G. Schumann, Ammar Al-Chalabi and John P. Quinn Tags: Research Source Type: research

WNT signaling suppresses oligodendrogenesis via Ngn2-dependent direct inhibition of Olig2 expression
Olig2 transcription factor is essential for the maintenance of neural progenitor cells (NPCs) in the pMN domain and their sequential specification into motor neurons (MNs) and oligodendrocyte precursor cells (OPC... (Source: Molecular Brain)
Source: Molecular Brain - November 13, 2020 Category: Neuroscience Authors: Min Jiang, Dan Yu, Binghua Xie, Hao Huang, Wenwen Lu, Mengsheng Qiu and Zhong-Min Dai Tags: Micro report Source Type: research

Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer ’s disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline with accumulation of amyloid beta (A β) and neurofibrillary tangles that usually begins 15–30 years before... (Source: Molecular Brain)
Source: Molecular Brain - November 13, 2020 Category: Neuroscience Authors: Md. Ali Bin Saifullah, Okiru Komine, Yutao Dong, Kazuya Fukumoto, Akira Sobue, Fumito Endo, Takashi Saito, Takaomi C. Saido, Koji Yamanaka and Hiroyuki Mizoguchi Tags: Research Source Type: research

Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus
The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic function; leptin also regulates many aspects of development and fu... (Source: Molecular Brain)
Source: Molecular Brain - November 12, 2020 Category: Neuroscience Authors: Camille Dumon, Yasmine Belaidouni, Diabe Diabira, Suzanne M. Appleyard, Gary A. Wayman and Jean-Luc Gaiarsa Tags: Short report Source Type: research

Functional identification of potential non-canonical N-glycosylation sites within Cav3.2 T-type calcium channels
Low-voltage-activated T-type calcium channels are important contributors to nervous system function. Post-translational modification of these channels has emerged as an important mechanism to control channel a... (Source: Molecular Brain)
Source: Molecular Brain - November 11, 2020 Category: Neuroscience Authors: Vendula Ficelova, Ivana A. Souza, Leos Cmarko, Maria A. Gandini, Robin N. Stringer, Gerald W. Zamponi and Norbert Weiss Tags: Micro report Source Type: research

The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception
The Sigma-1 receptor ( σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain. Ba... (Source: Molecular Brain)
Source: Molecular Brain - November 11, 2020 Category: Neuroscience Authors: Pilar S ánchez-Blázquez, Elsa Cortés-Montero, María Rodríguez-Muñoz, Manuel Merlos and Javier Garzón-Niño Tags: Research Source Type: research

Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity
Activity-dependent local protein synthesis is critical for synapse-specific, persistent plasticity. Abnormalities in local protein synthesis have been implicated in psychiatric disorders. We have recently iden... (Source: Molecular Brain)
Source: Molecular Brain - November 10, 2020 Category: Neuroscience Authors: Alan Jung Park, Mahesh Shivarama Shetty, Jay M. Baraban and Ted Abel Tags: Research Source Type: research

Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning
Protrudin is a protein that resides in the membrane of the endoplasmic reticulum and is highly expressed in the nervous system. Although mutations in the human protrudin gene (ZFYVE27, also known as SPG33) give r... (Source: Molecular Brain)
Source: Molecular Brain - November 10, 2020 Category: Neuroscience Authors: Michiko Shirane, Hirotaka Shoji, Yutaka Hashimoto, Hiroyuki Katagiri, Shizuka Kobayashi, Toshiya Manabe, Tsuyoshi Miyakawa and Keiichi I. Nakayama Tags: Research Source Type: research

Neuronal activity regulates alternative exon usage
Neuronal activity-regulated gene transcription underlies plasticity-dependent changes in the molecular composition and structure of neurons. A large number of genes regulated by different neuronal plasticity i... (Source: Molecular Brain)
Source: Molecular Brain - November 10, 2020 Category: Neuroscience Authors: Johanna Denkena, Andrea Zaisser, Barbara Merz, Bertram Klinger, Dietmar Kuhl, Nils Bl üthgen and Guido Hermey Tags: Research Source Type: research

Intrinsic braking role of descending locus coeruleus noradrenergic neurons in acute and chronic itch in mice
Itch is defined as an unpleasant sensation that provokes a desire to scratch. Our understanding of neuronal circuits for itch information transmission and processing in the spinal dorsal horn (SDH) has progres... (Source: Molecular Brain)
Source: Molecular Brain - October 27, 2020 Category: Neuroscience Authors: Keisuke Koga, Yuto Shiraishi, Ryo Yamagata, Hidetoshi Tozaki-Saitoh, Miho Shiratori-Hayashi and Makoto Tsuda Tags: Research Source Type: research

The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury
Traumatic injury to the spinal cord initiates a series of pathological cellular processes that exacerbate tissue damage at and beyond the original site of injury. This secondary damage includes oxidative stres... (Source: Molecular Brain)
Source: Molecular Brain - October 20, 2020 Category: Neuroscience Authors: Madhuvika Murugan, Jiaying Zheng, Gongxiong Wu, Rochelle Mogilevsky, Xin Zheng, Peiwen Hu, Junfang Wu and Long-Jun Wu Tags: Research Source Type: research

Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer ’s disease
To prevent or delay the onset of Alzheimer ’s disease (AD), we must understand its molecular basis. The great majority of AD cases arise sporadically with a late onset after 65 years of age (LOAD). However, rar... (Source: Molecular Brain)
Source: Molecular Brain - October 19, 2020 Category: Neuroscience Authors: Karissa Barthelson, Stephen Martin Pederson, Morgan Newman and Michael Lardelli Tags: Research Source Type: research

Stimulation-induced differential redistributions of clathrin and clathrin-coated vesicles in axons compared to soma/dendrites
Clathrin-mediated endocytosis plays an important role in the recycling of synaptic vesicle in presynaptic terminals, and in the recycling of transmitter receptors in neuronal soma/dendrites. The present study ... (Source: Molecular Brain)
Source: Molecular Brain - October 16, 2020 Category: Neuroscience Authors: Jung-Hwa Tao-Cheng Tags: Research Source Type: research

Inhibitory synaptic transmissions to the bed nucleus of the stria terminalis neurons projecting to the ventral tegmental area are enhanced in rats exposed to chronic mild stress
The comorbidities of depression and chronic pain have long been recognized in the clinic, and several preclinical studies have demonstrated depression-like behaviors in animal models of chronic pain. These fin... (Source: Molecular Brain)
Source: Molecular Brain - October 15, 2020 Category: Neuroscience Authors: Ryuto Hara, Daiki Takahashi, Tatsuhiro Takehara, Taiju Amano and Masabumi Minami Tags: Micro report Source Type: research

α2-Antiplasmin as a potential regulator of the spatial memory process and age-related cognitive decline
α2-Antiplasmin (α2AP), a principal physiological plasmin inhibitor, is mainly produced by the liver and kidneys, but it is also expressed in several parts of the brain, including the hippocampus and cerebral c... (Source: Molecular Brain)
Source: Molecular Brain - October 15, 2020 Category: Neuroscience Authors: Eri Kawashita, Keiichi Ishihara, Haruko Miyaji, Yu Tanishima, Akiko Kiriyama, Osamu Matsuo and Satoshi Akiba Tags: Research Source Type: research

AAV9-Retro mediates efficient transduction with axon terminal absorption and blood –brain barrier transportation
Recombinant adeno-associated viruses (rAAVs), particularly those that permit efficient gene transfer to neurons from axonal terminals or across the blood –brain barrier, are useful vehicles for structural and f... (Source: Molecular Brain)
Source: Molecular Brain - October 14, 2020 Category: Neuroscience Authors: Kunzhang Lin, Xin Zhong, Lei Li, Min Ying, Tian Yang, Zhijian Zhang, Xiaobin He and Fuqiang Xu Tags: Methodology Source Type: research

Endosomal dysfunction in iPSC-derived neural cells from Parkinson ’s disease patients with VPS35 D620N
Mutations in the Vacuolar protein sorting 35 (VPS35) gene have been linked to familial Parkinson ’s disease (PD), PARK17. VPS35 is a key component of the retromer complex, which plays a central role in endosomal t... (Source: Molecular Brain)
Source: Molecular Brain - October 8, 2020 Category: Neuroscience Authors: Keiko Bono, Chikako Hara-Miyauchi, Shunsuke Sumi, Hisayoshi Oka, Yasuyuki Iguchi and Hirotaka James Okano Tags: Research Source Type: research

Fear response-based prediction for stress susceptibility to PTSD-like phenotypes
Most individuals undergo traumatic stresses at some points in their life, but only a small proportion develop stress-related disorders such as anxiety diseases and posttraumatic stress disorder (PTSD). Althoug... (Source: Molecular Brain)
Source: Molecular Brain - October 7, 2020 Category: Neuroscience Authors: Min-Jae Jeong, Changhee Lee, Kibong Sung, Jung Hoon Jung, Jung Hyun Pyo and Joung-Hun Kim Tags: Research Source Type: research

Overexpression of Slit2 decreases neuronal excitotoxicity, accelerates glymphatic clearance, and improves cognition in a multiple microinfarcts model
Cerebral microinfarcts (MIs) lead to progressive cognitive impairments in the elderly, and there is currently no effective preventative strategy due to uncertainty about the underlying pathogenic mechanisms. O... (Source: Molecular Brain)
Source: Molecular Brain - October 7, 2020 Category: Neuroscience Authors: Xiao-fei He, Ge Li, Li-li Li, Ming-yue Li, Feng-yin Liang, Xi Chen and Xi-quan Hu Tags: Research Source Type: research

Decreased intrinsic excitability of cerebellar Purkinje cells following optokinetic learning in mice
The optokinetic response (OKR), a reflexive eye movement evoked by a motion of the visual field, is known to adapt its strength to cope with an environmental change throughout life, which is a type of cerebell... (Source: Molecular Brain)
Source: Molecular Brain - October 7, 2020 Category: Neuroscience Authors: Yong Gyu Kim and Sang Jeong Kim Tags: Micro report Source Type: research