miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2
Ferroptosis, a newly discovered form of iron-dependent regulated cell death, has been implicated in traumatic brain injury (TBI). MiR-212-5p has previously been reported to be downregulated in extracellular ve... (Source: Molecular Brain)
Source: Molecular Brain - September 18, 2019 Category: Neuroscience Authors: Xiao Xiao, Youjing Jiang, Weibo Liang, Yanyun Wang, Shuqiang Cao, He Yan, Linbo Gao and Lin Zhang Tags: Research Source Type: research

Circular RNA expression profile in the spinal cord of morphine tolerated rats and screen of putative key circRNAs
Morphine tolerance developed after repeated or continuous morphine treatment is a global health concern hindering the control of chronic pain. In our previous research, we have reported that the expression of ... (Source: Molecular Brain)
Source: Molecular Brain - September 18, 2019 Category: Neuroscience Authors: Yingqi Weng, Jing Wu, Lin Li, Jiali Shao, Zhengyiqi Li, Meiling Deng and Wangyuan Zou Tags: Research Source Type: research

Minor ginsenoside F1 improves memory in APP/PS1 mice
Ginseng has been shown to produce a cognitive improvement effect. The key molecular components in ginseng that produce pharmacological effects are ginsenosides. Previous studies reported a memory improvement e... (Source: Molecular Brain)
Source: Molecular Brain - September 5, 2019 Category: Neuroscience Authors: Junho Han, Jung-Pyo Oh, Miran Yoo, Chang-Hao Cui, Byeong-Min Jeon, Sun-Chang Kim and Jin-Hee Han Tags: Research Source Type: research

Anterior insular cortex mediates hyperalgesia induced by chronic pancreatitis in rats
This study was designed to examine the... (Source: Molecular Brain)
Source: Molecular Brain - September 4, 2019 Category: Neuroscience Authors: Yang Bai, Li-Tian Ma, Yan-Bing Chen, Dan Ren, Ying-Biao Chen, Ying-Qi Li, Hong-Ke Sun, Xin-Tong Qiu, Ting Zhang, Ming-Ming Zhang, Xi-Nan Yi, Tao Chen, Hui Li, Bo-Yuan Fan and Yun-Qing Li Tags: Research Source Type: research

Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels
Ankyrin B (AnkB) is an adaptor and scaffold for motor proteins and various ion channels that is ubiquitously expressed, including in the brain. AnkB has been associated with neurological disorders such as epil... (Source: Molecular Brain)
Source: Molecular Brain - September 2, 2019 Category: Neuroscience Authors: Catherine S. W. Choi, Ivana A. Souza, Juan C. Sanchez-Arias, Gerald W. Zamponi, Laura T. Arbour and Leigh Anne Swayne Tags: Research Source Type: research

Expression of the RNA methyltransferase Nsun5 is essential for developing cerebral cortex
Nsun5 gene, encoding a cytosine-5 RNA methyltransferase, is deleted in about 95% patients with Williams-Beuren syndrome (WBS). WBS is a neurodevelopmental disorder and characterized by cognitive disorder. We gene... (Source: Molecular Brain)
Source: Molecular Brain - August 28, 2019 Category: Neuroscience Authors: Peipei Chen, Tingting Zhang, Zihao Yuan, Bin Shen and Ling Chen Tags: Research Source Type: research

SUMOylation regulates USP5-Cav3.2 calcium channel interactions
Cav3.2 calcium channels play a key role in nociceptive signaling in the primary afferent pain pathway. We have previously reported the regulation of Cav3.2 calcium channels by the deubiquitinase USP5 and its i... (Source: Molecular Brain)
Source: Molecular Brain - August 27, 2019 Category: Neuroscience Authors: Agustin Garcia-Caballero, Fang-Xiong Zhang, Lina Chen, Said M ’Dahoma, Junting Huang and Gerald W. Zamponi Tags: Short report Source Type: research

Postsynaptic densities fragment into subcomplexes upon sonication
Postsynaptic density (PSD) fractions were isolated from rat forebrain and sonicated. Pellets from sonicated samples examined by electron microscopy revealed particles with an electron density similar to PSDs t... (Source: Molecular Brain)
Source: Molecular Brain - August 22, 2019 Category: Neuroscience Authors: Ayse Dosemeci, Jung-Hwa Tao-Cheng, Valerie Bakly and Thomas S. Reese Tags: Research Source Type: research

Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice
The P2Y12 receptor (P2Y12R) is a purinoceptor that is selectively expressed in microglia in the central nervous system. As a signature receptor, microglial P2Y12R mediates process chemotaxis towards ADP/ATP gr... (Source: Molecular Brain)
Source: Molecular Brain - August 19, 2019 Category: Neuroscience Authors: Jiyun Peng, Yong Liu, Anthony D. Umpierre, Manling Xie, Dai-Shi Tian, Jason R. Richardson and Long-Jun Wu Tags: Research Source Type: research

Increased depression-related behavior during the postpartum period in inbred BALB/c and C57BL/6 strains
Pregnancy and lactation are characterized by dramatic changes in the endocrine system and brain in mammalian females. These changes, with stress before pregnancy, are potential risk factors for the development... (Source: Molecular Brain)
Source: Molecular Brain - August 9, 2019 Category: Neuroscience Authors: Hirotaka Shoji and Tsuyoshi Miyakawa Tags: Research Source Type: research

Fluoxetine-induced dematuration of hippocampal neurons and adult cortical neurogenesis in the common marmoset
The selective serotonin reuptake inhibitor fluoxetine (FLX) is widely used to treat depression and anxiety disorders. Chronic FLX treatment reportedly induces cellular responses in the brain, including increas... (Source: Molecular Brain)
Source: Molecular Brain - August 5, 2019 Category: Neuroscience Authors: Koji Ohira, Hideo Hagihara, Miki Miwa, Katsuki Nakamura and Tsuyoshi Miyakawa Tags: Research Source Type: research

Improvement of PTSD-like behavior by the forgetting effect of hippocampal neurogenesis enhancer memantine in a social defeat stress paradigm
Post-traumatic stress disorder (PTSD) is a psychiatric disorder associated with memories of traumatic experiences. Recent studies have shown that the forgetting of contextual fear memory is promoted via increa... (Source: Molecular Brain)
Source: Molecular Brain - August 2, 2019 Category: Neuroscience Authors: Rie Ishikawa, Chiaki Uchida, Shiho Kitaoka, Tomoyuki Furuyashiki and Satoshi Kida Tags: Short report Source Type: research

LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration
LIMK1 and LIMK2 are key downstream targets to mediate the effects of the Rho family small GTPases and p21-activated kinases (PAK) in the regulation of the actin cytoskeleton. LIMKs are also critical for synapt... (Source: Molecular Brain)
Source: Molecular Brain - July 18, 2019 Category: Neuroscience Authors: Rui Mao, Rui Deng, Yan Wei, Lifang Han, Yanghong Meng, Wei Xie and Zhengping Jia Tags: Research Source Type: research

Proteomic analysis of cortical neuronal cultures treated with poly-arginine peptide-18 (R18) and exposed to glutamic acid excitotoxicity
Poly-arginine peptide-18 (R18) has recently emerged as a highly effective neuroprotective agent in experimental stroke models, and is particularly efficacious in protecting cortical neurons against glutamic ac... (Source: Molecular Brain)
Source: Molecular Brain - July 17, 2019 Category: Neuroscience Authors: Gabriella MacDougall, Ryan S. Anderton, Frank L. Mastaglia, Neville W. Knuckey and Bruno P. Meloni Tags: Research Source Type: research

NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP
Protein synthesis is crucial for maintaining synaptic plasticity and synaptic signalling. Here we have attempted to understand the role of RNA binding proteins, Fragile X Mental Retardation Protein (FMRP) and ... (Source: Molecular Brain)
Source: Molecular Brain - July 10, 2019 Category: Neuroscience Authors: Preeti Madhav Kute, Sarayu Ramakrishna, Nagammal Neelagandan, Sumantra Chattarji and Ravi. S. Muddashetty Tags: Research Source Type: research

A primate-specific short GluN2A-NMDA receptor isoform is expressed in the human brain
Glutamate receptors of the N-methyl-D-aspartate (NMDA) family are coincident detectors of pre- and postsynaptic activity, allowing Ca2+ influx into neurons. These properties are central to neurological disease me... (Source: Molecular Brain)
Source: Molecular Brain - July 4, 2019 Category: Neuroscience Authors: Hannah Warming, Chrysia-Maria Pegasiou, Aleksandra P. Pitera, Hanna Kariis, Steven D. Houghton, Ksenia Kurbatskaya, Aminul Ahmed, Paul Grundy, Girish Vajramani, Diederik Bulters, Xavier Altafaj, Katrin Deinhardt and Mariana Vargas-Caballero Tags: Short report Source Type: research

Interactions of Rabconnectin-3 with Cav2 calcium channels
This study describes the interaction between Cav2 calcium channels and Rabconnectin-3, a di-subunit protein that is associated with synaptic vesicles. Immunostaining reveals that both Rabconnectin-3 α (RB-3α) a... (Source: Molecular Brain)
Source: Molecular Brain - June 28, 2019 Category: Neuroscience Authors: Maria A. Gandini, Ivana A. Souza, Jing Fan, Katherine Li, Decheng Wang and Gerald W. Zamponi Tags: Short report Source Type: research

Disruption of Foxg1 impairs neural plasticity leading to social and cognitive behavioral defects
The transcription factor Foxg1 is known to be continuously expressed at a high level in mature neurons in the telencephalon, but little is known about its role in neural plasticity. Mutations in human FOXG1 cause... (Source: Molecular Brain)
Source: Molecular Brain - June 28, 2019 Category: Neuroscience Authors: Baocong Yu, Junhua Liu, Mingzhao Su, Chunlian Wang, Huanxin Chen and Chunjie Zhao Tags: Research Source Type: research

Helix-A peptide prevents gp120-mediated neuronal loss
The human-immunodeficiency virus (HIV) envelope protein gp120 promotes synaptic damage similar to that observed in people living with HIV who have neurocognitive disorders. The neurotoxic effect of gp120 appea... (Source: Molecular Brain)
Source: Molecular Brain - June 25, 2019 Category: Neuroscience Authors: Valeria Avdoshina, Francesca Taraballi, Ennio Tasciotti, Aykut Üren and Italo Mocchetti Tags: Micro report Source Type: research

Enriched expression of NF1 in inhibitory neurons in both mouse and human brain
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease caused by loss-of-function mutations in NF1 gene, which encodes a GTPase activating protein for RAS. NF1 affects multiple systems including brain an... (Source: Molecular Brain)
Source: Molecular Brain - June 24, 2019 Category: Neuroscience Authors: Hyun-Hee Ryu, Minkyung Kang, Jinsil Park, Sung-Hye Park and Yong-Seok Lee Tags: Micro report Source Type: research

Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study,... (Source: Molecular Brain)
Source: Molecular Brain - June 20, 2019 Category: Neuroscience Authors: Hye Lim Cha, Jung-Mi Choi, Huy-Hyen Oh, Narayan Bashyal, Sung-Soo Kim, Lutz Birnbaumer and Haeyoung Suh-Kim Tags: Research Source Type: research

Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain
Inositol polyphosphate multikinase (IPMK), the key enzyme responsible for the synthesis of higher inositol polyphosphates and phosphatidylinositol 3, 4, 5-trisphosphate, is known to mediate various biological ... (Source: Molecular Brain)
Source: Molecular Brain - June 20, 2019 Category: Neuroscience Authors: Jina Park, Seung Ju Park and Seyun Kim Tags: Micro report Source Type: research

The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis
Recessive mutations in the ubiquitously expressed POLR3A and POLR3B genes are the most common cause of POLR3-related hypomyelinating leukodystrophy (POLR3-HLD), a rare childhood-onset disorder characterized by de... (Source: Molecular Brain)
Source: Molecular Brain - June 20, 2019 Category: Neuroscience Authors: Karine Choquet, Maxime Pinard, Sharon Yang, Robyn D. Moir, Christian Poitras, Marie-Jos ée Dicaire, Nicolas Sgarioto, Roxanne Larivière, Claudia L. Kleinman, Ian M. Willis, Marie-Soleil Gauthier, Benoit Coulombe and Bernard Brais Tags: Short report Source Type: research

Altered cortical Cytoarchitecture in the Fmr1 knockout mouse
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by silencing of the FMR1 gene and subsequent loss of its protein product, fragile X retardation protein (FMRP). One of the most robust neuropatholo... (Source: Molecular Brain)
Source: Molecular Brain - June 14, 2019 Category: Neuroscience Authors: Frankie H. F. Lee, Terence K. Y. Lai, Ping Su and Fang Liu Tags: Research Source Type: research

Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients
Synaptic abnormalities, perturbed endosomal recycling mediated by loss of the small GTPase RAB11, and neuroinflammatory signaling have been associated with multiple neurodegenerative diseases including the mot... (Source: Molecular Brain)
Source: Molecular Brain - June 13, 2019 Category: Neuroscience Authors: Joy Mitra, Pavana M. Hegde and Muralidhar L. Hegde Tags: Micro report Source Type: research

Olfactory receptor neurons express olfactory marker protein but not calpain 5 from the same genomic locus
Gene expression is highly regulated to functionally diversify cells. Genes that cooperate in the same physiological processes occasionally reside within nearby regions in a chromosome. Olfactory marker protein... (Source: Molecular Brain)
Source: Molecular Brain - June 4, 2019 Category: Neuroscience Authors: Noriyuki Nakashima, Kie Nakashima, Akiko Takaku-Nakashima and Makoto Takano Tags: Short report Source Type: research

Evolutionary analysis of proline-directed phosphorylation sites in the mammalian growth cone identified using phosphoproteomics
The growth cone is essential for nerve growth and axon regeneration, which directly form and rearrange the neural network. Recently, to clarify the molecular signaling pathways in the growth cone that utilize ... (Source: Molecular Brain)
Source: Molecular Brain - May 31, 2019 Category: Neuroscience Authors: Michihiro Igarashi and Shujiro Okuda Tags: Micro report Source Type: research

Pairwise efficiency: a new mathematical approach to qPCR data analysis increases the precision of the calibration curve assay
The real-time quantitative polymerase chain reaction (qPCR) is routinely used for quantification of nucleic acids and is considered the gold standard in the field of relative nucleic acid measurements. The eff... (Source: Molecular Brain)
Source: Molecular Brain - May 30, 2019 Category: Neuroscience Authors: Yulia Panina, Arno Germond, Brit G. David and Tomonobu M. Watanabe Tags: Methodology article Source Type: research

Drosophila Netrin-B controls mushroom body axon extension and regulates courtship-associated learning and memory of a Drosophila fragile X syndrome model
Mushroom body (MB) is a prominent structure essential for olfactory learning and memory in the Drosophila brain. The development of the MB involves the appropriate guidance of axon lobes and sister axon branch... (Source: Molecular Brain)
Source: Molecular Brain - May 28, 2019 Category: Neuroscience Authors: Huaixing Kang, Juan Zhao, Xuan Jiang, Guangxu Li, Wen Huang, Huili Cheng and Ranhui Duan Tags: Research Source Type: research

A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction
Protein phosphorylation plays an important role in learning and memory. Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase involved in the regulation of neural synaptic plasticity. Here, to determ... (Source: Molecular Brain)
Source: Molecular Brain - May 21, 2019 Category: Neuroscience Authors: Jing Wang, Ran Xie, Xiaolin Kou, Yu Liu, Cui Qi, Rui Liu, Weiyan You, Jun Gao and Xiang Gao Tags: Research Source Type: research

Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels
Neonatal seizures are different from adult seizures, and many antiepileptic drugs that are effective in adults often fail to treat neonates. Here, we report that gluconate inhibits neonatal seizure by inhibiti... (Source: Molecular Brain)
Source: Molecular Brain - May 15, 2019 Category: Neuroscience Authors: Zheng Wu, Qingwei Huo, Liang Ren, Fengping Dong, Mengyang Feng, Yue Wang, Yuting Bai, Bernhard L üscher, Sheng-Tian Li, Guan-Lei Wang, Cheng Long, Yun Wang, Gangyi Wu and Gong Chen Tags: Research Source Type: research

Identification of plasma microRNA expression changes in multiple system atrophy and Parkinson ’s disease
MicroRNAs (miRNAs) are endogenous small (18 –25 nt), single-stranded, non-coding RNAs that play key roles in post-transcriptional gene expression regulation. The expression profiles of miRNAs in biofluids and t... (Source: Molecular Brain)
Source: Molecular Brain - May 14, 2019 Category: Neuroscience Authors: Hisashi Uwatoko, Yuka Hama, Ikuko Takahashi Iwata, Shinichi Shirai, Masaaki Matsushima, Ichiro Yabe, Jun Utsumi and Hidenao Sasaki Tags: Research Source Type: research

Simulated weightlessness procedure, head-down bed rest impairs adult neurogenesis in the hippocampus of rhesus macaque
The microgravity environment in space can impact astronauts ’ cognitive and behavioral activities. However, due to the limitations of research conditions, studies of biological changes in the primate brain, suc... (Source: Molecular Brain)
Source: Molecular Brain - May 9, 2019 Category: Neuroscience Authors: Xu Zhang, Xixia Chu, Lei Chen, Juan Fu, Shuai Wang, Jinjing Song, Guanghan Kan, Weizhong Jiang, Guang He, Xiaoping Chen and Weidong Li Tags: Micro report Source Type: research

Correction to: Region- and time-dependent gene regulation in the amygdala and anterior cingulate cortex of a PTSD-like mouse model
Following publication of the original article [1], the authors reported that one of the authors ’ names was spelled incorrectly. (Source: Molecular Brain)
Source: Molecular Brain - May 9, 2019 Category: Neuroscience Authors: Mikiei Tanaka, Hongyun Li, Xijun Zhang, Jatinder Singh, Clifton L. Dalgard, Matthew Wilkerson and Yumin Zhang Tags: Correction Source Type: research

Absence of BBSome function leads to astrocyte reactivity in the brain
In humans, dysfunctional primary cilia result in Bardet-Biedl syndrome (BBS), which presents with clinical features including intellectual disabilities, obesity, and retinal degeneration, and, in mouse models,... (Source: Molecular Brain)
Source: Molecular Brain - May 9, 2019 Category: Neuroscience Authors: Minati Singh, Janelle E. Garrison, Kai Wang and Val C. Sheffield Tags: Research Source Type: research

Visualization of spatiotemporal dynamics of human glioma stem cell invasion
Glioblastoma exhibits phenotypic and genetic heterogeneity, aggressive invasiveness, therapeutic resistance, and tumor recurrence, which can be explained by the existence of glioma stem cells (GSCs). In this s... (Source: Molecular Brain)
Source: Molecular Brain - May 6, 2019 Category: Neuroscience Authors: Ryota Tamura, Hiroyuki Miyoshi, Oltea Sampetrean, Munehisa Shinozaki, Yukina Morimoto, Chizuru Iwasawa, Raita Fukaya, Yutaka Mine, Hirotaka Masuda, Tetsuo Maruyama, Minoru Narita, Hideyuki Saya, Kazunari Yoshida, Hideyuki Okano and Masahiro Toda Tags: Research Source Type: research

SGIP1 α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses
Proper sorting of exocytosed synaptic vesicle (SV) proteins into individual SVs during endocytosis is of the utmost importance for the fidelity of subsequent neurotransmission. Recent studies suggest that each... (Source: Molecular Brain)
Source: Molecular Brain - May 3, 2019 Category: Neuroscience Authors: Sang-Eun Lee, Soomin Jeong, Unghwi Lee and Sunghoe Chang Tags: Research Source Type: research

Predictable chronic mild stress promotes recovery from LPS-induced depression
Clinical depression is frequently comorbid with chronic inflammatory disease, and neuroinflammation is currently proposed as a key mechanism in major depressive disorders. Different from unpredictable chronic ... (Source: Molecular Brain)
Source: Molecular Brain - May 3, 2019 Category: Neuroscience Authors: Ruili Dang, Yan-yan Guo, Kun Zhang, Pei Jiang and Ming-gao Zhao Tags: Research Source Type: research

Brain transcriptome analysis of a familial Alzheimer ’s disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production
To prevent or ameliorate Alzheimer ’s disease (AD) we must understand its molecular basis. AD develops over decades but detailed molecular analysis of AD brains is limited to postmortem tissue where the stresse... (Source: Molecular Brain)
Source: Molecular Brain - May 3, 2019 Category: Neuroscience Authors: Morgan Newman, Nhi Hin, Stephen Pederson and Michael Lardelli Tags: Micro report Source Type: research

Stimulation induces gradual increases in the thickness and curvature of postsynaptic density of hippocampal CA1 neurons in slice cultures
Activity can induce structural changes in glutamatergic excitatory synapses, including increase in thickness and curvature of the postsynaptic density (PSD); these structural changes can only be documented by ... (Source: Molecular Brain)
Source: Molecular Brain - May 3, 2019 Category: Neuroscience Authors: Jung-Hwa Tao-Cheng Tags: Research Source Type: research

Segregated expressions of autism risk genes Cdh11 and Cdh9 in autism-relevant regions of developing cerebellum
Results of recent genome-wide association studies (GWAS) and whole genome sequencing (WGS) highlighted type II cadherins as risk genes for autism spectrum disorders (ASD). To determine whether these cadherins ... (Source: Molecular Brain)
Source: Molecular Brain - May 2, 2019 Category: Neuroscience Authors: Chunlei Wang, Yi-Hsuan Pan, Yue Wang, Gene Blatt and Xiao-Bing Yuan Tags: Research Source Type: research

Regulation of global gene expression in brain by TMP21
TMP21, a type I transmembrane protein of thep24 protein family, mediates protein trafficking and maturation. Dysregulation of TMP21 is implicated in the pathogenesis of Alzheimer ’s disease (AD). However, under... (Source: Molecular Brain)
Source: Molecular Brain - April 29, 2019 Category: Neuroscience Authors: Xiaojie Zhang, Yili Wu, Fang Cai and Weihong Song Tags: Research Source Type: research

Contagious itch can be induced in humans but not in rodents
Itch contagion has been reported in human when people watch someone scratching in a video. The basic mechanism of contagious itch induced by scratching video is still being investigated. A recent study has rep... (Source: Molecular Brain)
Source: Molecular Brain - April 24, 2019 Category: Neuroscience Authors: Jing-Shan Lu, Qi-Yu Chen, Si-Bo Zhou, Feng-Yi Wu, Ren-Hao Liu, Zhao-Xiang Zhou, Hua Zhang and Min Zhuo Tags: Research Source Type: research

A comparative analysis of the OECD/INFE financial knowledge assessment using the Rasch model
Based on Item Response Theory, and more specifically the Rasch model, the financial knowledge domain included in the OECD/INFE adult financial literacy assessment conducted in 2015 was evaluated. This was done... (Source: Molecular Brain)
Source: Molecular Brain - April 15, 2019 Category: Neuroscience Authors: Bernadene de Clercq Tags: Research Source Type: research

Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses
Genetic and pharmacological manipulations targeting metabotropic glutamate receptor 5 (mGluR5) affect performance in behavioural paradigms that depend on cognitive flexibility. Many of these studies involved e... (Source: Molecular Brain)
Source: Molecular Brain - April 11, 2019 Category: Neuroscience Authors: Jisoo Lim, Eosu Kim, Hyun Jong Noh, Shinwon Kang, Benjamin U. Phillips, Dong Goo Kim, Timothy J. Bussey, Lisa Saksida, Christopher J. Heath and Chul Hoon Kim Tags: Research Source Type: research

Development of GABARAP family protein-sensitive LIR-based probes for neuronal autophagy
Autophagy allows for lysosomal cellular degradation of cytosolic components. In particular, neuronal autophagy is essential for cellular homeostasis and neuronal survival and is tightly regulated by several au... (Source: Molecular Brain)
Source: Molecular Brain - April 8, 2019 Category: Neuroscience Authors: Pureum Jeon, Ju-Hui Park, Yong-Woo Jun, You-Kyung Lee, Deok-Jin Jang and Jin-A Lee Tags: Micro report Source Type: research

Identification of a molecular gating determinant within the carboxy terminal region of Cav3.3  T-type channels
The physiological functions controlled by T-type channels are intrinsically dependent on their gating properties, and alteration of T-type channel activity is linked to several human disorders. Therefore, it i... (Source: Molecular Brain)
Source: Molecular Brain - April 8, 2019 Category: Neuroscience Authors: Bohumila Jurkovicova-Tarabova, Leos Cmarko, Renata Rehak, Gerald W. Zamponi, Lubica Lacinova and Norbert Weiss Tags: Research Source Type: research

Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington ’s pathology in zQ175 mice
Huntington ’s disease (HD) is a neurodegenerative disorder caused by a genetic abnormality in the huntingtin gene that leads to a polyglutamine repeat expansion of the huntingtin protein. The cleaved polyglutam... (Source: Molecular Brain)
Source: Molecular Brain - April 8, 2019 Category: Neuroscience Authors: Khaled S. Abd-Elrahman and Stephen S. G. Ferguson Tags: Short report Source Type: research

Anxiolytic effects of Formononetin in an inflammatory pain mouse model
In this study, we investigated the analgesic and anxiolytic effects of Formononetin (FMNT), an active component of tradi... (Source: Molecular Brain)
Source: Molecular Brain - April 8, 2019 Category: Neuroscience Authors: Xin-shang Wang, Shao-yu Guan, An Liu, Jiao Yue, Li-ning Hu, Kun Zhang, Liu-kun Yang, Liang Lu, Zhen Tian, Ming-gao Zhao and Shui-bing Liu Tags: Research Source Type: research

Overexpression of activated CaMKII in the CA1 hippocampus impairs context discrimination, but not contextual conditioning
Calcium/Calmodulin-dependent protein kinase II (CaMKII) plays a key role in the molecular mechanism of memory formation. CaMKII is known to be activated specifically in the activated spines during memory forma... (Source: Molecular Brain)
Source: Molecular Brain - April 5, 2019 Category: Neuroscience Authors: Sanghyun Ye, Ji-il Kim, Jooyoung Kim and Bong-Kiun Kaang Tags: Micro report Source Type: research