Bench-to-bedside imaging in brain metastases: a road to precision oncology
This article offers insight into the molecular biology underlying brain metastasis, its pathogenesis, imaging protocols, and algorithms. It also discusses disease-specific molecular imaging features, focusing on common tumors that spread to the brain, such as lung, breast, colorectal cancer, melanoma, and renal cell carcinoma. Additionally, it covers various targeted treatment options, criteria for assessing treatment response, and the role of artificial intelligence in diagnosing, managing, and predicting prognosis for patients with brain metastases.PMID:38637186 | DOI:10.1016/j.crad.2024.02.015 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 18, 2024 Category: Cancer & Oncology Authors: S Shukla A Karbhari S Rastogi U Agarwal P Rai A Mahajan Source Type: research
Bench-to-bedside imaging in brain metastases: a road to precision oncology
This article offers insight into the molecular biology underlying brain metastasis, its pathogenesis, imaging protocols, and algorithms. It also discusses disease-specific molecular imaging features, focusing on common tumors that spread to the brain, such as lung, breast, colorectal cancer, melanoma, and renal cell carcinoma. Additionally, it covers various targeted treatment options, criteria for assessing treatment response, and the role of artificial intelligence in diagnosing, managing, and predicting prognosis for patients with brain metastases.PMID:38637186 | DOI:10.1016/j.crad.2024.02.015 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 18, 2024 Category: Cancer & Oncology Authors: S Shukla A Karbhari S Rastogi U Agarwal P Rai A Mahajan Source Type: research
Bench-to-bedside imaging in brain metastases: a road to precision oncology
This article offers insight into the molecular biology underlying brain metastasis, its pathogenesis, imaging protocols, and algorithms. It also discusses disease-specific molecular imaging features, focusing on common tumors that spread to the brain, such as lung, breast, colorectal cancer, melanoma, and renal cell carcinoma. Additionally, it covers various targeted treatment options, criteria for assessing treatment response, and the role of artificial intelligence in diagnosing, managing, and predicting prognosis for patients with brain metastases.PMID:38637186 | DOI:10.1016/j.crad.2024.02.015 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 18, 2024 Category: Cancer & Oncology Authors: S Shukla A Karbhari S Rastogi U Agarwal P Rai A Mahajan Source Type: research
MRI radiomics predicts the efficacy of EGFR-TKI in EGFR-mutant non-small-cell lung cancer with brain metastasis
CONCLUSION: The C + R nomograms were more effective in predicting EGFR-TKI efficacy of EGFR-mutant NSCLC patients with brain metastases than single clinical or radiomics nomograms.PMID:38637187 | DOI:10.1016/j.crad.2024.02.016 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 18, 2024 Category: Cancer & Oncology Authors: H Qi Y Hou Z Zheng M Zheng X Sun L Xing Source Type: research
Bench-to-bedside imaging in brain metastases: a road to precision oncology
This article offers insight into the molecular biology underlying brain metastasis, its pathogenesis, imaging protocols, and algorithms. It also discusses disease-specific molecular imaging features, focusing on common tumors that spread to the brain, such as lung, breast, colorectal cancer, melanoma, and renal cell carcinoma. Additionally, it covers various targeted treatment options, criteria for assessing treatment response, and the role of artificial intelligence in diagnosing, managing, and predicting prognosis for patients with brain metastases.PMID:38637186 | DOI:10.1016/j.crad.2024.02.015 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 18, 2024 Category: Cancer & Oncology Authors: S Shukla A Karbhari S Rastogi U Agarwal P Rai A Mahajan Source Type: research
Bench-to-bedside imaging in brain metastases: a road to precision oncology
This article offers insight into the molecular biology underlying brain metastasis, its pathogenesis, imaging protocols, and algorithms. It also discusses disease-specific molecular imaging features, focusing on common tumors that spread to the brain, such as lung, breast, colorectal cancer, melanoma, and renal cell carcinoma. Additionally, it covers various targeted treatment options, criteria for assessing treatment response, and the role of artificial intelligence in diagnosing, managing, and predicting prognosis for patients with brain metastases.PMID:38637186 | DOI:10.1016/j.crad.2024.02.015 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 18, 2024 Category: Cancer & Oncology Authors: S Shukla A Karbhari S Rastogi U Agarwal P Rai A Mahajan Source Type: research
Bench-to-bedside imaging in brain metastases: a road to precision oncology
This article offers insight into the molecular biology underlying brain metastasis, its pathogenesis, imaging protocols, and algorithms. It also discusses disease-specific molecular imaging features, focusing on common tumors that spread to the brain, such as lung, breast, colorectal cancer, melanoma, and renal cell carcinoma. Additionally, it covers various targeted treatment options, criteria for assessing treatment response, and the role of artificial intelligence in diagnosing, managing, and predicting prognosis for patients with brain metastases.PMID:38637186 | DOI:10.1016/j.crad.2024.02.015 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 18, 2024 Category: Cancer & Oncology Authors: S Shukla A Karbhari S Rastogi U Agarwal P Rai A Mahajan Source Type: research
PRMT6-mediated transcriptional activation of ythdf2 promotes glioblastoma migration, invasion, and emt via the wnt- β-catenin pathway
CONCLUSIONS: Our results demonstrate the PRMT6-YTHDF2-Wnt-β-Catenin axis promotes GBM migration, invasion, and EMT in vitro and in vivo, potentially serving as a therapeutic target for GBM.PMID:38637831 | DOI:10.1186/s13046-024-03038-3 (Source: Cell Research)
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Peng Yu Tutu Xu Wenmeng Ma Xiang Fang Yue Bao Chengran Xu Jinhai Huang Yongqing Sun Guangyu Li Source Type: research
Deuterium metabolic imaging differentiates glioblastoma metabolic subtypes and detects early response to chemoradiotherapy
Cancer Res. 2024 Apr 18. doi: 10.1158/0008-5472.CAN-23-2552. Online ahead of print.ABSTRACTMetabolic subtypes of glioblastoma have different prognoses and responses to treatment. Deuterium metabolic imaging with 2H-labeled substrates is a potential approach to stratify patients into metabolic subtypes for targeted treatment. Here, we used 2H magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) measurements of [6,6'-2H2]glucose metabolism to identify metabolic subtypes and their responses to chemoradiotherapy in patient-derived glioblastoma xenografts in vivo. The metabolism of patient-derived cells was fi...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Jacob Chen Ming Low Jianbo Cao Friederike Hesse Alan J Wright Anastasia Tsyben Islam Alshamleh Richard Mair Kevin M Brindle Source Type: research
Vascular mimicry as a facilitator of melanoma brain metastasis
Cell Mol Life Sci. 2024 Apr 18;81(1):188. doi: 10.1007/s00018-024-05217-z.ABSTRACTMelanoma has the highest propensity among solid tumors to metastasize to the brain. Melanoma brain metastases (MBM) are a leading cause of death in melanoma and affect 40-60% of patients with late-stage disease. Therefore, uncovering the molecular mechanisms behind MBM is necessary to enhance therapeutic interventions. Vascular mimicry (VM) is a form of neovascularization linked to invasion, increased risk of metastasis, and poor prognosis in many tumor types, but its significance in MBM remains poorly understood. We found that VM density is ...
Source: Cellular and Molecular Life Sciences : CMLS - April 18, 2024 Category: Cytology Authors: Olivia K Provance Victor O Oria Thuy T Tran Jasmine I Caulfield Christopher R Zito Adam Aguirre-Ducler Kurt A Schalper Harriet M Kluger Lucia B Jilaveanu Source Type: research
The role of [18 F]FDOPA PET as an adjunct to conventional MRI in the diagnosis of aggressive glial lesions
CONCLUSION: Dynamic [18 F]FDOPA PET provides a similar diagnostic accuracy as contrast enhancement in MRI to identify the aggressiveness of suspected glial lesions at diagnosis. Both methods, however, are complementary and [18 F]FDOPA PET may be a useful additional tool in equivocal cases.PMID:38637354 | DOI:10.1007/s00259-024-06720-y (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Adeline Zinsz Celso Pouget Fabien Rech Luc Taillandier Marie Blonski Samir Amlal Laetitia Imbert Timoth ée Zaragori Antoine Verger Source Type: research
Association Between < sup > 18 < /sup > F-FDG PET Activity and HER2 Status in Breast Cancer Brain Metastases
CONCLUSION: The SUVmax ratio may help to identify the HER2 status of breast cancer brain metastases, if validated prospectively.PMID:38633284 | PMC:PMC11018722 | DOI:10.1007/s13139-024-00843-8 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Jonathan R Young Julie A Ressler Joanne E Mortimer Daniel Schmolze Mariko Fitzgibbons Bihong T Chen Source Type: research
UBE2C enhances temozolomide resistance by regulating the expression of p53 to induce aerobic glycolysis in glioma
In this study, we explore the role of UBE2C in regulating temozolomide (TMZ) resistance in glioma and investigate the underlying mechanisms involved. Twenty normal brain tissues and 100 glioma tissues from 50 TMZ-resistant patients and 50 TMZ-sensitive patients are included in this study. TMZ-resistant cell lines are constructed to explore the role of UBE2C in regulating glioma cell viability and TMZ resistance. Our results show that both the mRNA and protein levels of UBE2C are significantly elevated in the brain tissues of glioma patients, especially in those of TMZ-resistant patients. Consistently, UBE2C expression is m...
Source: Acta Biochimica et Biophysica Sinica - April 18, 2024 Category: Biochemistry Authors: Kun Zhou Dexin Wang Xiaolin Du Xia Feng Xiaoxi Zhu Cheng Wang Source Type: research
GBM Immunotherapy: Macrophage Impacts
CONCLUSION: This review provides a comprehensive overview of the latest research on the nature of TAMs and the development of therapeutic strategies targeting TAMs, focusing on the variety of macrophage properties, being modulated, as well as molecular targets.PMID:38634572 | DOI:10.1080/08820139.2024.2337022 (Source: Immunological Investigations)
Source: Immunological Investigations - April 18, 2024 Category: Allergy & Immunology Authors: Nina Loginova Denis Aniskin Peter Timashev Ilya Ulasov Rajesh Kumar Kharwar Source Type: research
Effects of dependent care theory-based post-surgical home care intervention on self-care, symptoms, and caregiver burden in patients with primary brain tumor and their caregivers: a randomized controlled trial
ConclusionDependent care theory-based post-surgical home care intervention increased patients ’ self-care and reduced symptoms and their effects. It also reduced the caregiver burden. Dependent care theory can guide the nursing practices of nurses who provide institutional and/or home care services to patients with chronic diseases and their caregivers.Trial RegistrationNCT05328739 on April 14, 2022 (retrospectively registered). (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 18, 2024 Category: Cancer & Oncology Source Type: research
