Association of HLA-DRB1 and -DQB1 alleles with type 1 (autoimmune) diabetes in African Arabs: systematic review and meta-analysis.
CONCLUSION: This meta-analysis was characterized by low heterogeneity, sensitivity, and publication bias, indicating the robustness and reliability of the results. PMID: 30004835 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - July 15, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

The Effect of Intravenous Selenium on Oxidative Stress in Critically Ill Patients with Acute Respiratory Distress Syndrome.
Authors: Mahmoodpoor A, Hamishehkar H, Shadvar K, Ostadi Z, Sanaie S, Saghaleini SH, Nader ND Abstract OBJECTIVE: To modulate the inflammatory response in respiratory distress syndrome (ARDS) with selenium. BACKGROUND: Selenium replenishes the glutathione peroxidase proteins that are the first line of defense for an oxidative injury to the lungs. METHODS: Forty patients with ARDS were randomized into two groups: the SEL+ group being administered sodium selenite and the SEL- group receiving normal saline for 10 days. Blood samples were taken on Day-0, DAY-7, and Day-14 for assessment of IL-1 beta, IL-6,...
Source: Immunological Investigations - July 13, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Letter from the Editor June 2018.
Authors: Rittenhouse-Olson K PMID: 29989507 [PubMed - in process] (Source: Immunological Investigations)
Source: Immunological Investigations - July 12, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association of IL17 and IL23R gene polymorphisms with rheumatic heart disease in South Indian population.
CONCLUSIONS: The results suggest that IL17A (rs2275913) polymorphism is associated with the development of RF/RHD in South Indian population. Further studies are required to substantiate the association of these genes with the disease risk. PMID: 29985710 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - July 11, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Defective Treg response in acute kidney injury was caused by a reduction in TIM-3+ Treg cells.
CONCLUSIONS: We demonstrated that TIM-3 downregulation impaired the function of Treg cells in AKI. The therapeutic potential of CD4+CD25+TIM-3+ T cells in AKI should be investigated in future studies. PMID: 29985717 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - July 11, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Interleukin-4 and Interleukin-4 Receptor Alpha Gene Polymorphisms in Recurrent Aphthous Stomatitis.
CONCLUSIONS: Certain polymorphisms of IL4 gene could predispose individuals to RAS. PMID: 29985726 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - July 11, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Genetic variant association of PTPN22, CTLA4, IL2RA, as well as HLA frequencies in susceptibility to alopecia areata.
Authors: Moravvej H, Tabatabaei-Panah PS, Abgoon R, Khaksar L, Sokhandan M, Tarshaei S, Ghaderian SMH, Ludwig RJ, Akbarzadeh R Abstract Alopecia areata (AA) is characterized by a genetically complex inheritance. HLA frequencies, as well as the single nucleotide polymorphism (SNP) in PTPN22, CTLA4, and IL2RA genes, have been described to be associated with AA susceptibility. So far, no independent replication of these studies has been reported, and no data exist on a possible association between AA disease and these SNPs or influence of HLA frequencies in Iranian population. A possible association between HLA-DRB1*1...
Source: Immunological Investigations - July 8, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association between HLA class II alleles and hepatitis B virus infection in Transylvania, Romania.
Authors: Matei HV, Vica ML, Siserman CV Abstract Infection with hepatitis B virus (HBV) is a major problem worldwide. The major histocompatibility complex plays an essential role in host immunity and can help eliminate the HBV of infected hepatocytes. Our study aimed to determine the role of certain human leukocyte antigen (HLA) class II molecules (i.e. HLA-DRB1 and HLA-DQB1) in the persistence or removal of HBV. Sixty patients confirmed to be HBV-positive via real-time polymerase chain reaction (PCR), i.e. people with chronic active hepatitis, were included in the study along with a control group of 100 healthy in...
Source: Immunological Investigations - July 8, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Serum of Patients with Psoriasis Modulates the Production of MMP-9 and TIMP-1 in Cells of Monocytic Lineage.
This study evaluates the effect of the sera of 55 patients with psoriasis and 41 non-psoriatic individuals on the production of MMP-9 and TIMP-1 in cultured monocytes from a single healthy blood donor and in U937 cells. The effect of IFN-γ stimulation was also evaluated. Serum and supernatant concentrations of IFN-γ, MMP-9, and TIMP-1 were measured by enzyme-linked immunoassays, and the MMP-9/TIMP-1 ratios were calculated. In monocytes, incubation with psoriasis' sera increased the production of MMP-9 and TIMP-1 in comparison with both baseline and monocytes incubated with non-psoriatic sera. Although the MMP-9...
Source: Immunological Investigations - July 8, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association between HLA-G 14bp Gene Polymorphism and Serum sHLA-G Protein Concentrations in Preeclamptic Patients and Normal Pregnant Women.
Authors: Rokhafrooz S, Ghadiri A, Ghandil P, Ghafourian M, Hossaini SH, Daraei N, Najafian M, Rouhizadeh A Abstract BACKGROUND: Preeclampsia (PE) is a multisystem syndrome that is a primary source of fetal-maternal morbidity and mortality. Human leukocyte antigen-G (HLA-G) is a nonclassical Major histocompatibility complex (MHC) class-Ib molecule expressed on the extravillous trophoblast and seems to have immunomodulatory functions during pregnancy. The purpose of our study was to investigate whether HLA-G may be a vital marker in the modulation of the pregnancy. METHODS: In this case-control study, a number of...
Source: Immunological Investigations - June 29, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Exogenous IL-9 Ameliorates Experimental Autoimmune Myasthenia Gravis Symptoms in Rats.
Authors: Yao X, Zhao J, Kong Q, Xie X, Wang J, Sun B, Xu L, Mu L, Li H Abstract Interleukin-9 (IL-9) is a multifunctional cytokine involved in protective immunity or immunopathology depending on the microenvironment and specific disease settings. Our early study determined that IL-9 and Th9 cells participate in and promote the progression of experimental autoimmune myasthenia gravis (EAMG). The data from this study showed that exogenous recombinant rat IL-9 (rrIL-9) acted as an IL-9 receptor antagonist, reduced the incidence of EAMG in rats, alleviated the severity of the disease, and reduced the anti-acetylcholine...
Source: Immunological Investigations - June 28, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Immunological examination of peripheral blood in patients with colorectal cancer compared to healthy controls.
The objective of this study was to investigate serum levels of immunosuppressive cytokines TGF beta 1 and VEGF and count of immune cells in peripheral blood in stage II and III colorectal cancer patients. METHODS: Blood samples were collected from 22 colorectal patients and 25 healthy controls before the start of treatment. All patients were examined by a clinical immunologist to exclude patients with immune disorders and autoimmune diseases. TGF beta 1 and VEGF were measured by ELISA, and anti-tumor cellular immunity cells (CD4, CD8, B cells, NK cells) were measured by flow cytometry. RESULTS: TGF beta 1 and VEGF ...
Source: Immunological Investigations - June 25, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Intensified Th9 Response is Associated with the Immunopathogenesis of Active Ulcerative Colitis.
CONCLUSION: Function and number of Th9 cells are up-regulated in the inflamed mucosa of UC patients as with the protein secretion of IL-9 and mRNA expressions of Irf4, Smad2, and Smad3, so Th9 cells and IL-9 may become remarkable therapeutic targets for IBD treatment in the future. PMID: 29927662 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - June 25, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Interleukin-6 as a Predictor of the Risk of Cardiovascular Disease: A Meta-Analysis of Prospective Epidemiological Studies.
CONCLUSION: Higher IL-6 levels in healthy individuals are associated with CVD risk, which is co-associated with hypertension and hypercholesterolemia. PMID: 29873573 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - June 8, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Altered Immunity in Endometriosis: What Came First?
CONCLUSIONS: This review confirms that despite decades of intensive research, the involvement of the immune system remains elusive, as we can recognize the changes, but still do not understand if these changes represent the results of endometriosis or if they are contributing factors. Based on these findings, we also discuss new treatment possibilities. PMID: 29873595 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - June 8, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Hyperglycemia Affects the Expression of Inflammatory Genes in Peripheral Blood Mononuclear Cells of Patients with Type 2 Diabetes.
CONCLUSION: The observed changes in both IL-1β and IL-6 mRNA levels in PBMCs may contribute to the development of inflammatory processes involved in the pathogenesis of T2D. Downregulation of IL1R1 in individuals with mild hyperglycemia may indicate an attempt to reduce the pro-inflammatory effects of IL-1β via auto-stimulation. PMID: 29851525 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - June 2, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Analysis of Helios gene expression and Foxp3 TSDR methylation in the newly diagnosed Rheumatoid Arthritis patients.
Authors: Zafari P, Yari K, Mostafaei S, Iranshahi N, Assar S, Fekri A, Taghadosi M Abstract BACKGROUND: The control of auto-reactive cells is defective in rheumatoid arthritis (RA). Regulatory T (Treg) cells which play a key role in the modulation of immune responses have an impaired function in RA. Foxp3 is a master regulator of Treg cells which its expression is under the tight control of epigenetic mechanisms. In the current study, we analyzed the epigenetic modulation of the Foxp3 Treg-specific demethylated region (TSDR) and Helios gene expression to determine Treg cells alteration in RA patients. METHODS: ...
Source: Immunological Investigations - June 2, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Tamoxifen Prevents D-galactosamine/Lipopolysaccharide-Induced Murine Acute Hepatic Failure through Inhibition of Oxidative Stress and Mmd-2 Upregulation.
Authors: Gong X, Cao P, Liu L, Lin Y, Yang Q, Zhou L, Wu T, Luo M Abstract Oxidative stress is considered one of the major mechanisms underlying lipopolysaccharide (LPS)-induced acute liver failure (ALF). Tamoxifen has been reported to ameliorate LPS-induced ALF via the induction of monocyte to macrophage differentiation-associated 2 (Mmd-2). Whether antioxidant effects are involved remains unknown. Mice were given tamoxifen (TAM) once a day for 3 days. Twelve hours later, d-galactosamine (GaIN) and LPS were injected intraperitoneally to induce ALF. N-Acetylcysteine (NAC) was administered immediately after ALF...
Source: Immunological Investigations - May 20, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Taishan Pinus massoniana Pollen Polysaccharides Enhance Immune Responses in Chickens Infected by Avian Leukosis Virus Subgroup B.
In this study, avian leukosis virus subgroup B (ALV-B) was chosen as immunosuppressive virus to artificially establish immunosuppressive models in chickens, and the immune modulatory ability of TPPPS on the immune response of chickens was evaluated. Four randomly assigned groups (Group I-IV) of these immunosuppressed chickens were administered with TPPPS at doses of 0, 100, 200, and 400 mg/kg (every kilogram chick), respectively. Group V was administered with saline as control. At seven day old, 10 chickens randomly selected from Group I-V were inoculated with the attenuated Newcastle disease (ND) vaccine. The results...
Source: Immunological Investigations - May 19, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

The HLA-G Genetic Contribution to Bipolar Disorder: A Trans-Ethnic Replication.
Authors: Sundaresh A, Wu CL, Chinnadurai RK, Rajkumar RP, Mariaselvam CM, LeMaoult J, Krishnamoorthy R, Leboyer M, Negi VS, Tamouza R Abstract Bipolar disorder (BD) is frequently associated with immune dysfunctions. Studying the genetic diversity of the immuno-modulatory human leukocyte antigen (HLA)-G locus in a French BD cohort, we previously reported an association between a functionally relevant 14 bp Ins/Del polymorphism and BD risk. The present study investigated the genetic and expression diversities of HLA-G in a geographically distinct South Indian population-group BD patients, as well as the influenc...
Source: Immunological Investigations - May 10, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Immune Profiling of T Cells Infiltrating Vitreous Humor in Tubercular Uveitis.
CONCLUSIONS: Our results indicate that local antigenic stimuli trigger T cell infiltration and activation of CD4 + T cells that are hyporesponsive to TLR9 stimulation. These infiltrating T cells might be responsible in further aggravating ocular inflammation. PMID: 29733740 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - May 9, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Correlates of Immune Response in Trichinella spiralis Infection.
In this study, rats were infected with 100, 1000, or 3000 larvae of T. spiralis (100 TS, 1000 TS, or 3000 TS). Correlates of eosinophils, antibody responses, and Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES) with worm burdens were evaluated at 1 week, 2 weeks, 1 month, and 2 months postinfection. Heavy infections (1000 TS and 3000 TS) showed significantly higher levels of eosinophil, IgG, and IgG1 antibody responses at 2 weeks postinfection compared to light infection (100 TS). The highest RANTES mRNA expression was also found in the heavy infection group (3000 TS). The results indicate, at early s...
Source: Immunological Investigations - May 5, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Vildagliptin Recruits Regulatory T Cells in Patients Undergoing Primary Percutaneous Coronary Intervention.
Authors: Rizk FH, Abdel Ghafar MT, Soliman NA, Shaaban AE, Atlam R, Elsaadany A, Eshra KA, Shalaby MM Abstract Regulatory T cells (Treg) has been documented to be protective against myocardial ischemia-reperfusion injury (MIRI). The administration of drugs which recruit Treg cells may participate in the cardioprotection of MIRI. The purpose of the present study was to investigate whether the add-on vildagliptin (vild) to standard treatment of MIRI prior to reperfusion could increase Treg recruitment, anti-inflammatory, and antioxidant effects of the standard treatment or not. Sixty diabetic patients with ST-segment...
Source: Immunological Investigations - April 27, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

LAG-3 Represents a Marker of CD4+ T Cells with Regulatory Activity in Patients with Bone Fracture.
In this study, we investigated the role of LAG-3 expression on CD4+ T cells in patients with long bone fracture. We found that LAG-3+ cells represented approximately 13% of peripheral blood CD4+ T cells on average. Compared to LAG-3- CD4+ T cells, LAG-3+ CD4+ T cells presented significantly higher Foxp3 and CTLA-4 expression. Directly ex vivo or with TCR stimulation, LAG-3+ CD4+ T cells expressed significantly higher levels of IL-10 and TGF-β than LAG-3- CD4+ T cells. Interestingly, blocking the LAG-3-MHC class II interaction actually increased the IL-10 expression by LAG-3+ CD4+ T cells. The frequency of LAG-3+ CD4+ ...
Source: Immunological Investigations - April 20, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Effects of Educated Monocytes with Xenogeneic Mesenchymal Stem Cell-Derived Conditioned Medium in a Mouse Model of Chronic Asthma.
CONCLUSION: The educated monocytes with MCM may be as a promising strategy for cell-based therapies of asthma. PMID: 29671652 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - April 20, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Functional Polymorphisms of the Type 1 and Type 2 Iodothyronine Deiodinase Genes in Autoimmune Thyroid Diseases.
In conclusion, the low frequency of the TT genotype D2 rs225014 polymorphism was associated with the development of AITD and severity of HD. PMID: 29648895 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - April 13, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Meta-analysis of the association of IL2RA polymorphisms rs2104286 and rs12722489 with multiple sclerosis risk.
Authors: Wang XX, Chen T Abstract BACKGROUND: The interleukin-2 receptor alpha (IL2RA) gene polymorphisms may be implicated in the genetic susceptibility to multiple sclerosis (MS). This meta-analysis aims to evaluate the relationship of the IL2RA polymorphisms rs2104286 and rs12722489 with MS risk in different populations. METHODS: Eligible association studies were identified through search in Pubmed, Medline, Web of Science, and Scopus (end of search: August 2017). Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects or fixed-effects models. All statistical analys...
Source: Immunological Investigations - April 13, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Single-Nucleotide Polymorphisms of FAS and FASL Genes and Risk of Idiopathic Aplastic Anemia.
This study provided information that endorsed the involvement of FAS/FASL system SNPs in the pathogenesis of AA; further studies should be designed to understand the exact role of SNPs that can help in early diagnosis and treatment. PMID: 29611722 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - April 5, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

The Potential Role of PTPN-22 C1858T Gene Polymorphism in the Pathogenesis of Type 1 Diabetes in Saudi Population.
In this study, we aimed to investigate the association of PTPN-22 C1858T polymorphism with T1D in Saudi children. METHODS: A cohort of 372 type 1 diabetic children and 372 diabetes-free subjects was enrolled in the current investigation. The PTPN-22 C1858T polymorphism was identified using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: Our data showed that the frequency of CT and TT genotypes of PTPN-22 C1858T was higher in T1D children (17.7% and 4.3%, respectively) compared to healthy controls (4.8% and 1.6%, respectively), and both genotypes were statistically ...
Source: Immunological Investigations - April 5, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Upregulated IL-1 Receptor-associated Kinase 1 (IRAK1) in Systemic Lupus Erythematosus: IRAK1 Inhibition Represses Th17 Differentiation with Therapeutic Potential.
In this study, we aimed to further explore the etiological role of IRAK1. The gene expression and phosphorylation of IRAK1 in CD4+ T cells from lupus patients and healthy controls were examined by quantitative reverse transcription-polymerase chain reaction and western blotting, respectively. The percentage of circulating Th17 cells and plasma IL-17A levels were evaluated by flow cytometry and enzyme-linked immunosorbent assay, respectively. The influence of IRAK1 suppression on Th17 development was assessed using an IRAK1 inhibitor and small interfering RNA. We found that IRAK1 transcript levels in CD4+ T cells were signi...
Source: Immunological Investigations - April 5, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Possible Allergenic Role of Tropomyosin in Patients with Adverse Reactions after Fish Intake.
Authors: González-Fernández J, Alguacil-Guillén M, Cuéllar C, Daschner A Abstract In a recent case report, patient's anti-fish tropomyosin IgE was associated with gastrointestinal symptoms. We aimed to demonstrate on a wider scale that the panallergen tropomyosin should not be limited to invertebrate species and that clinically relevant reactions could be elicited by vertebrate tropomyosin. On the whole, 19 patients with adverse reactions after fish intake and showing negative skin tests with commercial fish extracts were included. Fish tropomyosin was recognized by 10/19 patients' IgE b...
Source: Immunological Investigations - March 27, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Polyautoimmunity in Patients with LPS-Responsive Beige-Like Anchor (LRBA) Deficiency.
CONCLUSIONS: Mutation in LRBA gene is one of the causes of monogenic polyautoimmunity. Awareness of this association is important in order to make an early diagnosis and prompt treatment. PMID: 29528757 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - March 14, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Enhancing the apoptotic effect of IL-24/mda-7 on the human hepatic stellate cell through RGD peptide modification.
In conclusion, our findings demonstrated that both endogenous and soluble forms of IL-24/mda-7 induced apoptosis and senescence in activated LX-2 cells and more importantly, fusion of RGD peptide to this cytokine enhanced these activities. So, RGD-modified IL-24/mda-7 could be a suitable candidate for further molecular therapy of fibrosis. PMID: 29498551 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - March 4, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

A Novel PspA Protein Vaccine Intranasal Delivered by Bacterium-Like Particles Provides Broad Protection Against Pneumococcal Pneumonia in Mice.
CONCLUSION: Thus, targeted delivery of multiple bacterial antigens via BLPs may prevent pneumococcal disease by inducing both systemic and mucosal immune responses. PMID: 29498560 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - March 4, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Investigation of ERG Gene Expression in Iranian Patients with Multiple Sclerosis.
CONCLUSION: The findings of the current study revealed no association between ERG expression and MS, at least in the Iranian patients studied. However, more in-depth and comprehensive investigations should be included to evaluate the exact relevance of this gene to the development of autoimmune diseases such as MS. PMID: 29488813 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - March 1, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Upregulation of CD4+ T-Lymphocytes by Isomeric Mixture of Quercetin-3-O-Rutinoside and Quercetin-3-O-Robinobioside Isolated from Millettia aboensis.
CONCLUSION: M. aboensis expressed strong immune-enhancing properties, which may explain its ethnopharmacological use in disease management. PMID: 29405788 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - February 8, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Transient Effects of Anesthesia on Leukocyte Apoptosis and Monocyte Cytokine Stimulation: A Clinical Study.
Authors: Matsota P, Kostopanagiotou G, Kalimeris K, Pandazi A, Kotsaki A, Kontogiannopoulou S, Giamarellos-Bourboulis EJ Abstract The effects of anesthetics on immune cell apoptosis and cytokine stimulation were studied in a prospective study. American Society of Anesthesiologists I/II patients underwent elective inguinal hernia repair or varicose veins stripping surgery and were randomized to either epidural anesthesia (n = 14) or general anesthesia with sevoflurane (n = 19) or propofol (n = 15). Blood was sampled before anesthesia induction (T0), at the end of surgery (T1), and 6&nbs...
Source: Immunological Investigations - February 8, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

The role of TNF alpha polymorphism and expression in susceptibility to nasal polyposis.
CONCLUSION: The present meta-analysis revealed that TNF alpha rs1800629, increased TNF alpha expression and secretion of nasal mucosal cells were associated with an increased risk of nasal polyposis. PMID: 29388847 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - February 2, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Associations between vitamin D receptor polymorphisms and susceptibility to Behcet's disease: A meta-analysis.
CONCLUSION: This meta-analysis demonstrated the association between FokI and ApaI polymorphisms in VDR gene with the risk of BD, providing insights into the potential role of vitamin D receptor in the pathogenesis of BD. PMID: 29388852 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - February 2, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Identification of IL2RG and CYBB mutations in two Chinese primary immunodeficiency patients by whole-exome sequencing.
CONCLUSION: This study identifies one novel mutation in the IL2RG gene and another, previously described mutation in the CYBB genes. It is the first report establishing a diagnosis of X-SCID and X-CGD using WES in Chinese patients. PMID: 29388853 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - February 2, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

HLA-G Gene Polymorphism in Egyptian Patients with Non-Hodgkin Lymphoma and its Clinical Outcome.
Authors: Tawfeek GA, Alhassanin S Abstract BACKGROUND: Non-Hodgkin lymphoma (NHL) is a major cancer in Egypt and worldwide and has many risk factors including genes involved in the immune response. AIM: we investigated the HLA-G 14bp gene polymorphism as a risk factor for NHL and its clinic pathologic features. The study involved 150 patients with NHL and 100 healthy control. Full histories, clinical examination, C.T scan and laboratory investigations such as CBC, LDH, ?2microglobulin and HCV RNA by qualitative real time PCR were performed for all subjects. HLA-G 14bp ins/del gene polymorphism was determined by...
Source: Immunological Investigations - February 2, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Role of TGF- β activated kinase-1 inhibitor on the interaction between macrophages and mesangial cells on the condition of high glucose.
Role of TGF-β activated kinase-1 inhibitor on the interaction between macrophages and mesangial cells on the condition of high glucose. Immunol Invest. 2018 Jan 26;:1-12 Authors: Fan Z, Xu X, Qi X, Wu Y Abstract OBJECTIVE: To investigate the effect of TGF-β activated kinase-1(TAK1) inhibitor 5Z-7-oxozeaenol on the interaction between macrophages and mesangial cells exposed to high glucose. METHODS: The macrophages and mesangial cells were cultured separately or co-cultured and divided into seven groups: inhibitor control group, mannitol control group, normal control group, high glucose gr...
Source: Immunological Investigations - January 28, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Study of the osteoprotegerin/receptor activator of nuclear factor-kB ligand system association with inflammation and atherosclerosis in systemic sclerosis.
CONCLUSION: In cardiovascular risks, OPG serum level might increase as a preventive compensatory mechanism to neutralize the RANKL level increment. The determination of the OPG-RANKL system is a diagnostic indicator for the intensity of vascular calcification and atherosclerosis in SSc patients. PMID: 29336616 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - January 18, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Rheumatoid arthritis: A single-center Egyptian experience.
Authors: Sakr BR, Elfishawi MM, ElArousy MH, Hatw AK, AbdulKarim AN, Tammam AB, Kotp AN, Hamed ME, Genedy IE, Desouky EDE, Nawito ZO Abstract OBJECTIVE: Demonstration of rheumatoid arthritis (RA) characteristics in a large cohort of Egyptian patients. METHODS: Retrospective analysis of data of 3219 RA patients attending the Rheumatology outpatient clinic, Kasr Alainy Hospital, Cairo University; from January 1995 till December 2015. RESULTS: Mean age at disease onset was 36.1 ±13.4 years; 2774 (84%) were females and mean disease duration was 12.9 ±7.9 years. Regarding number of joint ...
Source: Immunological Investigations - January 18, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

The role of the PI3K/mTOR signaling pathway in Staphylococcus epidermidis small colony variants intracellular survival.
The objective of this study was to analyze how Staphylococcus epidermidis SCV and WT strains manipulate the PI3K/Akt/mTOR signaling pathway. Six S. epidermidis strains with normal phenotype (WT) and six S. epidermidis strains with SCV phenotype were isolated in parallel from six patients with the prosthetic hip joint infections. THP-1 activated cells were incubated with or without PI3K inhibitor-wortmannin or with mTOR inhibitor-rapamycin. Next, macrophages were exposed to S. epidermidis WT and SCV strains. After 4 h incubation, bacterial survival inside macrophages as well as PI3K-mTOR activation was analyzed. SCV strains...
Source: Immunological Investigations - January 18, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association of increased eomesodermin, BCL6, and granzyme B expression with major clinical manifestations of Hashimoto's thyroiditis - an observational study.
CONCLUSIONS: Our exploratory results suggest a role for GZMB, EOMES, and BCL6 in the context of HT, thyroid injury, and aggressive/advanced disease forms. Functions enriched within differentially expressed transcripts could be an important new target in understanding the pathogenesis of HT. PMID: 29319368 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - January 12, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association between CD266 polymorphism and soluble levels in rheumatoid arthritis: Relationship with clinical activity.
CONCLUSION: The CD226 T allele may be susceptibility risk factors for the development of RA and the higher serum level of CD226 may be involved in the pathogenesis of RA in Egyptian patients. The serum level of CD226 and not CD226 genotypes could be considered as an independent risk factor for the prediction of RA within healthy individuals and also for RA disease activity. PMID: 29319370 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - January 12, 2018 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association between cytokine genes polymorphisms and type 1 diabetes: a case-control study on Saudi population.
Authors: Allam G, Nasr A, Talaat IM, Abuelsaad ASA, Bakheit AM, Nemenqani D, Alsulaimani AA Abstract BACKGROUND: Association studies of genes encoding cytokines that play an important role in inflammatory response represent one approach to finding type 1 diabetes (T1D) disease genes. The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) within cytokine genes with T1D in a cohort of Saudi subjects. METHODS: A total of 300 well-characterized type 1 diabetic patients and 300 T1D-free control subjects were enrolled in this investigation. Cytokine SNPs were genotyped by u...
Source: Immunological Investigations - December 20, 2017 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association between the polymorphism of HLA and ESRD in Dalian Han population located in north of China.
In this study, 163 Han ESRD patients were recruited to participate. The blood samples were genotyped by sequence-specific oligonucleotide method. A group of 14,529 healthy Chinese Han individuals registered at the Dalian Blood Center as bone marrow donors, living in the same region and of the same ethnicity, were used as controls. RESULTS: We found that only one allele, HLA-DRB1*12, showed a positive association with ESRD (p = 0.004, pc = 0.028, odds ratio = 1.530, 95% confidence interval = 1.147-2.041); A*02-B*40-DRB1*09, A*02-B*40-DRB1*12, A*24-B*15-DRB1*12, and B*40-DRB1*12 we...
Source: Immunological Investigations - December 20, 2017 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Progesterone suppresses the lipopolysaccharide-induced pro-inflammatory response in primary mononuclear cells isolated from human placental blood.
Authors: Preciado-Martínez E, García-Ruíz G, Flores-Espinosa P, Bermejo-Martínez L, Espejel-Nuñez A, Estrada-Gutiérrez G, Razo-Aguilera G, Granados-Cepeda M, Helguera-Repetto AC, Irles C, Zaga-Clavellina V Abstract Progesterone is an essential hormone that induces deep immune adaptations favoring pregnancy maintenance. We aimed at evaluating the effects of progesterone on the synthesis of pro- and anti-inflammatory cytokines by mononuclear cells isolated from human placental blood stimulated with lipopolysaccharide, emulating an infection-inflammation environment. Mononucle...
Source: Immunological Investigations - December 14, 2017 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research