Sarm1 Controls the MYD88-Mediated Inflammatory Responses in Inflammatory Bowel Disease via the Regulation of TRAF3 Recruitment
CONCLUSIONS: In summary, our data suggest that Sarm1 controls the MYD88-mediated inflammatory responses in IBD via its regulation of TRAF3 recruitment.PMID:38651786 | DOI:10.1080/08820139.2024.2343889 (Source: Immunological Investigations)
Source: Immunological Investigations - April 23, 2024 Category: Allergy & Immunology Authors: Huijuan Fan Chun Song Jingyu Zhang Source Type: research
MSRB2 Ameliorates H < sub > 2 < /sub > O < sub > 2 < /sub > -induced Chondrocyte Oxidative Stress and Suppresses Apoptosis in Osteoarthritis
CONCLUSION: MSRB2 decreased in OA, and overexpression of MSRB2 alleviated oxidative stress and apoptosis of chondrocyte.PMID:38638027 | DOI:10.1080/08820139.2024.2343898 (Source: Immunological Investigations)
Source: Immunological Investigations - April 19, 2024 Category: Allergy & Immunology Authors: Keke Huang Wenhan Fu Anquan Wang Gongwen Du Hao Tang Li Yin Zongsheng Yin Weilu Gao Source Type: research
The Clinical Significance of Serum Interleukin-36 α Levels in Patients with Gout
CONCLUSION: In conclusion, serum IL-36α levels were elevated in patients with gout and correlated with the clinical markers of inflammation. Our findings suggest that IL-36α may be a novel inflammatory indicator for gout.PMID:38638029 | DOI:10.1080/08820139.2024.2341233 (Source: Immunological Investigations)
Source: Immunological Investigations - April 19, 2024 Category: Allergy & Immunology Authors: Sicen Meng Wubing Lu Zhi Li Yinxin Zhou Shanjun Shi Hui Zhao Mingcai Li Yan Li Source Type: research
Mannose Binding Lectin and C3 Serum Levels in Coronary Artery Disease: A Cross-Sectional Study
CONCLUSIONS: Higher concentrations of MBL were found to be associated with CAD, whereas C3 levels were found to be associated with cardiovascular risk factors.PMID:38634569 | DOI:10.1080/08820139.2024.2337023 (Source: Immunological Investigations)
Source: Immunological Investigations - April 18, 2024 Category: Allergy & Immunology Authors: Juliana Meneghetti da Rosa K árita Cláudia Freitas Lidani Fabiana Antunes Andrade L éia Sena Renato Nisihara Altair Rogerio Ambrosio Iara J Messias-Reason Source Type: research
GBM Immunotherapy: Macrophage Impacts
CONCLUSION: This review provides a comprehensive overview of the latest research on the nature of TAMs and the development of therapeutic strategies targeting TAMs, focusing on the variety of macrophage properties, being modulated, as well as molecular targets.PMID:38634572 | DOI:10.1080/08820139.2024.2337022 (Source: Immunological Investigations)
Source: Immunological Investigations - April 18, 2024 Category: Allergy & Immunology Authors: Nina Loginova Denis Aniskin Peter Timashev Ilya Ulasov Rajesh Kumar Kharwar Source Type: research
Mannose Binding Lectin and C3 Serum Levels in Coronary Artery Disease: A Cross-Sectional Study
CONCLUSIONS: Higher concentrations of MBL were found to be associated with CAD, whereas C3 levels were found to be associated with cardiovascular risk factors.PMID:38634569 | DOI:10.1080/08820139.2024.2337023 (Source: Immunological Investigations)
Source: Immunological Investigations - April 18, 2024 Category: Allergy & Immunology Authors: Juliana Meneghetti da Rosa K árita Cláudia Freitas Lidani Fabiana Antunes Andrade L éia Sena Renato Nisihara Altair Rogerio Ambrosio Iara J Messias-Reason Source Type: research
GBM Immunotherapy: Macrophage Impacts
CONCLUSION: This review provides a comprehensive overview of the latest research on the nature of TAMs and the development of therapeutic strategies targeting TAMs, focusing on the variety of macrophage properties, being modulated, as well as molecular targets.PMID:38634572 | DOI:10.1080/08820139.2024.2337022 (Source: Immunological Investigations)
Source: Immunological Investigations - April 18, 2024 Category: Allergy & Immunology Authors: Nina Loginova Denis Aniskin Peter Timashev Ilya Ulasov Rajesh Kumar Kharwar Source Type: research
Insights into the Roles of Natural Killer Cells in Osteoarthritis
Immunol Invest. 2024 Apr 15:1-22. doi: 10.1080/08820139.2024.2337025. Online ahead of print.ABSTRACTOsteoarthritis (OA) is now widely acknowledged as a low-grade inflammatory condition, in which the intrinsic immune system plays a significant role in its pathogenesis. While the involvement of macrophages and T cells in the development of OA has been extensively reviewed, recent research has provided mounting evidence supporting the crucial contribution of NK cells in both the initiation and advancement of OA. Accumulated evidence has emerged in recent years indicating that NK cells play a critical role in OA development an...
Source: Immunological Investigations - April 16, 2024 Category: Allergy & Immunology Authors: Chang-Qing Zheng Ling-Jun Zeng Zhi-Hong Liu Chen-Fang Miao Ling-Yan Yao Hong-Tao Song Xiao-Mu Hu Xin Zhou Source Type: research
Upregulation, Functional Association, and Correlated Expressions of TRPV1 and TRPA1 During Telmisartan-Driven Immunosuppression of T Cells
In this study, we investigated the potential role of TRPV1 and TRPA1 during TM-driven immunosuppression of T cells in vitro. We observed a significant elevation of both TRPV1 and TRPA1 during TM-induced immunosuppression of T cells.We found that TRPA1 activation-driven suppression of T cell activation and effector cytokine responses during TM treatment is partially, yet significantly overridden by TRPV1 activation. Moreover, the expressions of TRPV1 and TRPA1 were highly correlated in various conditions of T cell. Mechanistically, it might be suggested that TRPV1 and TRPA1 are differentially involved in regulating T cell a...
Source: Immunological Investigations - April 8, 2024 Category: Allergy & Immunology Authors: Tathagata Mukherjee Kshyama Subhadarsini Tung Parthasarathi Jena Chandan Goswami Subhasis Chattopadhyay Source Type: research
LINC00265 can Serve as a Potential Biomarker for Predicting Increased Disease Risk, Systemic Inflammation, Disease Severity and Poor Prognosis in Sepsis
CONCLUSION: LINC00265 is upregulated in patients with sepsis, and its high expression predicts increased disease severity, heightened inflammation, and a poorer prognosis.PMID:38589355 | DOI:10.1080/08820139.2024.2332791 (Source: Immunological Investigations)
Source: Immunological Investigations - April 8, 2024 Category: Allergy & Immunology Authors: Yiming Cui Nan Jiang Xin Liu Jianyuan Huang Wei Chen Source Type: research
Upregulation, Functional Association, and Correlated Expressions of TRPV1 and TRPA1 During Telmisartan-Driven Immunosuppression of T Cells
In this study, we investigated the potential role of TRPV1 and TRPA1 during TM-driven immunosuppression of T cells in vitro. We observed a significant elevation of both TRPV1 and TRPA1 during TM-induced immunosuppression of T cells.We found that TRPA1 activation-driven suppression of T cell activation and effector cytokine responses during TM treatment is partially, yet significantly overridden by TRPV1 activation. Moreover, the expressions of TRPV1 and TRPA1 were highly correlated in various conditions of T cell. Mechanistically, it might be suggested that TRPV1 and TRPA1 are differentially involved in regulating T cell a...
Source: Immunological Investigations - April 8, 2024 Category: Allergy & Immunology Authors: Tathagata Mukherjee Kshyama Subhadarsini Tung Parthasarathi Jena Chandan Goswami Subhasis Chattopadhyay Source Type: research
LINC00265 can Serve as a Potential Biomarker for Predicting Increased Disease Risk, Systemic Inflammation, Disease Severity and Poor Prognosis in Sepsis
CONCLUSION: LINC00265 is upregulated in patients with sepsis, and its high expression predicts increased disease severity, heightened inflammation, and a poorer prognosis.PMID:38589355 | DOI:10.1080/08820139.2024.2332791 (Source: Immunological Investigations)
Source: Immunological Investigations - April 8, 2024 Category: Allergy & Immunology Authors: Yiming Cui Nan Jiang Xin Liu Jianyuan Huang Wei Chen Source Type: research
Upregulation, Functional Association, and Correlated Expressions of TRPV1 and TRPA1 During Telmisartan-Driven Immunosuppression of T Cells
In this study, we investigated the potential role of TRPV1 and TRPA1 during TM-driven immunosuppression of T cells in vitro. We observed a significant elevation of both TRPV1 and TRPA1 during TM-induced immunosuppression of T cells.We found that TRPA1 activation-driven suppression of T cell activation and effector cytokine responses during TM treatment is partially, yet significantly overridden by TRPV1 activation. Moreover, the expressions of TRPV1 and TRPA1 were highly correlated in various conditions of T cell. Mechanistically, it might be suggested that TRPV1 and TRPA1 are differentially involved in regulating T cell a...
Source: Immunological Investigations - April 8, 2024 Category: Allergy & Immunology Authors: Tathagata Mukherjee Kshyama Subhadarsini Tung Parthasarathi Jena Chandan Goswami Subhasis Chattopadhyay Source Type: research
