Association of TNF- α G-308 a Promoter Polymorphism with the Course and Outcome of COVID-19 Patients.
Conclusion: People who carry the A allele of TNF-ɑ polymorphism are more prone to COVID-19 infection. The AA genotype of TNF-ɑ is associated with a more aggressive pattern of the disease. In those patients, the use of anti - TNF therapy may be promising. PMID: 33228423 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - November 25, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

MiR-135b Alleviates Airway Inflammation in Asthmatic Children and Experimental Mice with Asthma via Regulating CXCL12.
CONCLUSION: MiR-135b may inhibit immune responses of Th17 cells to alleviate airway inflammation and hyperresponsiveness in asthma possibly by targeting CXCL12, showing the potential value in asthma treatment. PMID: 33203292 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - November 21, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Evaluation of Expression of LRBA and CTLA-4 Proteins in Common Variable Immunodeficiency Patients.
In this study, 20 newly diagnosed CVID patients without infection only phenotype, and ten healthy individuals were enrolled. The expressions of LRBA and CTLA-4 proteins were assessed by western blotting and flow cytometry, respectively. The patients were divided into two groups of autoimmunity-positive (11 cases) and autoimmunity-negative (9 patients). LRBA and CTLA-4 expressions were significantly lower in autoimmune-positive patients than in healthy individuals (P = .03 and P = .03, respectively). Autoimmune-negative patients had lower expression of LRBA and CTLA-4 than the control group, although it was not si...
Source: Immunological Investigations - November 18, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association of TNFSF4 Gene Polymorphisms and Plasma TNFSF4 Level with Risk of Systemic Lupus Erythematosus in a Chinese Population.
Authors: Yue LY, Xu Y, Tao B, He CS Abstract Background: Systemic lupus erythematosus (SLE) is an autoimmune disease. Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is an inflammatory factor that has been discussed in different inflammatory diseases and cancers. However, relationship between TNFSF4 and SLE is limited. Material and methods: The present case-control study recruited 400 SLE patients and 600 healthy controls from Southern Chinese Han origin. Plasma levels of TNFSF4 were tested by enzyme linked-immunosorbent assay, and association of rs2205960, rs704840, rs844648, rs3850641 and rs17568 polym...
Source: Immunological Investigations - November 11, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Higher Peripheral Blood IFN- γ-/IL-4+ Th2 Lymphocytes Are Associated with Lower Rate of Relapse in Patients with Lymphoma.
CONCLUSION: Taken together, higher peripheral blood IFN-γ-/IL-4+ Th2 lymphocytes might be associated with a favorable prognosis like lower rate of relapse in lymphoma patients. PMID: 33148063 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - November 6, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Tetrandrine Attenuates Cartilage Degeneration, Osteoclast Proliferation, and Macrophage Transformation through Inhibiting P65 Phosphorylation in Ovariectomy-induced Osteoporosis.
CONCLUSION: TET attenuated bone structural parameters including BMD, BV/TV, Tb.N, Tb.Th and Tb.Sp, inhibited articular cartilage degeneration, promoted bone formation, inhibited the inflammatory response, and promoted macrophage transformation from M1 to M2 via NF-κB inactivation in osteoporosis. TET may be a promising drug for osteoporosis therapy. ABBREVIATION: TET: Tetrandrine; ACLT: anterior cruciate ligament transection; OVX: ovariectomy; TRAP: Tartrate-resistant acid phosphatase; BMD: bone mineral density; BV/TV: Bone volume/total volume; Tb.Th: trabecular thickness; Tb.N: trabecular number; Tb.Sp: trabecul...
Source: Immunological Investigations - November 5, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association of Polymorphism in IL-18 Gene with Periodontitis in Uyghur Adults in Xinjiang and Evidence from Six Case-Control Studies with a Comprehensive Analysis.
CONCLUSIONS: IL-18 137 G > C, 607 C > A could be associated with susceptibility to periodontitis in Uyghur population. Further case-control of candidate genes studies targeting larger sample sizes and different ethnic groups are needed to arrive more accurate conclusions. PMID: 33143466 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - November 5, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Assessment of the Relationship between Clinical Variants of Psoriasis and Killer Immunoglobulin-like Receptor (KIR) Genes: A Systematic Review with Meta-analysis.
CONCLUSION: This meta-analysis demonstrates that subjects that carry the KIR2DS1 gene could have a potential risk factor for the development of PsV. Conversely, KIR2DS4 and 3DL1 genes appear to confer protection against PsV. PMID: 33115277 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - October 30, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Increased Peripheral NKG2A-NKG2D+CD3-CD16+CD56dim NK Cell Subset Was Positively Correlated with Antiphospholipid Antibodies in Patients of Obstetric Antiphospholipid Syndrome.
In this study, we compared the distributional profiles of different NK cell subsets and the expressions of NK cell-activating receptors in peripheral blood of patients with OAPS and healthy women. Our results showed significantly increased NKG2A-NKG2D+ subset and decreased NKG2A+NKG2D- subset in CD3- CD16+CD56dim NK cells, CD3-CD16-CD56bright NK cells and CD56+T cells in OAPS patients compared with those in healthy control women. The CD27-CD11b+ subset significantly increased in CD3-CD16+CD56dim NK cells in OAPS patients compared with those in healthy control women. In addition, the NKG2A-NKG2D+ subset in CD3-CD16 + CD56di...
Source: Immunological Investigations - October 27, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

The Relationship between PTPN22 R620W Polymorphisms and the Susceptibility to Autoimmune Thyroid Diseases: An Updated Meta-analysis.
Authors: Wu H, Wan S, Qu M, Ren B, Liu L, Shen H Abstract The protein tyrosine phosphatase non-receptor 22 (PTPN22) R620W polymorphism has been related to susceptibility to autoimmune thyroid disease (AITD) with inconsistent results. Therefore, this meta-analysis was designed to assess a more accurate association between the PTPN22 R620W polymorphism and AITD susceptibility. A systematic search of the EMBASE, PubMed, Web of Science, CBM, CNKI, and WanFang databases was performed to determine relevant publications. Statistical analyses of the odds ratios (ORs), 95% confidence intervals (CIs), and p values were perfo...
Source: Immunological Investigations - October 27, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Tumor Necrosis Factor-alpha (TNF- α) -238 G/A Polymorphism Is Associated with the Treatment Resistance and Attempted Suicide in Schizophrenia.
Tumor Necrosis Factor-alpha (TNF-α) -238 G/A Polymorphism Is Associated with the Treatment Resistance and Attempted Suicide in Schizophrenia. Immunol Invest. 2020 Oct 22;:1-13 Authors: Aytac HM, Ozdilli K, Tuncel FC, Pehlivan M, Pehlivan S Abstract Abnormality of the immune system may play an important role in the pathogenesis of schizophrenia (SCZ). We aim to investigate the relationship between clinical features of SCZ and tumor necrosis factor-alpha (TNF-α) -238 G/A, -308 G/A polymorphisms in SCZ patients by comparing genotype distributions of TNF-α gene polymorphisms bet...
Source: Immunological Investigations - October 25, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Identification of Linear Peptide Immunogens with Verified Broad-spectrum Immunogenicity from the Conserved Regions within the Hemagglutinin Stem Domain of H1N1 Influenza Virus.
Conclusion: The linear epitopes fused with ferritin identified in this study can lay the foundation for future advancements in development of broad-spectrum subunit vaccine against IAV (H1N1), and give rise to the potential future applicability of ferritin-based antigen delivery nanoplatforms. PMID: 33078652 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - October 22, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

The Relationship between Extracellular/intracellular microRNAs and TLRs May Be Used as a Diagnostic and Therapeutic Approach in Sepsis.
In conclusion, this study has provided new insight into the role of microRNAs as a regulator of the TLRs which may lead to the aberrant inflammatory response in sepsis. Therefore, it suggests that both intracellular and extracellular microRNAs may play a therapeutic role in the treatment of sepsis via regulating TLRs. However, yet sepsis and septic shock are medical emergencies and further studies are needed to specify the exact role of microRNAs and TLRs in sepsis. PMID: 33054447 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - October 20, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

The Responsiveness of Thymic Stromal Cells to semaphorin-3A.
CONCLUSION: Our data strongly suggest the active participation of Sema3A in thymic physiology, highlighting its role as an immunomodulatory molecule. This may provide important knowledge for understanding the interactions of thymic cells. PMID: 33070651 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - October 20, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Letter from the Editor 2020: Annual Summary and Introduction of the Thematic Issue and Guest Editor.
Authors: Rittenhouse-Olson K PMID: 33043771 [PubMed - in process] (Source: Immunological Investigations)
Source: Immunological Investigations - October 15, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

When Little Things Make a Big Difference.
Authors: Shenoy GN PMID: 33043772 [PubMed - in process] (Source: Immunological Investigations)
Source: Immunological Investigations - October 15, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association between TH2 Cytokine Gene Polymorphisms and Risk of Bullous Pemphigoid.
Conclusions: Our results indicate that IL-13 rs1800925 variation may be a protective genetic marker for the development of BP. Given this preventive effect against BP, therapeutic strategies could potentially be developed interfering with the functions of IL-13 cytokine, which seems to be integral in the pathogenesis of eosinophilic inflammatory disorders, such as BP. PMID: 33047635 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - October 15, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Protein Kinase C-Delta Defect in Autoimmune Lymphoproliferative Syndrome-Like Disease: First Case from the National Iranian Registry and Review of the Literature.
CONCLUSION: PRKCD should be considered in the context of ALPS clinical manifestations with prominent dermatological involvements. PMID: 33047643 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - October 15, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

microRNAs Alterations of Myocardium and Brain Ischemia-Reperfusion Injury: Insight to Improve Infarction.
Authors: Sabet Sarvestani F, Azarpira N Abstract Heart and cerebral infarctions, as two important ischemic diseases, lead to the death of tissues due to inadequate blood supply and high mortality worldwide. These statuses are started via blockage of vessels and depletion of oxygen and nutrients which affected these areas. After reperfusion and restoration of oxygen supply, more severe injury was mediated by multifaceted cascades of inflammation and oxidative stress. microRNAs (miRNAs) as the regulator of biological and pathological pathways can adjust these conditions by interaction with their targets. Also, miRNAs...
Source: Immunological Investigations - October 10, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

The Role of Regulatory T and B Cells in the Etiopathogenesis of Idiopathic Granulomatous Mastitis.
This study includes 47 patients with pathologically proven IGM (Group P) and 26 healthy subjects (Group C). The patients in Group P were divided into two groups according to whether their lesions were active (Group PA, n: 21) or in remission (Group PR, n: 26). By using flow-cytometry, the frequencies of CD3+CD4+CD45RA-Foxp3high activated Tregs (aTregs), CD3+CD4+CD45RA-Foxp3low non-suppressive Tregs, CD3+CD4+CD45RA+Foxp3low resting Tregs (rTregs), CD3+CD4+CD25+Foxp3- T-effector cells (Teff), total Tregs and Bregs were analyzed in all subjects. RESULTS: The frequency of the Teff cells was statistically higher in Group P ...
Source: Immunological Investigations - October 10, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Dysregulated Expression of miR-146a and Its Associated Immune Effectors in Peripheral Blood Mononuclear Cells of Esophageal Carcinoma Patients.
Authors: Nariman-Saleh-Fam Z, Mansoori Y, Saadatian Z, Tavakkoly-Bazzaz J, Daraei A, Zununi Vahed S, Mahmoodzadeh H, Bastami M Abstract Esophageal cancer is one of the least studied aggressive tumors, with the squamous cell carcinoma (ESCC) being the most frequent histological type around the world. Growing evidence has shown that the abnormal expression of microRNAs (miRNAs) in peripheral blood mononuclear cells (PBMCs) is closely related to the pathogenesis of cancers. MiR-146a is a crucial regulator of inflammatory cascades. There is currently no data available regarding the possible role of miR-146a in PBMCs of...
Source: Immunological Investigations - October 4, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

The Mechanical Autophagy as a Part of Cellular Immunity; Facts and Features in Treating the Medical Disorders.
Authors: Khalil H, Abd ElHady A, Elawdan KA, Mohamed D, Mohamed DD, Abd El Maksoud AI, El-Chennawi FA, El-Fikiy B, El-Sayed IH Abstract Autophagy is a cellular housekeeping process that incorporates lysosomal-degradation to maintain cell survival and energy sources. In recent decades, the role of autophagy has implicated in the initiation and development of many diseases that affect humanity. Among these diseases are autoimmune diseases and neurodegenerative diseases, which connected with the lacking autophagy. Other diseases are connected with the increasing levels of autophagy such as cancers and infectious disea...
Source: Immunological Investigations - October 1, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

COVID-19 Infection: Concise Review Based on the Immunological Perspective.
Authors: Lotfinejad P, Asadzadeh Z, Najjary S, Somi MH, Hajiasgharzadeh K, Mokhtarzadeh A, Derakhshani A, Roshani E, Baradaran B Abstract The outbreak of coronavirus disease 2019 (COVID-19) has posed a serious threat to public health. There is an urgent need for discovery methods for the prevention and treatment of COVID-19 infection. Understanding immunogenicity together with immune responses are expected to provide further information about this virus. We hope that this narrative review article may create new insights for researchers to take great strides toward designing vaccines and novel therapies in the near ...
Source: Immunological Investigations - September 30, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association of HLA-DRB1 Alleles with Rheumatic Fever and Rheumatic Heart Disease: A Meta-analysis.
Authors: Poomarimuthu M, Ramasamy T, Govindan R, Andiappan R, Nagarajan G, Kadiam S, Mariakuttikan J Abstract BACKGROUND: Rheumatic fever (RF) and its sequel rheumatic heart disease (RHD) is an autoimmune disease caused by an abnormal host immune response to group A streptococcus (GAS) infection. The HLA class II molecules are entailed in immune-mediated infectious, inflammatory, and autoimmune diseases including RHD. However, HLA class II genes are reported to be associated with RF/RHD across different populations with a very little consistency. OBJECTIVE: The aim of the study is to investigate the association...
Source: Immunological Investigations - September 26, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Serum 14-3-3 η is a Marker that Complements Current Biomarkers for the Diagnosis of RA: Evidence from a Meta-analysis.
CONCLUSION: Serum 14-3-3η protein is a supplementary biomarker in the diagnosis of RA. PMID: 32967487 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - September 26, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

MiRNA-146a rs2910164 Confers a Susceptibility to Digestive System Cancer: A Meta-Analysis Involving 59,098 Subjects.
Authors: Lv L, Gu H, Chen Z, Tang W, Zhang S, Lin Z Abstract BACKGROUND: MicroRNA (miR)-146a might participate in the occurrence of malignant tumor. The aim of the current investigation was to evaluate the relationship of microRNA-146a (miR-146a) rs2910164 C> G locus to the development of digestive system cancer (DSC). METHODS: We retrieved publications from PubMed, China Biology Medicine and EMBASE databases up to August 29, 2019. Finally, 56 independent case-control studies with 59,098 participants were included. The strength of the relationship between rs2910164 locus and a risk of DSC was assessed. ...
Source: Immunological Investigations - September 23, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Combined anti-SARS-CoV-2 IgA, IgG, and IgM Detection as a Better Strategy to Prevent Second Infection Spreading Waves.
Authors: Nuccetelli M, Pieri M, Gisone F, Bernardini S Abstract Coronavirus disease (COVID-19) is challenging many health, economic, and social systems. RT-PCR assays are diagnosis gold standard; however, they can lead to false-negative results. Therefore, anti-SARS-CoV-2 IgG, IgM, and IgA investigation can play a complementary role in assessing the individuals immune status. Majority of serological tests focus on IgM and IgG although IgA are the main immunoglobulins involved in mucosal immunity. It has been reported that digestive symptoms may occur in the absence of any typical respiratory symptom. Thus, a comple...
Source: Immunological Investigations - September 20, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Peripheral Blood Mononuclear Cells Expression Levels of miR-196a and miR-100 in Coronary Artery Disease Patients.
In conclusion, this study reported a distinct miR-196a expression pattern in PBMCs of all patient groups and recommended a biomarker potential for miR-196a in discriminating ICADs from CADs or healthy controls. PMID: 32928012 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - September 17, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Genetic Study of Hereditary Angioedema Type I and Type II (First Report from Iranian Patients: Describing Three New Mutations).
CONCLUSION: Final diagnosis with mutation analysis of HAE after clinical evaluation and assessment of C1INH level and function can prevent potential risks and life-threatening manifestations of the disorder. In addition, genetic diagnosis can play a significant role in facilitating early diagnosis, pre-symptomatic diagnosis, early diagnosis of children, asymptomatic cases, and those patients who have the borderline biochemical results of C1-INH deficiency and/or C4. PMID: 32896191 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - September 10, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Fc Receptor is Involved in Nk Cell Functional Anergy Induced by Miapaca2 Tumor Cell Line.
Authors: Ostapchuk YO, Perfilyeva YV, Kali A, Tleulieva R, Yurikova OY, Stanbekova GE, Karalnik BV, Belyaev NN Abstract Impaired NK cytotoxicity has been linked to poor cancer prognosis, but its mechanisms are not clearly established. Increasing data demonstrate that NK cells lose cytotoxicity after interaction with NK cell-sensitive tumor cells. In this paper, we provide evidence that the human adenocarcinoma cell line MiaPaCa2 and TNFα and TGFβ-treated MiaPaCa2 cultures (MiaPaCa2-TT) induced functional anergy of NK cells via FGL2 protein. MiaPaCa2-TT cultures decreased expression of IFNγ, CD107a,...
Source: Immunological Investigations - September 2, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Investigation of the Role of Interleukin 6 in Vitiligo Pathogenesis.
Authors: Singh M, Jadeja SD, Vaishnav J, Mansuri MS, Shah C, Mayatra JM, Shah A, Begum R Abstract Interleukin-6 (IL6) is involved in pathogenesis of several autoimmune disorders including vitiligo. Hence, we aimed to investigate the association of IL6 -174 G/C and -572 G/C polymorphisms and its transcript levels with vitiligo; to evaluate the effect of IL-6 on normal human melanocyte (NHM) viability and expression of IL6R, MITF and TYR. IL6 -174 G/C and -572 G/C polymorphisms were genotyped by ARMS-PCR and PCR-RFLP respectively in 343 controls and 322 vitiligo patients. IL6 transcript levels were estimated from PBM...
Source: Immunological Investigations - September 2, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Associations between Gene Polymorphisms in Pro-inflammatory Cytokines and the Risk of Inflammatory Bowel Disease: A Meta-analysis.
In conclusion, this meta-analysis demonstrated that IL-1B rs1143627 and IL-6 rs1800795 polymorphisms were significantly associated with the risk of IBD in overall population and Caucasians. Moreover, IL-8 rs4073 polymorphism was significantly associated with the risk of IBD in overall population and Asians. In addition, we also noticed that IL-18 rs187238 polymorphism was significantly associated with the risk of CD, and IL-18 rs1946518 polymorphism was significantly associated with the risk of IBD in Asians. PMID: 32847380 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - August 28, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Methylation Status of VDR Gene and its Association with Vitamin D Status and VDR Gene Expression in Pediatric Tuberculosis Disease.
Authors: Maruthai K, Sankar S, Subramanian M Abstract Deficiency in circulatory vitamin D level and vitamin D receptor DNA methylation could be associated with weakened innate immune response and increased susceptibility to tuberculosis (TB) disease in children. Therefore, we aimed to study the effect of vitamin D receptor (VDR) gene methylation on plasma vitamin D level and the expression of the VDR gene in children with active-TB disease. A cross-sectional comparative study was conducted in 43 children with active-TB and 33 healthy control children (HC). The vitamin D level was measured in plasma, while the level...
Source: Immunological Investigations - August 28, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

In Vitro Activation of Macrophages by an MHC Class II-restricted Trichomonas Vaginalis TvZIP8-derived Synthetic Peptide.
CONCLUSION: These results support the potential of TvZIP8 as a promising antigen to stimulates a specific macrophage response against T. vaginalis, but further analyses are required to evaluate their possible potential as a novel antigen for immunodiagnosis and/or vaccine against trichomoniasis. PMID: 32838604 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - August 27, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Predictive Value of Blood Interleukin-6 Level in Patients with Acute Coronary Syndrome: A Meta-analysis.
CONCLUSION: Increased blood level of interleukin-6may be independently associated with higher risk of MACE, cardiovascular and all-cause mortality in patients with ACS. Measurement of blood interleukin-6 level has potential to improve risk stratification of ACS. PMID: 32811241 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - August 21, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

An Immunosuppressive Effect of Melanoma-derived Exosomes on NY-ESO-1 Antigen-specific Human CD8+ T Cells is Dependent on IL-10 and Independent of BRAFV600E Mutation in Melanoma Cell Lines.
This study investigated the relationship between the BRAF mutational status of melanoma cells and the inhibition of secreted HMEX exosomes on antigen-specific human T cells. Exosomes were isolated from two melanoma cell lines, 2183-Her4 and 888-mel, which are genetically wild-type BRAFWT and BRAFV600E, respectively. HMEX were isolated using a modified, size-exclusion chromatography (SEC) method shown to reduce co-isolation of non-exosome-associated cytokines compared to ultracentrifugation isolation. The immunoinhibitory effect of the exosomes was tested in vitro on patient-derived NY-ESO-1-specific CD8+ T cells challenged...
Source: Immunological Investigations - August 18, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Impact of Proinflammatory Cytokine Gene Polymorphisms and Circulating CD3 on Long-Term Renal Allograft Outcome in Egyptian Patients.
In conclusion, IFN-γ + 874 T and TNF-α - 308 A alleles are risk alleles for renal transplant rejection and these two single nucleotide polymorphisms (SNPs) may be implicated in the tendency of rejection after renal transplantation. CD3 may be used as non-invasive biomarker in monitoring of rejection and avoid exposing patients for biopsy risks and sampling error. PMID: 32799719 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - August 18, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association between IL-33 Gene Polymorphism (Rs7044343) and Risk of Allergic Rhinitis.
CONCLUSION: Our results suggest that the TT genotype of rs7044343 C> T may act as a protective agent against allergic rhinitis. PMID: 32787469 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - August 14, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

C3 Gene Functional Polymorphisms and C3 Serum Levels in Patients with Rheumatoid Arthritis.
Authors: Sena L, Oliveira-Toré CF, Skare T, de Messias-Reason IJ, Andrade FA Abstract The complement system is a key component of the innate immunity that plays a significant role in the development and clinical presentation of Rheumatoid arthritis (RA). Complement protein C3 is a central molecule in the activation of complement with a significant role in the inflammatory processes of RA. Nevertheless, the impact of C3 gene polymorphisms in the development of RA is still unknown. The current study aimed to investigate the possible influence of C3 gene polymorphisms in the susceptibility and clinical expressi...
Source: Immunological Investigations - August 14, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

A Review of Immunomodulatory Effects of Fluoroquinolones.
This study aims to review past research on the immunomodulatory effects of FQs on the expression of cytokines, especially IL-2 and to discuss controversial investigations. PMID: 32746743 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - August 13, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Correction.
Authors: PMID: 32748657 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - August 13, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Upregulation of microRNA-155 Enhanced Migration and Function of Dendritic Cells in Three-dimensional Breast Cancer Microenvironment.
CONCLUSION: MiR-155 is a potential molecular regulator that may improve the efficacy of DCs-based tumor immunotherapy. PMID: 32757734 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - August 13, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Wharton's Jelly Mesenchymal Stem Cells Exosomes and Conditioned Media Increased Neutrophil Lifespan and Phagocytosis Capacity.
Authors: Taghavi-Farahabadi M, Mahmoudi M, Rezaei N, Hashemi SM Abstract Neutrophils are the first cells involved in inflammation and pathogen elimination, but they have a short lifespan. So, strategies for enhancing neutrophil lifespan and activities can be useful in many situations such as patients with immunodeficiencies. Previous researches demonstrated that mesenchymal stem cell (MSC) has anti-apoptotic effects on neutrophils. These multipotent cells have immunomodulatory properties and can be isolated from different tissues. MSCs isolated from Wharton's jelly (WJ-MSCs), a mucosal connective tissue of the umbi...
Source: Immunological Investigations - August 13, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Transcriptomic Profiling of Circulating HLA-DR- Myeloid Cells, Compared with HLA-DR+ Myeloid Antigen-presenting Cells.
Authors: Saleh R, Taha RZ, Sasidharan Nair V, Toor SM, Alajez NM, Elkord E Abstract Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells with potent immunosuppressive functions, which can inhibit the activation of immune responses under a steady-state condition and pathological conditions. We performed transcriptomic profiling of circulating CD33+HLA-DR+ myeloid antigen-presenting cells (APCs) and CD33+HLA-DR- myeloid cells (potentially MDSCs) in healthy individuals. We sorted both subpopulations from peripheral blood mononuclear cells (PBMCs) of 10 healthy donors and performed RNA seque...
Source: Immunological Investigations - August 1, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association of Rs231775 Genetic Variant of Cytotoxic T-lymphocyte Associated Protein 4 with Alopecia Areata Disease in Males: A Case-Control Study.
Conclusions Individuals with homozygosity of rs231775 CTLA4 variant represented AA disease risk and increased severity than their counterparts. Abbreviations AA: Alopecia areata; CTLA4: Cytotoxic T-lymphocyte Associated Protein 4; SNP: Single nucleotide polymorphism; LADA: Latent autoimmune diabetes in adults; SLE: Systemic lupus erythematosus; SCU: Suez Canal University; SALT: Severity of Alopecia Tool; DNA: Deoxyribonucleic acid; RT-PCR: Real-time polymerase chain reaction, HWE: Hardy-Weinberg equation; RA: rheumatoid arthritis. PMID: 32731768 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - August 1, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Central Nervous System and Cardiac Involvement in the Hypereosinophilic Syndrome: A Case Report.
In this study, we presented a 49-year-old woman with cardiac tamponade in the context of Hypereosinophilic syndrome. Identifying hypereosinophilia as the underlying cause can have tremendous clinical implications for rapid initiation of appropriate treatment to minimize further end organ damage. PMID: 32718188 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - July 29, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Analysis of the Clinical Efficacy of Dendritic Cell -cytokine Induced Killer Cell-based Adoptive Immunotherapy for Colorectal Cancer.
Authors: Xu H, Qin W, Feng H, Song D, Yang X, Zhang J Abstract BACKGROUND: To analyze the efficacy and safety of dendritic cell - cytokine - induced killer (DC-CIK) immunotherapy combined with chemotherapy for colorectal cancer. Method: A retrospective analysis was conducted in 116 patients from February 2012 to December 2017, who were divided into postoperative adjuvant chemotherapy group alone, combined DC-CIK immunotherapy group, advanced cancer palliative care group, and palliative care + DC-CIK immunotherapy group, to evaluate cellular immune function, disease-free survival(DFS) and overall survival(OS). Resul...
Source: Immunological Investigations - July 29, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Immune Responses to the Novel Coronavirus-2: Friend or Foe?
Authors: Mahmoodpoor A, Nader ND PMID: 32689852 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - July 22, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Overexpression of lncRNA HULC Attenuates Myocardial Ischemia/reperfusion Injury in Rat Models and Apoptosis of Hypoxia/reoxygenation Cardiomyocytes via Targeting miR-377-5p through NLRP3/Caspase ‑1/IL‑1β Signaling Pathway Inhibition.
CONCLUSIONS: Overall, these results indicate that the protective effect of HULC against myocardial I/R injury and H/R cardiomyocyte apoptosis partially relies on the inhibition of NLRP3/Caspase‑1/IL‑1β signaling pathway. PMID: 32674625 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - July 18, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association of the IL-6 Rs1800796 SNP with Concentration/dose Ratios of Tacrolimus and Donor Liver Function after Transplantation.
In conclusion, the IL-6 rs1800796 polymorphism was associated with the C/D ratios of tacrolimus and post-transplant donor liver function. PMID: 32674627 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - July 18, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research