Association of STAT4 Gene Rs7574865, Rs10168266 Polymorphisms and Systemic Lupus Erythematosus Susceptibility: A Meta-analysis.
Authors: Wang JM, Xu WD, Huang AF Abstract Association of signal transducer and activator of transcription 4 (STAT4) gene rs7574865, rs10168266 polymorphisms with systemic lupus erythematosus (SLE) risk remains unclear. A meta-analysis was conducted on the correlation between rs7574865, rs10168266 polymorphisms and SLE. Twenty-six studies were recruited in our study (17,389 patients and 29,273 controls). For rs7574865, results showed significant associations between T allele and SLE susceptibility in overall population, Asians and Europeans (OR=1.557, 95%CI: 1.505-1.611, P
Source: Immunological Investigations - May 22, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Development and Evaluation of Novel Aptamers Specific for Human PD1 Using Hybrid Systematic Evolution of Ligands by Exponential Enrichment Approach.
Conclusion: Further studies are required to assess the therapeutic potential of C42 aptamer and other aptamers developed in this study. The introduced PD1 specific aptamers can be used for specific detection of PD1 in diagnostic assay such as immunohistochemistry and targeted drug delivery to PD+ T cells. PMID: 32429721 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - May 22, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Endometriosis: What is the Influence of Immune Cells?
Conclusion: The recognition of the direct involvement of these two important physiological mechanisms causes a change in the pathophysiological focus of the disease. Researching the activities of numerous cells involved in immune reactions may offer new therapeutic targets. PMID: 32408782 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - May 16, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Upregulation of TIGIT and PD-1 in Colorectal Cancer with Mismatch-repair Deficiency.
Authors: Zhou X, Ding X, Li H, Yang C, Ma Z, Xu G, Yang S, Zhang D, Xie X, Xin L, Luo X Abstract Background: The role of T cell Ig and ITIM domain (TIGIT) and programmed cell death-1 (PD-1) in colorectal cancer (CRC) with mismatch repair deficiency is unknown.Methods: This was a study of 60 CRC patients with mismatch repair deficiency and 30 healthy controls between June 2015 and October 2015.Results: The expression of Foxp3, PD-1, and TIGIT was higher in cancer tissues compared with adjacent mucosa (all P
Source: Immunological Investigations - May 15, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

In Ataxia-Telangiectasia, Oral Betamethasone Administration Ameliorates Lymphocytes Functionality through Modulation of the IL-7/IL-7R α Axis Paralleling the Neurological Behavior: A Comparative Report of Two Cases.
In this study, we compared several immunological functions, including PBMC proliferative responses, cell activation events and IL-7/IL-7 Rα axis functionality, with the neurological behavior during an in-vivo GCs treatment between the most Responder patient to GC and the Non-Responder at all. During in-vivo GC treatment, we observed an increase of lymphocyte proliferation upon stimulation with PHA or IL-7 only in the Responder. This finding paralleled the increase in the surface expression of IL-7 R and up-regulation of the CD69 T-cell activation marker. Internalization and recycling of IL-7 R occ...
Source: Immunological Investigations - May 15, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Frequency of HLA Class I and Class II Alleles in Patients with CVID from Turkey.
Authors: Ozbek B, Tan C, Yaz I, Kosukcu C, Esenboga S, Cetinkaya PG, Cagdas D, Tezcan I Abstract BACKGROUND: Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency. Certain gene loci are pointed out in several studies in CVID patients. Until now, monogenic defects have been identified in only 2-10% of CVID patients; therefore, association of the disease with HLA alleles may be important for elucidating immunological and genetic mechanisms behind CVID. The aim of this study is to investigate the relationship between CVID and HLA alleles. METHODS: HLA class I/II alleles we...
Source: Immunological Investigations - May 8, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Soluble TREM-1 Levels in Familial Mediterranean Fever Related AA-Amyloidosis.
Authors: Ugurlu S, Egeli BH, Bolayirli IM, Ozdogan H Abstract Objectives: Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) is a monocyte and neutrophil receptor functioning in innate immunity. TREM-1 activity has been studied in various autoimmune diseases such as RA and SLE but there is no data in autoinflammatory pathologies. We studied soluble TREM-1 (sTREM-1) activity in Familial Mediterranean Fever (FMF) cases to evaluate the clinical role of TREM-1 in amyloidosis. Methods: The study includes 62 patients with FMF (42 with amyloidosis) who are regular attendees of a tertiary center for autoinflammatory...
Source: Immunological Investigations - April 25, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Cytokine-Encapsulated Biodegradable Microspheres for Immune Therapy.
Authors: Egilmez NK Abstract Therapeutic macromolecules such as proteins are conventionally administered via bolus injection, an approach that presents significant limitations. Sustained-release biodegradable nano/microsphere depots, on the other hand, represent a more physiological delivery tool for biologics. Here, we focus on an emerging novel application of this technology, i.e., cytokine-encapsulated biodegradable microspheres as immune therapeutics. The overall pre-clinical experience, recent advances and the clinical potential of such formulations are discussed. PMID: 32316775 [PubMed - as supplied by pu...
Source: Immunological Investigations - April 23, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

The Inhibitory Effect of Human Beta-defensin-3 on Candida Glabrata Isolated from Patients with Candidiasis.
In conclusion, hBD-3 has antifungal activity against C. glabrata and synergistic effects with fluconazole at concentrations that alone, have no cytotoxicity. hBD-3 could be used as an adjunctive therapy with first-line antifungal agents for patients with C. glabrata infection particularly those infected with fluconazole-resistant strains. PMID: 32316784 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - April 23, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Exosomes Represent an Immune Suppressive T Cell Checkpoint in Human Chronic Inflammatory Microenvironments.
Conclusion: Immunosuppressive exosomes present in non-malignant chronic inflammatory tissues represent a new T cell checkpoint, and potentially represent a novel therapeutic target to enhance the response to current therapies and prevent disease recurrences. PMID: 32299258 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - April 19, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Analysis of Toll-Like Receptor-2 and 4 Expressions in Peripheral Monocyte Subsets in Patients with Type 1 Diabetes Mellitus.
Conclusions: The observed changes in both proportions and TLR-2 and TLR-4 expression of monocyte subsets can raise the possible role in the pathogenesis of early stages of T1DM and DKA.Abbreviations APC: allophycocyanin; CBC: complete blood picture; DKA: diabetic acidosis; DM: diabetes mellitus; FITC: fluorescein isothiocyanate; FSC: forward scatter; Hb: haemoglobin; MFI: mean channel fluorescence intensity; PE: phycoerythrin; PRR: pattern-recognition receptors; SPSS: statistical package for the social sciences; SSC: side scatter; T1DM: Type1DM; TLRs: toll-like receptors. PMID: 32281447 [PubMed - as supplied by publish...
Source: Immunological Investigations - April 15, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

The Role of Stroma in Ovarian Cancer.
Conclusion: We consider ovarian cancer as a heterogeneous disease, not only in the sense that different histological or molecular subtypes may be behind the same clinical result, but also that multiple cell types besides cancer cells, like other non-cellular components, need to be mobilized and coordinated to support tumor survival, growth, invasion and progression. PMID: 32264761 [PubMed - in process] (Source: Immunological Investigations)
Source: Immunological Investigations - April 9, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Serum Levels of Hepcidin in Rheumatoid Arthritis and Its Correlation with Disease Activity and Anemia: A Meta-analysis.
Authors: Chen Y, Xu W, Yang H, Shao M, Xu S, Deng J, Gao X, Liu H, Shuai Z, Xu S, Pan F Abstract Present studies on serum hepcidin levels in patients with rheumatoid arthritis (RA) are inconsistent. We aimed to synthetically evaluate the relationship between hepcidin and RA, and the correlation of serum hepcidin levels and RA disease activity as well as anemia associated with RA. Multiple electronic databases were searched. Pooled standard mean difference (SMD) with 95% confidence interval (CI) and correlation coefficients between hepcidin levels and rheumatoid factor (RF), disease activity for 28 joints (DAS28), a...
Source: Immunological Investigations - March 30, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Associations between TNFSF4 gene polymorphisms (rs2205960 G > A, rs704840 T > G and rs844648 G > A) and susceptibility to autoimmune diseases in Asians: a meta-analysis.
CONCLUSIONS: This current meta-analysis suggested that all of the three TNFSF4 polymorphisms may be associated with ADs susceptibility in Asians. PMID: 32208776 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - March 29, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Biological Function and Immunotherapy Utilizing Phosphatidylserine-based Nanoparticles.
Authors: Glassman FY, Dingman R, Yau HC, Balu-Iyer SV Abstract Phosphatidylserine (PS) is a naturally occurring anionic phospholipid that is primarily located in the inner leaflet of eukaryotic cell membranes. The role of PS during apoptosis is one of the most studied biological functions of PS. Externalization of PS during apoptosis mediates an "eat me" signal for phagocytic uptake, leading to clearance of apoptotic cells and thus maintain self-tolerance by immunological ignorance. However, an emerging view is that PS exposure-mediated cellular uptake is not an immunologically silent event, but rather pr...
Source: Immunological Investigations - March 26, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Chikungunya Virus Infection Outcome: A Systematic Review of Host Genetics.
Conclusion: Majority of the studies were conducted in India. Meta-analysis suggests that DRB1*14 is related to the susceptibility of symptomatic CHIKV infection in Indian population. The literature about CHIKV infection and genetic variations is scarce. The precise role of genetic variation in CHIKV is not clear yet. Further studies are necessary to provide more concrete evidences. PMID: 32204641 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - March 26, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Genetic polymorphisms of the HLA-DP and HLA-DQ genes could influence Hepatitis B virus infection in Yunnan population.
Authors: Song Y, Xia T, Xia X, Zhang AM Abstract Hepatitis B, caused by hepatitis B virus (HBV) infection, is one of the epidemic and infectious hepatitis diseases. The sigle-nucleotide polymorphisms were identified to associate with HBV infection in East Asian population by genome-wide association study (GWAS), but no study in Yunnan HBV population was reported. We recruited 493 HBV patients and 460 general controls to genotype 7 GWAS SNPs, and then, the association study was performed between these SNPs and biochemical features of HBV patients. The results showed that genotype and allele frequencies of SNPs in th...
Source: Immunological Investigations - March 20, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Breast Cancer Is Associated with Increased HLA-DRB1*11:01 and HLA-DRB1*10:01 Allele Frequency in a Population of Patients from Central Italy.
Authors: Aureli A, Canossi A, Del Beato T, Buonomo O, Rossi P, Roselli M, Papola F, Marziani B, Sconocchia G Abstract The relationship between HLA-DRB1 allele polymorphism and breast cancer (BC) development is still unclear and needs further investigation.To address this issue, we analyzed HLA-DRB1 allele frequency (AF) by sequence-based typing (SBT) in 47 patients from central Italy with BC and 156 sex and age-matched healthy controls. Two hundred ninety-seven individuals from the same region were utilized as historical controls. Pearson's chi-square analysis with Yate's correction or Fisher's Exact test with Bonf...
Source: Immunological Investigations - March 20, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

IL-10, IL-18 Gene Polymorphisms Might Influence Predisposition to Coronary Artery Disease in East Asians: A Meta-Analysis.
In conclusion, this meta-analysis suggested that IL-10 rs1800871, IL-10 rs1800896, IL-18 rs187238 and IL-18 rs1946518 polymorphisms might influence predisposition to CAD in East Asians. PMID: 32160807 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - March 13, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Effect of Class Switch Recombination Defect on the Phenotype of Ataxia-Telangiectasia Patients.
In this study, 41 patients with confirmed diagnosis of A-T (16 A-T patients with HIgM, 15 A-T patients with IgA-D, and 10 A-T patients with normal Ig levels) from Iranian immunodeficiency registry center were enrolled. B-cell proliferation, in vitro CSR toward IgE and IgA were compared between three groups as well as G2 radiosensitivity assay.Results: Earliest presentation of telangiectasia was a significant hallmark in A-T patients with CSR-D (p = .036). In this investigation, we found that the frequency of respiratory infection (p = .002), pneumonia (p = .02), otitis media (p = .008), chronic fever (p
Source: Immunological Investigations - March 3, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Modulation of Th17 Proliferation and IL-17A Gene Expression by Acetylated Form of Apigenin in Patients with Multiple Sclerosis.
This study aimed to investigate the in vitro effects of the Apigenin 3-Acetate on Th17 cells of MS patients and compare its efficacy with Apigenin and Methyl Prednisolone Acetate.IC50 for Apigenin 3-Acetate, and Methyl Prednisolone Acetate were determined using three healthy volunteers. The peripheral blood mononuclear cells (PBMCs) of five MS patients were isolated and co-cultured with a selected dose of Apigenin, Apigenin 3-Acetate, and Methyl Prednisolone Acetate for 48 hr, and then theproliferation of Th17 cells in isolated PBMCs was assessed by flow cytometry. The levels of RAR-related orphan receptor (RORC) and IL-17...
Source: Immunological Investigations - February 28, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Single-nucleotide Polymorphism rs17860041 A/C in the Promoter of the PPIA Gene is Associated with Susceptibility to Kawasaki Disease in Chinese Children.
Authors: Shi R, Luo Y, Li S, Kong M, Liu X, Yu M, Wu J, Huang L, Yang Z Abstract Background: Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology. Cyclophilin A (CypA), also known as PPIA, has been identified to play a vital role in the pathogenesis of cardiovascular or inflammatory diseases. However, no studies have examined the relationship between single-nucleotide polymorphisms (SNPs) in the peptidylprolyl isomerase A (PPIA) and the development of KD and KD with or without coronary artery lesions (CALs).Objective: The present study was conducted to evaluate whether PPIA SNPs are associated ...
Source: Immunological Investigations - February 23, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Infection of Epstein-Barr Virus is Associated with the Decrease of Helios+FoxP3+Regulatory T Cells in Active Ulcerative Colitis Patients.
Conclusion: Helios+FoxP3+Tregs are likely to play a pivotal role in disease activity of UC and may be influenced by EBV infection. PMID: 32046542 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - February 14, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association between IFN- λ 3 Gene Polymorphisms and Outcome of Treatment with Direct Acting Antivirals in Chronic HCV-Infected Egyptian Patients.
Association between IFN-λ 3 Gene Polymorphisms and Outcome of Treatment with Direct Acting Antivirals in Chronic HCV-Infected Egyptian Patients. Immunol Invest. 2020 Feb 05;:1-11 Authors: El-Garawani I, Hassab El-Nabi S, Gadallah M, Abdelsameea E Abstract Background: Single nucleotide polymorphisms (SNPs) of the interferon lambda 3 (IFN-λ 3) gene are associated with viral clearance and treatment response in chronic hepatitis C virus (HCV) infection.Aim: to assess whether specific IFN-λ 3 gene SNP, known as rs12979860 (C> T), could predict the outcome of treatment with direct act...
Source: Immunological Investigations - February 8, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Comparative of the Effectiveness and Safety of Biological Agents, Tofacitinib, and Fecal Microbiota Transplantation in Ulcerative Colitis: Systematic Review and Network Meta-Analysis.
CONCLUSION: Of the biological agents, vedolizumab and infliximab were the most effective, suggesting that biological agents are still a better choice. Nevertheless, tofacitinib and FMT may be promising alternatives with high efficacies. However, more safety and maintenance studies need to be conducted in future for the acquisition of more accurate results.Abbreviations: FMT: Fecal microbiota transplantation; UC: Ulcerative colitis; RCTs: Randomized controlled trials; IBD: Inflammatory bowel disease; CD: Crohn's disease; IBS: Irritable bowel syndrome; CDI: Clostridium difficile infections; ITT: Intention-to-treat; RR: Relat...
Source: Immunological Investigations - February 6, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy.
Authors: Jafarinia M, Alsahebfosoul F, Salehi H, Eskandari N, Ganjalikhani-Hakemi M Abstract In recent years, mesenchymal stem/stromal cells (MSCs) have widely been considered as therapeutic tools in basic researches and clinical trials. Accumulating evidence supports the idea that MSCs perform their therapeutic roles in paracrine manner especially through trophic factors and extracellular vesicles (EVs). Compared to cells, EVs have several advantages to be used as therapeutic agents, such as they lack self-replicating capabilities, dangers of ectopic differentiation, and tumor formation, genetic instability, and c...
Source: Immunological Investigations - February 6, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Study of Toll ‑Like Receptor 4 Gene Polymorphisms in Colorectal Cancer: Correlation with Clinicopathological Features.
Study of Toll‑Like Receptor 4 Gene Polymorphisms in Colorectal Cancer: Correlation with Clinicopathological Features. Immunol Invest. 2020 Jan 29;:1-14 Authors: Moaaz M, Youssry S, Moaz A, Abdelrahman M Abstract Polymorphisms of Toll-like receptor 4 (TLR4) as a key player in cell proliferation, apoptosis, and angiogenesis have been linked to colorectal cancer (CRC) in different populations. We aimed in this study to determine genetic associations of TLR4 variants with CRC progression in Egyptian patients. Genotype and allelic frequencies of Asp299Gly (rs4986790) and Thr399Ile (rs4986791) were compare...
Source: Immunological Investigations - February 1, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Activated γδ T Cells Promote Dendritic Cell Maturation and Exacerbate the Development of Experimental Autoimmune Uveitis (EAU) in Mice.
In this study we showed that mature DC numbers in TCR-δ-/- (KO) EAU mice were lower than those in wild-type (WT) C57BL/6 (B6) mice. The γδ T cells harvested from WT EAU mice secreted more interferon-γ (IFN-γ), however, after blocking IFN-γ, the maturation of DCs was significantly downregulated. By contrast, the percentage of IFN-γ- and IL-17-producing CD4+ T cells in KO EAU mice decreased to a greater extent than that in WT EAU mice during the inflammatory phase. Additionally, the levels of IFN-γ/IL-17 in serum were in agreement with those of CD4+ T cells. Furthermore, after ...
Source: Immunological Investigations - January 29, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Effect of H4R Antagonist N-(2-Aminoethyl)-5-Chloro-1H-Indole-2-Carboxamide (Compound A) in a Mouse Model of Allergic Asthma.
In this study we examined the effect of Compound A, N-(2-Aminoethyl)-5-chloro-1H-indol-2-carboxamide a H4 receptor antagonist in allergic asthma mice model. Objective: To investigate the anti-asthmatic effect of compound A in in vivo, airway inflammation in ovalbumin (OVA) induced allergic asthma mouse model was used.Methodology: Allergic asthma was induced in Balb/c mice using ovalbumin. BAL fluid was examined for the level of IgE, IL-4, IL-5, IL-13 and IL-17 using ELISA. Furthermore, infiltration of leucocytes by histopathology and effect of compound A on signalling molecules were examined in lung tissue.Results: In mice...
Source: Immunological Investigations - January 29, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

"Clinical Aspects of Chronic Granulomatous Disease in Upper Egypt".
"Clinical Aspects of Chronic Granulomatous Disease in Upper Egypt". Immunol Invest. 2020 Jan 22;:1-13 Authors: El-Mokhtar MA, Salama EH, Fahmy EM, Mohamed ME Abstract Chronic granulomatous disease (CGD) is a rare inherited primary immunodeficiency disorder that affects phagocytes and is characterized by a marked increased susceptibility to severe bacterial and fungal infections. We aimed to describe the clinical presentations of pediatric patients with CGD in Upper Egypt and to identify the defective component of NADPH oxidase. Pediatric patients diagnosed with CGD within one year from Januar...
Source: Immunological Investigations - January 23, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association Study between Psoriatic Arthritis and Killer Immunoglobulin-Like Receptor (KIR) Genes: A Meta-Analysis.
Authors: Enciso-Vargas M, Alvarado-Ruíz L, Suárez-Villanueva AS, Macías-Barragán J, Montoya-Buelna M, Oceguera-Contreras E, Alvarado-Navarro A, Graciano-Machuca O Abstract Background: Psoriatic Arthritis (PsA) is a seronegative spondyloarthropathy frequently associated with psoriasis. Studies have shown different members of the KIR (Killer Immunoglobulin-like Receptor) gene family may act as potential susceptibility factors; however, data have been inconsistent or with a reduced sample size. Therefore, the objective of this investigation was to determine associations between KIR genes an...
Source: Immunological Investigations - January 22, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

MiR-146a Promotes Tolerogenic Properties of Dendritic Cells and through Targeting Notch1 Signaling.
Conclusion: miRNA-146a promoted tolerogenic properties of DCs, at least partially, through targeting Notch1 signaling. PMID: 31957545 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - January 22, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Genetic Variation on TNF/LTA and TNFRSF1A Genes is Associated with Outcomes of Hepatitis C Virus Infection.
Authors: Yue M, Huang P, Wang C, Fan H, Tian T, Wu J, Luo F, Fu Z, Xia X, Zhu P, Li J, Han Y, Zhang Y, Hou W Abstract Hepatitis C virus (HCV) infections are a serious global-scaled public health problem. Tumor necrosis factor (TNF)/lymphotoxin alpha (LTA) has been found to play a crucial role in relation to the outcomes of HCV infection after it binds to TNF receptor superfamily member 1A (TNFRSF1A). Thus, we investigated whether or not the TNF/LTA gene cluster and TNFRSF1A gene polymorphisms were associated with the outcomes of HCV infection. 1103 control participants without HCV infection, 497 patients with spont...
Source: Immunological Investigations - January 15, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Increased Circulating Osteoprotegerin Levels in Type 1 Diabetes Mellitus: A Systematic Review and Meta-analysis Based on Observational Studies.
Authors: Duan CC, Ma C, Tang HQ Abstract Objectives: Type 1 diabetes mellitus (T1D) has been disclosed to be associated with an elevated risk of cardiovascular disease (CVD), as well as increased risks of losing bone mass and progression of osteoporosis (OP). Osteoprotegerin (OPG), as a decoy receptor, has been demonstrated to play a critical role in bone metabolism homeostasis and vascular atherosclerotic diseases. This meta-analysis aimed to investigate the associations between OPG levels and T1D.Methods: Related literatures were searched and identified from the database of the Cochrane Library database, PubMed a...
Source: Immunological Investigations - January 12, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Role of Zinc Sulphate in Immune Regulation in Artemisia annua Pollen-challenged P815 Mastocytoma Cells.
Conclusion: Zinc sulphate can promote the proliferation of P815 mastocytoma cells. It can also attenuate allergic response in the P815 mastocytoma cells induced by Artemisia annua pollen, which might provide a new treatment method for allergic diseases. PMID: 31913054 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - January 10, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Analysis of the Influence of Interleukin-1 β Gene Polymorphism on Gastric Inflammatory Response and Precancerous Lesions Development in Patients with Functional Dyspepsia.
In conclusion, our data suggest that genetic variants of the IL1B -31C/T polymorphism play a role in chronic inflammation of the gastric mucosa in H. pylori-infected FD patients. PMID: 31909646 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - January 9, 2020 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Role of CD226 Rs763361 Polymorphism in Susceptibility to Multiple Autoimmune Diseases.
Conclusion: These findings demonstrate that CD226 rs763361 polymorphism confers susceptibility to ADs in the overall population, Europeans, Asians, Africans, and South Americans. rs763361 polymorphism in CD226 gene may be a potential susceptible predictor of ADs especially RA, SLE, T1D, and MS. PMID: 31854233 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - December 21, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Nanobodies in Human Infections: Prevention, Detection, and Treatment.
Authors: Sanaei M, Setayesh N, Sepehrizadeh Z, Mahdavi M, Yazdi MH Abstract Despite the existence of vaccination, antibiotic therapy, and antibody therapies, infectious diseases still remain as one of the biggest challenges to human health all over the world. Among the different methods for treatment and prevention of infectious diseases, antibodies are well known but poorly developed. There is a new subclass of antibodies calledheavy-chain antibodies that belong to the IgG isotype. However, they are low in molecular weight and lost the first constant domain (CH1). Their single-domain antigen-binding fragments, ide...
Source: Immunological Investigations - December 21, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Elevated Circulating Interleukin-17 Levels in Patients with Systemic Lupus Erythematosus: A Meta-analysis.
Authors: Shen HH, Fan Y, Wang YN, Zhao CN, Zhang ZK, Pan HF, Wu GC Abstract Background: Previous studies concerning the circulating interleukin-17 (IL-17) in systemic lupus erythematosus (SLE) were contradictory.Aims: To further precisely investigate circulating IL-17 in SLE and evaluate its influential factors by meta-analysis.Methods: EMBASE, PubMed and Cochrane Library were comprehensively searched to obtain studies on circulating IL-17 in SLE patients by November 22, 2018. The results were illustrated by pooled standard mean difference (SMD) with corresponding 95% confidence interval (CI) using random-effects m...
Source: Immunological Investigations - December 20, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association between Monocyte Chemoattractant Protein-1 -2518 (A/G) Single Nucleotide Polymorphism and Chronic Periodontitis in End-stage Renal Disease Patients - A Case-control Study.
Authors: Ksiazek K, Buraczynska M Abstract Monocyte chemoattractant protein 1 (MCP-1) plays an important role in the development of periodontitis. The purpose of this investigation was to evaluate association of the  MCP-1 gene polymorphism with chronic periodontitis in patients with end-stage renal disease (ESRD). One hundred fifty ESRD patients with chronic periodontitis (CP), 100 without CP and 190 healthy controls were included in this study. Genomic DNA from all participants was genotyped for the -2518 (A/G) polymorphism by a polymerase chain reaction - restriction fragment length polymorphism (PCR--RFLP)...
Source: Immunological Investigations - December 20, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Comparative Expression Analysis of Stress-Inducible Genes in Murine Immune Cells.
Conclusion: These results suggest that singular and repetitive bouts of stress lead to differential gene expression in mice and stress-induced gene expression in thymocytes is distinct from that observed in splenocytes. Gilz, Rtp801, and Mkp-1 genes induced by short restraint stress are dependent on CRH in the spleen. PMID: 31833438 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - December 14, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Association of Interleukin-23R Gene Polymorphisms with Behcet's Disease Susceptibility: A Meta-Analysis of Case-control Studies.
This study aimed to investigate the association between IL-23R gene polymorphisms and BD susceptibility.Methods: Comprehensive literature search was performed across four online databases - PubMed, Embase, Cochrane Library, and Web of science. The included studies had to be published before May 15, 2019. The Newcastle-Ottawa scale was used to assess the quality of every included study, and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using the allele model of inheritance to evaluate the potential associations between IL-23R gene polymorphisms and BD risk.Results: In all, 12 case-control s...
Source: Immunological Investigations - December 11, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Soluble MICA and anti-MICA Antibodies as Biomarkers of Nasopharyngeal Carcinoma Disease.
Authors: Chaaben Arij B, Nesrine O, Hayet D, Fayza A, Hajer A, Tesnim M, Latifa H, Cathy F, Wahid B, Rajagopal K, Dominique C, Sonia G, Fethi G, Ryad T Abstract The MHC class I chain-related molecule A (MICA) is a ligand for the activating natural killer (NK) cell receptor NKG2D. A part from its genetic diversity, MICA is characterized by the presence of membrane-bound and soluble isoform (sMICA) and by the propensity to elicit antibody-mediated allogeneicity (MICA Abs). Altogether such properties are important in the cancer setting. Here, we investigated whether MICA polymorphism, serum level of sMICA and MICA ant...
Source: Immunological Investigations - December 11, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Assessment of the Prevalence of Non-Organ-Specific Autoantibodies in Egyptian Patients with HCV.
Authors: Emara M, Mohsen E, Shawky RM, El-Domany RA Abstract The relation between non-organ specific autoantibodies (NOSA) and hepatitis C virus (HCV) infection has been investigated within different communities resulting in different prevalence rates and patterns. The purpose of this study was to investigate the prevalence of some NOSA such as RF-IgG, ANA, ASMA, and LKM-1 in Egyptian patients with HCV group as compared with Egyptian healthy controls group. A total of 186 HCV positive serum samples in addition to 81 samples from healthy control were screened for the presence of some common autoantibodies (RF-IgG, A...
Source: Immunological Investigations - December 11, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Particulate Matter, Asian Sand Dust Delays Cyclophosphamide-induced Type 1 Diabetes in NOD Mice.
Authors: Morita K, Wang D, Baba R, Morimoto H, Song Y, Kanazawa T, Yoshida Y Abstract Although it is known that desert dust exacerbates allergic diseases, how it affects the onset of autoimmune diseases is unclear. No epidemiological investigations or animal experiments have been conducted so far to elucidate the effects of desert dust on autoimmune diseases. Here, we focused on particulate matter, such Asian sand dust (ASD) that has been known to cause adverse health effects in East Asian countries, and conducted animal experiments to examine how ASD influences type 1 diabetes (T1D), an autoimmune disease. An ASD ...
Source: Immunological Investigations - December 11, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Design and Optimization of PLGA Particles to Deliver Immunomodulatory Drugs for the Prevention of Skin Allograft Rejection.
Conclusion: We will discuss the mediating factors for rejection of alloskin graft, selective depletion of immune cells, controlled release mechanism, physiochemical properties, size-based body distribution of PLGA particles and their effect on overall host immune system. PMID: 31809611 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - December 7, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

The Inhibitory Effects of Pentacyclic Triterpenes from Loquat Leaf against Th17 Differentiation.
Conclusion: These results demonstrated that OA can improve the clinical manifestation of LN, indicating potential application in SLE therapy. PMID: 31795780 [PubMed - as supplied by publisher] (Source: Immunological Investigations)
Source: Immunological Investigations - December 6, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Dendritic Cells Therapy with Cytokine-Induced Killer Cells and Activated Cytotoxic T Cells Attenuated Th2 Bias Immune Response.
In this study, 112 patients with cancer were assigned to the DC/CIK treatment and 116 patients received the DC-ACT therapy. We detected the lymphocyte subsets and other immune indicators pre- and post-treatment to evaluate the changes of patient's immunity and compare the differences in immune status between two adoptive cellular immunotherapies.Results: DC/CIK therapy elevated the percentage of CD3+ HLA-DR+ T cells, NK cells and several serological cytokines such as IL-2, IL-6 after cell infusion (p
Source: Immunological Investigations - December 4, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Vaccine Efficacy Induced by 2009 Pandemic H1N1 Virus-Like Particles Differs from that Induced by Split Influenza Virus.
In this study, we generated VLPs vaccine containing hemagglutinin (HA) and matrix protein (M1) of the 2009 pandemic H1N1, and investigated the protective efficacies induced by VLPs vaccine and commercial monovalent H1N1 pandemic split vaccine from Sanofi-Pasteur. Mice were intramuscularly immunized with either VLPs vaccine or split vaccine and subsequently challenge-infected with homologous virus (A/California/04/2009, H1N1) or heterosubtypic virus (A/Philippines/82, H3N2) after 4.5 months. VLPs vaccination demonstrated a higher level of protective efficacy against homologous viruses compared to split vaccine, as lessened ...
Source: Immunological Investigations - November 29, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

Cutaneous Granulomatosis and Class Switching Defect as a Presenting Sign in Ataxia-Telangiectasia: First Case from the National Iranian Registry and Review of the Literature.
Authors: Amirifar P, Yazdani R, Moeini Shad T, Ghanadan A, Abolhassani H, Lavin M, Sotoudeh S, Aghamohammadi A Abstract Ataxia-telangiectasia (A-T) is a rare autosomal recessive syndrome characterized by progressive cerebellar ataxia, oculocutaneous telangiectasia, immunodeficiency and cancer predisposition, caused by mutations in the ataxia telangiectasia mutated (ATM) gene. The clinical and immunological manifestations of A-T are very heterogeneous, especially at an early age, leading to frequent misdiagnosis. Cutaneous granulomas with unknown pathogenesis occur uncommonly in a minority of A-T patients. We herein...
Source: Immunological Investigations - November 27, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research