Ankylosing Spondylitis Patients Display Aberrant < em > ERAP1 < /em > Gene DNA Methylation and Expression
This study aimed to evaluate the relationship between promoter methylation and mRNA levels of ERAP1 and AS susceptibility.METHODS: DNA methylation levels of 100 AS patients and 100 healthy controls (HCs) were tested using a targeted bisulfite sequencing assay. To verify the results of DNA methylation, mRNA levels of ERAP1 were measured in 20 AS patients and HCs used quantitative real-time reverse transcription-polymerase chain reaction.RESULTS: The DNA methylation levels of two CpG islands containing 31 loci in ERAP1 promoter were measured. ERAP1_1 (P
Source: Immunological Investigations - September 24, 2021 Category: Allergy & Immunology Authors: Yubo Ma Dazhi Fan Shanshan Xu Jixiang Deng Xing Gao Shiyang Guan Xu Zhang Faming Pan Source Type: research

Circ_0128846/miR-140-3p/JAK2 Network in Osteoarthritis Development
This study attempted to confirm the role of a novel circRNA circ_0128846 during osteoarthritis (OA) progression. Tissues and chondrocytes were isolated from OA patients. Overexpression and knockdown of target genes were generated using cell transfection and siRNA interference. Expression levels of genes were measured by qRT-PCR, Western blot, and immunohistochemistry, respectively. The interactions among circ_0128846, miR-140-3p, and JAK2 were verified by bioinformatics prediction, a dual-luciferase reporter assay, and RNA immunoprecipitation assay. The role of circ_0128846 in vivo was confirmed by the construction of expe...
Source: Immunological Investigations - September 21, 2021 Category: Allergy & Immunology Authors: Hongjun Li Zhongyu Liu Xiaoyun Guo Mei Zhang Source Type: research

Mechanism of the Fibroblast Growth Factor 23/ α-Klotho Axis in Peripheral Blood Mononuclear Cell Inflammation in Alzheimer's Disease
Immunol Invest. 2021 Sep 10:1-14. doi: 10.1080/08820139.2021.1970180. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a prevalent type of dementia and threatens the health of most elderly people and poses a huge burden to families and society. The fibroblast growth factor 23 (FGF23)/α-Klotho axis is associated with multiple aging-related diseases. Hence, this study explored the mechanism of the FGF23/α-Klotho axis in AD. FGF23/α-Klotho protein contents and levels of inflammatory cytokines in AD patients were measured, and the correlation between FGF23/α-Klotho protein contents and inflamma...
Source: Immunological Investigations - September 10, 2021 Category: Allergy & Immunology Authors: Baoshan Li Min Zhou Jing Peng Qiao Yang Jingxin Chu Ruoqing Li Yi Jiang Source Type: research

Epithelial-mesenchymal Transition of Peritoneal Mesothelial Cells Is Enhanced by M2c Macrophage Polarization
This study was to investigate the effect of macrophage polarization on EMT of PMCs.METHODS: Monocyte-macrophage cells (THP-1) were treated to induce macrophage subsets (M1, M2a, M2c). The inducing was assessed by detecting protein and mRNA expression of cytokines using ELISA and RT-PCR. Subsequently, PMCs were co-cultured with M1, M2a and M2c, respectively, in Transwell chambers for 48 h and then expressions of E-cadherin and α-SMA were determined in PMCs. The PMCs that were not co-cultured with macrophages served as control PMCs. One-way ANOVA and SNK-q test were used to conduct statistics and P
Source: Immunological Investigations - September 7, 2021 Category: Allergy & Immunology Authors: Lifang Tian Qiaoling Yu Dan Liu Zhao Chen Yuzhan Zhang Jiamei Lu Xiaoqin Ma Fumeng Huang Jin Han Lingting Wei Lei Zhang Jie Gao Li Wang Rongguo Fu Source Type: research

Contribution of pre-existing neoantigen-specific T cells to a durable complete response after tumor-pulsed dendritic cell vaccine plus nivolumab therapy in a patient with metastatic salivary duct carcinoma
In this study, we reported a case of refractory metastatic SDC that was treated with a tumor lysate-pulsed DC vaccine followed by a single injection of low-dose nivolumab, and a durable complete response was achieved. We retrospectively analyzed the immunological factors that contributed to these long-lasting clinical effects. First, we performed neoantigen analysis using resected metastatic tumor specimens obtained before treatment. We found that the tumor had 256 non-synonymous mutations and 669 class I high-affinity binding neoantigen peptides. Using synthetic neoantigen peptides and ELISpot analysis, we found that peri...
Source: Immunological Investigations - September 6, 2021 Category: Allergy & Immunology Authors: Shu Ichimiya Akiko Fujimura Muneyuki Masuda Shogo Masuda Ryuji Yasumatsu Masayo Umebayashi Hiroto Tanaka Norihiro Koya Shinichiro Nakagawa Poh Yin Yew Sachiko Yoshimura Hideya Onishi Masafumi Nakamura Yusuke Nakamura Takashi Morisaki Source Type: research

Letter from the Editor: 2021
Immunol Invest. 2021 Oct;50(7):735-739. doi: 10.1080/08820139.2021.1956723.NO ABSTRACTPMID:34459686 | DOI:10.1080/08820139.2021.1956723 (Source: Immunological Investigations)
Source: Immunological Investigations - August 30, 2021 Category: Allergy & Immunology Authors: Adam J Adler Source Type: research

Association of Elongation Factor Tu GTP-binding Domain-containing 2 Gene < em > (EFTUD2) < /em > Polymorphism with the Risk of Hepatitis B Virus Infection
Immunol Invest. 2021 Aug 26:1-13. doi: 10.1080/08820139.2021.1970763. Online ahead of print.ABSTRACTBACKGROUND: The elongation factor Tu GTP-binding domain-containing 2 gene (EFTUD2) participates in antiviral immune responses. However, the association between genetic polymorphisms of EFTUD2 and hepatitis B virus (HBV) infection susceptibility has not been well-studied. We analyzed the relationship between single nucleotide polymorphisms (SNPs) of EFTUD2 and HBV infection susceptibility and clarified the potential function.METHODS: In total, 448 control subjects and 379 patients with chronic HBV infection from Zhangjiagang ...
Source: Immunological Investigations - August 26, 2021 Category: Allergy & Immunology Authors: Anran Tian Yuwen Li Haozhi Fan Pingping Hu Ruirui Xu Hui Yuan Jinyuan Cai Wen Zhang Ming Yue Jun Li Chen Dong Chuanlong Zhu Source Type: research

Thymic and Peripheral T-cell Polarization in an Experimental Model of Russell's Viper Venom-induced Acute Kidney Injury
Immunol Invest. 2021 Aug 12:1-19. doi: 10.1080/08820139.2021.1960369. Online ahead of print.ABSTRACTVenom pathology is not restricted to the direct toxic effects of venom. Immunoinflammatory alteration as the etiology of snake venom-induced acute kidney injury (SAKI) is a less trodden path toward the development of alternative therapeutic approach. In the present study, we have associated the crest of renal damage stage to the immunological alteration, as reflected in thymic and peripheral T cell polarization in the murine model of SAKI. Renal injury in mice was confirmed from significant dysuresis and adversely altered bi...
Source: Immunological Investigations - August 12, 2021 Category: Allergy & Immunology Authors: Sreyasi Das Farhat Nasim Roshnara Mishra Raghwendra Mishra Source Type: research

Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis
CONCLUSION: Our data suggested that circ_0003972 might promote the proliferation and inflammation of HFLS-RA cells to accelerate RA progression via regulating miR-654-5p/FZD4.PMID:34325604 | DOI:10.1080/08820139.2021.1958837 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Juan Li Dan Liu Kunyi Wu Qun Chen Jianhong Lei Source Type: research

Psoriasis Susceptibility 1 Candidate 1 ( < em > PSORS1C1 < /em > ) Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population
CONCLUSION: This study suggests the influence of PSORS1C1 rs3778638 on the susceptibility to GDs, supporting this locus as a common autoimmunity risk factor.PMID:34325607 | DOI:10.1080/08820139.2021.1923734 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Yanfei Jiang Xudong Mao Ronghua Song Kaida Mu Yanping Yang Jin-An Zhang Source Type: research

Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis
CONCLUSION: Our data suggested that circ_0003972 might promote the proliferation and inflammation of HFLS-RA cells to accelerate RA progression via regulating miR-654-5p/FZD4.PMID:34325604 | DOI:10.1080/08820139.2021.1958837 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Juan Li Dan Liu Kunyi Wu Qun Chen Jianhong Lei Source Type: research

Psoriasis Susceptibility 1 Candidate 1 ( < em > PSORS1C1 < /em > ) Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population
CONCLUSION: This study suggests the influence of PSORS1C1 rs3778638 on the susceptibility to GDs, supporting this locus as a common autoimmunity risk factor.PMID:34325607 | DOI:10.1080/08820139.2021.1923734 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Yanfei Jiang Xudong Mao Ronghua Song Kaida Mu Yanping Yang Jin-An Zhang Source Type: research

Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis
CONCLUSION: Our data suggested that circ_0003972 might promote the proliferation and inflammation of HFLS-RA cells to accelerate RA progression via regulating miR-654-5p/FZD4.PMID:34325604 | DOI:10.1080/08820139.2021.1958837 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Juan Li Dan Liu Kunyi Wu Qun Chen Jianhong Lei Source Type: research

Psoriasis Susceptibility 1 Candidate 1 ( < em > PSORS1C1 < /em > ) Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population
CONCLUSION: This study suggests the influence of PSORS1C1 rs3778638 on the susceptibility to GDs, supporting this locus as a common autoimmunity risk factor.PMID:34325607 | DOI:10.1080/08820139.2021.1923734 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Yanfei Jiang Xudong Mao Ronghua Song Kaida Mu Yanping Yang Jin-An Zhang Source Type: research

Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis
CONCLUSION: Our data suggested that circ_0003972 might promote the proliferation and inflammation of HFLS-RA cells to accelerate RA progression via regulating miR-654-5p/FZD4.PMID:34325604 | DOI:10.1080/08820139.2021.1958837 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Juan Li Dan Liu Kunyi Wu Qun Chen Jianhong Lei Source Type: research

Psoriasis Susceptibility 1 Candidate 1 ( < em > PSORS1C1 < /em > ) Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population
CONCLUSION: This study suggests the influence of PSORS1C1 rs3778638 on the susceptibility to GDs, supporting this locus as a common autoimmunity risk factor.PMID:34325607 | DOI:10.1080/08820139.2021.1923734 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Yanfei Jiang Xudong Mao Ronghua Song Kaida Mu Yanping Yang Jin-An Zhang Source Type: research

Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis
CONCLUSION: Our data suggested that circ_0003972 might promote the proliferation and inflammation of HFLS-RA cells to accelerate RA progression via regulating miR-654-5p/FZD4.PMID:34325604 | DOI:10.1080/08820139.2021.1958837 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Juan Li Dan Liu Kunyi Wu Qun Chen Jianhong Lei Source Type: research

Psoriasis Susceptibility 1 Candidate 1 ( < em > PSORS1C1 < /em > ) Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population
CONCLUSION: This study suggests the influence of PSORS1C1 rs3778638 on the susceptibility to GDs, supporting this locus as a common autoimmunity risk factor.PMID:34325607 | DOI:10.1080/08820139.2021.1923734 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Yanfei Jiang Xudong Mao Ronghua Song Kaida Mu Yanping Yang Jin-An Zhang Source Type: research

Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis
CONCLUSION: Our data suggested that circ_0003972 might promote the proliferation and inflammation of HFLS-RA cells to accelerate RA progression via regulating miR-654-5p/FZD4.PMID:34325604 | DOI:10.1080/08820139.2021.1958837 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Juan Li Dan Liu Kunyi Wu Qun Chen Jianhong Lei Source Type: research

Psoriasis Susceptibility 1 Candidate 1 ( < em > PSORS1C1 < /em > ) Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population
CONCLUSION: This study suggests the influence of PSORS1C1 rs3778638 on the susceptibility to GDs, supporting this locus as a common autoimmunity risk factor.PMID:34325607 | DOI:10.1080/08820139.2021.1923734 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Yanfei Jiang Xudong Mao Ronghua Song Kaida Mu Yanping Yang Jin-An Zhang Source Type: research

Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis
CONCLUSION: Our data suggested that circ_0003972 might promote the proliferation and inflammation of HFLS-RA cells to accelerate RA progression via regulating miR-654-5p/FZD4.PMID:34325604 | DOI:10.1080/08820139.2021.1958837 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Juan Li Dan Liu Kunyi Wu Qun Chen Jianhong Lei Source Type: research

Psoriasis Susceptibility 1 Candidate 1 ( < em > PSORS1C1 < /em > ) Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population
CONCLUSION: This study suggests the influence of PSORS1C1 rs3778638 on the susceptibility to GDs, supporting this locus as a common autoimmunity risk factor.PMID:34325607 | DOI:10.1080/08820139.2021.1923734 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Yanfei Jiang Xudong Mao Ronghua Song Kaida Mu Yanping Yang Jin-An Zhang Source Type: research

Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis
CONCLUSION: Our data suggested that circ_0003972 might promote the proliferation and inflammation of HFLS-RA cells to accelerate RA progression via regulating miR-654-5p/FZD4.PMID:34325604 | DOI:10.1080/08820139.2021.1958837 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Juan Li Dan Liu Kunyi Wu Qun Chen Jianhong Lei Source Type: research

Psoriasis Susceptibility 1 Candidate 1 ( < em > PSORS1C1 < /em > ) Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population
CONCLUSION: This study suggests the influence of PSORS1C1 rs3778638 on the susceptibility to GDs, supporting this locus as a common autoimmunity risk factor.PMID:34325607 | DOI:10.1080/08820139.2021.1923734 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Yanfei Jiang Xudong Mao Ronghua Song Kaida Mu Yanping Yang Jin-An Zhang Source Type: research

Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis
CONCLUSION: Our data suggested that circ_0003972 might promote the proliferation and inflammation of HFLS-RA cells to accelerate RA progression via regulating miR-654-5p/FZD4.PMID:34325604 | DOI:10.1080/08820139.2021.1958837 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Juan Li Dan Liu Kunyi Wu Qun Chen Jianhong Lei Source Type: research

Psoriasis Susceptibility 1 Candidate 1 ( < em > PSORS1C1 < /em > ) Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population
CONCLUSION: This study suggests the influence of PSORS1C1 rs3778638 on the susceptibility to GDs, supporting this locus as a common autoimmunity risk factor.PMID:34325607 | DOI:10.1080/08820139.2021.1923734 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Yanfei Jiang Xudong Mao Ronghua Song Kaida Mu Yanping Yang Jin-An Zhang Source Type: research

Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis
CONCLUSION: Our data suggested that circ_0003972 might promote the proliferation and inflammation of HFLS-RA cells to accelerate RA progression via regulating miR-654-5p/FZD4.PMID:34325604 | DOI:10.1080/08820139.2021.1958837 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Juan Li Dan Liu Kunyi Wu Qun Chen Jianhong Lei Source Type: research

Psoriasis Susceptibility 1 Candidate 1 ( < em > PSORS1C1 < /em > ) Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population
CONCLUSION: This study suggests the influence of PSORS1C1 rs3778638 on the susceptibility to GDs, supporting this locus as a common autoimmunity risk factor.PMID:34325607 | DOI:10.1080/08820139.2021.1923734 (Source: Immunological Investigations)
Source: Immunological Investigations - July 30, 2021 Category: Allergy & Immunology Authors: Yanfei Jiang Xudong Mao Ronghua Song Kaida Mu Yanping Yang Jin-An Zhang Source Type: research