Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1 β-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes
Conclusion: Exosomal PCGEM1 from OA-FLSs facilitated IL-1β-induced apoptosis and cartilage matrix degradation in chondrocytes by sequestering miR-142-5p and upregulating RUNX2, which offered new insights into the pathogenesis of OA.PMID:34160339 | DOI:10.1080/08820139.2021.1936010 (Source: Immunological Investigations)
Source: Immunological Investigations - June 23, 2021 Category: Allergy & Immunology Authors: Guangxuan Zeng Gang Deng Shiliang Xiao Fei Li Source Type: research

Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling
Immunol Invest. 2021 Jun 16:1-17. doi: 10.1080/08820139.2021.1937208. Online ahead of print.ABSTRACTUnderstanding maternal immune tolerance is crucial for the development of therapeutics for immunological pregnancy complications. Decidual regulatory T cells (Tregs) play a pivotal role in the maintenance of maternal immune tolerance. Using a murine allogeneic pregnancy model in the current study, we identified the up-regulation of gonadotropin-releasing hormone receptor (GnRHR) in decidual T cell subsets including CD4+ conventional T cells, CD8+ T cells, and CD4+Foxp3+ Tregs. Using a lentivirus-mediated GnRHR overexpression...
Source: Immunological Investigations - June 16, 2021 Category: Allergy & Immunology Authors: Xuejin Wang Liangying Zhong Qiaodan Liu Peiya Cai Peiru Zhang Zhilan Lu Xiaoqin Li Jin Liu Source Type: research

Prolactin Protects the Structural Integrity of Human Fetal Membranes by Downregulating Inflammation-induced Secretion of Matrix Metalloproteinases
Immunol Invest. 2021 Jun 16:1-17. doi: 10.1080/08820139.2021.1936012. Online ahead of print.ABSTRACTProlactin (PRL) is a pleiotropic hormone with a key role in pregnancy. In fetal membranes, PRL can regulate the secretion of pro-inflammatory factors, which induces the activation of matrix metalloproteinases (MMPs). The increase and activation of MMPs deregulate the turnover of the extracellular matrix in the fetal membranes, altering its structure and function, causing premature rupture of the membranes and preterm labor. In this work, we evaluate the effect of PRL upon the secretion of MMP-1, MMP-2, MMP-9, MMP-13, and the...
Source: Immunological Investigations - June 16, 2021 Category: Allergy & Immunology Authors: Pilar Flores-Espinosa Andrea Olmos-Ort íz Martha Granados-Cepeda Braulio Quesada-Reyna Rodrigo Vega-S ánchez Pilar Vel ázquez Ver ónica Zaga-Clavellina Source Type: research

Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling
Immunol Invest. 2021 Jun 16:1-17. doi: 10.1080/08820139.2021.1937208. Online ahead of print.ABSTRACTUnderstanding maternal immune tolerance is crucial for the development of therapeutics for immunological pregnancy complications. Decidual regulatory T cells (Tregs) play a pivotal role in the maintenance of maternal immune tolerance. Using a murine allogeneic pregnancy model in the current study, we identified the up-regulation of gonadotropin-releasing hormone receptor (GnRHR) in decidual T cell subsets including CD4+ conventional T cells, CD8+ T cells, and CD4+Foxp3+ Tregs. Using a lentivirus-mediated GnRHR overexpression...
Source: Immunological Investigations - June 16, 2021 Category: Allergy & Immunology Authors: Xuejin Wang Liangying Zhong Qiaodan Liu Peiya Cai Peiru Zhang Zhilan Lu Xiaoqin Li Jin Liu Source Type: research

Prolactin Protects the Structural Integrity of Human Fetal Membranes by Downregulating Inflammation-induced Secretion of Matrix Metalloproteinases
Immunol Invest. 2021 Jun 16:1-17. doi: 10.1080/08820139.2021.1936012. Online ahead of print.ABSTRACTProlactin (PRL) is a pleiotropic hormone with a key role in pregnancy. In fetal membranes, PRL can regulate the secretion of pro-inflammatory factors, which induces the activation of matrix metalloproteinases (MMPs). The increase and activation of MMPs deregulate the turnover of the extracellular matrix in the fetal membranes, altering its structure and function, causing premature rupture of the membranes and preterm labor. In this work, we evaluate the effect of PRL upon the secretion of MMP-1, MMP-2, MMP-9, MMP-13, and the...
Source: Immunological Investigations - June 16, 2021 Category: Allergy & Immunology Authors: Pilar Flores-Espinosa Andrea Olmos-Ort íz Martha Granados-Cepeda Braulio Quesada-Reyna Rodrigo Vega-S ánchez Pilar Vel ázquez Ver ónica Zaga-Clavellina Source Type: research

Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling
Immunol Invest. 2021 Jun 16:1-17. doi: 10.1080/08820139.2021.1937208. Online ahead of print.ABSTRACTUnderstanding maternal immune tolerance is crucial for the development of therapeutics for immunological pregnancy complications. Decidual regulatory T cells (Tregs) play a pivotal role in the maintenance of maternal immune tolerance. Using a murine allogeneic pregnancy model in the current study, we identified the up-regulation of gonadotropin-releasing hormone receptor (GnRHR) in decidual T cell subsets including CD4+ conventional T cells, CD8+ T cells, and CD4+Foxp3+ Tregs. Using a lentivirus-mediated GnRHR overexpression...
Source: Immunological Investigations - June 16, 2021 Category: Allergy & Immunology Authors: Xuejin Wang Liangying Zhong Qiaodan Liu Peiya Cai Peiru Zhang Zhilan Lu Xiaoqin Li Jin Liu Source Type: research

Prolactin Protects the Structural Integrity of Human Fetal Membranes by Downregulating Inflammation-induced Secretion of Matrix Metalloproteinases
Immunol Invest. 2021 Jun 16:1-17. doi: 10.1080/08820139.2021.1936012. Online ahead of print.ABSTRACTProlactin (PRL) is a pleiotropic hormone with a key role in pregnancy. In fetal membranes, PRL can regulate the secretion of pro-inflammatory factors, which induces the activation of matrix metalloproteinases (MMPs). The increase and activation of MMPs deregulate the turnover of the extracellular matrix in the fetal membranes, altering its structure and function, causing premature rupture of the membranes and preterm labor. In this work, we evaluate the effect of PRL upon the secretion of MMP-1, MMP-2, MMP-9, MMP-13, and the...
Source: Immunological Investigations - June 16, 2021 Category: Allergy & Immunology Authors: Pilar Flores-Espinosa Andrea Olmos-Ort íz Martha Granados-Cepeda Braulio Quesada-Reyna Rodrigo Vega-S ánchez Pilar Vel ázquez Ver ónica Zaga-Clavellina Source Type: research

Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling
Immunol Invest. 2021 Jun 16:1-17. doi: 10.1080/08820139.2021.1937208. Online ahead of print.ABSTRACTUnderstanding maternal immune tolerance is crucial for the development of therapeutics for immunological pregnancy complications. Decidual regulatory T cells (Tregs) play a pivotal role in the maintenance of maternal immune tolerance. Using a murine allogeneic pregnancy model in the current study, we identified the up-regulation of gonadotropin-releasing hormone receptor (GnRHR) in decidual T cell subsets including CD4+ conventional T cells, CD8+ T cells, and CD4+Foxp3+ Tregs. Using a lentivirus-mediated GnRHR overexpression...
Source: Immunological Investigations - June 16, 2021 Category: Allergy & Immunology Authors: Xuejin Wang Liangying Zhong Qiaodan Liu Peiya Cai Peiru Zhang Zhilan Lu Xiaoqin Li Jin Liu Source Type: research

Prolactin Protects the Structural Integrity of Human Fetal Membranes by Downregulating Inflammation-induced Secretion of Matrix Metalloproteinases
Immunol Invest. 2021 Jun 16:1-17. doi: 10.1080/08820139.2021.1936012. Online ahead of print.ABSTRACTProlactin (PRL) is a pleiotropic hormone with a key role in pregnancy. In fetal membranes, PRL can regulate the secretion of pro-inflammatory factors, which induces the activation of matrix metalloproteinases (MMPs). The increase and activation of MMPs deregulate the turnover of the extracellular matrix in the fetal membranes, altering its structure and function, causing premature rupture of the membranes and preterm labor. In this work, we evaluate the effect of PRL upon the secretion of MMP-1, MMP-2, MMP-9, MMP-13, and the...
Source: Immunological Investigations - June 16, 2021 Category: Allergy & Immunology Authors: Pilar Flores-Espinosa Andrea Olmos-Ort íz Martha Granados-Cepeda Braulio Quesada-Reyna Rodrigo Vega-S ánchez Pilar Vel ázquez Ver ónica Zaga-Clavellina Source Type: research

Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling
Immunol Invest. 2021 Jun 16:1-17. doi: 10.1080/08820139.2021.1937208. Online ahead of print.ABSTRACTUnderstanding maternal immune tolerance is crucial for the development of therapeutics for immunological pregnancy complications. Decidual regulatory T cells (Tregs) play a pivotal role in the maintenance of maternal immune tolerance. Using a murine allogeneic pregnancy model in the current study, we identified the up-regulation of gonadotropin-releasing hormone receptor (GnRHR) in decidual T cell subsets including CD4+ conventional T cells, CD8+ T cells, and CD4+Foxp3+ Tregs. Using a lentivirus-mediated GnRHR overexpression...
Source: Immunological Investigations - June 16, 2021 Category: Allergy & Immunology Authors: Xuejin Wang Liangying Zhong Qiaodan Liu Peiya Cai Peiru Zhang Zhilan Lu Xiaoqin Li Jin Liu Source Type: research

Prolactin Protects the Structural Integrity of Human Fetal Membranes by Downregulating Inflammation-induced Secretion of Matrix Metalloproteinases
Immunol Invest. 2021 Jun 16:1-17. doi: 10.1080/08820139.2021.1936012. Online ahead of print.ABSTRACTProlactin (PRL) is a pleiotropic hormone with a key role in pregnancy. In fetal membranes, PRL can regulate the secretion of pro-inflammatory factors, which induces the activation of matrix metalloproteinases (MMPs). The increase and activation of MMPs deregulate the turnover of the extracellular matrix in the fetal membranes, altering its structure and function, causing premature rupture of the membranes and preterm labor. In this work, we evaluate the effect of PRL upon the secretion of MMP-1, MMP-2, MMP-9, MMP-13, and the...
Source: Immunological Investigations - June 16, 2021 Category: Allergy & Immunology Authors: Pilar Flores-Espinosa Andrea Olmos-Ort íz Martha Granados-Cepeda Braulio Quesada-Reyna Rodrigo Vega-S ánchez Pilar Vel ázquez Ver ónica Zaga-Clavellina Source Type: research

Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling
Immunol Invest. 2021 Jun 16:1-17. doi: 10.1080/08820139.2021.1937208. Online ahead of print.ABSTRACTUnderstanding maternal immune tolerance is crucial for the development of therapeutics for immunological pregnancy complications. Decidual regulatory T cells (Tregs) play a pivotal role in the maintenance of maternal immune tolerance. Using a murine allogeneic pregnancy model in the current study, we identified the up-regulation of gonadotropin-releasing hormone receptor (GnRHR) in decidual T cell subsets including CD4+ conventional T cells, CD8+ T cells, and CD4+Foxp3+ Tregs. Using a lentivirus-mediated GnRHR overexpression...
Source: Immunological Investigations - June 16, 2021 Category: Allergy & Immunology Authors: Xuejin Wang Liangying Zhong Qiaodan Liu Peiya Cai Peiru Zhang Zhilan Lu Xiaoqin Li Jin Liu Source Type: research

Prolactin Protects the Structural Integrity of Human Fetal Membranes by Downregulating Inflammation-induced Secretion of Matrix Metalloproteinases
Immunol Invest. 2021 Jun 16:1-17. doi: 10.1080/08820139.2021.1936012. Online ahead of print.ABSTRACTProlactin (PRL) is a pleiotropic hormone with a key role in pregnancy. In fetal membranes, PRL can regulate the secretion of pro-inflammatory factors, which induces the activation of matrix metalloproteinases (MMPs). The increase and activation of MMPs deregulate the turnover of the extracellular matrix in the fetal membranes, altering its structure and function, causing premature rupture of the membranes and preterm labor. In this work, we evaluate the effect of PRL upon the secretion of MMP-1, MMP-2, MMP-9, MMP-13, and the...
Source: Immunological Investigations - June 16, 2021 Category: Allergy & Immunology Authors: Pilar Flores-Espinosa Andrea Olmos-Ort íz Martha Granados-Cepeda Braulio Quesada-Reyna Rodrigo Vega-S ánchez Pilar Vel ázquez Ver ónica Zaga-Clavellina Source Type: research

The Postnatal Leptin Surge Supports Immune Cell Function in Rats
Conclusion: In conclusion, the neonatal leptin surge seems to be involved in the establishment of an adequate immune response and cytokine profile, which are crucial for the maintenance of a healthy life.PMID:34121590 | DOI:10.1080/08820139.2021.1940199 (Source: Immunological Investigations)
Source: Immunological Investigations - June 14, 2021 Category: Allergy & Immunology Authors: Caroline Hunsche Oskarina Hernandez Virginia Mela M Paz Viveros M ónica De la Fuente Source Type: research

SARS-CoV-2: Unique Challenges of the Virus and Vaccines
Immunol Invest. 2021 Jun 10:1-8. doi: 10.1080/08820139.2021.1936009. Online ahead of print.ABSTRACTIn November 2019, the highly infectious coronavirus SARS-CoV-2 emerged in Wuhan, China, and has since spread to almost all countries worldwide. Since its emergence, the COVID-19 infection has led to significant public health, economic and social problems. The current pandemic has inspired researchers to make every effort to design and develop an effective COVID-19 vaccine to provide sufficient protection against the virus and control the infection. In December 2020, the Pfizer vaccine was the first COVID-19 vaccine given Emer...
Source: Immunological Investigations - June 10, 2021 Category: Allergy & Immunology Authors: Ata Mahmoodpoor Sarvin Sanaie Parisa Samadi Mehdi Yousefi Nader D Nader Source Type: research

Clinical, Laboratory Features and Clinical Courses of Patients with Wiskott Aldrich Syndrome and X-linked Thrombocytopenia-A single center study
Conclusions: HSCT is the only curative treatment for WAS. The study confirms that early diagnosis is very important for the success of therapy, so we must increase awareness in society and physicians to keep an eye out for clues. Our study cohort and follow-up period are not sufficient to establish phenotype-genotype correlation, so a larger cohort from various centers with longer follow-up will be more decisive.PMID:34098853 | DOI:10.1080/08820139.2021.1933516 (Source: Immunological Investigations)
Source: Immunological Investigations - June 8, 2021 Category: Allergy & Immunology Authors: Hacer Neslihan Bildik Deniz Cagdas Aysenur Ozturk Kura Sevil Oskay Halacli Ozden Sanal Ilhan Tezcan Source Type: research

The TIM-3 Rs10053538 Polymorphism Is Associated with Clinical Prognosis of Colorectal Cancer
Conclusion: The rs10053538 may serve as an independent molecular marker for predicting the clinical outcome of CRC patients in the study population.PMID:34080945 | DOI:10.1080/08820139.2021.1936011 (Source: Immunological Investigations)
Source: Immunological Investigations - June 3, 2021 Category: Allergy & Immunology Authors: Yabin Liu Ya Duan Ning Yang Binghui Li Dexian Kong Source Type: research

Ethical Considerations in Vaccine Allocation
Immunol Invest. 2021 May 26:1-11. doi: 10.1080/08820139.2021.1924771. Online ahead of print.ABSTRACTIn an effort to establish a consensus position on the ethical principles and ideals that should guide vaccine allocation during the Covid-19 pandemic, various organizations, including the Centers for Disease Control (CDC) and National Academies of Science, Engineering, and Medicine, released sample allocation frameworks to help guide government entities charged with distributing vaccine doses. One area of agreement among these reports is that front line health care workers, especially those who come into regular contact with...
Source: Immunological Investigations - May 26, 2021 Category: Allergy & Immunology Authors: Samuel Reis-Dennis Megan K Applewhite Source Type: research

sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma
Conclusions: These results suggest that sRAGE may be a potential target for the treatment of mucus hypersecretion in NA.PMID:34018452 | DOI:10.1080/08820139.2021.1928183 (Source: Immunological Investigations)
Source: Immunological Investigations - May 21, 2021 Category: Allergy & Immunology Authors: Xiaobo Zhang Jun Xie Hongmei Sun Qin Wei Guangmin Nong Source Type: research

Predictive Role of AURKA rs 1047972 Gene Polymorphism and the Risk of Development of Hepatocellular Carcinoma
Immunol Invest. 2021 May 21:1-11. doi: 10.1080/08820139.2021.1920609. Online ahead of print.ABSTRACTAFP: alpha-fetoprotein; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; AURKA: aurora kinase A; BCLC: Barcelona- Clinic Liver Cancer; CBC: complete blood count; CT: computed tomography; DM: diabetes mellitus; DNA: deoxyribonucleic acid; EDTA: ethylene diamine tetraacetic acid; GGT: gamma-glutamyl transferase; HB: hemoglobin; HBV: hepatitis B virus; HBsAg: hepatitis B surface antigen; HCC: hepatocellular carcinoma; HCV: hepatitis C virus; INR: international normalized ratio; mRNA: me...
Source: Immunological Investigations - May 21, 2021 Category: Allergy & Immunology Authors: Ann Abd-Almonem Farid Nermin Abd-Almaksoud Afify Aml Abd-Alhamid Alsharnoby Eman Abdelsameea Hanan M Bedair Source Type: research

sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma
Conclusions: These results suggest that sRAGE may be a potential target for the treatment of mucus hypersecretion in NA.PMID:34018452 | DOI:10.1080/08820139.2021.1928183 (Source: Immunological Investigations)
Source: Immunological Investigations - May 21, 2021 Category: Allergy & Immunology Authors: Xiaobo Zhang Jun Xie Hongmei Sun Qin Wei Guangmin Nong Source Type: research

Predictive Role of AURKA rs 1047972 Gene Polymorphism and the Risk of Development of Hepatocellular Carcinoma
Immunol Invest. 2021 May 21:1-11. doi: 10.1080/08820139.2021.1920609. Online ahead of print.ABSTRACTAFP: alpha-fetoprotein; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; AURKA: aurora kinase A; BCLC: Barcelona- Clinic Liver Cancer; CBC: complete blood count; CT: computed tomography; DM: diabetes mellitus; DNA: deoxyribonucleic acid; EDTA: ethylene diamine tetraacetic acid; GGT: gamma-glutamyl transferase; HB: hemoglobin; HBV: hepatitis B virus; HBsAg: hepatitis B surface antigen; HCC: hepatocellular carcinoma; HCV: hepatitis C virus; INR: international normalized ratio; mRNA: me...
Source: Immunological Investigations - May 21, 2021 Category: Allergy & Immunology Authors: Ann Abd-Almonem Farid Nermin Abd-Almaksoud Afify Aml Abd-Alhamid Alsharnoby Eman Abdelsameea Hanan M Bedair Source Type: research

sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma
Conclusions: These results suggest that sRAGE may be a potential target for the treatment of mucus hypersecretion in NA.PMID:34018452 | DOI:10.1080/08820139.2021.1928183 (Source: Immunological Investigations)
Source: Immunological Investigations - May 21, 2021 Category: Allergy & Immunology Authors: Xiaobo Zhang Jun Xie Hongmei Sun Qin Wei Guangmin Nong Source Type: research

Predictive Role of AURKA rs 1047972 Gene Polymorphism and the Risk of Development of Hepatocellular Carcinoma
Immunol Invest. 2021 May 21:1-11. doi: 10.1080/08820139.2021.1920609. Online ahead of print.ABSTRACTAFP: alpha-fetoprotein; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; AURKA: aurora kinase A; BCLC: Barcelona- Clinic Liver Cancer; CBC: complete blood count; CT: computed tomography; DM: diabetes mellitus; DNA: deoxyribonucleic acid; EDTA: ethylene diamine tetraacetic acid; GGT: gamma-glutamyl transferase; HB: hemoglobin; HBV: hepatitis B virus; HBsAg: hepatitis B surface antigen; HCC: hepatocellular carcinoma; HCV: hepatitis C virus; INR: international normalized ratio; mRNA: me...
Source: Immunological Investigations - May 21, 2021 Category: Allergy & Immunology Authors: Ann Abd-Almonem Farid Nermin Abd-Almaksoud Afify Aml Abd-Alhamid Alsharnoby Eman Abdelsameea Hanan M Bedair Source Type: research

sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma
Conclusions: These results suggest that sRAGE may be a potential target for the treatment of mucus hypersecretion in NA.PMID:34018452 | DOI:10.1080/08820139.2021.1928183 (Source: Immunological Investigations)
Source: Immunological Investigations - May 21, 2021 Category: Allergy & Immunology Authors: Xiaobo Zhang Jun Xie Hongmei Sun Qin Wei Guangmin Nong Source Type: research

Predictive Role of AURKA rs 1047972 Gene Polymorphism and the Risk of Development of Hepatocellular Carcinoma
Immunol Invest. 2021 May 21:1-11. doi: 10.1080/08820139.2021.1920609. Online ahead of print.ABSTRACTAFP: alpha-fetoprotein; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; AURKA: aurora kinase A; BCLC: Barcelona- Clinic Liver Cancer; CBC: complete blood count; CT: computed tomography; DM: diabetes mellitus; DNA: deoxyribonucleic acid; EDTA: ethylene diamine tetraacetic acid; GGT: gamma-glutamyl transferase; HB: hemoglobin; HBV: hepatitis B virus; HBsAg: hepatitis B surface antigen; HCC: hepatocellular carcinoma; HCV: hepatitis C virus; INR: international normalized ratio; mRNA: me...
Source: Immunological Investigations - May 21, 2021 Category: Allergy & Immunology Authors: Ann Abd-Almonem Farid Nermin Abd-Almaksoud Afify Aml Abd-Alhamid Alsharnoby Eman Abdelsameea Hanan M Bedair Source Type: research

HLA-A, -C, -B, -DRB1, -DQA1, and -DQB1 Allele and Haplotype Repertoires in the Albanian Population from Kosovo
Immunol Invest. 2021 May 14:1-11. doi: 10.1080/08820139.2021.1924772. Online ahead of print.ABSTRACTTo give new insight into the huge polymorphism of HLA system and supplement the existing data, an analysis of HLA alleles and HLA-A~C~B~DRB1~DQA1~DQB1 haplotype distribution in 124 Albanian individuals from Kosovo was performed. All samples were HLA-typed applying the polymerase chain reaction-sequence specific oligonucleotide probing (PCR-SSOP) method and all ambiguous HLA typing results were additionally confirmed by the standard PCR-Sequence Specific Primers (PCR-SSP) high-resolution protocol. Twenty-two HLA-A, 21 HLA-C, ...
Source: Immunological Investigations - May 14, 2021 Category: Allergy & Immunology Authors: Atifete Ramosaj-Morina Marija Burek Kamenaric Alije Keka Syla Arbana Baloku Zorana Grubic Renata Zunec Source Type: research

Interplay of Anti-Viral Vaccines with Biologic Agents and Immunomodulators in Individuals with Autoimmune and Autoinflammatory Diseases
Immunol Invest. 2021 May 3:1-24. doi: 10.1080/08820139.2021.1900863. Online ahead of print.ABSTRACTVaccines are an essential part of a preventative healthcare strategy. However, response to vaccines may be less predictable in immunocompromised people. While outcomes for individuals with autoimmune and autoinflammatory diseases have dramatically improved with treatment using immunomodulating and biologic agents, infections have caused significant morbidity in these people today often more than due to their underlying diseases. Immune-based biologic therapies contribute to these infectious complications. This review addresse...
Source: Immunological Investigations - May 4, 2021 Category: Allergy & Immunology Authors: Barbara E Ostrov Daniel Amsterdam Source Type: research

A Variant of < em > IL1B < /em > Is Associated with the Risk and Blood Lipid Levels of Myocardial Infarction in Eastern Chinese Individuals
This study, conducted in a Chinese Han population, recruited 369 MI patients and 465 controls. The variant of IL1B gene (rs1143634 C/T polymorphism) was genotyped by PCR-RFLP method. In this study, a significant link was shown between the IL1B rs1143634 C/T polymorphism and MI risk. We found that the IL1B rs1143634 C/T polymorphism enhanced the risk of MI in this population. Subgroup analysis detected that the IL1B rs1143634 C/T polymorphism associated with MI susceptibility in males, smokers, and individuals with diabetes mellitus. In addition, the IL1B rs1143634 C/T polymorphism was related with the levels of blood lipid...
Source: Immunological Investigations - May 4, 2021 Category: Allergy & Immunology Authors: Quanhua Pan Ding Hui Chuangxian Hu Source Type: research

Interplay of Anti-Viral Vaccines with Biologic Agents and Immunomodulators in Individuals with Autoimmune and Autoinflammatory Diseases
Immunol Invest. 2021 May 3:1-24. doi: 10.1080/08820139.2021.1900863. Online ahead of print.ABSTRACTVaccines are an essential part of a preventative healthcare strategy. However, response to vaccines may be less predictable in immunocompromised people. While outcomes for individuals with autoimmune and autoinflammatory diseases have dramatically improved with treatment using immunomodulating and biologic agents, infections have caused significant morbidity in these people today often more than due to their underlying diseases. Immune-based biologic therapies contribute to these infectious complications. This review addresse...
Source: Immunological Investigations - May 4, 2021 Category: Allergy & Immunology Authors: Barbara E Ostrov Daniel Amsterdam Source Type: research