Live-Cell Imaging Quantifies Changes in Function and Metabolic NADH Autofluorescence During Macrophage-Mediated Phagocytosis of Tumor Cells
CONCLUSION: Overall, this work demonstrates that in vitro multiphoton imaging can be used to longitudinally track changes in phagocytosis and endogenous metabolic cofactors.PMID:37999933 | DOI:10.1080/08820139.2023.2284369 (Source: Immunological Investigations)
Source: Immunological Investigations - November 24, 2023 Category: Allergy & Immunology Authors: Shelby N Bess Matthew J Igoe Timothy J Muldoon Source Type: research

The Putative Effects of Neoadjuvant Chemotherapy on the Immune System of Advanced Epithelial Ovarian Carcinoma
Immunol Invest. 2023 Nov 21:1-24. doi: 10.1080/08820139.2023.2284885. Online ahead of print.ABSTRACTThe epithelial ovarian carcinoma (EOC) is one of leading causes of cancer-related mortality in females. For some patients, complete resection cannot be achieved, thus neoadjuvant chemotherapy (NACT) following interval debulking surgery (IDS) could be an alternative choice. In general-held belief, cytotoxic chemotherapy is assumed to be immunosuppressive, because of its toxicity to dividing cells in the bone marrow and peripheral lymphoid tissues. However, increasing evidence highlighted that the anticancer activity of chemot...
Source: Immunological Investigations - November 21, 2023 Category: Allergy & Immunology Authors: Yunyun Li Xiaoling Gan Fei Li Lina Hu Source Type: research

Emerging Role of Astrocyte-Derived Extracellular Vesicles as Active Participants in CNS Neuroimmune Responses
Immunol Invest. 2023 Nov 19:1-14. doi: 10.1080/08820139.2023.2281621. Online ahead of print.ABSTRACTAstrocyte-derived extracellular vesicles (ADEVs) have garnered attention as a fundamental mechanism of intercellular communication in health and disease. In the context of neurological diseases, for which prodromal diagnosis would be advantageous, ADEVs are also being explored for their potential utility as biomarkers. In this review, we provide the current state of data supporting our understanding on the manifold roles of ADEVs in several common neurological disorders. We also discuss these findings from a unique emerging ...
Source: Immunological Investigations - November 19, 2023 Category: Allergy & Immunology Authors: Pearl A Sutter Erica R Lavoie Evan T Lombardo Meghan K Pinter Stephen J Crocker Source Type: research

MicroRNA-Mediated Antiproliferative Effects of M1 Macrophage-Derived Extracellular Vesicles on Melanoma Cells
CONCLUSION: Although further research would be advisable, the study provides evidence supporting the potential of M1-sEVs and their miRNA load as a possible targeted immune therapy for melanoma.PMID:37981469 | DOI:10.1080/08820139.2023.2278774 (Source: Immunological Investigations)
Source: Immunological Investigations - November 19, 2023 Category: Allergy & Immunology Authors: Najla Adel Saleh Michele Patr ícia Rode J úlia Cisilotto Adny Henrique Silva Anne Natalie Prigol Fernanda da Luz Efe Evelyn Winter Fab íola Branco Filippin-Monteiro T ânia Beatriz Creczynski-Pasa Source Type: research

Dengue Vaccination: Towards a New Dawn of Curbing Dengue Infection
Immunol Invest. 2023 Nov 14:1-54. doi: 10.1080/08820139.2023.2280698. Online ahead of print.ABSTRACTDengue is an infectious disease caused by dengue virus (DENV) and is a serious global burden. Antibody-dependent enhancement and the ability of DENV to infect immune cells, along with other factors, lead to fatal Dengue Haemorrhagic Fever and Dengue Shock Syndrome. This necessitates the development of a robust and efficient vaccine but vaccine development faces a number of hurdles. In this review, we look at the epidemiology, genome structure and cellular targets of DENV and elaborate upon the immune responses generated by h...
Source: Immunological Investigations - November 14, 2023 Category: Allergy & Immunology Authors: Sidhant Jain Neha Vimal Nilza Angmo Madhumita Sengupta Suraj Thangaraj Source Type: research

The Protective Effects of Cinnamyl Alcohol Against Hepatic Steatosis, Oxidative and Inflammatory Stress in Nonalcoholic Fatty Liver Disease Induced by Childhood Obesity
CONCLUSION: CA alleviates HFHC-induced NAFLD in mice, which is associated with the amelioration in lipid metabolism, oxidative stress, and inflammation.PMID:37962037 | DOI:10.1080/08820139.2023.2280248 (Source: Immunological Investigations)
Source: Immunological Investigations - November 14, 2023 Category: Allergy & Immunology Authors: Yu Dai Xuemin Zhang Yao Xu Ya Wu Liqi Yang Source Type: research

Rat Experimental Autoimmune Gastritis Model
CONCLUSION: Wistar rats, immunized with gastric mucosa extract, developed EAG similar to human AIG. The advantages of received EAG model are the ease of obtaining, the rapid development of oxyntic mucosa damage, which may progress to ECL cell hyperplasia.PMID:37962068 | DOI:10.1080/08820139.2023.2283103 (Source: Immunological Investigations)
Source: Immunological Investigations - November 14, 2023 Category: Allergy & Immunology Authors: Liubov Beduleva Kseniya Fomina Alexandr Sidorov Alexey Terentiev Pavel Ivanov Igor Menshikov Source Type: research

Dengue Vaccination: Towards a New Dawn of Curbing Dengue Infection
Immunol Invest. 2023 Nov 14:1-54. doi: 10.1080/08820139.2023.2280698. Online ahead of print.ABSTRACTDengue is an infectious disease caused by dengue virus (DENV) and is a serious global burden. Antibody-dependent enhancement and the ability of DENV to infect immune cells, along with other factors, lead to fatal Dengue Haemorrhagic Fever and Dengue Shock Syndrome. This necessitates the development of a robust and efficient vaccine but vaccine development faces a number of hurdles. In this review, we look at the epidemiology, genome structure and cellular targets of DENV and elaborate upon the immune responses generated by h...
Source: Immunological Investigations - November 14, 2023 Category: Allergy & Immunology Authors: Sidhant Jain Neha Vimal Nilza Angmo Madhumita Sengupta Suraj Thangaraj Source Type: research

The Protective Effects of Cinnamyl Alcohol Against Hepatic Steatosis, Oxidative and Inflammatory Stress in Nonalcoholic Fatty Liver Disease Induced by Childhood Obesity
CONCLUSION: CA alleviates HFHC-induced NAFLD in mice, which is associated with the amelioration in lipid metabolism, oxidative stress, and inflammation.PMID:37962037 | DOI:10.1080/08820139.2023.2280248 (Source: Immunological Investigations)
Source: Immunological Investigations - November 14, 2023 Category: Allergy & Immunology Authors: Yu Dai Xuemin Zhang Yao Xu Ya Wu Liqi Yang Source Type: research