In-Vitro and in-Vivo Evaluation of the Developed Curcumin-Cyclosporine-Loaded Nanoemulgel for the Management of Rheumatoid Arthritis
CONCLUSION: This study highlights the potential of the developed nanoemulgel for the management of RA by enhancing the topical permeation of CUR and CYC.PMID:38197806 | DOI:10.1080/08820139.2024.2301997 (Source: Immunological Investigations)
Source: Immunological Investigations - January 10, 2024 Category: Allergy & Immunology Authors: Sankalp Gharat Vivek Basudkar Munira Momin Source Type: research
MicroRNA-98-5p Inhibits IFI44L-Mediated Differentiation of Dendritic Cells and Activation of Interferon Pathway in Systemic Lupus Erythematosus
In this study, we identified miR-98-5p lowly expressed in both peripheral blood mononuclear cells (PBMCs) and monocytes of SLE patients along with high expression of IFI44L. IFI44L serves as target gene of miR-98-5p which inhibits differentiation of Mo-DCs and IFI44L-mediated activation of interferon pathway. We further showed that miR-98-5p promotes methylation of the IFI44L promoter to down-regulate its expression in SLE. Our results reveal an important role for miR-98-5p in the IFI44L-mediated immune imbalance of SLE and suggest a potential therapeutic target for SLE in the future.PMID:38198612 | DOI:10.1080/08820139.20...
Source: Immunological Investigations - January 10, 2024 Category: Allergy & Immunology Authors: Xin Huang Yixin Tan Ruifang Wu Qianwen Li Shuaihantian Luo Source Type: research
The Hydrogel Based Allergen-Coated Gold Nanoparticles for Topical Administration: A Possible Epicutaneous Immunotherapy in Pollen-Sensitized Mice?
CONCLUSION: Our results suggest that topical administration of AuNPs loaded with P. orientalis total pollen extract on intact skin could be a potential application for EPIT in the P. orientalis pollen -sensitized mice.PMID:38166585 | DOI:10.1080/08820139.2023.2298397 (Source: Immunological Investigations)
Source: Immunological Investigations - January 3, 2024 Category: Allergy & Immunology Authors: Safoora Pordel MohammadAli Rezaee Malihe Moghadam Mojtaba Sankian Source Type: research
Association between < em > TRAF1/C5 < /em > Gene Polymorphisms and IgA Vasculitis in Chinese Children
CONCLUSIONS: There is an association between locus rs3761847 of TRAF1/C5 gene single nucleotide polymorphisms and susceptibility to IgAV. The T allele at locus rs3761847 of TRAF1/C5 gene may be a protective factor for IgAV. The C allele at locus rs3761847 and the T allele at locus rs10818488 of TRAF1/C5 gene may be associated with kidney injury in IgAV.PMID:38117213 | DOI:10.1080/08820139.2023.2295477 (Source: Immunological Investigations)
Source: Immunological Investigations - December 20, 2023 Category: Allergy & Immunology Authors: Meng Yu Yeyi Yang Juan Zhang Rui Liu Lihua Huang Jiping Wu Zhijuan Kang Jin Zhou Zuocheng Yang Source Type: research
