The Impact of Tumor-Associated Macrophages Found at Mammary Carcinoma Sites is Dependent Upon the Tumor Type
CONCLUSIONS: Collectively, these data demonstrate that targeting TAM or metabolism at early tumor sites can impact tumor progression. However, variability in the responses underscore the fact that the impact of macrophages differs even within three different syngeneic mammary carcinoma models.PMID:37647339 | DOI:10.1080/08820139.2023.2252463 (Source: Immunological Investigations)
Source: Immunological Investigations - August 30, 2023 Category: Allergy & Immunology Authors: Musea Chang Katherine Ellmaker Abigail Esposito Amanda Lauricella Sophea Pa Meghan Roberts Robert A Kurt Source Type: research
Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status
CONCLUSION: LAYN is differentially expressed in monocytes and their subpopulations and has corresponding functional differences. Changes in LAYN expression on monocytes are associated with complement C4 levels in SLE patients. These suggest that LAYN may be involved in the pathogenesis of SLE.ABBREVIATION: ANOVA: analysis of variance; anti-dsDNA: anti-double-stranded DNA; anti-ENA: anti-extractable nuclear antigen; anti-SSA: anti-Sjogren syndrome A; anti-SSB: anti-Sjogren syndrome B; anti-U1RNP: anti-U1 ribonucleoprotein; AUC: area under the ROC curve; CBC: complete blood count; CD62L: L-selectin; CD74/Ii: MHC class II inv...
Source: Immunological Investigations - August 29, 2023 Category: Allergy & Immunology Authors: Chen Liu Yiying Wang Ya-Hui Zhang Zihang Yuan Zhonghui Zhang Xingyue Zeng Zhao Guan Ayibaota Bahabayi Songsong Lu Source Type: research
The Multifunction Role of Tumor-Associated Mesenchymal Stem Cells and Their Interaction with Immune Cells in Breast Cancer
Immunol Invest. 2023 Aug 24:1-23. doi: 10.1080/08820139.2023.2249025. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) are a heterogeneous group of progenitor cells that play a multifunctional role including tissue regeneration, self-renewal properties, and differentiate into cells of mesodermal lineage such as adipocytes, osteoblasts, and chondrocytes. MSCs come into contact with tumor microenvironment (TME) and differentiate into tumor-associated MSCs (TA-MSCs). Various substances such as chemokines, cytokines, growth factors, and others are released by tumor cells to recruit MSCs. TA-MSCs induced epithelial-m...
Source: Immunological Investigations - August 24, 2023 Category: Allergy & Immunology Authors: Anita Chauhan Sonam Agarwal Marilyn Masih Pramod Kumar Gautam Source Type: research
