Cytokines Expression Compared to the Determinants of Cellular Apoptosis Prominently Attributes to the Deleterious Effects of 'A' Determinant Surface Gene Mutations in HBV Transfected Hepatoma Cell Line
CONCLUSION: Cytokines expression predominantly contributes to the detrimental effects associated with the 'a' determinant region mutations particularly sG145R mutant. It may also be inferred that mechanisms associated with cellular apoptosis apparently do not play any major role to assign the 'a' determinant small surface gene mutation(s) for their pathological outcome.PMID:38095846 | DOI:10.1080/08820139.2023.2288841 (Source: Immunological Investigations)
Source: Immunological Investigations - December 14, 2023 Category: Allergy & Immunology Authors: Saniya Khan Ayesha Anwer Jayesh Kumar Sevak Nirupama Trehanpati Syed Naqui Kazim Source Type: research
Role of MicroRNAs in Inflammatory Joint Diseases: A Review
Immunol Invest. 2023 Dec 14:1-25. doi: 10.1080/08820139.2023.2293095. Online ahead of print.ABSTRACTInflammatory arthritis commonly initiates in the soft tissues lining the joint. This lining swells, as do the cells in it and inside the joint fluid, producing chemicals that induce inflammation signs such as heat, redness, and swelling. MicroRNA (miRNA), a subset of non-coding small RNA molecules, post-transcriptionally controls gene expression by targeting their messenger RNA. MiRNAs modulate approximately 1/3 of the human genome with their multiple targets. Recently, they have been extensively studied as key modulators of...
Source: Immunological Investigations - December 14, 2023 Category: Allergy & Immunology Authors: Nazmul Huda Syed Ali Mussa Abdirahman Hussein Elmi Mutaz Jamal Al-Khreisat Muhammad Rajaei Ahmad Mohd Zain Asma Abdullah Nurul Source Type: research
Cytokines Expression Compared to the Determinants of Cellular Apoptosis Prominently Attributes to the Deleterious Effects of 'A' Determinant Surface Gene Mutations in HBV Transfected Hepatoma Cell Line
CONCLUSION: Cytokines expression predominantly contributes to the detrimental effects associated with the 'a' determinant region mutations particularly sG145R mutant. It may also be inferred that mechanisms associated with cellular apoptosis apparently do not play any major role to assign the 'a' determinant small surface gene mutation(s) for their pathological outcome.PMID:38095846 | DOI:10.1080/08820139.2023.2288841 (Source: Immunological Investigations)
Source: Immunological Investigations - December 14, 2023 Category: Allergy & Immunology Authors: Saniya Khan Ayesha Anwer Jayesh Kumar Sevak Nirupama Trehanpati Syed Naqui Kazim Source Type: research
Role of MicroRNAs in Inflammatory Joint Diseases: A Review
Immunol Invest. 2023 Dec 14:1-25. doi: 10.1080/08820139.2023.2293095. Online ahead of print.ABSTRACTInflammatory arthritis commonly initiates in the soft tissues lining the joint. This lining swells, as do the cells in it and inside the joint fluid, producing chemicals that induce inflammation signs such as heat, redness, and swelling. MicroRNA (miRNA), a subset of non-coding small RNA molecules, post-transcriptionally controls gene expression by targeting their messenger RNA. MiRNAs modulate approximately 1/3 of the human genome with their multiple targets. Recently, they have been extensively studied as key modulators of...
Source: Immunological Investigations - December 14, 2023 Category: Allergy & Immunology Authors: Nazmul Huda Syed Ali Mussa Abdirahman Hussein Elmi Mutaz Jamal Al-Khreisat Muhammad Rajaei Ahmad Mohd Zain Asma Abdullah Nurul Source Type: research
A Comparative Transcriptomic Study and Key Gene Targeting of Lamprey Gonadal Immune Response
In this study, we extracted RNA from testis and ovary tissues of lampreys at 0 hour, 8 hours and 17 days after lipopolysaccharides (LPS) stimulation and performed transcriptome sequencing. While the transcriptome profiles of the two tissues were different for the most part, genes LIP, LECT2, LAL2, GRN, ITLN, and C1q were found to be the most significantly up-regulated genes in both. Quantitative Real-time PCR (qRT-PCR) analysis confirmed that these genes were upregulated after stimulation. Furthermore, immunohistochemical staining showed that these genes in lamprey gonads are expressed in high quantities and have a specifi...
Source: Immunological Investigations - December 11, 2023 Category: Allergy & Immunology Authors: Xiangting Xu Jing Xu Mingyue Qiu Yang Yu Meng Gou Yue Pang Qingwei Li Peng Su Source Type: research
Resistin - A Plausible Therapeutic Target in the Pathogenesis of Psoriasis
Immunol Invest. 2023 Dec 6:1-45. doi: 10.1080/08820139.2023.2288836. Online ahead of print.ABSTRACTResistin, a cytokine hormone predominantly secreted by adipose tissue, is elevated in various metabolic disorders such as obesity, type 2 diabetes, and cardiovascular disease. In addition to its involvement in metabolic regulation, resistin has been implicated in the pathogenesis of psoriasis, a chronic inflammatory skin disorder. Numerous studies have reported increased resistin levels in psoriatic skin lesions, suggesting a possible association between resistin and psoriasis. Recent studies have suggested the potential invo...
Source: Immunological Investigations - December 6, 2023 Category: Allergy & Immunology Authors: Manupati Srikanth Mahaboobkhan Rasool Source Type: research
The Mechanistic Target of Rapamycin Complex 1 Pathway Contributes to the Anti-Tumor Effect of Granulocyte-Macrophage-Colony-Stimulating Factor-Producing T Helper Cells in Mouse Colorectal Cancer
CONCLUSION: mTORC1 is essential for the anti-CRC activity of ThGM cells.PMID:38050895 | DOI:10.1080/08820139.2023.2290631 (Source: Immunological Investigations)
Source: Immunological Investigations - December 5, 2023 Category: Allergy & Immunology Authors: Hongjian Zhou Bin Jiang Yuyuan Qian Chao Ke Source Type: research
A State-of-the-Art Review on the Recent Advances of Mesenchymal Stem Cell Therapeutic Application in Systematic Lupus Erythematosus
This study aimed to review the mechanisms of immune system modulation by MSCs and the role of these cells in the treatment of SLE. MSCs suppress T lymphocytes through various mechanisms, including the production of transforming growth factor-beta (TGF-B), prostaglandin E2 (PGE2), nitric oxide (NO), and indolamine 2 and 3-oxygenase (IDO). In addition, MSCs inhibit the production of their autoantibodies by inhibiting the differentiation of lymphocytes. The production of autoantibodies against nuclear antigens is an important feature of SLE. On the other hand, MSCs inhibit antigen delivery by antigen-presenting cells (APCs) t...
Source: Immunological Investigations - November 30, 2023 Category: Allergy & Immunology Authors: Farshid Karimi Babak Nejati Fatemeh Rahimi Vahid Alivirdiloo Iraj Alipourfard Ali Aghighi Alireza Raji-Amirhasani Majid Eslami Ali Babaeizad Farhood Ghazi Akram Firouzi Amandi Mehdi Dadashpour Source Type: research
