The Multifunction Role of Tumor-Associated Mesenchymal Stem Cells and Their Interaction with Immune Cells in Breast Cancer
Immunol Invest. 2023 Aug 24:1-23. doi: 10.1080/08820139.2023.2249025. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) are a heterogeneous group of progenitor cells that play a multifunctional role including tissue regeneration, self-renewal properties, and differentiate into cells of mesodermal lineage such as adipocytes, osteoblasts, and chondrocytes. MSCs come into contact with tumor microenvironment (TME) and differentiate into tumor-associated MSCs (TA-MSCs). Various substances such as chemokines, cytokines, growth factors, and others are released by tumor cells to recruit MSCs. TA-MSCs induced epithelial-m...
Source: Immunological Investigations - August 24, 2023 Category: Allergy & Immunology Authors: Anita Chauhan Sonam Agarwal Marilyn Masih Pramod Kumar Gautam Source Type: research
Regulatory Rheumatoid Factor is Specific to PD-1 and Uses PD-1 Pathway to Control CD4 T Lymphocytes
CONCLUSION: RegRF uses PD-1 pathway to control activated CD4+ T lymphocytes.PMID:37615124 | DOI:10.1080/08820139.2023.2250818 (Source: Immunological Investigations)
Source: Immunological Investigations - August 24, 2023 Category: Allergy & Immunology Authors: Tatyana Khramova Liubov Beduleva Alexandr Sidorov Alexey Terentiev Igor Menshikov Source Type: research
Circulating and Synovial Monocytes in Arthritis and Ex-Vivo Model to Evaluate Therapeutic Modulation of Synovial Monocytes
Immunol Invest. 2023 Aug 24:1-24. doi: 10.1080/08820139.2023.2247438. Online ahead of print.ABSTRACTMonocytes are innate immune cells that play a dual role in protection of host against pathogens and initiation and perpetuation of inflammatory disorders including joint diseases. During inflammation, monocytes migrate from peripheral blood to tissues via chemokine receptors where they produce inflammatory factors. Monocytes are classified into three subsets, namely: classical, intermediate and non-classical, each subset has particular function. Synovium of patients with inflammatory joint diseases, such as rheumatoid arthri...
Source: Immunological Investigations - August 24, 2023 Category: Allergy & Immunology Authors: Adam Slavick Victoria Furer Ari Polachek Reut Tzemach Ori Elkayam Smadar Gertel Source Type: research
The Multifunction Role of Tumor-Associated Mesenchymal Stem Cells and Their Interaction with Immune Cells in Breast Cancer
Immunol Invest. 2023 Aug 24:1-23. doi: 10.1080/08820139.2023.2249025. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) are a heterogeneous group of progenitor cells that play a multifunctional role including tissue regeneration, self-renewal properties, and differentiate into cells of mesodermal lineage such as adipocytes, osteoblasts, and chondrocytes. MSCs come into contact with tumor microenvironment (TME) and differentiate into tumor-associated MSCs (TA-MSCs). Various substances such as chemokines, cytokines, growth factors, and others are released by tumor cells to recruit MSCs. TA-MSCs induced epithelial-m...
Source: Immunological Investigations - August 24, 2023 Category: Allergy & Immunology Authors: Anita Chauhan Sonam Agarwal Marilyn Masih Pramod Kumar Gautam Source Type: research
Regulatory Rheumatoid Factor is Specific to PD-1 and Uses PD-1 Pathway to Control CD4 T Lymphocytes
CONCLUSION: RegRF uses PD-1 pathway to control activated CD4+ T lymphocytes.PMID:37615124 | DOI:10.1080/08820139.2023.2250818 (Source: Immunological Investigations)
Source: Immunological Investigations - August 24, 2023 Category: Allergy & Immunology Authors: Tatyana Khramova Liubov Beduleva Alexandr Sidorov Alexey Terentiev Igor Menshikov Source Type: research
Circulating and Synovial Monocytes in Arthritis and Ex-Vivo Model to Evaluate Therapeutic Modulation of Synovial Monocytes
Immunol Invest. 2023 Aug 24:1-24. doi: 10.1080/08820139.2023.2247438. Online ahead of print.ABSTRACTMonocytes are innate immune cells that play a dual role in protection of host against pathogens and initiation and perpetuation of inflammatory disorders including joint diseases. During inflammation, monocytes migrate from peripheral blood to tissues via chemokine receptors where they produce inflammatory factors. Monocytes are classified into three subsets, namely: classical, intermediate and non-classical, each subset has particular function. Synovium of patients with inflammatory joint diseases, such as rheumatoid arthri...
Source: Immunological Investigations - August 24, 2023 Category: Allergy & Immunology Authors: Adam Slavick Victoria Furer Ari Polachek Reut Tzemach Ori Elkayam Smadar Gertel Source Type: research
The Multifunction Role of Tumor-Associated Mesenchymal Stem Cells and Their Interaction with Immune Cells in Breast Cancer
Immunol Invest. 2023 Aug 24:1-23. doi: 10.1080/08820139.2023.2249025. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) are a heterogeneous group of progenitor cells that play a multifunctional role including tissue regeneration, self-renewal properties, and differentiate into cells of mesodermal lineage such as adipocytes, osteoblasts, and chondrocytes. MSCs come into contact with tumor microenvironment (TME) and differentiate into tumor-associated MSCs (TA-MSCs). Various substances such as chemokines, cytokines, growth factors, and others are released by tumor cells to recruit MSCs. TA-MSCs induced epithelial-m...
Source: Immunological Investigations - August 24, 2023 Category: Allergy & Immunology Authors: Anita Chauhan Sonam Agarwal Marilyn Masih Pramod Kumar Gautam Source Type: research
Regulatory Rheumatoid Factor is Specific to PD-1 and Uses PD-1 Pathway to Control CD4 T Lymphocytes
CONCLUSION: RegRF uses PD-1 pathway to control activated CD4+ T lymphocytes.PMID:37615124 | DOI:10.1080/08820139.2023.2250818 (Source: Immunological Investigations)
Source: Immunological Investigations - August 24, 2023 Category: Allergy & Immunology Authors: Tatyana Khramova Liubov Beduleva Alexandr Sidorov Alexey Terentiev Igor Menshikov Source Type: research
Circulating and Synovial Monocytes in Arthritis and Ex-Vivo Model to Evaluate Therapeutic Modulation of Synovial Monocytes
Immunol Invest. 2023 Aug 24:1-24. doi: 10.1080/08820139.2023.2247438. Online ahead of print.ABSTRACTMonocytes are innate immune cells that play a dual role in protection of host against pathogens and initiation and perpetuation of inflammatory disorders including joint diseases. During inflammation, monocytes migrate from peripheral blood to tissues via chemokine receptors where they produce inflammatory factors. Monocytes are classified into three subsets, namely: classical, intermediate and non-classical, each subset has particular function. Synovium of patients with inflammatory joint diseases, such as rheumatoid arthri...
Source: Immunological Investigations - August 24, 2023 Category: Allergy & Immunology Authors: Adam Slavick Victoria Furer Ari Polachek Reut Tzemach Ori Elkayam Smadar Gertel Source Type: research
The Cooperation of IL-29 and PLGA Nanoparticles Improves the Protective Immunity of the gD-1 DNA Vaccine Against Herpes Simplex Virus Type 1 in Mice
In this study, the pIL-29 encapsulated in PLGA nanoparticles (nanoIL-29) and the pgD1 encapsulated in PLGA nanoparticles (nanoVac) were simultaneously applied to boost immunologic responses against HSV-1. We generated spherical nanoparticles with encapsulation efficiency of 75 ± 5% and sustained the release of plasmids from them. Then, Balb/c mice were subcutaneously immunized twice with nanoVac+nanoIL-29, Vac+IL-29, nanoVac, Vac, nanoIL-29, and/or IL-29 in addition to negative and positive control groups. Cellular immunity was evaluated via lymphocyte proliferation assay, cytotoxicity test, and IFN-γ, IL-4, and IL-2 mea...
Source: Immunological Investigations - August 23, 2023 Category: Allergy & Immunology Authors: Parisa Amir Kalvanagh Hesam Karimi Hoorieh Soleimanjahi Massoumeh Ebtekar Parviz Kokhaei Zahra Matloubi Roghieh Rahimi Nazanin Atieh Kazemi-Sefat Hajar Rajaei Source Type: research
Silencing of Perilipin 3 Inhibits Lung Adenocarcinoma Cell Immune Resistance by Regulating the Transcription of PD-L1 Through c-Myc
CONCLUSION: Silencing of PLIN3 inhibited tumour growth by regulating the Myc/PD-L1 pathway.PMID:37578465 | DOI:10.1080/08820139.2023.2244976 (Source: Immunological Investigations)
Source: Immunological Investigations - August 14, 2023 Category: Allergy & Immunology Authors: Xuelin Men Wei Zhu Source Type: research
