Upregulation, Functional Association, and Correlated Expressions of TRPV1 and TRPA1 During Telmisartan-Driven Immunosuppression of T Cells
In this study, we investigated the potential role of TRPV1 and TRPA1 during TM-driven immunosuppression of T cells in vitro. We observed a significant elevation of both TRPV1 and TRPA1 during TM-induced immunosuppression of T cells.We found that TRPA1 activation-driven suppression of T cell activation and effector cytokine responses during TM treatment is partially, yet significantly overridden by TRPV1 activation. Moreover, the expressions of TRPV1 and TRPA1 were highly correlated in various conditions of T cell. Mechanistically, it might be suggested that TRPV1 and TRPA1 are differentially involved in regulating T cell a...
Source: Immunological Investigations - April 8, 2024 Category: Allergy & Immunology Authors: Tathagata Mukherjee Kshyama Subhadarsini Tung Parthasarathi Jena Chandan Goswami Subhasis Chattopadhyay Source Type: research
LINC00265 can Serve as a Potential Biomarker for Predicting Increased Disease Risk, Systemic Inflammation, Disease Severity and Poor Prognosis in Sepsis
CONCLUSION: LINC00265 is upregulated in patients with sepsis, and its high expression predicts increased disease severity, heightened inflammation, and a poorer prognosis.PMID:38589355 | DOI:10.1080/08820139.2024.2332791 (Source: Immunological Investigations)
Source: Immunological Investigations - April 8, 2024 Category: Allergy & Immunology Authors: Yiming Cui Nan Jiang Xin Liu Jianyuan Huang Wei Chen Source Type: research
Upregulation, Functional Association, and Correlated Expressions of TRPV1 and TRPA1 During Telmisartan-Driven Immunosuppression of T Cells
In this study, we investigated the potential role of TRPV1 and TRPA1 during TM-driven immunosuppression of T cells in vitro. We observed a significant elevation of both TRPV1 and TRPA1 during TM-induced immunosuppression of T cells.We found that TRPA1 activation-driven suppression of T cell activation and effector cytokine responses during TM treatment is partially, yet significantly overridden by TRPV1 activation. Moreover, the expressions of TRPV1 and TRPA1 were highly correlated in various conditions of T cell. Mechanistically, it might be suggested that TRPV1 and TRPA1 are differentially involved in regulating T cell a...
Source: Immunological Investigations - April 8, 2024 Category: Allergy & Immunology Authors: Tathagata Mukherjee Kshyama Subhadarsini Tung Parthasarathi Jena Chandan Goswami Subhasis Chattopadhyay Source Type: research
LINC00265 can Serve as a Potential Biomarker for Predicting Increased Disease Risk, Systemic Inflammation, Disease Severity and Poor Prognosis in Sepsis
CONCLUSION: LINC00265 is upregulated in patients with sepsis, and its high expression predicts increased disease severity, heightened inflammation, and a poorer prognosis.PMID:38589355 | DOI:10.1080/08820139.2024.2332791 (Source: Immunological Investigations)
Source: Immunological Investigations - April 8, 2024 Category: Allergy & Immunology Authors: Yiming Cui Nan Jiang Xin Liu Jianyuan Huang Wei Chen Source Type: research
Upregulation, Functional Association, and Correlated Expressions of TRPV1 and TRPA1 During Telmisartan-Driven Immunosuppression of T Cells
In this study, we investigated the potential role of TRPV1 and TRPA1 during TM-driven immunosuppression of T cells in vitro. We observed a significant elevation of both TRPV1 and TRPA1 during TM-induced immunosuppression of T cells.We found that TRPA1 activation-driven suppression of T cell activation and effector cytokine responses during TM treatment is partially, yet significantly overridden by TRPV1 activation. Moreover, the expressions of TRPV1 and TRPA1 were highly correlated in various conditions of T cell. Mechanistically, it might be suggested that TRPV1 and TRPA1 are differentially involved in regulating T cell a...
Source: Immunological Investigations - April 8, 2024 Category: Allergy & Immunology Authors: Tathagata Mukherjee Kshyama Subhadarsini Tung Parthasarathi Jena Chandan Goswami Subhasis Chattopadhyay Source Type: research
LINC00265 can Serve as a Potential Biomarker for Predicting Increased Disease Risk, Systemic Inflammation, Disease Severity and Poor Prognosis in Sepsis
CONCLUSION: LINC00265 is upregulated in patients with sepsis, and its high expression predicts increased disease severity, heightened inflammation, and a poorer prognosis.PMID:38589355 | DOI:10.1080/08820139.2024.2332791 (Source: Immunological Investigations)
Source: Immunological Investigations - April 8, 2024 Category: Allergy & Immunology Authors: Yiming Cui Nan Jiang Xin Liu Jianyuan Huang Wei Chen Source Type: research
Upregulation, Functional Association, and Correlated Expressions of TRPV1 and TRPA1 During Telmisartan-Driven Immunosuppression of T Cells
In this study, we investigated the potential role of TRPV1 and TRPA1 during TM-driven immunosuppression of T cells in vitro. We observed a significant elevation of both TRPV1 and TRPA1 during TM-induced immunosuppression of T cells.We found that TRPA1 activation-driven suppression of T cell activation and effector cytokine responses during TM treatment is partially, yet significantly overridden by TRPV1 activation. Moreover, the expressions of TRPV1 and TRPA1 were highly correlated in various conditions of T cell. Mechanistically, it might be suggested that TRPV1 and TRPA1 are differentially involved in regulating T cell a...
Source: Immunological Investigations - April 8, 2024 Category: Allergy & Immunology Authors: Tathagata Mukherjee Kshyama Subhadarsini Tung Parthasarathi Jena Chandan Goswami Subhasis Chattopadhyay Source Type: research
LINC00265 can Serve as a Potential Biomarker for Predicting Increased Disease Risk, Systemic Inflammation, Disease Severity and Poor Prognosis in Sepsis
CONCLUSION: LINC00265 is upregulated in patients with sepsis, and its high expression predicts increased disease severity, heightened inflammation, and a poorer prognosis.PMID:38589355 | DOI:10.1080/08820139.2024.2332791 (Source: Immunological Investigations)
Source: Immunological Investigations - April 8, 2024 Category: Allergy & Immunology Authors: Yiming Cui Nan Jiang Xin Liu Jianyuan Huang Wei Chen Source Type: research
Immune Dysregulation in Chronic Obstructive Pulmonary Disease
Immunol Invest. 2024 Apr 4:1-43. doi: 10.1080/08820139.2024.2334296. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is a disease whose incidence increase with age and is characterised by chronic inflammation and significant immune dysregulation. Inhalation of toxic substances cause oxidative stress in the lung tissue as well as airway inflammation, under the recruitment of chemokines, immune cells gathered and are activated to play a defensive role. However, persistent inflammation damages the immune system and leads to immune dysregulation, which is mainly manifested in the reduction of the bod...
Source: Immunological Investigations - April 4, 2024 Category: Allergy & Immunology Authors: Xichen Pang Xiaoju Liu Source Type: research
Immunological Regulation of Gut-Tropic Immune Cells by Extracellular Vesicles
Immunol Invest. 2024 Jan;53(1):40-69. doi: 10.1080/08820139.2023.2284887. Epub 2023 Nov 21.ABSTRACTThe remarkable diversity of lymphocytes, essential components of the immune system, serves as an ingenious mechanism for maximizing the efficient utilization of limited host defense resources. While cell adhesion molecules, notably in gut-tropic T cells, play a central role in this mechanism, the counterbalancing molecular details have remained elusive. Conversely, we've uncovered the molecular pathways enabling extracellular vesicles secreted by lymphocytes to reach the gut's mucosal tissues, facilitating immunological regul...
Source: Immunological Investigations - March 21, 2024 Category: Allergy & Immunology Authors: Yasunari Matsuzaka Ryu Yashiro Source Type: research
