Immunological Regulation of Gut-Tropic Immune Cells by Extracellular Vesicles

Immunol Invest. 2024 Jan;53(1):40-69. doi: 10.1080/08820139.2023.2284887. Epub 2023 Nov 21.ABSTRACTThe remarkable diversity of lymphocytes, essential components of the immune system, serves as an ingenious mechanism for maximizing the efficient utilization of limited host defense resources. While cell adhesion molecules, notably in gut-tropic T cells, play a central role in this mechanism, the counterbalancing molecular details have remained elusive. Conversely, we've uncovered the molecular pathways enabling extracellular vesicles secreted by lymphocytes to reach the gut's mucosal tissues, facilitating immunological regulation. This discovery sheds light on immune fine-tuning, offering insights into immune regulation mechanisms.PMID:38509665 | DOI:10.1080/08820139.2023.2284887
Source: Immunological Investigations - Category: Allergy & Immunology Authors: Source Type: research