Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain metastasis in NSCLC via synergistically promoting microglia M1 polarization
Brain metastasis is one of the main causes of recurrence and death in non-small cell lung cancer (NSCLC). Although radiotherapy is the main local therapy for brain metastasis, it is inevitable that some cancer... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 29, 2024 Category: Cancer & Oncology Authors: Lichao Liu, Jian Wang, Ying Wang, Lingjuan Chen, Ling Peng, Yawen Bin, Peng Ding, Ruiguang Zhang, Fan Tong and Xiaorong Dong Tags: Research Source Type: research
Cancers, Vol. 16, Pages 1742: Long-Term Results of Stereotactic Radiotherapy in Patients with at Least 10 Brain Metastases at Diagnosis
Conclusions: SRT was highly efficient in controlling the BM, with minimal side effects. In this setting, an SRT treatment should be proposed even in patients with ≥10 BMs at diagnosis. (Source: Cancers)
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: R émy Kinj Andreas Felix Hottinger Till Tobias B öhlen Mahmut Ozsahin V éronique Vallet Vincent Dunet Hasna Bouchaab Solange Peters Constantin Tuleasca Jean Bourhis Luis Schiappacasse Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1743: Quantitative Assessment of Tumor Contact with Neurogenic Zones and Its Effects on Survival: Insights beyond Traditional Predictors
In this study, we assessed the impact of GBM’s relationship with the cortex, SVZ and SGZ on clinical variables using fully automated segmentation methods. In 177 glioblastoma patients, we calculated optimal cutpoints of minimal distances to the SVZ and SGZ to distinguish poor from favorable survival. The impact of tumor contact with neurogenic zones on clinical parameters, such as overall survival, multifocality, MGMT promotor methylation, Ki-67 and KPS score was also examined by multivariable regression analysis, chi-square test and Mann–Whitney-U. The analysis confirmed shorter survival in tum...
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: Jung Kempter Prokop Herrmann Griessmair Kim Delbridge Meyer Bernhardt Combs Zimmer Wiestler Schmidt-Graf Metz Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1740: The Molecular Landscape of Primary CNS Lymphomas (PCNSLs) in Children and Young Adults
We examined PCNSLs in 34 young patients aged between 7 and 39 years for gene rearrangements of BCl2, BCL6, CCND1, IRF4, IGH, IGL, IGK, and MYC, homozygous deletions (HD) of CDKN2A, and HLA by FISH. Sequencing was performed using WES, panel target sequencing, or Sanger sequencing due to the small amount of available tissues. The median OS was 97.5 years and longer than that for older patients with PCNSLs. Overall, only 14 instances of gene rearrangement were found (5%), and patients with any gene rearrangement were significantly older (p = 0.029). CDKN2A HD was associated with a shorter OS (p < 0.001). Only 10/31...
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: Zhi-Feng Shi Kay Ka-Wai Li Anthony Pak-Yin Liu Nellie Yuk-Fei Chung Sze-Ching Wong Hong Chen Peter Yat-Ming Woo Danny Tat-Ming Chan Ying Mao Ho-Keung Ng Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1733: A Role for iNOS in Erastin Mediated Reduction of P-Glycoprotein Transport Activity
This study investigated how nano-molar levels of the selective chemotherapeutic erastin affect the activity or expression of P-glycoprotein transporter in brain capillaries and in human tumor cell lines. We chose erastin because it signals to iNOS for NO production at low concentrations. Furthermore, erastin inhibits the cellular uptake of cystine through the XC− cystine/glutamate antiporter. Since previous reports indicate that NO production from iNOS can rapidly inhibit P-gp activity in tumor cells, we wondered if induction of iNOS by erastin could also rapidly reduce P-glycoprotein transport activity in br...
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: Shalyn M. Brown Birandra K. Sinha Ronald E. Cannon Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1715: Clinical Theranostics in Recurrent Gliomas: A Review
R. Witcher
Gliomas represent the most commonly occurring tumors in the central nervous system and account for approximately 80% of all malignant primary brain tumors. With a high malignancy and recurrence risk, the prognosis of high-grade gliomas is poor, with a mean survival time of 12–18 months. While contrast-enhanced MRI serves as the standard diagnostic imaging modality for gliomas, it faces limitations in the evaluation of recurrent gliomas, failing to distinguish between treatment-related changes and tumor progression, and offers no direct therapeutic options. Recent advances in imaging modalities...
Source: Cancers - April 28, 2024 Category: Cancer & Oncology Authors: Austin R. Hoggarth Sankar Muthukumar Steven M. Thomas James Crowley Jackson Kiser Mark R. Witcher Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1716: Direct Implantation of Patient Brain Tumor Cells into Matching Locations in Mouse Brains for Patient-Derived Orthotopic Xenograft Model Development
Conclusions: The protocol is easy to follow, without a sterotactic frame, in order to generate large cohorts of tumor-bearing mice to meet the needs of biological studies and preclinical drug testing. (Source: Cancers)
Source: Cancers - April 28, 2024 Category: Cancer & Oncology Authors: Lin Qi Patricia Baxter Mari Kogiso Huiyuan Zhang Frank K. Braun Holly Lindsay Sibo Zhao Sophie Xiao Aalaa Sanad Abdallah Milagros Suarez Zilu Huang Wan Yee Teo Litian Yu Xiumei Zhao Zhigang Liu Yulun Huang Jack M. Su Tsz-Kwong Man Ching C. Lau Laszlo Perl Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1723: Integration of Computational Pipeline to Streamline Efficacious Drug Nomination and Biomarker Discovery in Glioblastoma
R. Stephanie Huang
Glioblastoma multiforme (GBM) is the deadliest, most heterogeneous, and most common brain cancer in adults. Not only is there an urgent need to identify efficacious therapeutics, but there is also a great need to pair these therapeutics with biomarkers that can help tailor treatment to the right patient populations. We built patient drug response models by integrating patient tumor transcriptome data with high-throughput cell line drug screening data as well as Bayesian networks to infer relationships between patient gene expression and drug response. Through these discovery pipelines, we identified...
Source: Cancers - April 28, 2024 Category: Cancer & Oncology Authors: Danielle Maeser Robert F. Gruener Robert Galvin Adam Lee Tomoyuki Koga Florina-Nicoleta Grigore Yuta Suzuki Frank B. Furnari Clark Chen R. Stephanie Huang Tags: Article Source Type: research
Peak Resembling N-acetylaspartate (NAA) on Magnetic Resonance Spectroscopy of Brain Metastases
Conclusions: The identification of a prominent peak at 2.0 ppm could be a valuable diagnostic marker for distinguishing single ring-enhancing lesions, potentially associated with mucin-expressing metastases, offering a new avenue for diagnostic specificity in challenging cases.PMID:38674308 | PMC:PMC11052432 | DOI:10.3390/medicina60040662 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Jelena Ostojic Dusko Kozic Milana Panjkovic Biljana Georgievski-Brkic Dusan Dragicevic Aleksandra Lovrenski Jasmina Boban Source Type: research
Regional cerebral blood flow in a patient with asystole episodes associated with anti-NMDA receptor encephalitis
Neurocase. 2024 Apr 27:1-4. doi: 10.1080/13554794.2024.2348221. Online ahead of print.ABSTRACTAnti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare and severe autoimmune encephalitis that displays neuropsychiatric symptoms and autonomic instability, e.g., hypoventilation and cardiac arrhythmia. Severe arrhythmia including asystole associated with this encephalitis is rare. Several causes have been suggested. Nevertheless, no report of the literature has described examination by functional brain imaging of a patient with asystole during anti-NMDA receptor encephalitis. This case is that of a 34-year-old woman dia...
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Gaku Aboshi Takaki Akahane Keisuke Noto Ryota Kobayashi Masakazu Akiho Akihito Suzuki Source Type: research
Letter to the editor
Environ Int. 2024 Apr 18;187:108665. doi: 10.1016/j.envint.2024.108665. Online ahead of print.ABSTRACTSome have looked forward to the publication of the results of the COSMOS study on brain tumors, because the potential biases from retrospective investigations predominating the search for brain tumor risks of mobile phone use since the late 1990 s were deemed unresolvable by further investigations of that type. Indeed, prospective cohort studies typically have the advantage of being not or less affected by differential exposure misclassification, recall and selection bias, and, as they proceed in the direction of the time ...
Source: Environment International - April 27, 2024 Category: Environmental Health Authors: Michael Kundi Source Type: research
Regional cerebral blood flow in a patient with asystole episodes associated with anti-NMDA receptor encephalitis
Neurocase. 2024 Apr 27:1-4. doi: 10.1080/13554794.2024.2348221. Online ahead of print.ABSTRACTAnti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare and severe autoimmune encephalitis that displays neuropsychiatric symptoms and autonomic instability, e.g., hypoventilation and cardiac arrhythmia. Severe arrhythmia including asystole associated with this encephalitis is rare. Several causes have been suggested. Nevertheless, no report of the literature has described examination by functional brain imaging of a patient with asystole during anti-NMDA receptor encephalitis. This case is that of a 34-year-old woman dia...
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Gaku Aboshi Takaki Akahane Keisuke Noto Ryota Kobayashi Masakazu Akiho Akihito Suzuki Source Type: research
Randomized self-controlled study comparing open-face vs. closed immobilization masks in fractionated cranial radiotherapy
CONCLUSIONS: Open-face masks are associated with decreased patient discomfort without compromising patient positioning and immobilisation accuracy.PMID:38677329 | DOI:10.1016/j.radonc.2024.110314 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 27, 2024 Category: Radiology Authors: Mich èle Keane Nienke Weitkamp Indira Madani Jonathan Day Riccardo Dal Bello Mariangela Zamburlini Antonia Schiess Amanda Moreira Sophie Perryck Katja Tomuschat Marilyn Spencer Stephanie Tanadini-Lang Matthias Guckenberger Michelle Brown Source Type: research
Peak Resembling N-acetylaspartate (NAA) on Magnetic Resonance Spectroscopy of Brain Metastases
Conclusions: The identification of a prominent peak at 2.0 ppm could be a valuable diagnostic marker for distinguishing single ring-enhancing lesions, potentially associated with mucin-expressing metastases, offering a new avenue for diagnostic specificity in challenging cases.PMID:38674308 | PMC:PMC11052432 | DOI:10.3390/medicina60040662 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Jelena Ostojic Dusko Kozic Milana Panjkovic Biljana Georgievski-Brkic Dusan Dragicevic Aleksandra Lovrenski Jasmina Boban Source Type: research
Letter to the editor
Environ Int. 2024 Apr 18;187:108665. doi: 10.1016/j.envint.2024.108665. Online ahead of print.ABSTRACTSome have looked forward to the publication of the results of the COSMOS study on brain tumors, because the potential biases from retrospective investigations predominating the search for brain tumor risks of mobile phone use since the late 1990 s were deemed unresolvable by further investigations of that type. Indeed, prospective cohort studies typically have the advantage of being not or less affected by differential exposure misclassification, recall and selection bias, and, as they proceed in the direction of the time ...
Source: Environment International - April 27, 2024 Category: Environmental Health Authors: Michael Kundi Source Type: research
