367. Effect of Neuregulin1 in Brain Microvascular Endothelial Cells Stimulated With Tumor Necrosis Alpha (TNF- α): A Possible Protective Role in Blood Brain Barrier Injury

Traumatic brain injury (TBI), caused by exposure to explosions is common among returning war Veterans that have suffered trauma during their deployment. Neuroinflammation is a key feature after TBI characterized by increased pro- and anti-inflammatory cytokines, disruption of blood-brain-barrier (BBB) permeability, resulting in many neuropsychiatric diseases. Perturbation of BBB is pivotal in TBI as dysfunctional barrier allows inflammatory cells trafficking resulting in impairment of neurovascular unit.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research