Reply to: Clinical brain PET research must embrace multi-centre collaboration and data sharing or risk its demise: emphasis should also be placed on the critical role of image analysis schemes
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - June 17, 2020 Category: Nuclear Medicine Source Type: research

Reactions to COVID-19: actions of nuclear medicine healthcare personnel in China
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - June 17, 2020 Category: Nuclear Medicine Source Type: research

[18F]-FDG PET/CT for suspected lymphoma relapse in a patient with concomitant pneumococcal pneumonia during COVID-19 outbreak: unexpected SARS-Cov-2 co-infection despite double RT-PCR negativity
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - June 17, 2020 Category: Nuclear Medicine Source Type: research

Positive FAPI-PET/CT in a metastatic castration-resistant prostate cancer patient with PSMA-negative/FDG-positive disease
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - June 17, 2020 Category: Nuclear Medicine Source Type: research

False-negative 18 F-PSMA-1007 PET/CT in metastatic prostate cancer related to high physiologic liver uptake
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - June 17, 2020 Category: Nuclear Medicine Source Type: research

Visualization of malignant infiltration of the thoracic duct on 68 Ga PSMA-11 PET/CT in a prostate cancer patient with biochemical recurrence
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - June 17, 2020 Category: Nuclear Medicine Source Type: research

Low-dose dynamic myocardial perfusion imaging by CZT-SPECT in the identification of obstructive coronary artery disease
AbstractBackgroundWe measured myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) by a dynamic low-dose CZT-SPECT protocol in patients with suspected or known coronary artery disease (CAD) and investigated the capability of dynamic data in predicting obstructive CAD. A total of 173 patients with suspected or known CAD underwent dynamic CZT-SPECT after the injection of 155  MBq and 370 MBq of99mTc-sestamibi for rest and stress imaging, respectively. Standard rest and stress imaging were performed at the end of each dynamic scan. A total perfusion defect (TPD)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

Comparison between quantitative cardiac magnetic resonance perfusion imaging and [ 15 O]H 2 O positron emission tomography
AbstractPurposeTo compare cardiac magnetic resonance imaging (CMR) with [15O]H2O positron emission tomography (PET) for quantification of absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR) in patients with coronary artery disease (CAD).MethodsFifty-nine patients with stable CAD underwent CMR and [15O]H2O PET. The CMR imaging protocol included late gadolinium enhancement to rule out presence of scar tissue and perfusion imaging using a dual sequence, single bolus technique. Absolute MBF was determined for the three main vascular territories at rest and during vasodilator stress.ResultsCMR measurements of...
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

COVID-19 pandemic: guidance for nuclear medicine departments
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

Letter to editor
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

Nuclear medicine in responding to global pandemic COVID-19 —American College of Nuclear Medicine member experience
AbstractIn the global pandemic COVID-19, it is important for everyone including nuclear medicine personnel to know how to stop transmission and contain and prevent the spread of COVID-19. Here, we summarize our American College of Nuclear Medicine members ’ experiences from Wuhan, China; Singapore; and the USA, so to provide advice to the nuclear medicine personnel for their clinical practice and management strategies in responding to COVID-19. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

Reply to “No time like the present: time to rethink our habits in science and continuous medical education?”
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

CT, [ 18 F]FDG-PET/CT and clinical findings before and during early Covid-19 onset in a patient affected by vascular tumour
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

No time like the present: time to re-think our habits in science and continuous medical education?
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

Radioaerosols and the updated EANM guideline in ventilation/perfusion imaging
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

A case of COVID-19 lung infection first detected by [18F]FDG PET-CT
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

FDG-PET/CT findings highly suspicious for COVID-19 in an Italian case series of asymptomatic patients
ConclusionsThe [18F]FDG-PET/CT can identify probable Covid-19 disease in the absence or before symptoms onset and can guide patient management. Nuclear medicine staff needs to be aware of the possibility of contact with patients affected by the SARS-CoV-2 infection even if they do not present any symptom. Therefore, safety measures need to be adopted for other patients and hospital staff in order to block the spread of infection. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

Suggestions for safety and protection control in Department of Nuclear Medicine during the outbreak of COVID-19
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

The indispensable role of chest CT in the detection of coronavirus disease 2019 (COVID-19)
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

The potential added value of FDG PET/CT for COVID-19 pneumonia
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

Facing a disruptive threat: how can a nuclear medicine service be prepared for the coronavirus outbreak 2020?
ConclusionSince our hospital received the first patient with COVID-19 in Singapore, our centre has managed 16 COVID-19 cases to date. There has not been any healthcare worker in our institution who has contracted COVID-19 through patient contact. We have highlighted for discussion some of the policies and processes to prepare a nuclear medicine service for the COVID-19 threat. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

Jeffrey A Brown, Julie G Pilitsis, Michael Schulder (Eds). Functional Neurosurgery: The Essentials
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

PET imaging of COVID-19: the target and the number
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

Waleed Brinjikji, Timo Krings: Imaging in Neurovascular Disease. A Case-Based Approach
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 25, 2020 Category: Nuclear Medicine Source Type: research

Individualized discrimination of tumor recurrence from radiation necrosis in glioma patients using an integrated radiomics-based model
AbstractPurposeTo develop and validate an integrated model for discriminating tumor recurrence from radiation necrosis in glioma patients.MethodsData from 160 pathologically confirmed glioma patients were analyzed. The diagnostic model was developed in a primary cohort (n = 112). Textural features were extracted from postoperative18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET),11C-methionine (11C-MET) PET, and magnetic resonance images. The least absolute shrinkage and selection operator regression model was used for feature selection and radiomics signature building. Multivariable logistic regression a...
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 28, 2020 Category: Nuclear Medicine Source Type: research

Assessment of treatment responses in children and adolescents with Ewing sarcoma with metabolic tumor parameters derived from 18 F-FDG-PET/CT and circulating tumor DNA
AbstractPurposeThe purpose of this study was to perform a prospective integrated analysis of18F-fluorodeoxyglucose (18F-FDG)-positron emission tomography (PET)/computed tomography (CT) and circulating tumor DNA (ctDNA) to assess responses to multimodal chemotherapy in children and adolescents suffering from Ewing sarcoma (EwS).MethodsA total of 20 patients with histologically confirmed EwS underwent multiple18F-FDG-PET/CT, performed at the time of each patient ’s initial diagnosis and after the second and fifth induction chemotherapy block (EWING2008 treatment protocol, NCT00987636). Additional PET examinations were ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 28, 2020 Category: Nuclear Medicine Source Type: research

Correction to: Staging and quantification of florbetaben PET images using machine learning: impact of predicted regional cortical tracer uptake and amyloid stage on clinical outcomes
The Table 2 in the original version of this article contained a mistake in the alignment. Correct Table 2 presentation is presented here. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 28, 2020 Category: Nuclear Medicine Source Type: research

FDG-PET/CT in the detection of pituitary stalk ACTH-secreting adenoma
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 28, 2020 Category: Nuclear Medicine Source Type: research

Considerations on bone volume normalization in quantifying skeletal burden in fibrous dysplasia using sodium fluoride PET/CT
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 28, 2020 Category: Nuclear Medicine Source Type: research

Editorial commentary to “ 18 F-Fluorocholine PET uptake correlates with pathologic evidence of recurrent tumor after stereotactic radiosurgery for brain metastases” by Grkovski and colleagues
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 28, 2020 Category: Nuclear Medicine Source Type: research

Tumor uptake in glioblastoma multiforme after IV injection of [ 177 Lu]Lu-PSMA-617
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 28, 2020 Category: Nuclear Medicine Source Type: research

Correction to: A new Centiloid method for 18 F-florbetaben and 18 F-flutemetamol PET without conversion to PiB
Funding information from the original version of this article was incomplete. Complete information is presented here. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 28, 2020 Category: Nuclear Medicine Source Type: research

Correction to: Assessment of treatment responses in children and adolescents with Ewing sarcoma with metabolic tumor parameters derived from 18 F-FDG-PET/CT and circulating tumor DNA
The author names and family names of the originally published article was inversed. Correct presentation is presented here. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 28, 2020 Category: Nuclear Medicine Source Type: research

Correction to: Superior performance of 18F-fluorocholine digital PET/CT in the detection of parathyroid adenomas
The correct administered activity of 18F-FCH is 0.1 –0.14 mCi/Kg, which is equivalent to 3.7–5.2 MBq/kg. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 28, 2020 Category: Nuclear Medicine Source Type: research

18 F-FDG PET/CT findings of COVID-19: a series of four highly suspected cases
ConclusionsAlthough18F-FDG PET/CT cannot be routinely used in an emergency setting and is generally not recommended for infectious diseases, our pilot data shed light on the potential clinical utility of this imaging technique in the differential diagnosis of complex cases. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

Influx rate constant of 18 F-FDG increases in metastatic lymph nodes of non-small cell lung cancer patients
AbstractPurposePrimary tumor (PT) and metastatic lymph node (MLN) status have a great influence on diagnosis and treatment of lung cancer. Our main purpose was to investigate the imaging characteristics of PT or MLN by applying the18F-FDG PET dynamic modeling approach for non-small cell lung cancer (NSCLC).MethodsDynamic18F-FDG PET scans were performed for 76 lung cancer patients, and 62 NSCLC cases were finally included in this study: 37 with newly diagnosed early and locally advanced lung cancer without distant metastases (group M0) and 25 metastatic lung cancer (group M1). Patlak graphic analysis (Ki calculation) based ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

New insight on the correlation of metabolic status on 18 F-FDG PET/CT with immune marker expression in patients with non-small cell lung cancer
AbstractBackgroundMetabolic information obtained through18F-flurodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is used to evaluate malignancy by calculating the glucose uptake rate, and these parameters play important roles in determining the prognosis of non-small cell lung cancer (NSCLC). The expression of immune-related markers in tumor tissue reflects the immune status in the tumor microenvironment. However, there is lack of reports on the association between metabolic variables and intra-tumor immune markers. Herein, we investigate the correlation between metabolic status on18F-FDG PET...
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

Quantification of 18F-fluorodeoxyglucose uptake to detect residual nodal disease in locally advanced head and neck squamous cell carcinoma after chemoradiotherapy: results from the ECLYPS study
ConclusionFDG quantification detects nodal relapse in LAHNSCC patients. When using EARL standardized PET acquisitions and reconstruction, absolute SUV metrics (SUV70 threshold 2.2) prove robust, yet ratios (SUV50/SUVliver, threshold 0.96) may be more useful in routine clinical care. In this setting, the diagnostic value of quantification is comparable to the Hopkins criteria.Trial registrationUS National Library for Medicine, NCT01179360. Registered 11 August 2010,https://clinicaltrials.gov/ct2/show/NCT01179360 (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

Radiomics of 18 F-FDG PET/CT images predicts clinical benefit of advanced NSCLC patients to checkpoint blockade immunotherapy
ConclusionPET/CT-based signature can be used prior to initiation of immunotherapy to identify NSCLC patients most likely to benefit from immunotherapy. As such, these data may be leveraged to improve more precise and individualized decision support in the treatment of patients with advanced NSCLC. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

18 F-FDG PET/CT in diagnostic and prognostic evaluation of patients with cardiac masses: a retrospective study
AbstractPurposeCorrect diagnosis and prognostic assessment of cardiac masses are crucial before therapy. We evaluated the diagnostic and prognostic value of18F-FDG PET/CT in patients with cardiac masses.Methods18F-FDG PET/CT images of 64 patients with 65 cardiac masses were retrospectively analysed (34 men, 30 women; average age, 51.2  ± 17.5 years). Comparisons of CT features and18F-FDG metabolic indices between benign and malignant entities, as well as among primary and secondary malignancies and lymphoma, were performed. The diagnostic values of PET/CT for distinguishing benign versus malignant...
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

18 F-FDG PET/CT radiomic predictors of pathologic complete response (pCR) to neoadjuvant chemotherapy in breast cancer patients
AbstractPurposePathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) is commonly accepted as the gold standard to assess outcome after NAC in breast cancer patients.18F-Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) has unique value in tumor staging, predicting prognosis, and evaluating treatment response. Our aim was to determine if we could identify radiomic predictors from PET/CT in breast cancer patient therapeutic efficacy prior to NAC.MethodsThis retrospective study included 100 breast cancer patients who received NAC; there were 2210 PET/CT radiomic features extracted. Un...
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

Biological correlates of tumor perfusion and its heterogeneity in newly diagnosed breast cancer using dynamic first-pass 18 F-FDG PET/CT
ConclusionsThe study of breast cancer perfusion shows a higher BF in large tumors and in tumors with lymph node involvement, not paralleled by similar modifications in tumor global metabolism. In addition, the observed correlation between the perfusion heterogeneity and the metabolism heterogeneity suggests that tumor perfusion and consequently the process of tumor angiogenesis might be involved in the metabolism heterogeneity previously shown in BC. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

Quantitative PET imaging of PD-L1 expression in xenograft and syngeneic tumour models using a site-specifically labelled PD-L1 antibody
AbstractPurposeDespite remarkable clinical responses and prolonged survival across several cancers, not all patients benefit from PD-1/PD-L1 immune checkpoint blockade. Accordingly, assessment of tumour PD-L1 expression by immunohistochemistry (IHC) is increasingly applied to guide patient selection, therapeutic monitoring, and improve overall response rates. However, tissue-based methods are invasive and prone to sampling error. We therefore developed a PET radiotracer to specifically detect PD-L1 expression in a non-invasive manner, which could be of diagnostic and predictive value.MethodsAnti-PD-L1 (clone 6E11, Genentec...
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

Evaluating response to immunotherapy with 18 F-FDG PET/CT: where do we stand?
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

“Luke! Luke! Don’t! It’s a trap!”—spotlight on bias in animal experiments in nuclear oncology
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

McCune-Albright syndrome confirmed by 99m Tc-MDP
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

Imaging features of 2019 novel coronavirus pneumonia
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 27, 2020 Category: Nuclear Medicine Source Type: research

Biodistribution and first clinical results of 18 F-SiFA lin -TATE PET: a novel 18 F-labeled somatostatin analog for imaging of neuroendocrine tumors
AbstractIntroductionPET/CT using68Ga-labeled somatostatin analogs (SSA) targeting somatostatin receptors (SSR) on the cell surface of well-differentiated neuroendocrine tumors (NET) represents the clinical reference standard for imaging. However, economic and logistic challenges of the68Ge/68Ga generator-based approach have disadvantages over18F-labeled compounds. Here, we present the first in-human data of18F-SiFAlin-TATE, a novel18F-labeled, SSR-targeting peptide. The aim was to compare the intra-individual biodistribution, tumor uptake, and image quality of18F-SiFAlin-TATE to the clinical reference standard68Ga-DOTA-TOC...
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 19, 2020 Category: Nuclear Medicine Source Type: research

Clinical quantification of the integrin αvβ6 by [ 18 F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study)
ConclusionsLung uptake of [18F]FB-A20FMDV2, a measure of expression of the integrin αvβ6, was markedly increased in subjects with PF compared with healthy subjects. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 18, 2020 Category: Nuclear Medicine Source Type: research

Combination treatments to enhance peptide receptor radionuclide therapy of neuroendocrine tumours
AbstractThe incidence of neuroendocrine tumours (NETs) is increasing, but curative therapeutic options are limited because diagnosis is often delayed until the tumour has metastasized. Peptide receptor radionuclide therapy (PRRT) is among the most effective therapeutic options for metastatic NETs because of targeted delivery of radioactivity to the tumour via the somatostatin receptor (SSTR) and relatively low systemic toxicity. However, current PRRT regimes result in palliation rather than cure, and higher doses of PRRT that might achieve remission would also be too toxic to the patients. Therefore, there is a need to imp...
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 18, 2020 Category: Nuclear Medicine Source Type: research