Impact of the COVID-19 pandemic on nuclear medicine departments in Europe
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 14, 2021 Category: Nuclear Medicine Source Type: research

Stereotactic radiotherapy to oligoprogressive lesions detected with 68Ga-PSMA-PET/CT in castration-resistant prostate cancer patients
ConclusionThis study demonstrated the feasibility of MDT using SBRT to treat oligoprogressive lesions by68Ga-PSMA-PET/CT in CRPC patients is efficient and well-tolerated, prolonging the effectiveness of ADT by delaying NEST. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 14, 2021 Category: Nuclear Medicine Source Type: research

Patterns of disease detection using [18F]DCFPyL PET/CT imaging in patients with detectable PSA post prostatectomy being considered for salvage radiotherapy: a prospective trial
AbstractPurposeProstate-specific membrane antigen (PSMA) PET/CT is increasingly used in patients with biochemical recurrence post prostatectomy to detect local recurrence and metastatic disease at low PSA levels. The aim of this study was to assess patterns of disease detection, predictive factors and safety using [18F]DCFPyL PET/CT versus diagnostic CT in patients being considered for salvage radiotherapy with biochemical recurrence post prostatectomy.MethodsWe conducted a prospective trial recruiting 100 patients with detectable PSA post prostatectomy (PSA 0.2 –2.0 ng/mL) and referred for salvage radiotherapy ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 14, 2021 Category: Nuclear Medicine Source Type: research

Simultaneous injection of 18F-BF3- Cy3-ACUPA and non-radioactive Cy7-ACUPA probes: a promising pre-biopsy PET and ex vivo fluorescence imaging approach to evaluate prostate cancer
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 14, 2021 Category: Nuclear Medicine Source Type: research

Imaging superiority of [68Ga]-FAPI-04 over [18F]-FDG PET/CT in alveolar soft part sarcoma (ASPS)
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 14, 2021 Category: Nuclear Medicine Source Type: research

Correction to: [18F]FDG PET radiomics to predict disease-free survival in cervical cancer: a multi-scanner/center study with external validation
A correction to this paper has been published:https://doi.org10.1007/s00259-021-05397-x (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 14, 2021 Category: Nuclear Medicine Source Type: research

68Ga-FAPI-46 and 18F-FDG PET/CT in a patient with immune-related thyroiditis induced by immune checkpoint inhibitors
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 14, 2021 Category: Nuclear Medicine Source Type: research

[68Ga]Ga-DOTA-TATE uptake due to COVID-19 vaccination
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 14, 2021 Category: Nuclear Medicine Source Type: research

RGD-functionalised melanin nanoparticles for intraoperative photoacoustic imaging-guided breast cancer surgery
ConclusionThese results highlight that cRGD-MNP-mediated PAI provide a powerful tool for breast cancer imaging and precise tumour resection. cRGD-MNPs with fine PA properties have great potential for clinical translation. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 10, 2021 Category: Nuclear Medicine Source Type: research

Integrating artificial intelligence into radiology practice: undergraduate students ’ perspective
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 10, 2021 Category: Nuclear Medicine Source Type: research

The limits of the “holy gray” in radioembolization and beyond
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 8, 2021 Category: Nuclear Medicine Source Type: research

[89Zr]Zr-huJ591 immuno-PET targeting PSMA in IDH mutant anaplastic oligodendroglioma
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 8, 2021 Category: Nuclear Medicine Source Type: research

Vasculitis and bursitis on [18F]FDG-PET/CT following COVID-19 mRNA vaccine: post hoc ergo propter hoc?
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 8, 2021 Category: Nuclear Medicine Source Type: research

177 Lu-PSMA-617 radioligand therapy of metastatic castration-resistant prostate cancer: Initial 254-patient results from a prospective registry (REALITY Study)
AbstractPurposePreliminary data from retrospective analyses and recent data from large randomized controlled trials suggest safety and efficacy of radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA) in men with metastatic castration-resistant prostate cancer (mCRPC). Limited data on this modality have been published regarding large samples treated in everyday practice.MethodsWe analyzed prospectively collected registry data regarding lutetium-177 (177Lu)-PSMA-617 RLT of 254 consecutive men with mCRPC seen in everyday academic practice. Since177Lu-PSMA-617 was experimental salvage treatment followi...
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 7, 2021 Category: Nuclear Medicine Source Type: research

Prediction of TERTp-mutation status in IDH-wildtype high-grade gliomas using pre-treatment dynamic [18F]FET PET radiomics
ConclusionsRadiomics based on TTP images extracted fromdynamic [18F]FET PET can predict the TERTp-mutation status of IDH-wildtype diffuse astrocytic high-grade gliomas with high accuracy preoperatively. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 7, 2021 Category: Nuclear Medicine Source Type: research

Influence of sarcopenia, clinical data, and 2-[18F] FDG PET/CT in outcome prediction of patients with early-stage adenocarcinoma esophageal cancer
AbstractPurposeTo determine the prognostic value of sarcopenia measurements done on staging 2-[18F] FDG PET/CT together with metabolic activity of the tumor in patients with adenocarcinoma esophagogastric cancer with surgical treatment.MethodsPatients with early-stage, surgically treated esophageal adenocarcinoma and available pre-treatment 2-[18F] FDG PET/CT were included. The standard uptake value (SUV) and SUV normalized by lean body mass (SUL) were recorded. Skeletal muscle index (SMI) was measured at the L3 level on the CT component of the PET/CT. Sarcopenia was defined as SMI  
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 7, 2021 Category: Nuclear Medicine Source Type: research

Myocardial perfusion SPECT findings in postCOVID period
AbstractPurposeTo investigate if (i) the risk of ischemia on myocardial perfusion scan (MPS), (ii) number of coronary angiographies (CAG) performed, and (iii) necessity for invasive (stent implantation or coronary artery bypass grafting (CABG)) or medical treatment increased in patients infected with COVID-19.MethodsPatients who were referred to MPS between August 2020 and April 2021 with a history of active symptomatic COVID-19 infection (confirmed by PCR positivity) in the last 6  months were involved in the study group. Age-and gender-matched control group was composed of randomly chosen patients who attended for M...
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 7, 2021 Category: Nuclear Medicine Source Type: research

Two experts and a newbie: [18F]PARPi vs [18F]FTT vs [18F]FPyPARP —a comparison of PARP imaging agents
ConclusionThese findings imply that [18F]FPyPARP is an alternative to [18F]PARPi and [18F]FTT for PET imaging of PARP enzymes. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 6, 2021 Category: Nuclear Medicine Source Type: research

The prognostic power of inflammatory indices and clinical factors in metastatic castration-resistant prostate cancer patients treated with radium-223 (BIO-Ra study)
AbstractPurposeTo combine peripheral blood indices and clinical factors in a prognostic score for metastatic castration-resistant prostate cancer (mCRPC) patients treated with radium-223 dichloride ([223Ra]RaCl2).Patients and methodsBaseline neutrophil-to-lymphocyte ratio (NLR), derived NLR (donor), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), systemic inflammation index (SII), Eastern Cooperative Oncology Group performance status (ECOG PS), Gleason score (GS) group, number of bone metastases, prostate-specific antigen (PSA), alkaline phosphatase (ALP), line of therapy, previous chemotherapy, and...
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 6, 2021 Category: Nuclear Medicine Source Type: research

[18F]FDG PET-CT in patients with DLBCL treated with CAR-T cell therapy: a practical approach of reporting pre- and post-treatment studies
AbstractPurposeThe introduction of CD19-specific chimeric antigen receptor T-cell therapy (CAR-T) for treatment of relapsed/refractory diffuse large B cell lymphoma (R/R DLBCL) gives hope to patients with otherwise dismal prognosis. Therapy outcomes, however, depend upon selection of patients and accurate early identification of non-responders. Patients treated with CAR-T usually undergo [18F]FDG PET-CT at time of decision (TD), time of CAR-T transfusion (TT), 1  month (M1), and 3 months (M3) post-therapy. The purpose of the current study was to identify the specific parameters that should be addressed when repor...
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 4, 2021 Category: Nuclear Medicine Source Type: research

Comparison of nodal staging between CT, MRI, and [18F]-FDG PET/MRI in patients with newly diagnosed breast cancer
AbstractPurposeTo compare CT, MRI, and [18F]-fluorodeoxyglucose positron emission tomography ([18F]-FDG PET/MRI) for nodal status, regarding quantity and location of metastatic locoregional lymph nodes in patients with newly diagnosed breast cancer.Materials and methodsOne hundred eighty-two patients (mean age 52.7  ± 11.9 years) were included in this prospective double-center study. Patients underwent dedicated contrast-enhanced chest/abdomen/pelvis computed tomography (CT) and whole-body ([18F]-FDG PET/) magnet resonance imaging (MRI). Thoracal datasets were evaluated separately regarding quanti...
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 3, 2021 Category: Nuclear Medicine Source Type: research

Aberrant patterns of PET response during treatment for DLBCL patients with MYC gene rearrangements
ConclusionMYC + DLBCL patients demonstrate aberrant PET response patterns compared to MYC- patients with more frequent progression during treatment after I-PET negative assessment and new lesions at sites that were not initially involved.Trial registration number and date of registrationHOVON-84: EudraCT: 2006 –005,174-42, retrospectively registered 01–08-2008. HOVON-130: EudraCT: 2014–002,654-39, registered 26–01-2015 (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 2, 2021 Category: Nuclear Medicine Source Type: research

Explaining a XX century horse behaviour
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 1, 2021 Category: Nuclear Medicine Source Type: research

C. Tinoco Mesquita, M. F. Rezende: Nuclear Cardiology Basic and Advanced Concepts in Clinical Practice
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 1, 2021 Category: Nuclear Medicine Source Type: research

The importance of lung hyperperfusion patterns in COVID-19-related AVDS
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 1, 2021 Category: Nuclear Medicine Source Type: research

Is it time to include [18F]FDG-PET/CT in the diagnostic work-up for lymph node staging in cN0 vulvar cancer patients?
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 1, 2021 Category: Nuclear Medicine Source Type: research

Women on board: mind the (gender) gap
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 1, 2021 Category: Nuclear Medicine Source Type: research

Dafang Wu: Clinical Nuclear Medicine Neuroimaging: An Instructional Casebook
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 1, 2021 Category: Nuclear Medicine Source Type: research

Benefit of [18F]-FDG PET/CT for treatment-na ïve nasopharyngeal carcinoma
AbstractBackgroundTo test the advantages of positron emission tomography and computed tomography (PET/CT) for diagnosing lymph nodes and staging nasopharyngeal carcinoma and to investigate its benefits for survival and treatment decisions.MethodsThe performance of PET/CT and magnetic resonance imaging (MRI) in diagnosis was compared based on 460 biopsied lymph nodes. Using the propensity matching method, survival differences of T3N1M0 patients with (n = 1093) and without (n = 1377) PET/CT were compared in diverse manners. A radiologic score model was developed and tested in a subset of T3N1M0 pa...
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 1, 2021 Category: Nuclear Medicine Source Type: research

Can someone look after my children while I write this COVID-19 paper?
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 1, 2021 Category: Nuclear Medicine Source Type: research

Eribulin improves tumor oxygenation demonstrated by 18F-DiFA hypoxia imaging, leading to radio-sensitization in human cancer xenograft models
ConclusionThese results demonstrated that18F-DiFA PET/CT clearly detected eribulin-induced tumor oxygenation and that eribulin efficiently enhanced the antitumor activity of radiation by improving tumor oxygenation. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 1, 2021 Category: Nuclear Medicine Source Type: research

Analytical performance of aPROMISE: automated anatomic contextualization, detection, and quantification of [18F]DCFPyL (PSMA) imaging for standardized reporting
ConclusionIn this analytical study, we demonstrated the segmentation accuracy of the deep learning algorithm, the consistency in quantitative assessment across multiple readers, and the high sensitivity in detecting potential lesions. The study provides a foundational framework for clinical evaluation of aPROMISE in standardized reporting of PSMA PET/CT. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2021 Category: Nuclear Medicine Source Type: research

Decrease in the cortex/striatum metabolic ratio on [18F]-FDG PET: a biomarker of autoimmune encephalitis
AbstractPurposeThe aim of this [18F]-FDG PET study was to determine the diagnostic value of the cortex/striatum metabolic ratio in a large cohort of patients suffering from autoimmune encephalitis (AE) and to search for correlations with the course of the disease.MethodsWe retrospectively collected clinical and paraclinical data of patients with AE, including brain18F-FDG PET/CT. Whole-brain statistical analysis was performed using SPM8 software after activity parametrization to the striatum in comparison to healthy subjects. The discriminative performance of this metabolic ratio was evaluated in patients with AE using rec...
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2021 Category: Nuclear Medicine Source Type: research

Let ’s embrace optical imaging: a growing branch on the clinical molecular imaging tree
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2021 Category: Nuclear Medicine Source Type: research

Investigating ultra-low-dose total-body [18F]-FDG PET/CT in colorectal cancer: initial experience
ConclusionsTotal-body PET/CT with an ultra-low dose of [18F]-FDG can maintain satisfactory image quality and lesion detectability in CRC. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 30, 2021 Category: Nuclear Medicine Source Type: research

68Ga-labeled ODAP-Urea-based PSMA agents in prostate cancer: first-in-human imaging of an optimized agent
ConclusionThe optimized ODAP-Urea-based ligand [68Ga]Ga-P137 can image PSMA in xenograft models and humans, with lower bladder accumulation to the Glu-Urea-based agent, [68Ga]Ga-PSMA-617, in a preliminary, first-in-human study.Trial registrationClinicalTrials.gov Identifier: NCT04560725, Registered 23 September 2020.https://clinicaltrials.gov/ct2/show/NCT04560725 (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 28, 2021 Category: Nuclear Medicine Source Type: research

International consensus on the use of [18F]-FDG PET/CT in pediatric patients affected by epilepsy
ConclusionThis is the first international consensus and practice guideline for brain [18F]-FDG  PET/CT in pediatric epilepsy patients. It will be an international standard for this purpose in clinical practice. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 28, 2021 Category: Nuclear Medicine Source Type: research

68Ga-PSMA and 68Ga-DOTATOC PET/CT imaging mismatch of primary pancreatic adenocarcinoma in prostate cancer patient
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 28, 2021 Category: Nuclear Medicine Source Type: research

Dosing 225Ac-DOTATOC in patients with somatostatin-receptor-positive solid tumors: 5-year follow-up of hematological and renal toxicity
ConclusionTreatment activities of approx. 20 MBq per cycle (4 monthly repetition) and cumulative doses up to 60 –80 MBq generally avoided both acute and chronic grade 3/4 hematotoxicity in patients with advanced stage malignancies. Chronic renal toxicity was observed at these doses, but pre-existing renal risk factors were important co-factors. These data represent a starting point for additional research t o more precisely define safety thresholds of225Ac-DOTATOC. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 26, 2021 Category: Nuclear Medicine Source Type: research

Combination of whole body [18F]FDG PET angiography and PET/CT for giant cell arteritis
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 26, 2021 Category: Nuclear Medicine Source Type: research

PSMA PET-CT: the winner takes it all
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 25, 2021 Category: Nuclear Medicine Source Type: research

Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging
AbstractThe ability of hyperpolarized carbon-13 MR metabolic imaging to acquire dynamic metabolic information in real time is crucial to gain mechanistic insights into metabolic pathways, which are complementary to anatomic and other functional imaging methods. This review presents the advantages of this emerging functional imaging technology, describes considerations in clinical translations, and summarizes current human brain applications. Despite rapid development in methodologies, significant technological and physiological related challenges continue to impede broader clinical translation. (Source: European Journal of...
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 25, 2021 Category: Nuclear Medicine Source Type: research

PSMA PET-CT: the winner takes it all
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 25, 2021 Category: Nuclear Medicine Source Type: research

Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging
AbstractThe ability of hyperpolarized carbon-13 MR metabolic imaging to acquire dynamic metabolic information in real time is crucial to gain mechanistic insights into metabolic pathways, which are complementary to anatomic and other functional imaging methods. This review presents the advantages of this emerging functional imaging technology, describes considerations in clinical translations, and summarizes current human brain applications. Despite rapid development in methodologies, significant technological and physiological related challenges continue to impede broader clinical translation. (Source: European Journal of...
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 25, 2021 Category: Nuclear Medicine Source Type: research

Simultaneous adrenal tuberculosis and renal oncocytoma mimicking malignant masses incidentally detected by 18F-FDG PET/CT in a patient with lymphoma
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 24, 2021 Category: Nuclear Medicine Source Type: research

First clinical experience of 106  cm, long axial field-of-view (LAFOV) PET/CT: an elegant balance between standard axial (23 cm) and total-body (194 cm) systems
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 23, 2021 Category: Nuclear Medicine Source Type: research

Noninvasive assessment of coronary microvascular dysfunction using SPECT myocardial perfusion imaging and myocardial perfusion entropy quantification in a rodent model of type 2 diabetes
AbstractPurposeCoronary microvascular dysfunction (CMVD) plays a major role in the occurrence of cardiovascular events (CVE). We recently suggested the clinical potential of myocardial perfusion entropy (MPE) quantification from SPECT myocardial perfusion images (MPI) for the prognosis of CVE occurrence. We hypothesized that the quantification of MPE from SPECT MPI would allow the assessment of CMVD-related MPE variations in a preclinical model of type 2 diabetes (T2D) including treatment with the anti-diabetic incretin liraglutide (LIR).MethodsOptimal conditions for the preclinical quantification of MPE using201Tl SPECT M...
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 21, 2021 Category: Nuclear Medicine Source Type: research