Performance of 18 F-fluciclovine PET/MR in the evaluation of osseous metastases from castration-resistant prostate cancer
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 17, 2019 Category: Nuclear Medicine Source Type: research

[ 18 F]Fluorocholine PET/CT-guided stereotactic body radiotherapy in patients with recurrent oligometastatic prostate cancer
AbstractBackgroundIn the last years, functional imaging has given a significant contribution to the clinical decision-making of biochemically relapsed prostate cancer (PCa). Hereby, we present a prospective study aiming to validate the role of [18F]Fluoro-Methyl Choline ([18F]FMCH) PET/CT in the selection of PCa patients suitable for stereotactic body radiotherapy (SBRT).MethodsPatients with biochemical recurrence limited up to three lesions revealed by [18F]FMCH PET/CT were enrolled in the present study and treated with SBRT on all active lesions. Systemic therapy-free survival since the [18F]FMCH PET/CT was considered as...
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 16, 2019 Category: Nuclear Medicine Source Type: research

Fitting of late dynamic [ 18 F]MK6240 PET scans for in vivo tau quantification
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 16, 2019 Category: Nuclear Medicine Source Type: research

Duccio Volterrani, Paola Anna Erba, Ignasi Carri ó, H. William Strauss, Giuliano Mariani. Nuclear Medicine Textbook Methodology and Clinical Application, 2 Volumes . Springer Nature Switzerland AG 2019, ISBN 978-3-319-95563-6
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 16, 2019 Category: Nuclear Medicine Source Type: research

Differentiated thyroid cancer patients potentially benefitting from postoperative I-131 therapy: a review of the literature of the past decade
ConclusionLiterature published in the last decade offers data that support adjuvant postoperative RIT in DTC patients with a tumor diameter exceeding 1  cm. Therefore, at least until randomized prospective studies prove otherwise, the prescription of adjuvant I-131 treatment to all DTC patients with a primary tumor diameter exceeding 1 cm remains a reasonable option. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 15, 2019 Category: Nuclear Medicine Source Type: research

Head-to-head comparison of tau positron emission tomography tracers [ 18 F]flortaucipir and [ 18 F]RO948
Conclusion[18F]RO948 and [18F]flortaucipir bound comparably in neocortical regions, but [18F]RO948 showed higher retention in the medial temporal lobe and lower intracerebral “off-target” binding. Time-dependent bias of SUVR estimates may prove less of a factor with [18F]RO948, compared with previous tau ligands. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 14, 2019 Category: Nuclear Medicine Source Type: research

Comparison of 18 F-FDG PET/MRI, MRI, and 18 F-FDG PET/CT for the detection of synchronous cancers and distant metastases in patients with oropharyngeal and hypopharyngeal squamous cell carcinoma
We examined 198 consecutive patients with biopsy-proven OHSCC who agreed to receive chemoradiation. All patients underwent pretreatment PET/MRI and PET/CT on the same day. Patients were followed-up for a minimum of 12  months or until death. The McNemar’s test and receiver-operating characteristic (ROC) curves were used to compare sensitivity/specificity and the diagnostic capabilities of PET/MRI, MRI, and PET/CT, respectively.ResultsWe identified 55 patients (27.7%) who had synchronous cancers and/or distant metastases (number of involved sites: 83). The results of site-based analysis revealed that the sensitiv...
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 12, 2019 Category: Nuclear Medicine Source Type: research

Characterization of the serotonin 2A receptor selective PET tracer (R)-[ 18 F]MH.MZ in the human brain
Conclusion(R)-[18F]MH.MZ is a suitable PET tracer to image and quantify the 5-HT2AR system in humans. In comparison with [11C]MDL 100907, faster and more precise outcome measure could be obtained using (R)-[18F]MH.MZ. We believe that (R)-[18F]MH.MZ has the potential to become the antagonist radiotracer of choice to investigate the human 5-HT2AR system. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 12, 2019 Category: Nuclear Medicine Source Type: research

Three-year changes of cortical 18 F-FDG in amnestic vs. non-amnestic sporadic early-onset Alzheimer ’s disease
AbstractPurposeTo examine and compare longitudinal changes of cortical glucose metabolism in amnestic and non-amnestic sporadic forms of early-onset Alzheimer ’s disease and assess potential associations with neuropsychological performance over a 3-year period time.MethodsEighty-two participants meeting criteria for early-onset (
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 12, 2019 Category: Nuclear Medicine Source Type: research

Augmented planar bone scintigraphy obtained from a whole-body SPECT recording of less than 20  min with a high-sensitivity 360° CZT camera
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 12, 2019 Category: Nuclear Medicine Source Type: research

Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 1, 2019 Category: Nuclear Medicine Source Type: research

Comparison of PSMA-ligand PET/CT and multiparametric MRI for the detection of recurrent prostate cancer in the pelvis
ConclusionsPSMA-PET/CT detected more pelvic lesions characteristic for rPC when compared to MRI. In order to detect rPC, a potential future scenario could be conducting first a PSMA-PET/CT. Combining the advantages of both modalities in hybrid PET/MRI scanners would be an ideal future scenario. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

A multiparametric analysis based on DCE-MRI to improve the accuracy of parotid tumor discrimination
AbstractBackgroundRecently, semiquantitative time-intensity curve (TIC) analysis based on DCE-MRI and apparent diffusion coefficient (ADC) value-based diffusion-weighted imaging (DWI) were used to improve the diagnostic efficiency when diagnosing parotid tumors (PTs). However, quantitative DCE-MRI biomarkers have not been emphasized previously.PurposeTo explore the diagnostic efficiency of perfusion parameters alone or in combination based on quantitative DCE-MRI and DWI in the differential diagnosis of PTs.MethodsIn total, 112 patients with parotid masses were prospectively recruited in our hospital from August 2013 to Ma...
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Low-calorie sweeteners augment tissue-specific insulin sensitivity in a large animal model of obesity
AbstractPurposesWhether low-calorie sweeteners (LCS), such as sucralose and acesulfame K, can alter glucose metabolism is uncertain, particularly given the inconsistent observations relating to insulin resistance in recent human trials. We hypothesized that these discrepancies are accounted for by the surrogate tools used to evaluate insulin resistance and that PET18FDG, given its capacity to quantify insulin sensitivity in individual organs, would be more sensitive in identifying changes in glucose metabolism. Accordingly, we performed a comprehensive evaluation of the effects of LCS on whole-body and organ-specific gluco...
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Prognostic and theranostic 18F-FDG PET biomarkers for anti-PD1 immunotherapy in metastatic melanoma: association with outcome and transcriptomics
AbstractPurposeAn imaging-based stratification tool is needed to identify melanoma patients who will benefit from anti Programmed Death-1 antibody (anti-PD1). We aimed at identifying biomarkers for survival and response evaluated in lymphoid tissue metabolism in spleen and bone marrow before initiation of therapy.MethodsThis retrospective study included 55 patients from two institutions who underwent 18F-FDG PET/CT before anti-PD1. Parameters extracted were SUVmax, SUVmean, HISUV (SUV-based Heterogeneity Index), TMTV (total metabolic tumor volume), TLG (total lesion glycolysis), BLR (Bone marrow-to-Liver SUVmax ratio), and...
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Clinical impact of PET/MR in treated colorectal cancer patients
AbstractPurposeThe primary aim of the present study was to evaluate if PET/MR induced management changes versus standard of care imaging (SCI) in treated colorectal cancer patients. The secondary aim was to assess the staging performance of PET/MR and of SCI versus the final oncologic stage.MethodsTreated CRC patients who underwent PET/MR with18F-FDG and SCI between January 2016 and October 2018 were enrolled in this retrospective study. Their medical records were evaluated to ascertain if PET/MR had impacted on their clinical management versus SCI. The final oncologic stage, as reported in the electronic medical record, w...
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

The use of 68 Ga-PET/CT PSMA in the staging of primary and suspected recurrent renal cell carcinoma
Conclusions68Ga-PSMA PET/CT directly changed management in 42.1% of cases. Strongest detection rates occurred in those patients with clear cell RCC. The results of this study suggest there may be merit in the use of the modality in the staging of RCC. Further analysis, both with respect to histological confirmation, efficacy and cost-benefit, is required to determine whether there is a role for routine68Ga-PSMA PET/CT imaging. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Subcortical amyloid relates to cortical morphology in cognitively normal individuals
ConclusionsIn cognitively normal individuals, subcortical A β is associated with cortical volume, and this effect was driven by surface area with or without thickness. Aβ-associated cortical changes were found in the default mode network and affected cognitive performance. Our findings demonstrate the importance of studying subcortical Aβ and cortical sur face area in normal ageing. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Personalised radioembolization improves outcomes in refractory intra-hepatic cholangiocarcinoma: a multicenter study
This study aimed to identify patient- and treatment-related variables predictive for radioembolization outcome.MethodsThis retrospective multicenter study enrolled 58 patients with unresectable and chemorefractory IH-CCA treated with resin90Y-microspheres. Clinicopathologic data were collected from patient records. Metabolic parameters of liver tumor(s) and presence of lymph node metastasis were measured on baseline18F-FDG-PET/CT.99mTc-MAA tumor to liver uptake ratio (TLRMAA) was computed for each lesion on the SPECT-CT. Activity prescription using body-surface-area (BSA) or more personalized partition-model was recorded. ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Prognostic value of somatostatin receptor expressing tumor volume calculated from 68 Ga-DOTATATE PET/CT in patients with well-differentiated neuroendocrine tumors
ConclusionΣSRETV calculated from68Ga-DOTATATE PET/CT may have prognostic value of PFS in WD-NET patients. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Enlarged perivascular spaces and florbetapir uptake in patients with intracerebral hemorrhage
ConclusionsAmong patients with spontaneous ICH, high degree of CSO-EPVS but not BG-EPVS is associated with amyloid PET positivity. The findings provide further evidence that CSO-EPVS are markers of vascular amyloid burden that may be useful in diagnosing CAA. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [ 11 C]PBR28 HRRT PET study
ConclusionThese findings provide evidence that individual biological properties may contribute significantly to the high variation shown in TSPO binding estimates, and suggest that age, BMI and sex can be confounding factors in clinical studies. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

EANM commitment towards involvement and engagement of patients and the public: learning from the UK experience
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Molecular imaging of impulse control disorders in Parkinson ’s disease
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Current experts ’ views on precision nuclear medicine imaging of phaeochromocytoma and paraganglioma
AbstractThe EANM/SNMMI 2019 guidelines for radionuclide imaging of phaeochromocytoma and paraganglioma (PPGL) describe the current experts ’ views on molecular imaging in the era of precision medicine, and contain all of the information needed by nuclear physicians for performing, interpreting, and reporting the results of imaging investigations. This editorial, from a clinician’s perspective, describes the first-choice radiopharma ceutical for a particular clinical setting as an important element of the revised guidelines. It also gives new evidence-based data showing the steadily growing role of nuclear imagi...
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Scan preparation for patients with type I diabetes treated with continuous sub-cutaneous insulin infusion (CSII) pumps
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Radiation-induced myocardial damage indicated by focal defect on 123 I-MIBG SPECT
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Al 18 F-NOTA-octreotide: first comparison with 68 Ga-DOTATATE in a neuroendocrine tumour patient
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Al 18 F-NOTA-octreotide and 18 F-SiFA lin -TATE: two ‘new kids on the block’ in somatostatin receptor imaging
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

First-in-human 18 F-SiFA lin -TATE PET/CT for NET imaging and theranostics
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

Inflammatory response to the anti PD-L1 drug, atezolizumab, masquerades as breast implant rupture
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research

European Association of Nuclear Medicine Practice Guideline/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma
ConclusionSince the European Association of Nuclear Medicine 2012 guidelines, the excellent results obtained with gallium-68 (68Ga)-labelled somatostatin analogues (SSAs) in recent years have simplified the imaging approach for PPGL patients that can also be used for selecting patients for peptide receptor radionuclide therapy as a potential alternative or complement to the traditional theranostic approach with iodine-123 (123I)/iodine-131 (131I)-labelled meta-iodobenzylguanidine. Genomic characterisation of subgroups with differing risk of lesion development and subsequent metastatic spread is refining the use of molecula...
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

Evaluation of neurotensin receptor 1 as potential biomarker for prostate cancer theranostic use
ConclusionWe have demonstrated that NTSR1 is a promising molecular marker for prostate cancer based on patient tissue staining. The NTSR targeted probe18F-DEG-VS-NT demonstrated high tumor to background contrast in animal models, which could be valuable in selecting patients for therapies targeting NTSR1 as well as monitoring therapeutic efficacy during treatment accordingly. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

[ 11 C]JNJ54173717, a novel P2X7 receptor radioligand as marker for neuroinflammation: human biodistribution, dosimetry, brain kinetic modelling and quantification of brain P2X7 receptors in patients with Parkinson ’s disease and healthy volunteers
Conclusion[11C]JNJ717 is safe and suitable for quantifying P2X7R expression in human brain. In this pilot study, no significant differences in P2X7R binding were found between HV and PD patients. The results also suggest that genotype effects need to be incorporated in future P2X7R PET analyses. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

Longitudinal cognitive decline in mild cognitive impairment subjects with early amyloid- β neocortical deposition
ConclusionThis study demonstrated that early amyloid deposition predicts cognitive decline in subjects with aMCI, with a higher rate of decline in those with SUVr above a threshold of 1.21. Detection of early amyloid positivity may help in selecting the target population for preventive therapeutic interventions and in designing treatment trials (Trial number, EudraCT 2015-001184-39). (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

Discovery and preclinical characterization of [ 18 F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer ’s disease and other tauopathies
ConclusionsTherefore, [18F]PI-2620 was selected for clinical validation. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

Prospective evaluation of the performance of [ 68 Ga]Ga-PSMA-11 PET/CT(MRI) for lymph node staging in patients undergoing superextended salvage lymph node dissection after radical prostatectomy
ConclusionPSMA-11 PET/CT(MRI) has a very good performance for the identification of LN metastases in patients with BCR after RP. The high diagnostic accuracy in the regional and subregional analyses demonstrates the potential of this approach to enable a region-directed instead of a complete bilateral therapeutic intervention. The performance of PSMA-11 PET/CT(MRI) is dependent on the PSA level and the size of the metastatic deposit. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

[ 18 F]GTP1 (Genentech Tau Probe 1), a radioligand for detecting neurofibrillary tangle tau pathology in Alzheimer ’s disease
AbstractObjectiveNeurofibrillary tangles (NFTs), consisting of intracellular aggregates of the tau protein, are a pathological hallmark of Alzheimer ’s disease (AD). Here we report the identification and initial characterization of Genentech Tau Probe 1 ([18F]GTP1), a small-molecule PET probe for imaging tau pathology in AD patients.MethodsAutoradiography using human brain tissues from AD donors and protein binding panels were used to determine [18F]GTP1 binding characteristics. Stability was evaluated in vitro and in vivo in mice and rhesus monkey. In the clinic, whole-body imaging was performed to assess biodistrib...
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

Prospective diagnostic performance of semiconductor SPECT myocardial perfusion imaging: wall thickening analysis reduces the need for an additional prone acquisition
AbstractPurposeTo determine whether the assessment of regional wall thickening (WT) in addition to myocardial perfusion from stress supine acquisitions could compensate for the lack of prone acquisition and the corresponding decrease in the diagnostic performance of SPECT myocardial perfusion imaging (MPI) in patients with known or suspected coronary artery disease (CAD).MethodsThe study group comprised 41 patients (123 vessels) with known or suspected CAD prospectively recruited for systematic prone and supine201Tl stress SPECT MPI. The diagnostic performance of SPECT MPI was determined for various image sets including no...
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

Multiple cardiovascular involvements in Beh çet’s disease: unique utility of 18 F-FDG PET/CT in diagnosis and follow-up
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

PET and SPECT in psychiatry: the past and the future
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

Galderisi Silvana, DeLisi Lynn E., Borgwardt Stefan (Eds.). Neuroimaging of Schizophrenia and Other Primary Psychotic Disorders. Achievements and Perspectives
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

Correction to: Multiple cardiovascular involvements in Beh çet’s disease: unique utility of 18 F-FDG PET/CT in diagnosis and follow-up
Figure c of the original version of this article was not converted properly. Correct figure is presented here. The original article has been corrected. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

Correction to: 225 Ac-PSMA-617 in chemotherapy-naive patients with advanced prostate cancer: a pilot study
The author of this article wanted to change the ethical approval statement of the originally published version of this article. Correct statement is indicated below. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 30, 2019 Category: Nuclear Medicine Source Type: research

Increase of precuneus metabolism correlates with reduction of PTSD symptoms after EMDR therapy in military veterans: an 18F-FDG PET study during virtual reality exposure to war
The objective of this study is to identify, after EMDR therapy, the regions of brain metabolism that evolve during the stress exposure of a war scene with symptomatic remission in a group of military veterans suffering from PTSD, and to secondarily search for predictive metabolic features.MethodsWe recruited 15  military veterans suffering from PTSD who performed an18F-FDG PET sensitized by the exposure to a virtual war scene, before (T0) and after (T1) EMDR therapy. Statistical parametric mapping was used to compare brain metabolism before and after treatment and to study correlations between metabolism and evolution...
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 12, 2019 Category: Nuclear Medicine Source Type: research

Brain metabolic patterns in patients with suspected non-Alzheimer ’s pathophysiology (SNAP) and Alzheimer’s disease (AD): is [ 18 F] FDG a specific biomarker in these patients?
ConclusionsSNAP subjects show milder impairment of brain [18F] FDG uptake as compared to AD. The partial overlap of the metabolic pattern between SNAP and AD limits the use of [18F] FDG PET/CT in effectively discriminating these clinical entities. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 12, 2019 Category: Nuclear Medicine Source Type: research

Global disease score (GDS) is the name of the game!
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 12, 2019 Category: Nuclear Medicine Source Type: research

A multiparametric [ 18 F]FDG PET/MRI diagnostic model including imaging biomarkers of the tumor and contralateral healthy breast tissue aids breast cancer diagnosis
AbstractPurposeTo develop a multiparametric [18F]FDG positron emission tomography/magnetic resonance imaging (PET/MRI) model for breast cancer diagnosis incorporating imaging biomarkers of breast tumors and contralateral healthy breast tissue.MethodsIn this prospective study and retrospective data analysis, 141 patients (mean 57  years) with an imaging abnormality detected on mammography and/or ultrasound (BI-RADS 4/5) underwent combined multiparametric [18F]FDG PET/MRI with PET/computed tomography and multiparametric MRI of the breast at 3  T. Images were evaluated and the following were recorded: for the tumor,...
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 12, 2019 Category: Nuclear Medicine Source Type: research

18 F-FDG PET metabolic-to-morphological volume ratio predicts PD-L1 tumour expression and response to PD-1 blockade in non-small-cell lung cancer
ConclusionThis study introduces MMVR as a new imaging biomarker and its ability to noninvasively capture increased PD-L1 tumour expression and predict clinical benefit from checkpoint blockade in NSCLC should be further evaluated. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 12, 2019 Category: Nuclear Medicine Source Type: research

Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for 89 Zr-immunoPET
AbstractPurposeCurrently, the most commonly used chelator for labelling antibodies with89Zr for immunoPET is desferrioxamine B (DFO). However, preclinical studies have shown that the limited in vivo stability of the89Zr-DFO complex results in release of89Zr, which accumulates in mineral bone. Here we report a novel chelator DFOcyclo*, a preorganized extended DFO derivative that enables octacoordination of the89Zr radiometal. The aim was to compare the in vitro and in vivo stability of [89Zr]Zr-DFOcyclo*, [89Zr]Zr-DFO* and [89Zr]Zr-DFO.MethodsThe stability of89Zr-labelled chelators alone and after conjugation to trastuzumab...
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 12, 2019 Category: Nuclear Medicine Source Type: research