P2X7 receptor-specific radioligand 18F-FTTM for atherosclerotic plaque PET imaging
ConclusionWe innovatively apply a new type P2X7-targeted PET probe (18F-FTTM) to identify vulnerable atherosclerotic plaques, to detect the inflammatory response of atherosclerosis, and to provide a powerful non-invasive method for the diagnosis of atherosclerotic lesions and new drug screening for accurate treatment. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 20, 2022 Category: Nuclear Medicine Source Type: research

Lung cancer with PET/CT-defined occult nodal metastasis yields favourable prognosis and benefits from adjuvant therapy: a multicentre study
AbstractPurposeTo investigate the surgical prognosis and efficacy of adjuvant therapy in non-small cell lung cancer (NSCLC) with occult lymph node metastasis (ONM) defined by positron emission tomography/computed tomography (PET/CT).MethodsA total of 3537 NSCLC patients receiving surgical resection were included in this study. The prognosis between patients with ONM and evident nodal metastasis, ONM patients with and without adjuvant therapy was compared, respectively.ResultsONM was associated with significantly better prognosis than evident nodal metastasis whether for patients with N1 (5-year OS: 56.8% versus 52.3%, adju...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 20, 2022 Category: Nuclear Medicine Source Type: research

EANM position on the in-house preparation of radiopharmaceuticals
AbstractThe EANM herewith clearly expresses its commitment and support to the non-commercial in-house preparation of radiopharmaceuticals for direct use in accordance with European and national regulations. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 20, 2022 Category: Nuclear Medicine Source Type: research

Targeting visualization of malignant tumor based on the alteration of DWI signal generated by hTERT promoter –driven AQP1 overexpression
ConclusionCancers can be specifically visualized based on the DWI signal alteration which triggered byhTERT-AQP1 lentivirus system that combined AQP1 gene and hTERT promoter. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 19, 2022 Category: Nuclear Medicine Source Type: research

Preclinical and exploratory human studies of novel 68Ga-labeled D-peptide antagonist for PET imaging of TIGIT expression in cancers
Conclusion68Ga-GP12 is a promising radiotracer for PET imaging of TIGIT expression in cancers, indicating its potential as a potential companion diagnostic for anti-TIGIT therapies.Graphical abstract (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 17, 2022 Category: Nuclear Medicine Source Type: research

A two-stage cardiac PET and late gadolinium enhancement MRI co-registration method for improved assessment of non-ischemic cardiomyopathies using integrated PET/MR
In this study, we present a two-stage cardiac PET and MR late gadolinium enhancement (LGE) co-registration method, which seeks to improve diagnostic accuracy of non-ischemic cardiomyopathies via better image co-registration using an integrated whole-body PET/MR system.MethodsThe proposed PET and LGE two-stage co-registration method was evaluated through comparison with one-stage direct co-registration and no-registration. One hundred and ninety-one slices of LGE and forty lesions were studied. Two trained nuclear medicine physicians independently assessed the displacement between LGE and PET to qualitatively evaluate the c...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 15, 2022 Category: Nuclear Medicine Source Type: research

Retrospective analysis of PSMA PET/CT thyroid incidental uptake in adults: incidence, diagnosis, and treatment/outcome in a tertiary cancer referral center and University Medical Center
ConclusionThe incidence of thyroid incidentalomas on PSMA PET/CT was low (1.1%) in this large, two-center experience. Less than half of the PTI cases were analyzed and the risk of malignancy, despite being low, was not negligible. The clinical outcome was good using a standard diagnostic workup for PTI, while the prognosis of the patient was determined by the primary malignancy. The consideration to analyze and treat PTI cases should be part of the shared decision-making in cancer patients. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 15, 2022 Category: Nuclear Medicine Source Type: research

Using radiomics-based modelling to predict individual progression from mild cognitive impairment to Alzheimer ’s disease
ConclusionThe preliminary results demonstrated that the developed RPM approach has the potential to monitor progression in high-risk populations with AD. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 15, 2022 Category: Nuclear Medicine Source Type: research

EANM Springer Prizes 2021 awarded at EANM 2021
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 15, 2022 Category: Nuclear Medicine Source Type: research

EANM Springer Prizes 2020 awarded at EANM 2021
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 15, 2022 Category: Nuclear Medicine Source Type: research

A two-stage cardiac PET and late gadolinium enhancement MRI co-registration method for improved assessment of non-ischemic cardiomyopathies using integrated PET/MR
In this study, we present a two-stage cardiac PET and MR late gadolinium enhancement (LGE) co-registration method, which seeks to improve diagnostic accuracy of non-ischemic cardiomyopathies via better image co-registration using an integrated whole-body PET/MR system.MethodsThe proposed PET and LGE two-stage co-registration method was evaluated through comparison with one-stage direct co-registration and no-registration. One hundred and ninety-one slices of LGE and forty lesions were studied. Two trained nuclear medicine physicians independently assessed the displacement between LGE and PET to qualitatively evaluate the c...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 15, 2022 Category: Nuclear Medicine Source Type: research

Retrospective analysis of PSMA PET/CT thyroid incidental uptake in adults: incidence, diagnosis, and treatment/outcome in a tertiary cancer referral center and University Medical Center
ConclusionThe incidence of thyroid incidentalomas on PSMA PET/CT was low (1.1%) in this large, two-center experience. Less than half of the PTI cases were analyzed and the risk of malignancy, despite being low, was not negligible. The clinical outcome was good using a standard diagnostic workup for PTI, while the prognosis of the patient was determined by the primary malignancy. The consideration to analyze and treat PTI cases should be part of the shared decision-making in cancer patients. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 15, 2022 Category: Nuclear Medicine Source Type: research

Using radiomics-based modelling to predict individual progression from mild cognitive impairment to Alzheimer ’s disease
ConclusionThe preliminary results demonstrated that the developed RPM approach has the potential to monitor progression in high-risk populations with AD. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 15, 2022 Category: Nuclear Medicine Source Type: research

EANM Springer Prizes 2021 awarded at EANM 2021
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 15, 2022 Category: Nuclear Medicine Source Type: research

EANM Springer Prizes 2020 awarded at EANM 2021
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 15, 2022 Category: Nuclear Medicine Source Type: research

CEST MRI provides amide/amine surrogate biomarkers for treatment-na ïve glioma sub-typing
This study investigated the clinical value of different chemical exchange saturation transfer (CEST) metrics for glioma classification and assessed the diagnostic effect of the presence of abundant fluid in glioma subpopulations.MethodsForty-five treatment-na ïve glioma patients with known isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion status received CEST MRI (B1rms = 2 μT,Tsat = 3.5 s) at 3 T. Magnetization transfer ratio asymmetry and CEST metrics (amides: offset range 3 –4 ppm, amines: 1.5–2.5 ppm, amide/amine ratio) were calculated with two models: ‘asymmetry-based’ (AB) ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 14, 2022 Category: Nuclear Medicine Source Type: research

Theranostic PSMA ligands with optimized backbones for intraoperative multimodal imaging and photodynamic therapy of prostate cancer
Abstract  IntroductionThe first generation ligands for prostate-specific membrane antigen (PSMA) –targeted radio- and fluorescence-guided surgery followed by adjuvant photodynamic therapy (PDT) have already shown the potential of this approach. Here, we developed three new photosensitizer-based dual-labeled PSMA ligands by crucial modification of existing PSMA ligand backbone structures (PSMA -1007/PSMA-617) for multimodal imaging and targeted PDT of PCa.MethodsVarious new PSMA ligands were synthesized using solid-phase chemistry and provided with a DOTA chelator for111In labeling and the fluorophore/photosensit...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 14, 2022 Category: Nuclear Medicine Source Type: research

CEST MRI provides amide/amine surrogate biomarkers for treatment-na ïve glioma sub-typing
This study investigated the clinical value of different chemical exchange saturation transfer (CEST) metrics for glioma classification and assessed the diagnostic effect of the presence of abundant fluid in glioma subpopulations.MethodsForty-five treatment-na ïve glioma patients with known isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion status received CEST MRI (B1rms = 2 μT,Tsat = 3.5 s) at 3 T. Magnetization transfer ratio asymmetry and CEST metrics (amides: offset range 3 –4 ppm, amines: 1.5–2.5 ppm, amide/amine ratio) were calculated with two models: ‘asymmetry-based’ (AB) ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 14, 2022 Category: Nuclear Medicine Source Type: research

Theranostic PSMA ligands with optimized backbones for intraoperative multimodal imaging and photodynamic therapy of prostate cancer
Abstract  IntroductionThe first generation ligands for prostate-specific membrane antigen (PSMA) –targeted radio- and fluorescence-guided surgery followed by adjuvant photodynamic therapy (PDT) have already shown the potential of this approach. Here, we developed three new photosensitizer-based dual-labeled PSMA ligands by crucial modification of existing PSMA ligand backbone structures (PSMA -1007/PSMA-617) for multimodal imaging and targeted PDT of PCa.MethodsVarious new PSMA ligands were synthesized using solid-phase chemistry and provided with a DOTA chelator for111In labeling and the fluorophore/photosensit...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 14, 2022 Category: Nuclear Medicine Source Type: research

Role of sex hormones in modulating myocardial perfusion and coronary flow reserve
ConclusionOur experimental data in mice indicate that sex differences in myocardial perfusion are primarily driven by testosterone. Given the diagnostic importance of PET-MPI in clinical routine, further studies are warranted to determine whether testosterone levels affect the interpretation of myocardial perfusion findings in patients. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2022 Category: Nuclear Medicine Source Type: research

First-in-human in vivo  undefined imaging and quantification of monoacylglycerol lipase in the brain: a PET study with 18F-T-401
ConclusionsHere, we provide the first demonstration of in vivo visualization of MAGL in the human brain.18F-T-401 showed excellent test –retest reliability, reversible kinetics, and stable estimation of VT values consistent with known regional MAGL expressions. PET with18F-T-401-PET is promising tool for measurement of central MAGL. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2022 Category: Nuclear Medicine Source Type: research

Joint EANM/SNMMI/ESTRO practice recommendations for the use of 2-[18F]FDG PET/CT external beam radiation treatment planning in lung cancer V1.0
AbstractPurpose2-[18F]FDG PET/CT is of utmost importance for radiation treatment (RT) planning and response monitoring in lung cancer patients, in both non-small and small cell lung cancer (NSCLC and SCLC). This topic has been addressed in guidelines composed by experts within the field of radiation oncology. However, up to present, there is no procedural guideline on this subject, with involvement of the nuclear medicine societies.MethodsA literature review was performed, followed by a discussion between a multidisciplinary team of experts in the different fields involved in the RT planning of lung cancer, in order to g...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2022 Category: Nuclear Medicine Source Type: research

Andrea Varrone, Silvia Morbelli, Valentina Garibotto (Editors). Clinical nuclear medicine in neurology. An Atlas of challenging cases. Springer Nature Switzerland AG 2022. ISBN 978 –3-030–83,597-2
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2022 Category: Nuclear Medicine Source Type: research

Role of sex hormones in modulating myocardial perfusion and coronary flow reserve
ConclusionOur experimental data in mice indicate that sex differences in myocardial perfusion are primarily driven by testosterone. Given the diagnostic importance of PET-MPI in clinical routine, further studies are warranted to determine whether testosterone levels affect the interpretation of myocardial perfusion findings in patients. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2022 Category: Nuclear Medicine Source Type: research

First-in-human in vivo  undefined imaging and quantification of monoacylglycerol lipase in the brain: a PET study with 18F-T-401
ConclusionsHere, we provide the first demonstration of in vivo visualization of MAGL in the human brain.18F-T-401 showed excellent test –retest reliability, reversible kinetics, and stable estimation of VT values consistent with known regional MAGL expressions. PET with18F-T-401-PET is promising tool for measurement of central MAGL. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2022 Category: Nuclear Medicine Source Type: research

Joint EANM/SNMMI/ESTRO practice recommendations for the use of 2-[18F]FDG PET/CT external beam radiation treatment planning in lung cancer V1.0
AbstractPurpose2-[18F]FDG PET/CT is of utmost importance for radiation treatment (RT) planning and response monitoring in lung cancer patients, in both non-small and small cell lung cancer (NSCLC and SCLC). This topic has been addressed in guidelines composed by experts within the field of radiation oncology. However, up to present, there is no procedural guideline on this subject, with involvement of the nuclear medicine societies.MethodsA literature review was performed, followed by a discussion between a multidisciplinary team of experts in the different fields involved in the RT planning of lung cancer, in order to g...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2022 Category: Nuclear Medicine Source Type: research

Andrea Varrone, Silvia Morbelli, Valentina Garibotto (Editors). Clinical nuclear medicine in neurology. An Atlas of challenging cases. Springer Nature Switzerland AG 2022. ISBN 978 –3-030–83,597-2
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2022 Category: Nuclear Medicine Source Type: research

Preclinical evaluation of [99mTc]Tc-labeled anti-EpCAM nanobody for EpCAM receptor expression imaging by immuno-SPECT/CT
Conclusion[99mTc]Tc-NB4 is a broad-spectrum, specific, and sensitive SPECT radiotracer for the noninvasive imaging of EpCAM expression in the epithelium-derived cancer and revealed a great potential for the clinical translation. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 11, 2022 Category: Nuclear Medicine Source Type: research

Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer ’s disease
ConclusionsCompared to LOAD, the degree of lateral temporal and occipitoparietal tau pathology and relative cerebral blood-flow is more strongly associated with cognition in EOAD. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 8, 2022 Category: Nuclear Medicine Source Type: research

Usefulness of the 2-year iodine-123 metaiodobenzylguanidine-based risk model for post-discharge risk stratification of patients with acute decompensated heart failure
AbstractPurposeA four-parameter risk model that included cardiac iodine-123 metaiodobenzylguanidine (MIBG) imaging and readily available clinical parameters was recently developed for prediction of 2-year cardiac mortality risk in patients with chronic heart failure. We sought to validate the ability of this risk model to predict post-discharge clinical outcomes in patients with acute decompensated heart failure (ADHF) and to compare its prognostic value with that of the Acute Decompensated Heart Failure National Registry (ADHERE) and Get With The Guidelines-Heart Failure (GWTG-HF) risk scores.MethodsWe studied 407 consecu...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 8, 2022 Category: Nuclear Medicine Source Type: research

Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer ’s disease
ConclusionsCompared to LOAD, the degree of lateral temporal and occipitoparietal tau pathology and relative cerebral blood-flow is more strongly associated with cognition in EOAD. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 8, 2022 Category: Nuclear Medicine Source Type: research

Usefulness of the 2-year iodine-123 metaiodobenzylguanidine-based risk model for post-discharge risk stratification of patients with acute decompensated heart failure
AbstractPurposeA four-parameter risk model that included cardiac iodine-123 metaiodobenzylguanidine (MIBG) imaging and readily available clinical parameters was recently developed for prediction of 2-year cardiac mortality risk in patients with chronic heart failure. We sought to validate the ability of this risk model to predict post-discharge clinical outcomes in patients with acute decompensated heart failure (ADHF) and to compare its prognostic value with that of the Acute Decompensated Heart Failure National Registry (ADHERE) and Get With The Guidelines-Heart Failure (GWTG-HF) risk scores.MethodsWe studied 407 consecu...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 8, 2022 Category: Nuclear Medicine Source Type: research

68Ga-FAPI PET/CT detected non-FDG-avid bone metastases in breast cancer
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 7, 2022 Category: Nuclear Medicine Source Type: research

Impaired coronary flow reserve in patients with supra-normal left ventricular ejection fraction at rest
AbstractPurposeRecently, a “U” hazard ratio curve between resting left ventricular ejection fraction (LVEF) and prognosis has been observed in patients referred for routine clinical echocardiograms. The present study sought to explore whether a similar “U” curve existed between resting LVEF and coronary flow reserve ( CFR) in patients without severe cardiovascular disease (CVD) and whether impaired CFR played a role in the adverse outcome of patients with supra-normal LVEF (snLVEF, LVEF ≥ 65%).MethodsTwo hundred ten consecutive patients (mean age 52.3  ± 9.3&nbs...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 6, 2022 Category: Nuclear Medicine Source Type: research

[68  Ga]Ga-FAPI uptake correlates with the state of chronic kidney disease
ConclusionThere is a significant negative correlation between renal parenchymal [68 Ga]Ga-FAPI uptake and GFR, which was not the case for [68 Ga]Ga-DOTATOC and [68 Ga]Ga-PSMA. This correlation suggests a specific binding of FAPI rather than a potential unspecific retention in the renal parenchyma, underlining the potential value of [68 Ga]Ga-FAPI for the noninvasive quantitative evaluation of kidney fibrosis. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 6, 2022 Category: Nuclear Medicine Source Type: research

Impaired coronary flow reserve in patients with supra-normal left ventricular ejection fraction at rest
AbstractPurposeRecently, a “U” hazard ratio curve between resting left ventricular ejection fraction (LVEF) and prognosis has been observed in patients referred for routine clinical echocardiograms. The present study sought to explore whether a similar “U” curve existed between resting LVEF and coronary flow reserve ( CFR) in patients without severe cardiovascular disease (CVD) and whether impaired CFR played a role in the adverse outcome of patients with supra-normal LVEF (snLVEF, LVEF ≥ 65%).MethodsTwo hundred ten consecutive patients (mean age 52.3  ± 9.3&nbs...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 6, 2022 Category: Nuclear Medicine Source Type: research

[68  Ga]Ga-FAPI uptake correlates with the state of chronic kidney disease
ConclusionThere is a significant negative correlation between renal parenchymal [68 Ga]Ga-FAPI uptake and GFR, which was not the case for [68 Ga]Ga-DOTATOC and [68 Ga]Ga-PSMA. This correlation suggests a specific binding of FAPI rather than a potential unspecific retention in the renal parenchyma, underlining the potential value of [68 Ga]Ga-FAPI for the noninvasive quantitative evaluation of kidney fibrosis. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 6, 2022 Category: Nuclear Medicine Source Type: research

Fibroblast activation protein imaging in reperfused ST-elevation myocardial infarction: comparison with cardiac magnetic resonance imaging
AbstractPurposeThe aim of this study was to explore the correlation of18F-labeled fibroblast activation protein inhibitor (FAPI) and cardiovascular magnetic resonance (CMR) parameters in ST-elevation myocardial infarction (STEMI) patients with successful primary percutaneous coronary intervention (PPCI) and to investigate the value of FAPI imaging in predicting cardiac functional recovery, as well as the correlation between FAPI activity and circulating fibroblast activation protein (FAP) and inflammatory biomarkers.MethodsFourteen first-time STEMI patients (11 men, mean age: 62  ± 11 years) after...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 5, 2022 Category: Nuclear Medicine Source Type: research

Prediction of myocardial blood flow under stress conditions by means of a computational model
ConclusionThe results of this pilot work demonstrate the accuracy and reliability of the proposed computational model in reproducing MBF under stress conditions. This consistency test is a preliminary step in the framework of a more ambitious project which is currently under investigation, i.e., the construction of a computational tool able to predict MBF avoiding the stress protocol and potential side effects while reducing radiation exposure. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 5, 2022 Category: Nuclear Medicine Source Type: research

Metabolic correlates of olfactory dysfunction in COVID-19 and Parkinson ’s disease (PD) do not overlap
Abstract   PurposeHyposmia is a common feature of COVID-19 and Parkinson ’s disease (PD). As parkinsonism has been reported after COVID-19, a link has been hypothesized between SARS-CoV2 infection and PD. We aimed to evaluate brain metabolic correlates of isolated persistent hyposmia after mild-to-moderate COVID-19 and to compare them with metabolic signature of hyposm ia in drug-naïve PD patients.MethodsForty-four patients who experienced hyposmia after SARS-COV2 infection underwent brain [18F]-FDG PET in the first 6  months after recovery. Olfaction was assessed by means of the 16-item “Sn...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 5, 2022 Category: Nuclear Medicine Source Type: research

The ICPO Foundation —on the way toward collaborative growth of theranostics
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 5, 2022 Category: Nuclear Medicine Source Type: research

Fibroblast activation protein imaging in reperfused ST-elevation myocardial infarction: comparison with cardiac magnetic resonance imaging
AbstractPurposeThe aim of this study was to explore the correlation of18F-labeled fibroblast activation protein inhibitor (FAPI) and cardiovascular magnetic resonance (CMR) parameters in ST-elevation myocardial infarction (STEMI) patients with successful primary percutaneous coronary intervention (PPCI) and to investigate the value of FAPI imaging in predicting cardiac functional recovery, as well as the correlation between FAPI activity and circulating fibroblast activation protein (FAP) and inflammatory biomarkers.MethodsFourteen first-time STEMI patients (11 men, mean age: 62  ± 11 years) after...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 5, 2022 Category: Nuclear Medicine Source Type: research

Prediction of myocardial blood flow under stress conditions by means of a computational model
ConclusionThe results of this pilot work demonstrate the accuracy and reliability of the proposed computational model in reproducing MBF under stress conditions. This consistency test is a preliminary step in the framework of a more ambitious project which is currently under investigation, i.e., the construction of a computational tool able to predict MBF avoiding the stress protocol and potential side effects while reducing radiation exposure. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 5, 2022 Category: Nuclear Medicine Source Type: research

Metabolic correlates of olfactory dysfunction in COVID-19 and Parkinson ’s disease (PD) do not overlap
Abstract   PurposeHyposmia is a common feature of COVID-19 and Parkinson ’s disease (PD). As parkinsonism has been reported after COVID-19, a link has been hypothesized between SARS-CoV2 infection and PD. We aimed to evaluate brain metabolic correlates of isolated persistent hyposmia after mild-to-moderate COVID-19 and to compare them with metabolic signature of hyposm ia in drug-naïve PD patients.MethodsForty-four patients who experienced hyposmia after SARS-COV2 infection underwent brain [18F]-FDG PET in the first 6  months after recovery. Olfaction was assessed by means of the 16-item “Sn...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 5, 2022 Category: Nuclear Medicine Source Type: research

The ICPO Foundation —on the way toward collaborative growth of theranostics
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 5, 2022 Category: Nuclear Medicine Source Type: research

[18F]FDG-PET/CT to prevent futile surgery in indeterminate thyroid nodules: a blinded, randomised controlled multicentre trial
AbstractPurposeTo assess the impact of an [18F]FDG-PET/CT-driven diagnostic workup to rule out malignancy, avoid futile diagnostic surgeries, and improve patient outcomes in thyroid nodules with indeterminate cytology.MethodsIn this double-blinded, randomised controlled multicentre trial, 132 adult euthyroid patients with scheduled diagnostic surgery for a Bethesda III or IV thyroid nodule underwent [18F]FDG-PET/CT and were randomised to an [18F]FDG-PET/CT-driven or diagnostic surgery group. In the [18F]FDG-PET/CT-driven group, management was based on the [18F]FDG-PET/CT result: when the index nodule was visually [18F]FDG-...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 4, 2022 Category: Nuclear Medicine Source Type: research

First results on kinetic modelling and parametric imaging of dynamic 18F-FDG datasets from a long  axial FOV PET scanner in oncological patients
ConclusionWe performed pharmacokinetic modelling of multiple organs using linear and non-linear models using dynamic total-body18F-FDG images. Although parametric images did not reveal more tumors than SUV images, the results confirmed that parametric imaging furnishes improved tumor contrast. We thus demonstrate the feasibility of total-body kinetic modelling and parametric imaging in basic research and oncological studies. LAFOV PET can enhance dynamic imaging capabilities by providing high sensitivity parametric images and allowing total-body pharmacokinetic analysis. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 4, 2022 Category: Nuclear Medicine Source Type: research

[18F]FDG-PET/CT to prevent futile surgery in indeterminate thyroid nodules: a blinded, randomised controlled multicentre trial
AbstractPurposeTo assess the impact of an [18F]FDG-PET/CT-driven diagnostic workup to rule out malignancy, avoid futile diagnostic surgeries, and improve patient outcomes in thyroid nodules with indeterminate cytology.MethodsIn this double-blinded, randomised controlled multicentre trial, 132 adult euthyroid patients with scheduled diagnostic surgery for a Bethesda III or IV thyroid nodule underwent [18F]FDG-PET/CT and were randomised to an [18F]FDG-PET/CT-driven or diagnostic surgery group. In the [18F]FDG-PET/CT-driven group, management was based on the [18F]FDG-PET/CT result: when the index nodule was visually [18F]FDG-...
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 4, 2022 Category: Nuclear Medicine Source Type: research