Pyrotinib Sensitizes 5-Fluorouracil-resistant HER2+ Breast 4 Cancer Cells to 5-Fluorouracil.
In conclusion,our findings suggest that pyrotinib could restore sensitivity of 5-FU-resistant HER2+breast cancer cells to 5-FU through downregulating the expression levels of TS andABCG2. PMID: 32727638 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - July 31, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-186repressesproliferation, migration,invasionand EMTof hepatocellular carcinomavia directly targeting CDK6.
In conclusion, miR-186 represses proliferation, migration, invasion and EMT, and induces apoptosis through targeting CDK6 in HCC, which may provide a new therapeutic target for HCC. PMID: 32698940 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - July 24, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

IL-24-armed oncolytic vaccinia virus exerts potent antitumor effects via multiple pathways in colorectal cancer.
Authors: Deng L, Yang X, Fan J, Ding Y, Peng Y, Xu D, Huang B, Hu Z Abstract Colorectal cancer is an aggressive malignancy for which there are limited treatment options. Oncolytic vaccinia virus isbeing developed as a novel strategy for cancer therapy. Arming vaccinia virus with immunostimulatory cytokines can enhance the tumor cell-specific replication and antitumor efficacy. Interleukin-24 (IL-24) is an important immune mediator, as well as a broad-spectrum tumor suppressor. Here, we constructed a targeted vaccinia virus of Guang9 strain harbored IL-24 (VG9-IL-24) to evaluate its antitumor effects. In vitro, VG9-...
Source: Oncology Research - July 10, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Proteasome inhibitors diminish c-Met expression and induce cell death in non-small cell lung cancer cells.
This study reveals that different proteasomeinhibitors produce varied inhibitory effects in NSCLS cell lines. PMID: 32580819 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - June 27, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Anticancer Activity of Novel NF- κB Inhibitor DHMEQ by Intraperitoneal Administration.
Anticancer Activity of Novel NF-κB Inhibitor DHMEQ by Intraperitoneal Administration. Oncol Res. 2020 Jun 23;: Authors: Umezawa K, Breborowicz A, Gantsev S Abstract There have been great advances in the therapy of cancer and leukemia. But there are still many neoplastic diseases that are difficult to treat. For example, it is often difficult to find effective therapies for aggressive cancer and leukemia. Meanwhile, an NF-κB inhibitor named dehydroxymethylepoxyquinomicin (DHMEQ) was discovered in 2000. This compound was designed based on the structure of epoxyquinomicin isolated from a micro...
Source: Oncology Research - June 26, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Long non-coding RNA LINC02163 accelerates malignant tumor behaviors in breast cancer by regulating the microRNA-511-3p/HMGA2 axis.
In this study, LINC02163 was upregulated in breast cancer, and its expression level was closely associated with tumor size, lymph node metastasis, and TNM stage. Patients with breast cancer presenting high LINC02163 expression exhibited shorter overall survival than those presenting low LINC02163 expression. Knockdown of LINC02163 resulted in a decrease in breast cancer cell proliferation, migration, and invasion and an increase in cell apoptosis in vitro. In addition, silencing of LINC02163 impeded breast cancer tumor growth in vivo. Mechanistic investigation revealed that LINC02163 served as a competing endogenous RNA fo...
Source: Oncology Research - June 24, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Programmed Death Ligand-1 (PD-L1) regulated by NRF- 2/MicroRNA-1 Regulatory Axis Enhances Drug Resistance and Promotes Tumorigenic Properties in Sorafenib-Resistant Hepatoma Cells.
In conclusion, our data suggested a NRF-2/miR-1/PD-L1 regulatory axis contributed to development and maintenance of drugCopyright© 2020 Cognizant Communication Corporation4ORM-A-3264 Oncology Research E-pubresistance and other tumorigenic properties in sorafenib-resistant hepatoma cells andprovided a potential therapeutic target for overcoming sorafenib resistance in HCC. PMID: 32560747 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - June 22, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

CD13-A key player in multi-drug resistance in cancer chemotherapy.
Authors: Guo Q, Li X, Cui MN, Sun JL, Ji HY, Ni BB, Yan MX Abstract Cancer is one of the most serious diseases that are harmful to human health. Systemicchemotherapy is an optimal therapeutic strategy for the treatment of cancer, but greatdifficulty has been encountered in its administration in the form of multidrug resistance(MDR). As an enzyme on the outer cell surface, CD13 is documented to be involved inthe MDR development of tumor cells. In this review, we will focus on the role of CD13in MDR generation based on the current evidence. PMID: 32532363 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - June 14, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Microenvironment analysis of prognosis and molecular signature of immune-related genes in lung adenocarcinoma.
In this study, 22 immune cell components in the lung adenocarcinoma(LUAD) TME were analyzed using gene expression profile from The Cancer GenomeAtlas (TCGA), Gene Expression Omnibus (GEO) . The TME based molecular subtypesof LUAD were defined to evaluate further the relationship between molecular subtypes,prognosis, and clinical characteristics. A TME risk score model was constructed byusing the differentially expressed genes (DEGs) of molecular subtypes. The relationshipbetween the TME score and clinical characteristics and genomic mutations wascompared to identify the genes that have significant associations with the TME...
Source: Oncology Research - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Pivarubicin is more effective than doxorubicin against triple-negative breast cancer in vivo.
This study describes the mechanistic analyses of the novel anthracycline, pivarubicin, and its in vivo efficacy against human primary TNBC.Pivarubicin directly activates PKC-delta, triggers rapid mitochondrial-dependent apoptosis and circumvents resistance conferred by overexpression of P-glycoprotein, Bcl-2, Bcl-XL and Bcr-Abl. As a consequence, pivarubicin is more cytotoxic than doxorubicin against MDA-MB-231 and SUM159 TNBC cell lines grown in both monolayer culture and tumorspheres. Comparative in vivo efficacy of pivarubicin and doxorubicin was performed in an orthotopic NSG mouse model implanted with MDA-MB-231 human...
Source: Oncology Research - May 21, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

The AKT/GSK3 β mediated Slug expression contributes to oxaliplatin resistance in 4 colorectal cancer via up-regulation of ERCC1.
The AKT/GSK3β mediated Slug expression contributes to oxaliplatin resistance in 4 colorectal cancer via up-regulation of ERCC1. Oncol Res. 2020 Apr 24;: Authors: Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H Abstract Although oxaliplatin serves as one of the first-line drugs prescribed for treating26 colorectal cancer (CRC), the therapeutic effect is disappointing due to drug resistance.27 So far, the molecular mechanisms mediating oxaliplatin resistance remain unclear. In28 this study, we found the chemo-resistance in oxaliplatin-resistant HCT116 cells29 (HCT116/OXA) was ...
Source: Oncology Research - April 27, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Tripartite motif-containing 46 promotes viability and inhibits apoptosis of osteosarcoma cells by activating NF- κB signaling through ubiquitination of PPARα.
We report an increase in the expression of TRIM46 in OS andits association with tumor size, Enneking's stage, and patient prognosis. TRIM46 knockdown inhibitsOS cell viability and cell cycle progression and induces apoptosis, while TRIM46 overexpression exertsinverse effects, which are inhibited by peroxisome proliferator-activated receptor alpha (PPARα)overexpression and the nuclear factor kappa B (NF-κB) inhibitor, pyrrolidine dithiocarbamate (PDTC).Furthermore, TRIM46 negatively regulates PPAR expression via ubiquitination-mediated proteindegradation and modification. PPAR overexpression also inacti...
Source: Oncology Research - April 18, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-202 suppresses hepatocellular carcinoma progression via down-regulating BCL2 expression.
In conclusion, miR-202 serves as a tumor suppressor in HCC progression by downregulating BCL2 expression, indicating miR-202 might be as a potential target for HCC. PMID: 32272979 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - April 11, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Cylindromatosis is required for survival of a subset of melanoma cells.
Authors: La T, Jin L, Liu XY, Song ZH, Farrelly M, Feng YC, Yan XG, Zhang YY, Thorne RF, Zhang XD, Teng L Abstract The deubiquitinase cyclindromatosis (CYLD) functions as a tumour suppressor inhibiting cell proliferation in many cancer types including melanoma. Here we present evidence that a proportion of melanoma cells are nonetheless addicted to CYLD for survival. The expression levels of CYLD varied widely in melanoma cell lines and melanomas in vivo, with a subset of melanoma cell lines and melanomas displaying even higher levels of CYLD than melanocyte lines and nevi, respectively. Strikingly, although shRNA ...
Source: Oncology Research - April 8, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Corosolic acid inhibits cancer progress through inactivating YAP in hepatocellular carcinoma.
Authors: Jia M, Xiong Y, Li M, Mao Q Abstract Chemotherapy is critical for the treatment of hepatocellular carcinoma (HCC). Despite the pro-apoptotic effects of corosolic acid (CA) treatment, its underlying mechanism is not completely clear. The aim of this study was to determine the molecular mechanism of CA in HCC treatment. MTT assay was used to determine the IC50 of CA. Immunoprecipitation and immunofluorescence were used to detect the interaction between and subcellular localization of Yes-associated protein (YAP) and mouse double minute 2 (MDM2). In addition, in vivo xenotransplantation was performed to asses...
Source: Oncology Research - March 31, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

miR-4792 inhibits acute myeloid leukemia cells proliferation and invasion, and promotes cells apoptosis by targeting Kindlin-3.
Authors: Qin Y, Wang Y, Liu D Abstract It has been reported that Kindlin-3 expression is closely associated with progression ofmany cancers and microRNA (miRNA) processing. However, the effects and its precisemechanisms of Kindlin-3 in acute myeloid leukemia (AML) have not been wellclarified. Our study aimed to explore the interaction between Kindlin-3 and miR-4792in AML. In our study, we found that the expression of Kindlin-3 was dramaticallyincreased in AML samples and cell lines, and the miR-4792 level was significantlydown-regulated. Interestingly, the low miR-4792 level was closely associated withup-regulated ...
Source: Oncology Research - March 19, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

EIF5A2 is highly expressed in anaplastic thyroid carcinoma and is associated with tumor growth by modulating TGF- β signals.
EIF5A2 is highly expressed in anaplastic thyroid carcinoma and is associated with tumor growth by modulating TGF-β signals. Oncol Res. 2020 Mar 05;: Authors: Huang Y, Zhu Q, Lu L, Sun S, Hao F, Zhang J, Liu Z, Miao Y, Jiao X, Chen D Abstract Anaplastic thyroid carcinoma (ATC) are resistant to standard therapies and has no effective treatment. Eukaryotic translation initiation factor 5A2 (EIF5A2) has shown to be upregulated inmany malignant tumors and proposed to be a critical gene involved in tumor metastasis. In thisstudy, we aim to investigate the expression status of EIF5A2 in human ATC tissues...
Source: Oncology Research - March 8, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Sulforaphane: Expected to Become a Novel Anti-tumor Compound.
Authors: Wu G, Yan Y, Zhou Y, Duan Y, Zeng S, Wang X, Lin W, Ou C, Zhou J, Xu Z Abstract Natural products are becoming increasingly popular in a variety of traditional, complementary and alternative systems due to their potency and slight side effects. Natural compounds have been shown to be effective against many human diseases, especially cancers. Sulforaphane (SFE) is a traditional Chinese herbal medicine. In recent years, an increasing number of studies have been conducted to evaluate the anti-tumor effect of SFE. The roles of SFE in cancers are mainly through the regulation of potential biomarkers to activate ...
Source: Oncology Research - March 2, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

A novel BCL-2 inhibitor APG-2575 exerts synthetic lethality with BTK or MDM2-P53 inhibitor in Diffuse Large B-Cell Lymphoma.
In this study, our aim is to explore a rational combination of BCL-2 inhibitor plus Bruton's tyrosine kinase (BTK) blockade or p53 activation for treating DLBCL with the above characteristics. We demonstrated that a novel BCL-2 selective inhibitor APG-2575 effectively suppressed DLBCL with BCL-2 high expression via activating the mitochondrial apoptosis pathway. BTK inhibitor ibrutinib combined with BCL-2 inhibitors showed synergistic antitumor effect in DLBCL with mean expression of BCL-2 and myeloid cell leukemia-1 (MCL-1) through upregulating the expression level of BIM and modulating MCL-1 and p-Akt expression. For p53...
Source: Oncology Research - February 27, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

miRNA-mRNA profiling reveals prognostic impact of SMC1A 4 expression in acute myeloid leukemia.
Authors: Gadewal N, Kumar R, Aher S, Gardane A, Gaur T, Varma AK, Khattry N, Hasan SK Abstract Acute myeloid leukemia (AML) with NPM1 mutation is a disease driving genetic alteration with good prognosis. Although it has been suggested that NPM1 mutation induces chemo-sensitivity in leukemic cells, the underlying cause for the better survival of NPM1 mutated patients is still not clear. Mutant NPM1 AML has a unique microRNA and their target gene (mRNA) signature compared to wildtype NPM1. Dynamic regulation of miRNA-mRNA has been reported to influence the prognostic outcome. In the present study, in-silico expressio...
Source: Oncology Research - February 17, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

In Memoriam: Naoki Koide 1968-2019.
Authors: Umezawa K PMID: 32029024 [PubMed - in process] (Source: Oncology Research)
Source: Oncology Research - February 8, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

lncRNA HOXA11-AS promotes proliferation and migration via sponging miR-155 in hypopharyngeal squamous cell carcinoma.
This study identifies a tumor promoting role of HOXA11-AS in HSCC and suggests HOXA11-AS might be a potential diagnostic and therapeutic target for HSCC. PMID: 31987067 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - January 29, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MafF is regulated via circ-ITCH/miR-224-5p axis and acts as a tumor suppressor in hepatocellular carcinoma.
This study verified that MafF acted as a tumorsuppressor in HCC and revealed the upstream regulation mechanism of MafF, which provided anew perspective for potential therapeutic targets of HCC. PMID: 31969212 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - January 25, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Correlating Transcriptional Networks to Papillary Renal Cell Carcinoma Survival: A Large-Scale Co-expression Analysis and Clinical Validation.
Authors: Feng X, Zhang M, Meng J, Wang Y, Liu Y, Liang C, Fan S Abstract We aimed to investigate the potential mechanisms of progression and identify novelprognosis-related biomarkers for papillary renal cell carcinoma (PRCC) patients. The relateddata were derived from The Cancer Genome Atlas (TCGA), and then, analyzed by Weightedgene co-expression network analysis (WGCNA). The correlation between each module andthe clinical traits were analyzed by Pearson's correlation analysis. Pathway analysis wasconducted to reveal potential mechanisms. Hub genes within each module were screenedby intra-module analysis, and vis...
Source: Oncology Research - January 19, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Fzd2 contributes to breast cancer cell mesenchymal-like stemness and drug resistance.
Authors: Yin P, Wang W, Gao J, Bai Y, Wang Z, Na L, Sun Y, Zhao C Abstract Cancer cell stemness is responsible for cancer relapse, distal metastasis, and drug resistance. Herewe identified that Frizzled 2 (Fzd2), one member of Wnt receptor Frizzled family, induced humanbreast cancer (BC) cell stemness via non-canonical Wnt pathways. Fzd2 was overexpressed inhuman BC tissues, and Fzd2 overexpression was associated with an unfavorable outcome. Fzd2knockdown (KD) disturbed the mesenchymal-like phenotype, migration and invasion of BC cells.Moreover, Fzd2 KD impaired BC cell mammosphere formation, reduced Lgr5+ BC cells...
Source: Oncology Research - January 8, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

The comprehensive analysis of efficacy and safety of CalliSpheres ® drug-eluting beads transarterial chemoembolization in 367 liver cancer patients: a multiplecenter, cohort study.
This study aimed to investigate the efficacy, safety and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. 367 liver cancer patients from 24 medical centers were consecutively enrolled in this multiple-center, prospective cohort study including 275 hepatocellular carcinoma (HCC) cases, 37 intrahepatic cholangiocarcinoma (ICC) cases and 55 secondary liver cancer cases. All the patients received CalliSpheres® DEB-TACE treatment. Treatment response, overall survival (OS), change of liver function and adverse events (AEs) were assessed. DEB-T...
Source: Oncology Research - December 22, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

RPSAP52 lncRNA inhibits p21Waf1/CIP expression by interacting with the RNA binding protein HuR.
This study unveils another RPSAP52-mediated molecular mechanism in pituitary tumorigenesis. PMID: 31831098 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - December 15, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiRNA-101 targets TGF- βR1 to retard the progression of oral squamous cell carcinoma.
In this study, miR-101 expression was markedly downregulated in the OSCC cell lines and tissues. CCK-8, EdU, and colony formation assays showed that miR-101 inhibited the proliferation of OSCC cells. Flow cytometry and caspase-3 activity assays indicated that miR-101 induced OSCC cell apoptosis. Transwell assays demonstrated that this miRNA also repressed OSCC cell migration and invasion. Moreover, tube formation assay showed that miR-101 abated the pro-angiogenesis of OSCC cells. Dual luciferase reporter assay confirmed that miR-101 directly targeted TGF-βR1 in OSCC. Ectopic expression of TGF-βR1 counteracted th...
Source: Oncology Research - December 15, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Vinorelbine in non-small cell lung cancer: Real-World data from a singleinstitution experience.
Authors: Nobili S, Lavacchi D, Perrone G, Vicini G, Tassi R, Landini I, Grosso A, Roviello G, Mazzanti R, Santomaggio C, Mini E Abstract The use of vinorelbine as single agent or in combination regimens in NSCLC is associated with satisfactory clinical activity. However, the role of vinorelbine-based chemotherapy in chemonaive locally advanced unresectable or metastatic NSCLC patients, according to real-world treatment patterns, has still not widely explored. Eighty-one patient treated at a single institution were retrospectively analyzed. Thirty-seven received standard first-line single-agent vinorelbine, 44 vinor...
Source: Oncology Research - December 8, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MicroRNA-6884-5p regulates the proliferation, invasion and EMT of gastric cancer cells by directly targeting S100A16.
Authors: Lv H, Hou H, Lei H, Nie C, Chen B, Bie L, Han L, Chen X Abstract S100 binding protein A16 (S100A16) expression levels are closely associated with microRNA (miRNA) processing. Higher levels of S100A16 are reported during the progression of many cancers. Our study mainly explored the interaction between S100A16 and miR-6884-5p in gastric cancer (GC). qRT-PCR was used to determine the level of S100A16 and miR-6884-5p in GC tissues and cell lines. The si-S100A16, pcDNA-S100A16, miR-6884-5p mimic or inhibitor were transfected into GC cells, and the effects of S100A16 and miR-6884-5p on the proliferation, invasi...
Source: Oncology Research - December 6, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

IOX-101 reverses drug resistance through suppression of Akt/mTOR/NF κB signaling in cancer stem cell like, sphere forming NSCLC cells.
In this study we used drug resistant lung cancer stem like cells (A549-CS) to compare the efficacy of standard drugs like cisplatin (DDP) and gemcitabine (GEM) with a novel arylidene derivative IOX-101. A549-CS was derived from regular A549 cells by growing in special media. Resistance proteins were detected using Western Blotting. Cell proliferations were assessed by MTT assay. Cytokine release was enumerated using ELISA. Effect of drugs on apoptosis and cell cycle were studied with flow cytometry protocols. Apoptosis related proteins, caspases and other signaling protein expressions like Akt, mTOR were assessed by Wester...
Source: Oncology Research - November 29, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Circ_0071662, a novel tumor biomarker, suppresses bladder cancer cell proliferation and invasion by sponging miR-146b-3p.
In conclusion, circ_0071662 suppresses bladder cancer cell proliferation and invasion by sponging miR-146b-3p. PMID: 31757227 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - November 25, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Inhibition of Long Non-Coding RNA CRNDE Increases Chemosensitivity of Medulloblastoma Cells by Targeting MiR-29c-3p.
Authors: Sun XH, Fan WJ, An ZJ, Sun Y Abstract Long non-coding RNA CRNDE (CRNDE) recently emerged as a carcinogenic promoter in various cancers including medulloblastoma. However, the functions and molecular mechanisms of CRNDE to the acquired drug resistance of medulloblastoma are still unclear. The transcript levels of CRNDE were examined in four medulloblastoma cell lines exposed to cisplatin treatment and IC50 values were calculated. Effects of CRNDE knockdown or miR-29c-3p overexpression on cell viability, colony formation, apoptosis, migration and invasion were assessed using the CCK-8, colony formation assay...
Source: Oncology Research - November 23, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells through G2/M Cell Cycle Arrest and Delayed DNA Double-strand Break Repair.
This study offers a great potential for ECL as an alternative safer radiosensitizer for increasing the RT efficiency against NSCLC. PMID: 31727206 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - November 16, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MicroRNA-561 affects proliferation and cell cycle transition through PTEN/AKT signaling pathway by targeting P-REX2a in NSCLC.
In this study, we discovered that miR-561 expression was downregulated in human NSCLC tissues and cell lines. The overexpression of miR-561 inhibited NSCLC cell proliferation and cell cycle G1-S transition and induced apoptosis. The inhibition of miR-561 facilitated cell proliferation and G1-S transition and suppressed apoptosis. MiR-561 expression was inversely correlated with P-REX2a expression in NSCLC tissues. P-REX2a was confirmed to be a direct target of miR-561 by using a luciferase reporter assay. The overexpression of miR-561 decreased P-REX2a expression, and the suppression of miR-561 increased P-REX2a expression...
Source: Oncology Research - November 13, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Long non-coding RNA KCNQ1OT1 accelerates the progression of ovarian cancer via microRNA-212-3/ LCN2 axis.
Authors: Lu X, Wang F, Fu M, Li Y, Wang L Abstract Long non-coding RNA KCNQ1OT1 (KCNQ1OT1) has been identified to be deregulated in several kinds of cancers. However, its expression pattern and functions in ovarian cancer remains unknown. Bioinformatics analysis showed that miR-212-3p, an identified suppressor in ovarian cancer, was a direct target of KCNQ1OT1, suggesting that KCNQ1OT1 may play a role in ovarian cancer progression via targeting miR-212-3p. Here, we aimed to explore the effect of KCNQ1OT1 on the carcinogenesis of ovarian cancer, as well as to investigate miR-212-3p roles in this process. The express...
Source: Oncology Research - October 29, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Apatinib monotherapy or combination therapy for non-small cell lung cancer patients with brain metastases.
In this study, we aimed to explore the efficacy and safety profile of apatinib monotherapy, or combined with chemotherapy or endothelial growth factor receptor (EGFR)-TKI in heavily pretreated non-small cell lung cancer (NSCLC) patients with brain metastases. We performed a retrospective analysis for relapsed NSCLC patients with brain metastases from our institute, whom received apatinib (250mg or 500mg p.o. qd) monotherapy, or combination with EGFR-TKI or chemotherapy as second- or more line systemic therapy until disease progression or unacceptable toxicity occurred. The objective response rate (ORR), disease control rat...
Source: Oncology Research - October 17, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Cost-utility analysis of pembrolizumab versus chemotherapy as first-line treatment for metastatic non-small cell lung cancer with different PD-L1 expression levels.
Authors: Weng X, Luo S, Lin S, Zhong L, Li M, Xin R, Huang P, Xu X Abstract To evaluate the cost-utility of pembrolizumab versus chemotherapy as the first-line setting for metastatic non-small cell lung cancer (NSCLC) from the US health care system perspective. A Markov model was developed to compare the life-time cost and effectiveness of pembrolizumab versus chemotherapy for untreated metastatic NSCLC, based on the clinical data derived from phase III randomized controlled trial (KEYNOTE-042, ClinicalTrials.gov, NCT02220894). Weibull distribution was fitted to simulate the parametric survival functions. Drug cost...
Source: Oncology Research - October 17, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Pathway mutations in breast cancer using whole-exome sequencing.
Authors: Chang YS, Chang CM, Lin CY, Chao DS, Huang HY, Chang JG Abstract The genomic landscape of breast cancer (BC) is complex. The purpose of this study was to decipher the mutational profiles of Taiwanese patients with BC using next-generation sequencing. We performed whole-exome sequencing on DNA from 24 tumor tissue specimens from BC patients. Sanger sequencing was used to validate the identified variants. Sanger sequencing was also performed on paired adjacent non-tumor tissues. After genotype calling and algorithmic annotations, we identified 49 deleterious variants in canonical cancer-related genes in our ...
Source: Oncology Research - October 3, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Efficacy and safety of drug-eluting beads transarterial chemoembolization by CalliSpheres ® in 275 hepatocellular carcinoma patients: results from the Chinese CalliSpheres® Transarterial Chemoembolization In Liver Cancer (CTILC) study.
Efficacy and safety of drug-eluting beads transarterial chemoembolization by CalliSpheres® in 275 hepatocellular carcinoma patients: results from the Chinese CalliSpheres® Transarterial Chemoembolization In Liver Cancer (CTILC) study. Oncol Res. 2019 Sep 26;: Authors: Sun J, Zhou G, Xie X, Gu W, Huang J, Zhu D, Hu W, Hou Q, Shi C, Li T, Zhang X, Ji W, Ying S, Peng Z, Zhou J, Yu Z, Ji J, Du H, Guo X, Fang J, Han J, Xu H, Sun Z, Yu W, Shao G, Wu X, Hu H, Li L, Zheng J, Luo J, Chen Y, Cao G, Hu T Abstract The purpose of this study was to investigate the efficacy and safety of drug-eluting beads tr...
Source: Oncology Research - September 29, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Loss of Fingerprints as a Side Effect of Capecitabine Therapy: Case Report and Literature Review.
This report describes a patient who lost her fingerprints during the early stage of chemotherapy. Our aim is to draw the medical profession's attention to this problem. Consent from the patient's family and approval by the ethics committee of our hospital have been obtained. PMID: 31558182 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - September 29, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Overexpression of the long non-coding RNA FOXD2-AS1 promotes cisplatin resistance in esophageal squamous cell carcinoma through the miR-195-Akt-mTOR axis.
This study explored the impact of the lncRNA FOXD2-AS1 on cisplatin resistance in ESCC and its possible mechanisms. Upregulation of FOXD2-AS was detected in patients with ESCC and ESCC cells that are resistant to cisplatin. In an in vitro assay, knockdown of FOXD2-AS1 noticeably inhibited cell invasion and growth, triggered cell death, and repressed the stimulation of the Akt/mTOR axis in cisplatin-resistant ESCC cells (TE-1DDP). Conversely, the overexpression of FOXD2-AS1 remarkably increased cell invasion and growth, repressed cell death, and triggered the stimulation of the Akt/mTOR axis in TE-1/DDP cells. These finding...
Source: Oncology Research - September 29, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-122 inhibits hepatocarcinoma cell progression by targeting LMNB2.
Authors: Li XN, Yang H, Yang T Abstract In the present study, we proposed to investigate the role of miR-122 in hepatocarcinoma progression and to explore the mechanism. In hepatocarcinoma tissues and cells, we used qRT-PCR to validate the miR-122 expression level. Next, we used colony formation by crystal violet staining assay to compare cell proliferation ability, and we used scratch test or transwell assay to compare cell migration or invasion ability. And then we conducted bioinformatics or luciferase reporter gene assay to prove the regulation effect of miR-122 on lamin B2 (LMNB2), and the biological function ...
Source: Oncology Research - September 29, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

PRKAA1 promotes proliferation and inhibits apoptosis of gastric cancer cells through activating JNK1 and Akt pathways.
In conclusion, our findings suggest that PRKAA1 increases proliferation and restrains apoptosis of gastric cancer cells through activating JNK1 and Akt pathways. PMID: 31558185 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - September 29, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

The lncRNA FEZF1-AS1 promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p.
In this study, we identified an lncRNA, FEZF1 antisense RNA 1 (FEZF1-AS1), and further explored its function and mechanism in CRC. We verified that FEZF1-AS1 is highly expressed in CRC tissues and cell lines. Through functional experiments, we found that reduced levels of FEZF1-AS1 significantly suppressed CRC cell migration, invasion and proliferation and inhibited tumor growth in vivo. Mechanistically, we discovered that reduced levels of the lncRNA FEZF1-AS1 inhibited the activation of epithelial-mesenchymal transition (EMT), the overexpression of OTX1 (Orthodenticle homeobox 1) partially rescued the FEZF1-AS1-induced i...
Source: Oncology Research - July 5, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Profilin 2 Promotes Proliferation and Metastasis of Head and Neck Cancer Cells by Regulating PI3K/AKT/ β-catenin Signaling Pathway.
Profilin 2 Promotes Proliferation and Metastasis of Head and Neck Cancer Cells by Regulating PI3K/AKT/β-catenin Signaling Pathway. Oncol Res. 2019 May 15;: Authors: Zhou K, Chen J, Wu J, Xu Y, Wu Q, Yue J, Song Y, Li S, Zhou P, Tu W, Yang G, Jiang S Abstract Profilin 2 (PFN2) was found to be mainly expressed in neurons and involved in the development of the brain. In recent years, emerging evidence indicated that PFN2 is also significantly up-regulated in various cancers including the head and neck cancer (HNSC) and influences cancer cell proliferation, migration and invasion. However, the role of...
Source: Oncology Research - May 29, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Triptolide inhibits breast cancer cell metastasis through inducing the expression of miR-146a, a negative regulator of Rho GTPase.
Authors: Liu Q, Wang W, Li F, Yu D, Xu C, Hu H Abstract Triptolide, an extract of Tripterygium wilfordii, has been shown to have a potent anti-cancer activity. In the present study, it was found that triptolide could effectively induce apoptosis and inhibit proliferation and invasion in malignant MDA-MB-231 breast cancer cells. The study focused on its effect on inhibiting invasion, which has not been extensively reported to date. We predicted that triptolide may change invasion activity via microRNAs (miRNAs), which have been recognized as important regulators of gene expression. miRNAome variation in MDA-MB-231 c...
Source: Oncology Research - May 12, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Reactive oxygen species mediated Cezanne inactivation by oxidation of its catalytic cysteine residue in hepatocellular carcinoma.
Authors: Yin Z, Yang L, Wu F, Fan J, Xu J, Jin Y, Yang G Abstract Cysteine oxidation occurs at the active site of deubiquitinases (DUBs) during many biologic signaling cascades. Here we report that hepatocellular carcinoma cells (HCC) generated higher levels of endogenous reactive oxygen species (ROS). This elevated ROS production was inhibited by NADPH oxidase inhibitor diphenylene iodonium (DPI) and mitochondria electron chain inhibitor rotenone in HCC cells. Moreover, we found that H₂O₂ could activate NF-κB dependent inflammatory effect through increased induction of matrix metalloproteinase 2 (MMP2), ...
Source: Oncology Research - May 12, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

CRISPR/Cas9-mediated gene knockout of ARID1A promotes primary progesterone resistance by downregulating progesterone receptor B in endometrial cancer cells.
Authors: Wang H, Tang Z, Li T, Liu M, Li Y, Xing B Abstract Medroxyprogesterone (MPA) is used for the conservative treatment of endometrial cancer. Unfortunately, progesterone resistance seriously affects its therapeutic effect. The purpose of the current study was to investigate the influence of deletion of AT-Rich Interactive Domain 1A (ARID1A) in progesterone resistance in Ishikawa cells. Ablation of ARID1A was conducted through the CRISPR/Cas9 technology. Acquired progesterone-resistant Ishikawa (Ishikawa-PR) cells were generated by chronic exposure of Ishikawa cells to MPA. The sensitivity of the parental Ishi...
Source: Oncology Research - May 12, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-186 suppresses the progression of cholangiocarcinoma cells through inhibition of Twist1.
In conclusion, miR-186 inhibited cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) through targeting Twist1 in human CCA. Thus miR-186/Twist1 axis may benefit the development of therapies of CCA. PMID: 31072421 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - May 12, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research