(-)-Epigallocatechin-3-gallate inhibits EBV lytic replication via targeting LMP1-mediated MAPK signal axes
Oncol Res. 2021 Feb 17. doi: 10.3727/096504021X16135618512563. Online ahead of print.ABSTRACTEpstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) plays an important oncogenic role in the viral latent infection. Recently, increasing evidence indicate that the high expression of LMP1 during EBV lytic cycle is related to the viral lytic replication. However, the mechanism by which LMP1 regulates EBV lytic replication remains unclear. (-)-Epigallocatechin-3-gallate (EGCG) prevents carcinogenesis by directly targeting numerous membrane proteins and effectively inhibits EBV lytic cascade. Here we demonstrated that L...
Source: Oncology Research - February 25, 2021 Category: Cancer & Oncology Authors: Hongde Li Yueshuo Li Jianmin Hu Sufang Liu Xiangjian Luo Min Tang Ann M Bode Zigang Dong Xinqi Liu Weihua Liao Ya Cao Source Type: research

Therapeutic targeting PLK1 by ON-01910.Na is effective in local treatment of retinoblastoma.
Authors: Ma H, Nie C, Chen Y, Li J, Xie Y, Tang Z, Gao Y, Ai S, Mao Y, Sun Q, Lu R Abstract Cell cycle deregulation is involved in pathogenesis of many cancers, and often associated with protein kinase aberrations, including the polo-like kinase 1 (PLK1). Wehereby used retinoblastoma, an intraocular malignancy that lacks targeted therapy, as a disease model and set out to reveal targetability of PLK1 with a small molecularinhibitor ON-01910.Na. First, transcriptomic analysis on patient retinoblastoma tissues suggested that cell cycle progression was deregulated and confirmed that PLK1pathway was upregulated. Next, ...
Source: Oncology Research - February 14, 2021 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

The usefulness of pre-treatment MR-based radiomics on early response of neoadjuvant chemotherapy in patients with locally advanced nasopharyngeal carcinoma.
Authors: Yongfeng P, Chuner J, Lei W, Fengqin Y, Zhimin Y, Zhenfu F, Haitao J, Yangmin J, Fangzhen W Abstract xhtml:span xmlns:xhtml="http://www.w3.org/1999/xhtml" xml:lang="en">To explore the predictive role of pre-treatment MRI-based radiomics on early response of neoadjuvant chemotherapy(NAC)in locoregionally advanced nasopharyngeal carcinoma(NPC) patients. Between January 2016 and December 2016, a total of 108newly diagnosed NPC patients who hospitalized in Cancer Hospital of the University of Chinese Academy of Sciences, were respectively reviewed. All patients had complete data of enhan...
Source: Oncology Research - February 2, 2021 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

miR-325-3p promotes the proliferation, invasion and EMT of breast cancer cells by directly targeting S100A2.
This study was designed to investigate the precise mechanisms of miR-325-3p/S100A2 axis in breast cancer (BC). In this study, we found that the level of miR-325-3p was dramatically increased in BC tissues and cell lines, and the expression of S100A2 was significantly decreased. And the high level of miR-325-3p was closely associated with low expression of S100A2 in BC tissues. Moreover, introduction of miR-325-3p significantly promoted proliferation, invasion and EMT of BC cells. Bioinformatics analysis predicted that the S100A2 was a potential target gene of miR-325-3p. Luciferase reporter assay demonstrated that miR-325-...
Source: Oncology Research - January 10, 2021 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Erratum.
In conclusion, lncRNA CCAT2 plays an important role in glioma tumorigenesis and progression and may act as a potential biomarker for therapeutic strategy and prognostic prediction. PMID: 33349307 [PubMed - in process] (Source: Oncology Research)
Source: Oncology Research - December 24, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Erratum.
In this study, we investigated the role of miR-107 in the regulation of CRC cell proliferation and apoptosis. First, the expression of miR-107 was observed to be aberrantly increased in human CRC tumor tissues and cell lines when compared to the colonic control tissues and colon epithelial cells. Further study showed that the proliferative and apoptotic capacities of human CRC SW480 and LoVo cells were aberrantly regulated by miR-107. The proliferation of SW480 and LoVo cells was remarkably enhanced by the miR-107 mimic but suppressed by the miR-107 inhibitor when compared to the negative control. On the contrary, the apop...
Source: Oncology Research - December 24, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Erratum.
In this study, we found that TRAF4 was highly expressed in HCC cell lines and HCC tissues compared with normal liver cell lines and adjacent noncancerous tissues. TRAF4 overexpression in HCC tissues was correlated with tumor quantity and vascular invasion. In vitro studies showed that TRAF4 was associated with HCC cell migration and invasion. An in vivo study verified that TRAF4 overexpression facilitated metastasis in nude mice. In addition, overexpressed TRAF4 promoted the phosphorylation of Akt and induced Slug overexpression, leading to downregulated E-cadherin and upregulated vimentin, while silencing TRAF4 moderated ...
Source: Oncology Research - December 24, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Targeted therapeutic approaches in squamous cell vulvar cancer (VSCC): Case series and review of the literature.
Authors: Woelber L, Mathey S, Prieske K, Kuerti S, Hillen C, Burandt E, Coym A, Mueller V, Schmalfeldt B, Jaeger A Abstract Therapeutic options in recurrent or metastasized VSCC not amenable to radiotherapy or radical surgery are limited. Evidence for the use of targeted therapies is sparse. All patients with VSCC treated at the Gynecological Cancer Center Hamburg-Eppendorf 2013 - 2019 were retrospectively evaluated for targeted therapeutic approaches. Furthermore, a MEDLINE, EMBASE-, Web of Science-, Scopus- and OVID database search was performed using the terms: 'vulvar cancer' AND 'targeted therapy', 'erlotinib'...
Source: Oncology Research - December 16, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MicroRNA-188-5p targeting Forkhead Box L1 promotes colorectal cancer progression via activating Wnt/ β-catenin signaling.
This study aimed to explore its role in colorectal cancer (CRC). Human CRC tissues paired with normal tissues, and several CRC cell lines were utilized. Real-time quantitative PCR was applied to measure the expression of miR-188. Overexpression and knockdown were used to access the function of miR-188 and to investigate whether FOXL1/Wnt signaling mediates such function. The proliferation, migration and invasion of cancer cells were evaluated by CCK8, wound-healing and transwell assays, respectively. Whether FOXL1 acted as a direct target of miR-188 was verified by dual-luciferase reporter assays. Levels of miR-188 were up...
Source: Oncology Research - November 26, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

PNN and KCNQ1OT1 can predict the efficacy of adjuvant fluoropyrimidine-based chemotherapy in colorectal cancer patients.
Authors: Lapucci A, Perrone G, Di Paolo A, Napoli C, Landini I, Roviello G, Calosi L, Naccarato AG, Falcone A, Bani D, Mini E, Nobili S Abstract The benefit of adjuvant chemotherapy in early stages of colorectal cancer (CRC) is still disappointing and the prediction of treatment outcome quite difficult. Recently, through a transcriptomic approach, we evidenced a role of PNN and KCNQ1OT1 gene expression in predicting response to fluoropyrimidine-based adjuvant chemotherapy in stage III CRC patients. Thus, the aim of this study was to validate in an independent cohort of stage II-III CRC patients our previous finding...
Source: Oncology Research - November 21, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

microRNA-548m suppresses cell migration and invasion by targeting aryl hydrocarbon receptor in breast cancer cells.
Authors: Nor WMFSBW, Chung I, Said NABM Abstract Breast cancer is the most commonly diagnosed cancer among women and one of the leading causes of cancer mortality worldwide, in which the most severe form happens when it metastasizes to other regions of the body. Metastasis is responsible for most treatment failures in advanced breast cancer. Epithelial-mesenchymal transition (EMT) plays a significant role in promoting metastatic processes in breast cancer. MicroRNAs (miRNAs) are highly conserved endogenous short non-coding RNAs that play a role in regulating a broad range of biological processes, including cancer i...
Source: Oncology Research - October 29, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Identification of a novel cancer stemness-associated ceRNA axis in lung adenocarcinoma via stemness indices analysis.
This study provides a deeper understanding of the lncRNA-miRNA-mRNA ceRNA network and, more importantly, reveals a novel ceRNA regulatory axis, which may provide new insights into novel molecular therapeutic targets for inhibiting LUAD stem characteristics. PMID: 33106209 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - October 28, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Frizzled receptors in tumors, focusing on signaling, roles, modulation mechanisms, and targeted therapies.
Authors: Sun Y, Wang W, Zhao C Abstract Wnt molecules play crucial roles in development and adult homeostasis through their receptors Frizzled proteins (Fzds). Fzds mediate canonical β-catenin pathway and various non-canonical β-catenin-independent pathways. Aberrant Fzd signaling is involved in many diseases including cancer. Wnt/β-catenin is a well-established oncogenic pathway involved in almost every aspects of tumor development. However, Fzd-mediated non-canonical Wnt pathways function as both tumor promoters and tumor suppressors depending on cellular context. Fzd-targeted therapies have proven...
Source: Oncology Research - October 2, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Curcumol inhibits lung adenocarcinoma growth and metastasis via inactivation of PI3K/AKT and Wnt/ ß-catenin pathway.
Curcumol inhibits lung adenocarcinoma growth and metastasis via inactivation of PI3K/AKT and Wnt/ß-catenin pathway. Oncol Res. 2020 Jun 16;: Authors: Li S, Zhou G, Liu W, Ye J, Yuan F, Zhang Z Abstract Curcumol (Cur), isolated from the Traditional Chinese Medical plant Rhizoma Curcumae, is the bioactive component of sesquiterpene reported to possess anti-tumor activity. However, its bioactivity and mechanisms against lung adenocarcinoma are still unclear. We investigated its effect on lung adenocarcinoma and elucidated its underlying molecular mechanisms. In vitro, Cur effectively suppressed prol...
Source: Oncology Research - September 5, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Prognostic Value of EGFR Expression for Patients with Stage III Colorectal Cancer Receiving Fluoropyrimidine Metronomic Maintenance Therapy After Radical Resection and Adjuvant Oxaliplatin-Based Chemotherapy.
This study evaluated the survival effects of metronomic maintenance therapy with oral fluoropyrimidine in patients with stage III colorectal cancer (CRC) according to epidermal growth factor receptor (EGFR) expression. We enrolled 197 patients with stage III CRC who had undergone radical resection and FOLFOX regimen adjuvant chemotherapy. The clinicopathological features and effects of metronomic maintenance therapy with oral capecitabine (daily dose of 850 mg/m2, twice daily, on days 1-14 days every 3 weeks for 6 months) on survival according to treatment group and EGFR expression were analyzed. By conducting an in vitro ...
Source: Oncology Research - August 30, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Erratum.
In this study, we investigated the expression of miR-10b in cervical cancer tissues, carcinoma in situ tissues, mild dysplasia, moderate dysplasia, severe dysplasia tissues, and normal controls. We found that miR-10b was significantly downregulated during cervical cancer progression, and the lower level of miR-10b in cervical cancer was significantly associated with a more aggressive tumor phenotype. Moreover, overexpression of miR-10b in cervical cancer cells could inhibit the cell proliferation and invasion, and the further mechanism study suggested that its role was possibly through directly targeting HOXA1. These resul...
Source: Oncology Research - August 30, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Long noncoding RNA WEE2-AS1 plays an oncogenic role in glioblastoma by functioning as a molecular sponge for microRNA-520f-3p.
In this study, we investigated the expression and roles of WEE2-AS1 inglioblastoma (GBM). Furthermore, the molecular mechanisms behind the oncogenicactions of WEE2-AS1 in GBM cells were explored in detail. WEE2-AS1 expressionwas detected using quantitative real-time polymerase chain reaction. The roles ofWEE2-AS1 in GBM cells were evaluated by the Cell Counting Kit-8 assay, flowcytometric analysis, and Transwell cell migration and invasion assays, and tumorxenograft experiments. WEE2-AS1 expression was evidently enhanced in GBM tissuesand cell lines compared with their normal counterparts. An increased level of WEE2-AS1 wa...
Source: Oncology Research - August 26, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Outcomes of patients with acute myeloid leukemia who relapse after 5 years of complete remission.
Authors: Patel A, Agha M, Raptis A, Hou JZ, Farah R, Redner RL, Im A, Dorritie KA, Sehgal A, Rossetti J, Saul M, Normolle D, Lontos K, Boyiadzis M PMID: 32753091 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - August 13, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Pyrotinib Sensitizes 5-Fluorouracil-resistant HER2+ Breast 4 Cancer Cells to 5-Fluorouracil.
In conclusion,our findings suggest that pyrotinib could restore sensitivity of 5-FU-resistant HER2+breast cancer cells to 5-FU through downregulating the expression levels of TS andABCG2. PMID: 32727638 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - July 31, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-186repressesproliferation, migration,invasionand EMTof hepatocellular carcinomavia directly targeting CDK6.
In conclusion, miR-186 represses proliferation, migration, invasion and EMT, and induces apoptosis through targeting CDK6 in HCC, which may provide a new therapeutic target for HCC. PMID: 32698940 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - July 24, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

IL-24-armed oncolytic vaccinia virus exerts potent antitumor effects via multiple pathways in colorectal cancer.
Authors: Deng L, Yang X, Fan J, Ding Y, Peng Y, Xu D, Huang B, Hu Z Abstract Colorectal cancer is an aggressive malignancy for which there are limited treatment options. Oncolytic vaccinia virus isbeing developed as a novel strategy for cancer therapy. Arming vaccinia virus with immunostimulatory cytokines can enhance the tumor cell-specific replication and antitumor efficacy. Interleukin-24 (IL-24) is an important immune mediator, as well as a broad-spectrum tumor suppressor. Here, we constructed a targeted vaccinia virus of Guang9 strain harbored IL-24 (VG9-IL-24) to evaluate its antitumor effects. In vitro, VG9-...
Source: Oncology Research - July 10, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Proteasome inhibitors diminish c-Met expression and induce cell death in non-small cell lung cancer cells.
This study reveals that different proteasomeinhibitors produce varied inhibitory effects in NSCLS cell lines. PMID: 32580819 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - June 27, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Anticancer Activity of Novel NF- κB Inhibitor DHMEQ by Intraperitoneal Administration.
Anticancer Activity of Novel NF-κB Inhibitor DHMEQ by Intraperitoneal Administration. Oncol Res. 2020 Jun 23;: Authors: Umezawa K, Breborowicz A, Gantsev S Abstract There have been great advances in the therapy of cancer and leukemia. But there are still many neoplastic diseases that are difficult to treat. For example, it is often difficult to find effective therapies for aggressive cancer and leukemia. Meanwhile, an NF-κB inhibitor named dehydroxymethylepoxyquinomicin (DHMEQ) was discovered in 2000. This compound was designed based on the structure of epoxyquinomicin isolated from a micro...
Source: Oncology Research - June 26, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Long non-coding RNA LINC02163 accelerates malignant tumor behaviors in breast cancer by regulating the microRNA-511-3p/HMGA2 axis.
In this study, LINC02163 was upregulated in breast cancer, and its expression level was closely associated with tumor size, lymph node metastasis, and TNM stage. Patients with breast cancer presenting high LINC02163 expression exhibited shorter overall survival than those presenting low LINC02163 expression. Knockdown of LINC02163 resulted in a decrease in breast cancer cell proliferation, migration, and invasion and an increase in cell apoptosis in vitro. In addition, silencing of LINC02163 impeded breast cancer tumor growth in vivo. Mechanistic investigation revealed that LINC02163 served as a competing endogenous RNA fo...
Source: Oncology Research - June 24, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Programmed Death Ligand-1 (PD-L1) regulated by NRF- 2/MicroRNA-1 Regulatory Axis Enhances Drug Resistance and Promotes Tumorigenic Properties in Sorafenib-Resistant Hepatoma Cells.
In conclusion, our data suggested a NRF-2/miR-1/PD-L1 regulatory axis contributed to development and maintenance of drugCopyright© 2020 Cognizant Communication Corporation4ORM-A-3264 Oncology Research E-pubresistance and other tumorigenic properties in sorafenib-resistant hepatoma cells andprovided a potential therapeutic target for overcoming sorafenib resistance in HCC. PMID: 32560747 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - June 21, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

CD13-A key player in multi-drug resistance in cancer chemotherapy.
Authors: Guo Q, Li X, Cui MN, Sun JL, Ji HY, Ni BB, Yan MX Abstract Cancer is one of the most serious diseases that are harmful to human health. Systemicchemotherapy is an optimal therapeutic strategy for the treatment of cancer, but greatdifficulty has been encountered in its administration in the form of multidrug resistance(MDR). As an enzyme on the outer cell surface, CD13 is documented to be involved inthe MDR development of tumor cells. In this review, we will focus on the role of CD13in MDR generation based on the current evidence. PMID: 32532363 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - June 14, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Microenvironment analysis of prognosis and molecular signature of immune-related genes in lung adenocarcinoma.
In this study, 22 immune cell components in the lung adenocarcinoma(LUAD) TME were analyzed using gene expression profile from The Cancer GenomeAtlas (TCGA), Gene Expression Omnibus (GEO) . The TME based molecular subtypesof LUAD were defined to evaluate further the relationship between molecular subtypes,prognosis, and clinical characteristics. A TME risk score model was constructed byusing the differentially expressed genes (DEGs) of molecular subtypes. The relationshipbetween the TME score and clinical characteristics and genomic mutations wascompared to identify the genes that have significant associations with the TME...
Source: Oncology Research - May 31, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Pivarubicin is more effective than doxorubicin against triple-negative breast cancer in vivo.
This study describes the mechanistic analyses of the novel anthracycline, pivarubicin, and its in vivo efficacy against human primary TNBC.Pivarubicin directly activates PKC-delta, triggers rapid mitochondrial-dependent apoptosis and circumvents resistance conferred by overexpression of P-glycoprotein, Bcl-2, Bcl-XL and Bcr-Abl. As a consequence, pivarubicin is more cytotoxic than doxorubicin against MDA-MB-231 and SUM159 TNBC cell lines grown in both monolayer culture and tumorspheres. Comparative in vivo efficacy of pivarubicin and doxorubicin was performed in an orthotopic NSG mouse model implanted with MDA-MB-231 human...
Source: Oncology Research - May 21, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

The AKT/GSK3 β mediated Slug expression contributes to oxaliplatin resistance in 4 colorectal cancer via up-regulation of ERCC1.
The AKT/GSK3β mediated Slug expression contributes to oxaliplatin resistance in 4 colorectal cancer via up-regulation of ERCC1. Oncol Res. 2020 Apr 24;: Authors: Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H Abstract Although oxaliplatin serves as one of the first-line drugs prescribed for treating26 colorectal cancer (CRC), the therapeutic effect is disappointing due to drug resistance.27 So far, the molecular mechanisms mediating oxaliplatin resistance remain unclear. In28 this study, we found the chemo-resistance in oxaliplatin-resistant HCT116 cells29 (HCT116/OXA) was ...
Source: Oncology Research - April 27, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Tripartite motif-containing 46 promotes viability and inhibits apoptosis of osteosarcoma cells by activating NF- κB signaling through ubiquitination of PPARα.
We report an increase in the expression of TRIM46 in OS andits association with tumor size, Enneking's stage, and patient prognosis. TRIM46 knockdown inhibitsOS cell viability and cell cycle progression and induces apoptosis, while TRIM46 overexpression exertsinverse effects, which are inhibited by peroxisome proliferator-activated receptor alpha (PPARα)overexpression and the nuclear factor kappa B (NF-κB) inhibitor, pyrrolidine dithiocarbamate (PDTC).Furthermore, TRIM46 negatively regulates PPAR expression via ubiquitination-mediated proteindegradation and modification. PPAR overexpression also inacti...
Source: Oncology Research - April 18, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-202 suppresses hepatocellular carcinoma progression via down-regulating BCL2 expression.
In conclusion, miR-202 serves as a tumor suppressor in HCC progression by downregulating BCL2 expression, indicating miR-202 might be as a potential target for HCC. PMID: 32272979 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - April 11, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Cylindromatosis is required for survival of a subset of melanoma cells.
Authors: La T, Jin L, Liu XY, Song ZH, Farrelly M, Feng YC, Yan XG, Zhang YY, Thorne RF, Zhang XD, Teng L Abstract The deubiquitinase cyclindromatosis (CYLD) functions as a tumour suppressor inhibiting cell proliferation in many cancer types including melanoma. Here we present evidence that a proportion of melanoma cells are nonetheless addicted to CYLD for survival. The expression levels of CYLD varied widely in melanoma cell lines and melanomas in vivo, with a subset of melanoma cell lines and melanomas displaying even higher levels of CYLD than melanocyte lines and nevi, respectively. Strikingly, although shRNA ...
Source: Oncology Research - April 8, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Corosolic acid inhibits cancer progress through inactivating YAP in hepatocellular carcinoma.
Authors: Jia M, Xiong Y, Li M, Mao Q Abstract Chemotherapy is critical for the treatment of hepatocellular carcinoma (HCC). Despite the pro-apoptotic effects of corosolic acid (CA) treatment, its underlying mechanism is not completely clear. The aim of this study was to determine the molecular mechanism of CA in HCC treatment. MTT assay was used to determine the IC50 of CA. Immunoprecipitation and immunofluorescence were used to detect the interaction between and subcellular localization of Yes-associated protein (YAP) and mouse double minute 2 (MDM2). In addition, in vivo xenotransplantation was performed to asses...
Source: Oncology Research - March 31, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

miR-4792 inhibits acute myeloid leukemia cells proliferation and invasion, and promotes cells apoptosis by targeting Kindlin-3.
Authors: Qin Y, Wang Y, Liu D Abstract It has been reported that Kindlin-3 expression is closely associated with progression ofmany cancers and microRNA (miRNA) processing. However, the effects and its precisemechanisms of Kindlin-3 in acute myeloid leukemia (AML) have not been wellclarified. Our study aimed to explore the interaction between Kindlin-3 and miR-4792in AML. In our study, we found that the expression of Kindlin-3 was dramaticallyincreased in AML samples and cell lines, and the miR-4792 level was significantlydown-regulated. Interestingly, the low miR-4792 level was closely associated withup-regulated ...
Source: Oncology Research - March 19, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

EIF5A2 is highly expressed in anaplastic thyroid carcinoma and is associated with tumor growth by modulating TGF- β signals.
EIF5A2 is highly expressed in anaplastic thyroid carcinoma and is associated with tumor growth by modulating TGF-β signals. Oncol Res. 2020 Mar 05;: Authors: Huang Y, Zhu Q, Lu L, Sun S, Hao F, Zhang J, Liu Z, Miao Y, Jiao X, Chen D Abstract Anaplastic thyroid carcinoma (ATC) are resistant to standard therapies and has no effective treatment. Eukaryotic translation initiation factor 5A2 (EIF5A2) has shown to be upregulated inmany malignant tumors and proposed to be a critical gene involved in tumor metastasis. In thisstudy, we aim to investigate the expression status of EIF5A2 in human ATC tissues...
Source: Oncology Research - March 8, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Sulforaphane: Expected to Become a Novel Anti-tumor Compound.
Authors: Wu G, Yan Y, Zhou Y, Duan Y, Zeng S, Wang X, Lin W, Ou C, Zhou J, Xu Z Abstract Natural products are becoming increasingly popular in a variety of traditional, complementary and alternative systems due to their potency and slight side effects. Natural compounds have been shown to be effective against many human diseases, especially cancers. Sulforaphane (SFE) is a traditional Chinese herbal medicine. In recent years, an increasing number of studies have been conducted to evaluate the anti-tumor effect of SFE. The roles of SFE in cancers are mainly through the regulation of potential biomarkers to activate ...
Source: Oncology Research - March 2, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

A novel BCL-2 inhibitor APG-2575 exerts synthetic lethality with BTK or MDM2-P53 inhibitor in Diffuse Large B-Cell Lymphoma.
In this study, our aim is to explore a rational combination of BCL-2 inhibitor plus Bruton's tyrosine kinase (BTK) blockade or p53 activation for treating DLBCL with the above characteristics. We demonstrated that a novel BCL-2 selective inhibitor APG-2575 effectively suppressed DLBCL with BCL-2 high expression via activating the mitochondrial apoptosis pathway. BTK inhibitor ibrutinib combined with BCL-2 inhibitors showed synergistic antitumor effect in DLBCL with mean expression of BCL-2 and myeloid cell leukemia-1 (MCL-1) through upregulating the expression level of BIM and modulating MCL-1 and p-Akt expression. For p53...
Source: Oncology Research - February 27, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

miRNA-mRNA profiling reveals prognostic impact of SMC1A 4 expression in acute myeloid leukemia.
Authors: Gadewal N, Kumar R, Aher S, Gardane A, Gaur T, Varma AK, Khattry N, Hasan SK Abstract Acute myeloid leukemia (AML) with NPM1 mutation is a disease driving genetic alteration with good prognosis. Although it has been suggested that NPM1 mutation induces chemo-sensitivity in leukemic cells, the underlying cause for the better survival of NPM1 mutated patients is still not clear. Mutant NPM1 AML has a unique microRNA and their target gene (mRNA) signature compared to wildtype NPM1. Dynamic regulation of miRNA-mRNA has been reported to influence the prognostic outcome. In the present study, in-silico expressio...
Source: Oncology Research - February 17, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

In Memoriam: Naoki Koide 1968-2019.
Authors: Umezawa K PMID: 32029024 [PubMed - in process] (Source: Oncology Research)
Source: Oncology Research - February 8, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

lncRNA HOXA11-AS promotes proliferation and migration via sponging miR-155 in hypopharyngeal squamous cell carcinoma.
This study identifies a tumor promoting role of HOXA11-AS in HSCC and suggests HOXA11-AS might be a potential diagnostic and therapeutic target for HSCC. PMID: 31987067 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - January 29, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MafF is regulated via circ-ITCH/miR-224-5p axis and acts as a tumor suppressor in hepatocellular carcinoma.
This study verified that MafF acted as a tumorsuppressor in HCC and revealed the upstream regulation mechanism of MafF, which provided anew perspective for potential therapeutic targets of HCC. PMID: 31969212 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - January 25, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Correlating Transcriptional Networks to Papillary Renal Cell Carcinoma Survival: A Large-Scale Co-expression Analysis and Clinical Validation.
Authors: Feng X, Zhang M, Meng J, Wang Y, Liu Y, Liang C, Fan S Abstract We aimed to investigate the potential mechanisms of progression and identify novelprognosis-related biomarkers for papillary renal cell carcinoma (PRCC) patients. The relateddata were derived from The Cancer Genome Atlas (TCGA), and then, analyzed by Weightedgene co-expression network analysis (WGCNA). The correlation between each module andthe clinical traits were analyzed by Pearson's correlation analysis. Pathway analysis wasconducted to reveal potential mechanisms. Hub genes within each module were screenedby intra-module analysis, and vis...
Source: Oncology Research - January 19, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Fzd2 contributes to breast cancer cell mesenchymal-like stemness and drug resistance.
Authors: Yin P, Wang W, Gao J, Bai Y, Wang Z, Na L, Sun Y, Zhao C Abstract Cancer cell stemness is responsible for cancer relapse, distal metastasis, and drug resistance. Herewe identified that Frizzled 2 (Fzd2), one member of Wnt receptor Frizzled family, induced humanbreast cancer (BC) cell stemness via non-canonical Wnt pathways. Fzd2 was overexpressed inhuman BC tissues, and Fzd2 overexpression was associated with an unfavorable outcome. Fzd2knockdown (KD) disturbed the mesenchymal-like phenotype, migration and invasion of BC cells.Moreover, Fzd2 KD impaired BC cell mammosphere formation, reduced Lgr5+ BC cells...
Source: Oncology Research - January 8, 2020 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

The comprehensive analysis of efficacy and safety of CalliSpheres ® drug-eluting beads transarterial chemoembolization in 367 liver cancer patients: a multiplecenter, cohort study.
This study aimed to investigate the efficacy, safety and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. 367 liver cancer patients from 24 medical centers were consecutively enrolled in this multiple-center, prospective cohort study including 275 hepatocellular carcinoma (HCC) cases, 37 intrahepatic cholangiocarcinoma (ICC) cases and 55 secondary liver cancer cases. All the patients received CalliSpheres® DEB-TACE treatment. Treatment response, overall survival (OS), change of liver function and adverse events (AEs) were assessed. DEB-T...
Source: Oncology Research - December 22, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

RPSAP52 lncRNA inhibits p21Waf1/CIP expression by interacting with the RNA binding protein HuR.
This study unveils another RPSAP52-mediated molecular mechanism in pituitary tumorigenesis. PMID: 31831098 [PubMed - as supplied by publisher] (Source: Oncology Research)
Source: Oncology Research - December 15, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiRNA-101 targets TGF- βR1 to retard the progression of oral squamous cell carcinoma.
In this study, miR-101 expression was markedly downregulated in the OSCC cell lines and tissues. CCK-8, EdU, and colony formation assays showed that miR-101 inhibited the proliferation of OSCC cells. Flow cytometry and caspase-3 activity assays indicated that miR-101 induced OSCC cell apoptosis. Transwell assays demonstrated that this miRNA also repressed OSCC cell migration and invasion. Moreover, tube formation assay showed that miR-101 abated the pro-angiogenesis of OSCC cells. Dual luciferase reporter assay confirmed that miR-101 directly targeted TGF-βR1 in OSCC. Ectopic expression of TGF-βR1 counteracted th...
Source: Oncology Research - December 15, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research