Stem cell technology for antitumor drug loading and delivery in oncology
Oncol Res. 2024 Feb 6;32(3):433-437. doi: 10.32604/or.2023.046497. eCollection 2024.ABSTRACTThe main aim of antineoplastic treatment is to maximize patient benefit by augmenting the drug accumulation within affected organs and tissues, thus incrementing drug effects and, at the same time, reducing the damage of non-involved tissues to cytotoxic agents. Mesenchymal stromal cells (MSC) represent a group of undifferentiated multipotent cells presenting wide self-renewal features and the capacity to differentiate into an assortment of mesenchymal family cells. During the last year, they have been proposed as natural carriers f...
Source: Oncology Research - February 16, 2024 Category: Cancer & Oncology Authors: Francesco Petrella Enrico Mario Cassina Lidia Libretti Emanuele Pirondini Federico Raveglia Antonio Tuoro Source Type: research

Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)
In conclusion, ALYREF may serve as an oncogenic biomarker in numerous cancers, meriting further research attention.PMID:38361753 | PMC:PMC10865740 | DOI:10.32604/or.2024.045050 (Source: Oncology Research)
Source: Oncology Research - February 16, 2024 Category: Cancer & Oncology Authors: Xing Ye Zhouting Tuo Kai Chen Ruicheng Wu Jie Wang Qingxin Yu Luxia Ye Akira Miyamoto Koo Han Yoo Chi Zhang Wuran Wei Dengxiong Li Dechao Feng Source Type: research

MicroRNA (let-7b-5p)-targeted DARS2 regulates lung adenocarcinoma growth by PI3K/AKT signaling pathway
CONCLUSION: In summary, let-7b-5p downregulated DARS2 expression, regulating the progression of LUAD cells by the PI3K/AKT signaling pathway.PMID:38361754 | PMC:PMC10865744 | DOI:10.32604/or.2023.030293 (Source: Oncology Research)
Source: Oncology Research - February 16, 2024 Category: Cancer & Oncology Authors: Yuanyuan Xu Xiaoke Chen Source Type: research

Role of oncogenic long noncoding RNA KCNQ1OT1 in colon cancer
Oncol Res. 2024 Feb 6;32(3):585-596. doi: 10.32604/or.2023.029349. eCollection 2024.ABSTRACTThe role of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) in colon cancer involves various tumorigenic processes and has been studied widely. However, the mechanism by which it promotes colon cancer remains unclear. Retroviral vector pSEB61 was retrofitted in established HCT116-siKCN and SW480-siKCN cells to silence KCNQ1OT1. Cellular proliferation was measured using CCK8 assay, and flow cytometry (FCM) detected cell cycle changes. RNA sequencing (RNA-Seq) analysis showed differentially expressed genes (DEGs). Gene ...
Source: Oncology Research - February 16, 2024 Category: Cancer & Oncology Authors: Gang Liu Lei Shi Bin Wang Zehui Wu Haiyuan Zhao Tianyu Zhao Lianghui Shi Source Type: research

A review of the literature on the use of CRISPR/Cas9 gene therapy to treat hepatocellular carcinoma
Oncol Res. 2024 Feb 6;32(3):439-461. doi: 10.32604/or.2023.044473. eCollection 2024.ABSTRACTNoncoding RNAs instruct the Cas9 nuclease to site-specifically cleave DNA in the CRISPR/Cas9 system. Despite the high incidence of hepatocellular carcinoma (HCC), the patient's outcome is poor. As a result of the emergence of therapeutic resistance in HCC patients, clinicians have faced difficulties in treating such tumor. In addition, CRISPR/Cas9 screens were used to identify genes that improve the clinical response of HCC patients. It is the objective of this article to summarize the current understanding of the use of the CRISPR/...
Source: Oncology Research - February 16, 2024 Category: Cancer & Oncology Authors: Elham Amjad Raffaele Pezzani Babak Sokouti Source Type: research

Glycogen metabolism-mediated intercellular communication in the tumor microenvironment influences liver cancer prognosis
Oncol Res. 2024 Feb 6;32(3):563-576. doi: 10.32604/or.2023.029697. eCollection 2024.ABSTRACTGlycogen metabolism plays a key role in the development of hepatocellular carcinoma (HCC), but the function of glycogen metabolism genes in the tumor microenvironment (TME) is still to be elucidated. Single-cell RNA-seq data were obtained from ten HCC tumor samples totaling 64,545 cells, and 65 glycogen metabolism genes were analyzed by a nonnegative matrix factorization (NMF). The prognosis and immune response of new glycogen TME cell clusters were predicted by using HCC and immunotherapy cohorts from public databases. HCC single-c...
Source: Oncology Research - February 16, 2024 Category: Cancer & Oncology Authors: Yang Zhang Nannan Qin Xijun Wang Rui Liang Quan Liu Ruoyi Geng Tianxiao Jiang Yunfei Liu Jinwei Li Source Type: research

Bone marrow microRNA-34a is a good indicator for response to treatment in acute myeloid leukemia
CONCLUSION: miR-34a could be a beneficial diagnostic biomarker for AML patients. In addition, it serves as a good indicator for response to therapy, which could possibly identify patients who are refractory to treatment with 100% sensitivity and 75% specificity.PMID:38361758 | PMC:PMC10865737 | DOI:10.32604/or.2023.043026 (Source: Oncology Research)
Source: Oncology Research - February 16, 2024 Category: Cancer & Oncology Authors: Mona S Abdellateif Naglaa M Hassan Mahmoud M Kamel Yomna M El-Meligui Source Type: research

Low expression of fatty acid oxidation related gene ACADM indicates poor prognosis of renal clear cell carcinoma and is related to tumor immune infiltration
In conclusion, our findings suggest that reduced ACADM expression in KIRC patients is indicative of poor prognosis. These results imply that ACADM may be a diagnostic and prognostic marker for individuals with KIRC, offering a reference for clinicians in diagnosis and treatment.PMID:38361759 | PMC:PMC10865730 | DOI:10.32604/or.2023.030462 (Source: Oncology Research)
Source: Oncology Research - February 16, 2024 Category: Cancer & Oncology Authors: Jiechuan Qiu Tianmin Yang Yanning Sun Kai Sun Yingkun Xu Qinghua Xia Source Type: research

The anti-neoplastic effects of metformin modulate the acquired phenotype of fibroblast cells in the breast cancer-normal fibroblast co-culture system
In conclusion, our work shows that co-culture with breast cancer cells may cause significant alterations in the phenotype and secretion of normal fibroblasts. Metformin, however, may change this state and affect fibroblasts' acquired phenotypes. Moreover, mitochondrial inhibition by metformin after 8 days of treatment, significantly hinders tumor growth in mouse model of breast cancer.PMID:38361760 | PMC:PMC10865743 | DOI:10.32604/or.2023.043926 (Source: Oncology Research)
Source: Oncology Research - February 16, 2024 Category: Cancer & Oncology Authors: Samaneh Mostafavi Zuhair Mohammad Hassan Source Type: research

A prognosis model for predicting immunotherapy response of esophageal cancer based on oxidative stress-related signatures
In conclusion, we have constructed an OSRGs model for ESCC to predict patients' prognosis, offering a novel insight into the potential application of the OSRGs model in ESCC.PMID:38196829 | PMC:PMC10774069 | DOI:10.32604/or.2023.030969 (Source: Oncology Research)
Source: Oncology Research - January 10, 2024 Category: Cancer & Oncology Authors: Jing Guo Changyong Tong Jianguang Shi Xinjian Li Xueqin Chen Source Type: research

Identification of < em > TNFRSF1A < /em > as a novel regulator of carfilzomib resistance in multiple myeloma
Oncol Res. 2023 Dec 28;32(2):325-337. doi: 10.32604/or.2023.030770. eCollection 2023.ABSTRACTMultiple myeloma (MM) is a hematological tumor with high mortality and recurrence rate. Carfilzomib is a new-generation proteasome inhibitor that is used as the first-line therapy for MM. However, the development of drug resistance is a pervasive obstacle to treating MM. Therefore, elucidating the drug resistance mechanisms is conducive to the formulation of novel therapeutic therapies. To elucidate the mechanisms of carfilzomib resistance, we retrieved the GSE78069 microarray dataset containing carfilzomib-resistant LP-1 MM cells ...
Source: Oncology Research - January 8, 2024 Category: Cancer & Oncology Authors: Jie Zhao Xuantao Yang Haixi Zhang Xuezhong Gu Source Type: research

Extensive prediction of drug response in mutation-subtype-specific LUAD with machine learning approach
CONCLUSION: This work extensively investigated the mRNA and mutation signatures associated with drug response in LUAD using a machine-learning approach and proposed a priority algorithm to predict drug response for different drugs.PMID:38186568 | PMC:PMC10765129 | DOI:10.32604/or.2023.042863 (Source: Oncology Research)
Source: Oncology Research - January 8, 2024 Category: Cancer & Oncology Authors: Kegang Jia Yawei Wang Q I Cao Youyu Wang Source Type: research

TGF- β-regulated different iron metabolism processes in the development and cisplatin resistance of ovarian cancer
In conclusion, DIMP plays multifaceted roles in the initiation, chemo-resistance, and prognosis of ovarian cancer. Therapeutically targeting DIMP may pave the way for more tailored treatment approaches for ovarian cancer.PMID:38186569 | PMC:PMC10765122 | DOI:10.32604/or.2023.031404 (Source: Oncology Research)
Source: Oncology Research - January 8, 2024 Category: Cancer & Oncology Authors: Jianfa Wu Qianyi Liao L I Zhang Suqin Wu Zhou Liu Source Type: research

Polo-like kinase 1 as a biomarker predicts the prognosis and immunotherapy of breast invasive carcinoma patients
CONCLUSIONS: PLK1 expression and immune cell infiltration can predict post-immunotherapy prognosis of BRCA patients.PMID:38186570 | PMC:PMC10765123 | DOI:10.32604/or.2023.030887 (Source: Oncology Research)
Source: Oncology Research - January 8, 2024 Category: Cancer & Oncology Authors: Juan Shen Weiyu Zhang Qinqin Jin Fuyu Gong Heping Zhang Hongliang Xu Jiejie Li Hui Yao Xiya Jiang Yinting Yang Lin Hong Jie Mei Yang Song Shuguang Zhou Source Type: research

GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling
This study aimed to investigate whether GAIP interacting protein, C terminus 1 (GIPC1) represents a therapeutic target and its regulating mechanism in GC. GIPC1 expression was elevated in GC tissues, liver metastasis tissues, and lymph node metastases. GIPC1 knockdown or GIPC1 blocking peptide blocked the platelet-derived growth factor receptor (PDGFR)/PI3K/AKT signaling pathway, and inhibited the proliferation and migration of GC cells. Conversely, GIPC1 overexpression markedly activated the PDGFR/PI3K/AKT signaling pathway, and promoted GC cell proliferation and migration. Furthermore, platelet-derived growth factor subu...
Source: Oncology Research - January 8, 2024 Category: Cancer & Oncology Authors: Tingting Li Wei Zhong Liu Yang Zhiyu Zhao L I Wang Cong Liu Wanyun Li Haiyan Lv Shengyu Wang Jianghua Yan Ting Wu Gang Song Fanghong Luo Source Type: research