IL-17 induces NSCLC cell migration and invasion by elevating MMP19 gene transcription and expression through the interaction of p300-dependent STAT3-K631 acetylation and its Y705-phosphorylation
Oncol Res. 2024 Mar 20;32(4):625-641. doi: 10.32604/or.2023.031053. eCollection 2024.ABSTRACTThe cancer cell metastasis is a major death reason for patients with non-small cell lung cancer (NSCLC). Although researchers have disclosed that interleukin 17 (IL-17) can increase matrix metalloproteinases (MMPs) induction causing NSCLC cell metastasis, the underlying mechanism remains unclear. In the study, we found that IL-17 receptor A (IL-17RA), p300, p-STAT3, Ack-STAT3, and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17. p300, STAT3 and MMP19 overexpression or knockdown could raise or red...
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Wen Ge Y A Li Yuting Ruan Ningxia Wu Pei Ma Tongpeng Xu Yongqian Shu Yingwei Wang Wen Qiu Chenhui Zhao Source Type: research
Development of a cell adhesion-based prognostic model for multiple myeloma: Insights into chemotherapy response and potential reversal of adhesion effects
This study integrated four RNA sequencing datasets (CoMMpass, GSE136337, GSE9782, and GSE2658) and focused on analyzing 1706 adhesion-related genes. Rigorous univariate Cox regression analysis identified 18 key prognosis-related genes, including KIF14, TROAP, FLNA, MSN, LGALS1, PECAM1, and ALCAM, which demonstrated the strongest associations with poor overall survival (OS) in MM patients. To comprehensively evaluate the impact of cell adhesion on MM prognosis, an adhesion-related risk score (ARRS) model was constructed using Lasso Cox regression analysis. The ARRS model emerged as an independent prognostic factor for predi...
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Qian Hu Mengyao Wang Jinjin Wang Yali Tao Ting Niu Source Type: research
Clinical implications of single cell sequencing for bladder cancer
Oncol Res. 2024 Mar 20;32(4):597-605. doi: 10.32604/or.2024.045442. eCollection 2024.ABSTRACTBladder cancer (BC) is the 10th most common cancer worldwide, with about 0.5 million reported new cases and about 0.2 million deaths per year. In this scoping review, we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA guidelines. We searched PubMed, CENTRAL, Embase, and supplemented with manual searches through the Scopus, and Web of Science for published studies until February 2023. We included original studies that used at least one single-cell techno...
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Reza Yadollahvandmiandoab Mehrsa Jalalizadeh Franciele Aparecida Vechia Dionato Keini Buosi Patr ícia A F Leme Luciana S B Dal Col Cristiane F Giacomelli Alex Dias Assis Nasim Bashirichelkasari Leonardo Oliveira Reis Source Type: research
Codelivery of anti-CD47 antibody and chlorin e6 using a dual pH-sensitive nanodrug for photodynamic immunotherapy of osteosarcoma
Oncol Res. 2024 Mar 20;32(4):691-702. doi: 10.32604/or.2023.030767. eCollection 2024.ABSTRACTOsteosarcoma is a malignant tumor originating from bone tissue that progresses rapidly and has a poor patient prognosis. Immunotherapy has shown great potential in the treatment of osteosarcoma. However, the immunosuppressive microenvironment severely limits the efficacy of osteosarcoma treatment. The dual pH-sensitive nanocarrier has emerged as an effective antitumor drug delivery system that can selectively release drugs into the acidic tumor microenvironment. Here, we prepared a dual pH-sensitive nanocarrier, loaded with the pho...
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Jijie Xiao Hong Xiao Yujun Cai Jianwei Liao Jue Liu Lin Yao Shaolin Li Source Type: research
GRIK1 promotes glioblastoma malignancy and is a novel prognostic factor of poor prognosis
Oncol Res. 2024 Mar 20;32(4):727-736. doi: 10.32604/or.2023.043391. eCollection 2024.ABSTRACTPrimary tumors of the central nervous system (CNS) are classified into over 100 different histological types. The most common type of glioma is derived from astrocytes, and the most invasive glioblastoma (WHO IV) accounts for over 57% of these tumors. Glioblastoma (GBM) is the most common and fatal tumor of the CNS, with strong growth and invasion capabilities, which makes complete surgical resection almost impossible. Despite various treatment methods such as surgery, radiotherapy, and chemotherapy, glioma is still an incurable di...
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Guoqiang Hou Xinhang Xu Weixing Hu Source Type: research
Neural Wiskott-Aldrich syndrome protein (N-WASP) promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2
In this study, we investigated whether Neural Wiskott-Aldrich syndrome protein (N-WASP) plays a role in distant metastasis of PDAC. We found that N-WASP is markedly expressed in clinical patients with PDAC. Clinical analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group. N-WASP was noted to be a novel mediator of epithelial-mesenchymal transition (EMT) via gene expression profile studies. Knockdown of N-WASP in pancreatic cancer cells significantly inhibited cell invasion, migration, and EMT. We also observed positive association of lysyl oxidase-like 2 (LOXL2) a...
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Hyung Sun Kim Yun Sun Lee Seung Myung Dong Hyo Jung Kim DA Eun Lee Hyeon Woong Kang Myeong Jin Kim Joon Seong Park Source Type: research
DPY19L3 promotes vasculogenic mimicry by its < em > C < /em > -mannosyltransferase activity
In this study, we focused on DPY19L3, a C-mannosyltransferase, and aimed to unravel its role in VM. Knockout of DPY19L3 inhibited the formation of VM in HT1080 human fibrosarcoma cells. Re-expression of wild-type DPY19L3 recovered VM formation; however, DPY19L3 isoform2, an enzymatic activity-defect mutant, did not restore it, suggesting that the C-mannosyltransferase activity of DPY19L3 is crucial to its function. Furthermore, the knockdown of DPY19L3 in MDA-MB-231 breast cancer cells hindered its network formation ability. Altogether, our findings suggest that DPY19L3 is required for VM formation and stipulate the releva...
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Hassan Baydoun Yuji Kato Hiroki Kamo Anna H üsch Hayato Mizuta Ryota Kawahara Siro Simizu Source Type: research
Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases
In conclusion, our study provided strong evidence that these pH-sensitive dual ligand-targeted polymeric micelles may be a successful treatment strategy for breast cancer bone metastasis.PMID:38560569 | PMC:PMC10972726 | DOI:10.32604/or.2023.044276 (Source: Oncology Research)
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Huan Gao Jie Zhang Tony G Kleijn Zhaoyong Wu Bing Liu Yujin Ma Baoyue Ding Dongfeng Yin Source Type: research
miR-125b reverses cisplatin resistance by regulating autophagy via targeting RORA/BNIP3L axis in lung adenocarcinoma
In this study, miR-125b was identified as a specific cisplatin (DDP)-resistant gene in LUAD, as indicated by the bioinformatics analysis and the real-time quantitative PCR assay. The decreased serum level of miR-125b in LUAD patients was correlated with the poor treatment response rate and short survival time. MiR-125b decreased the A549/DDP proliferation, and the multiple drug resistance- and autophagy-related protein expression levels, which were all reversed by the inhibition of miR-125b. In addition, xenografts of human tumors in nude mice were suppressed by miR-125b, demonstrating that through autophagy regulation, mi...
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Lei Liu N A Guo Xiangling Li Qian Xu Ruilong He Limin Cheng Chunyan Dang Xinyu Bai Yiying Bai Xin Wang Qianhui Chen L I Zhang Source Type: research
Developing risk models and subtypes of autophagy-associated LncRNAs for enhanced prognostic prediction and precision in therapeutic approaches for liver cancer patients
CONCLUSION: The 8 signatures based on ARLncRNAs present novel targets for prognostic prediction in HCC. The drug candidate Paclitaxel may effectively treat HCC by impacting ARLncRNAs expression. With the identification of ARLncRNAs-related isoforms, these results provide valuable insights for clinical exploration of autophagy mechanisms in HCC pathogenesis and offer potential avenues for precision medicine.PMID:38560571 | PMC:PMC10972734 | DOI:10.32604/or.2023.030988 (Source: Oncology Research)
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: L U Zhang Jinguo Chu Yushan Yu Source Type: research
IQGAP3 promotes the progression of glioma as an immune and prognostic marker
Conclusion: IQGAP3 shows promise as a valuable biomarker for diagnosis, prognosis, and immunotherapeutic strategies in gliomas.PMID:38560572 | PMC:PMC10972721 | DOI:10.32604/or.2023.046712 (Source: Oncology Research)
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Xiaofeng Gao Juanjuan Ge Xuzheng Gao N A Mei Yanting Su Shigang Shan Wenbin Qian Jiangheng Guan Zhenwang Zhang Long Wang Source Type: research
Identifying and validating MMP family members (MMP2, MMP9, MMP12, and MMP16) as therapeutic targets and biomarkers in kidney renal clear cell carcinoma (KIRC)
This study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma (KIRC) through a comprehensive approach encompassing both computational and molecular analyses. STRING, Cytoscape, UALCAN, GEPIA, OncoDB, HPA, cBioPortal, GSEA, TIMER, ENCORI, DrugBank, targeted bisulfite sequencing (bisulfite-seq), conventional PCR, Sanger sequencing, and RT-qPCR based analyses were used in the present study to analyze MMP gene family members to accurately determine a few hub genes that can be utilized as both therapeutic targets and diagnostic ...
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Kunlun Li Dandan Li Barbod Hafez Mounir M Salem Bekhit Yousef A Bin Jardan Fars Kaed Alanazi Ehab I Taha Sayed H Auda Faiqah Ramzan Muhammad Jamil Source Type: research
The role of polymorphic cytochrome P450 gene (CYP2B6) in B-chronic lymphocytic leukemia (B-CLL) incidence and outcome among Egyptian patients
In conclusion, our findings showed that the CYP2B6*9 (G516T) polymorphism is associated with B-CLL susceptibility among Egyptian patients. This variant greatly affected the clinical outcome and can serve as a good therapeutic marker in predicting response to cyclophosphamide treatment.PMID:38560574 | PMC:PMC10972729 | DOI:10.32604/or.2024.047021 (Source: Oncology Research)
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Menna Al-Adl Magdy M Youssef Ahmed El-Sebaie Sherif Refaat Afaf El-Said Source Type: research
Degradation of FAK-targeting by proteolytic targeting chimera technology to inhibit the metastasis of hepatocellular carcinoma
This study examined the correlation between FAK expression and the prognosis of HCC. Additionally, we explored the impact of FAK degradation on HCC metastasis through wound healing experiments, transwell invasion experiments, and a xenograft tumor model. The expression of proteins related to epithelial-mesenchymal transition (EMT) was measured to elucidate the underlying mechanisms. The results showed that FAK PROTAC can degrade FAK, inhibit the migration and invasion of HCC cells in vitro, and notably decrease the lung metastasis of HCC in vivo. Increased expression of E-cadherin and decreased expression of vimentin indic...
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Xinfeng Zhang Shuang Li Meiru Song Yue Chen Liangzheng Chang Zherui Liu Hongyuan Dai Yutao Wang Gangqi Yang Yun Jiang Yinying Lu Source Type: research
Investigation of the feasibility of NRAV as a biomarker for hepatocellular carcinoma
Oncol Res. 2024 Mar 20;32(4):717-726. doi: 10.32604/or.2023.043575. eCollection 2024.ABSTRACTThe long non-coding RNA, Negative Regulator of Antiviral Response (NRAV) has been identified as a participant in both respiratory virus replication and immune checkpoints, however, its involvement in pan-cancer immune regulation and prognosis, particularly those of hepatocellular carcinoma (HCC), remains unclear. To address this knowledge gap, we analyzed expression profiles obtained from The Cancer Genome Atlas (TCGA) database, comparing normal and malignant tumor tissues. We found that NRAV expression is significantly upregulated...
Source: Oncology Research - April 1, 2024 Category: Cancer & Oncology Authors: Jun Liu Wenli Li Ruyue Lu Jiaqing Xu Chunhui Jiang Junlin Duan Lingzhi Zhang Guanfu Wang Jiaxi Chen Source Type: research
