MicroRNA-329-3p inhibits the Wnt/ β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1
This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in all examined OS cell lines. Additionally, a clinical comparison study was performed using the TCGA database. Subsequently, the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo experiments. When m...
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Hui Sun Masanori Kawano Tatsuya Iwasaki Ichiro Itonaga Yuta Kubota Hiroshi Tsumura Kazuhiro Tanaka Source Type: research
Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells
In conclusion, inhibition of miR-214-3p can increase the sensitivity of vascular endothelial cells to Apatinib, thereby promoting the antiangiogenic effect of Apatinib, suggesting a potential combination therapy for advanced gastric cancer.PMID:38370339 | PMC:PMC10874472 | DOI:10.32604/or.2023.046676 (Source: Oncology Research)
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Weixue Wang Tongtong Wang Yan Zhang Ting Deng Haiyang Zhang Y I Ba Source Type: research
MicroRNA-329-3p inhibits the Wnt/ β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1
This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in all examined OS cell lines. Additionally, a clinical comparison study was performed using the TCGA database. Subsequently, the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo experiments. When m...
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Hui Sun Masanori Kawano Tatsuya Iwasaki Ichiro Itonaga Yuta Kubota Hiroshi Tsumura Kazuhiro Tanaka Source Type: research
Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells
In conclusion, inhibition of miR-214-3p can increase the sensitivity of vascular endothelial cells to Apatinib, thereby promoting the antiangiogenic effect of Apatinib, suggesting a potential combination therapy for advanced gastric cancer.PMID:38370339 | PMC:PMC10874472 | DOI:10.32604/or.2023.046676 (Source: Oncology Research)
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Weixue Wang Tongtong Wang Yan Zhang Ting Deng Haiyang Zhang Y I Ba Source Type: research
MicroRNA-329-3p inhibits the Wnt/ β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1
This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in all examined OS cell lines. Additionally, a clinical comparison study was performed using the TCGA database. Subsequently, the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo experiments. When m...
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Hui Sun Masanori Kawano Tatsuya Iwasaki Ichiro Itonaga Yuta Kubota Hiroshi Tsumura Kazuhiro Tanaka Source Type: research
Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells
In conclusion, inhibition of miR-214-3p can increase the sensitivity of vascular endothelial cells to Apatinib, thereby promoting the antiangiogenic effect of Apatinib, suggesting a potential combination therapy for advanced gastric cancer.PMID:38370339 | PMC:PMC10874472 | DOI:10.32604/or.2023.046676 (Source: Oncology Research)
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Weixue Wang Tongtong Wang Yan Zhang Ting Deng Haiyang Zhang Y I Ba Source Type: research
MicroRNA-329-3p inhibits the Wnt/ β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1
This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in all examined OS cell lines. Additionally, a clinical comparison study was performed using the TCGA database. Subsequently, the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo experiments. When m...
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Hui Sun Masanori Kawano Tatsuya Iwasaki Ichiro Itonaga Yuta Kubota Hiroshi Tsumura Kazuhiro Tanaka Source Type: research
Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells
In conclusion, inhibition of miR-214-3p can increase the sensitivity of vascular endothelial cells to Apatinib, thereby promoting the antiangiogenic effect of Apatinib, suggesting a potential combination therapy for advanced gastric cancer.PMID:38370339 | PMC:PMC10874472 | DOI:10.32604/or.2023.046676 (Source: Oncology Research)
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Weixue Wang Tongtong Wang Yan Zhang Ting Deng Haiyang Zhang Y I Ba Source Type: research
MicroRNA-329-3p inhibits the Wnt/ β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1
This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in all examined OS cell lines. Additionally, a clinical comparison study was performed using the TCGA database. Subsequently, the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo experiments. When m...
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Hui Sun Masanori Kawano Tatsuya Iwasaki Ichiro Itonaga Yuta Kubota Hiroshi Tsumura Kazuhiro Tanaka Source Type: research
Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells
In conclusion, inhibition of miR-214-3p can increase the sensitivity of vascular endothelial cells to Apatinib, thereby promoting the antiangiogenic effect of Apatinib, suggesting a potential combination therapy for advanced gastric cancer.PMID:38370339 | PMC:PMC10874472 | DOI:10.32604/or.2023.046676 (Source: Oncology Research)
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Weixue Wang Tongtong Wang Yan Zhang Ting Deng Haiyang Zhang Y I Ba Source Type: research
MicroRNA-329-3p inhibits the Wnt/ β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1
This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in all examined OS cell lines. Additionally, a clinical comparison study was performed using the TCGA database. Subsequently, the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo experiments. When m...
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Hui Sun Masanori Kawano Tatsuya Iwasaki Ichiro Itonaga Yuta Kubota Hiroshi Tsumura Kazuhiro Tanaka Source Type: research
Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells
In conclusion, inhibition of miR-214-3p can increase the sensitivity of vascular endothelial cells to Apatinib, thereby promoting the antiangiogenic effect of Apatinib, suggesting a potential combination therapy for advanced gastric cancer.PMID:38370339 | PMC:PMC10874472 | DOI:10.32604/or.2023.046676 (Source: Oncology Research)
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Weixue Wang Tongtong Wang Yan Zhang Ting Deng Haiyang Zhang Y I Ba Source Type: research
MicroRNA-329-3p inhibits the Wnt/ β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1
This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in all examined OS cell lines. Additionally, a clinical comparison study was performed using the TCGA database. Subsequently, the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo experiments. When m...
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Hui Sun Masanori Kawano Tatsuya Iwasaki Ichiro Itonaga Yuta Kubota Hiroshi Tsumura Kazuhiro Tanaka Source Type: research
Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells
In conclusion, inhibition of miR-214-3p can increase the sensitivity of vascular endothelial cells to Apatinib, thereby promoting the antiangiogenic effect of Apatinib, suggesting a potential combination therapy for advanced gastric cancer.PMID:38370339 | PMC:PMC10874472 | DOI:10.32604/or.2023.046676 (Source: Oncology Research)
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Weixue Wang Tongtong Wang Yan Zhang Ting Deng Haiyang Zhang Y I Ba Source Type: research
MicroRNA-329-3p inhibits the Wnt/ β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1
This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in all examined OS cell lines. Additionally, a clinical comparison study was performed using the TCGA database. Subsequently, the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo experiments. When m...
Source: Oncology Research - February 19, 2024 Category: Cancer & Oncology Authors: Hui Sun Masanori Kawano Tatsuya Iwasaki Ichiro Itonaga Yuta Kubota Hiroshi Tsumura Kazuhiro Tanaka Source Type: research
