Targeting Receptors of Advanced Glycation End Products (RAGE): Preventing diabetes induced cancer and diabetic complications
Publication date: Available online 19 September 2019Source: Pathology - Research and PracticeAuthor(s): Abu Sufiyan Chhipa, Swapnil P. Borse, Ruma Baksi, Sunali Lalotra, Manish NivsarkarAbstractCancer and diabetes are the two major disorders that affect a large proportion of the world’s population. Results from multiple epidemiological studies have concluded that diabetes and cancer are linked and diabetic patients live at much higher risks of developing cancer and diabetic complications at the later phase of disease. Inflammation is the central pathway that mediates both diabetic complications as well as cancer. Rec...
Source: Pathology Research and Practice - September 21, 2019 Category: Pathology Source Type: research

Analysis of NTRK Expression in gastric and esophageal adenocarcinoma (AGE) with Pan-TRK Immunohistochemistry
Publication date: Available online 19 September 2019Source: Pathology - Research and PracticeAuthor(s): A. Arnold, S. Daum, M. von Winterfeld, E. Berg, M. Hummel, D. Horst, B. Rau, U. Stein, C. TreeseAbstractSmall molecule inhibitors such as Larotrectinib have been recently approved in the treatment of patients with fusions of the neurotrophic-tropomyosin receptor tyrosine kinase (NTRK) genes 1-3. These genomic rearrangements have been reported across different tumor subtypes with a high prevalence in rare tumors. However, in gastric and esophageal adenocarcinoma (AGE) NTRK fusions have also been described in a subset of A...
Source: Pathology Research and Practice - September 21, 2019 Category: Pathology Source Type: research

Editorial Board
Publication date: October 2019Source: Pathology - Research and Practice, Volume 215, Issue 10Author(s): (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 21, 2019 Category: Pathology Source Type: research

Publisher's Note
Publication date: October 2019Source: Pathology - Research and Practice, Volume 215, Issue 10Author(s): (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 21, 2019 Category: Pathology Source Type: research

Endoglin-based assessment of neoangiogenesis in sporadic VIII cranial nerve schwannoma
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Gino Marioni, Stella Blandamura, Lorenzo Nicolè, Luca Denaro, Diego Cazzador, Chiara Pavone, Luciano Giacomelli, Vincenza Guzzardo, Ambrogio Fassina, Antonio Mazzoni, Domenico D’Avella, Alessandro Martini, Elisabetta ZanolettiAbstractAlthough the diagnosis and treatment of sporadic vestibular schwannoma has improved in recent years, no factors capable of predicting its growth have been identified as yet. Endoglin (CD105) is a proliferation-associated protein expressed in angiogenic endothelial cells, and a p...
Source: Pathology Research and Practice - September 19, 2019 Category: Pathology Source Type: research

Programmed Necrosis and its Role in Management of Breast Cancer
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Banita Thakur, Yashwant Kumar, Alka BhatiaAbstractBreast cancer is one of the major causes of cancer related deaths in women worldwide. A major factor responsible for treatment failure in breast cancer is the development of resistance to commonly used chemotherapeutic drugs leading to disease relapse. Several studies have shown dysregulation of molecular machinery of apoptosis, the major programmed cell death pathway in breast malignancies. Thus, there is an unmet need to search for an alternative cell death pathway whic...
Source: Pathology Research and Practice - September 19, 2019 Category: Pathology Source Type: research

Long Noncoding RNA HOTTIP overexpression: a potential prognostic biomarker in prostate cancer
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Yoo Jin Lee, Harim Oh, Eojin Kim, Bokyung Ahn, Jeong Hyeon Lee, Youngseok Lee, Yang Seok Chae, Sung Gu Kang, Chul Hwan KimAbstractHOXA transcript at the distal tip (HOTTIP) is a long noncoding RNA (lncRNA), which is>200 nucleotides in length. HOTTIP expression has been demonstrated to play a crucial oncogenic role in cancer pathogenesis, and is said to be associated with poor human cancer prognosis. In prostate cancer, HOTTIP has been identified as an oncogene, but its clinicopathologic significance remains unclear. A...
Source: Pathology Research and Practice - September 19, 2019 Category: Pathology Source Type: research

Enhancement of cisplatin-induced cytotoxicity against cervical cancer spheroid cells by targeting long non-coding RNAs
In this study, we investigated the cytotoxic effect of cisplatin, a clinical chemotherapeutic for cervical cancer treatment, on parental and spheroid CVC cells and surveyed the effect of LncRNA on drug-resistance. We found that spheroid CVC cells showed much more resistant to cisplatin-induced cytotoxicity compared with parental CVC cells. Furthermore, cisplatin significantly induced apoptotic cell death, while it induced cell cycle arrest in G0/G1 phase at the same dose (10 μg/ml). We also found the significant expression of EGFR in spheroid instead of parental CVC cells. Interestingly, we revealed that protrudi...
Source: Pathology Research and Practice - September 19, 2019 Category: Pathology Source Type: research

IL17RB expression might predict prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer
ConclusionsIL17RB predicts the prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 19, 2019 Category: Pathology Source Type: research

Targeted Next-generation Sequencing Revealed Distinct Clinicopathologic and Molecular Features of VCL-ALK RCC: A Unique Case from An Older Patient without Clinical Evidence of Sickle Cell Trait
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Xiao-tong Wang, Ru Fang, Sheng-bing Ye, Ru-song Zhang, Rui Li, Xuan Wang, Rong-hao Ji, Zhen-feng Lu, Heng-hui Ma, Xiao-jun Zhou, Qiu-yuan Xia, Qiu RaoAbstractAnaplastic lymphoma kinase (ALK)-rearranged renal cell carcinoma (RCC) is a novel entity of rare tumors with only 10 cases reported in the literature. Three RCC cases bearing VCL-ALK gene fusion were all young African American patients and associated with sickle cell trait notably. In contrast to the 3 reported cases, this neoplasm occurred in a middle-age woman (57...
Source: Pathology Research and Practice - September 19, 2019 Category: Pathology Source Type: research

Somatic mutations of candidate tumor suppressor genes folliculin-interacting proteins FNIP1 and FNIP2 in gastric and colon cancers
Publication date: Available online 16 September 2019Source: Pathology - Research and PracticeAuthor(s): Ha Yoon Mo, Hyun Ji Son, Eun Ji Choi, Nam Jin Yoo, Chang Hyeok An, Sug Hyung Lee (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 17, 2019 Category: Pathology Source Type: research

Potential role of TET2 in gastric cancer cisplatin resistance
Publication date: Available online 16 September 2019Source: Pathology - Research and PracticeAuthor(s): Kun Zhou, Huan Guo, Jun Zhang, Dongmei Zhao, Yuzhen Zhou, Zunrong Zheng, Yuhong Xu, Yanli Li, Donghua WangAbstractGastric cancer (GC) represents one of the most predominant malignancies with high incidence and mortality rates. Although traditional chemotherapeutics, including cisplatin are effective in the treatment of GC, patients often develop drug resistance in clinic. The present study aimed to explore the underlying mechanism of cisplatin-induced drug resistance in GC. The potential role of DNA demethylase ten-eleve...
Source: Pathology Research and Practice - September 17, 2019 Category: Pathology Source Type: research

Somatic mutations in long-non-coding RNA RMRP in acute leukemias
Publication date: Available online 16 September 2019Source: Pathology - Research and PracticeAuthor(s): Hyun Ji Son, Eun Ji Choi, Nam Jin Yoo, Sug Hyung Lee (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 17, 2019 Category: Pathology Source Type: research

miR-183-5p acts as a potential prognostic biomarker in gastric cancer and regulates cell functions by modulating EEF2
ConclusionmiR-183-5p acts as a potential prognostic biomarker in gastric cancer and regulates cell functions by modulating EEF2. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 17, 2019 Category: Pathology Source Type: research

The expression of C-MYC in gastric adenocarcinoma is associated with PD-L1 and FOXP3 expression: C-MYC overexpression is a good prognostic factor
ConclusionWe discovered that the immune regulatory effect of C-MYC and PD-L1, and the tumor suppressor function of tumoral FOXP3 had a significant influence on the tumor microenvironment (Tregs, CD8 + T cells, and tumor infiltrating lymphocytes) in a complex manner. The C-MYC overexpression is a good prognostic factor in gastric adenocarcinoma (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 17, 2019 Category: Pathology Source Type: research

Associations between clinical-pathological parameters and biomarkers, HER-2, TYMS, RRMI, and 21-Gene Recurrence Score in breast cancer
Publication date: Available online 16 September 2019Source: Pathology - Research and PracticeAuthor(s): Yu-Hui Zhou, Yang Liu, Wei Zhang, Chao Liu, Jian-Jun He, Xiao-Jiang TangABSTRACTBackgroundChemotherapy is the predominant treatment option for patients with breast cancer. Selection of patients according to biomarker will improve chemotherapy efficacy. In the present study, we examined the relations of the expression of candidate genes and 21-recurrence score (RS) results to patients’ demographic characteristics, histopathological factors, and outcomes.MethodsA total of 146 patients were enrolled in this study. The...
Source: Pathology Research and Practice - September 17, 2019 Category: Pathology Source Type: research

Immunofluorescence analysis of DNA damage response protein p53-binding protein 1 in a case of uterine dedifferentiated leiomyosarcoma arising from leiomyoma
ConclusionsThis study revealed that diffuse-type 53BP1 expression may be beneficial to estimate genomic instability during dedifferentiation from LM to DLMS. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 17, 2019 Category: Pathology Source Type: research

High level of lncRNA H19 expression is associated with shorter survival in esophageal squamous cell cancer patients
ConclusionOur LncH19 ISH data verify the involvement of LncH19 in ESCC. Higher levels of LncH19 expression were not only detected in tumors with larger size and in clinical late stage, but also significantly associated with shorter survival, strongly indicating its clinical significance in the malignant progression of ESCC and useful value as a poor prognostic factor for the patients. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 17, 2019 Category: Pathology Source Type: research

Negative prognostic value of intra-ductal fat infiltrate in Breast Cancer
ConclusionResults of our study highlighted the possible role of fat in breast cancer progression suggesting a negative prognostic value of IDFi. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 14, 2019 Category: Pathology Source Type: research

Ovarian borderline tumors, a subtype of neoplasm with controversial behavior. Role of Ki67 as a prognostic factor
Publication date: Available online 12 September 2019Source: Pathology - Research and PracticeAuthor(s): Elia Guadagno, Sara Pignatiello, Giorgio Borrelli, Mariarosaria Cervasio, Luigi Della Corte, Giuseppe Bifulco, Luigi InsabatoAbstractIntroductionOvarian borderline tumors (OBT) are tumors with an intermediate grade of malignancy whose diagnosis is purely based on morphological criteria. They usually occur in young women (under 40 years) and are characterized by a cellular proliferation with slight nuclear atypia and lacking stromal invasion with a destructive pattern. Aim of this study was to explore the immunohistochemi...
Source: Pathology Research and Practice - September 13, 2019 Category: Pathology Source Type: research

Correlation of Clinicopathological Features and Leucine-rich repeat-containing G-protein-coupled receptor 5 Expression in Pancreatic Ductal Adenocarcinoma
Publication date: Available online 5 September 2019Source: Pathology - Research and PracticeAuthor(s): Yasuhiro Kuraishi, Takeshi Uehara, Yukihiro Kobayashi, Tomoyuki Nakajima, Takayuki Watanabe, Akira Shimizu, Hiroyoshi Ota, Eiji TanakaAbstractPancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. Previous studies have established leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) as a cancer stem cell marker in gastrointestinal cancers. However, few reports have examined LGR5 in PDAC. Here we examined LGR5 expression and its clinicopathological significance in PDAC. We evalu...
Source: Pathology Research and Practice - September 7, 2019 Category: Pathology Source Type: research

Perineural And Intraneural Involvement In Ductal Carcinoma In-situ Of Breast: Case Report
Publication date: Available online 6 September 2019Source: Pathology - Research and PracticeAuthor(s): Osama Elfituri (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 7, 2019 Category: Pathology Source Type: research

Down-regulation of UTP23 promotes paclitaxel resistance and predicts poorer prognosis in ovarian cancer
ConclusionOur findings elucidated a previously unknown function for UTP23 in regulating paclitaxel sensitivity and UTP23 could serve as a potential prognostic predictor for ovarian cancer. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 7, 2019 Category: Pathology Source Type: research

Knockdown of long non-coding RNA TINCR decreases radioresistance in colorectal cancer cells
Publication date: Available online 3 September 2019Source: Pathology - Research and PracticeAuthor(s): Zhengchun Kang, E Jifu, Kai Guo, Xiuzhu Ma, Yingyi Zhang, Enda YuAbstractAn increasing number of studies have revealed the role of long non-coding RNAs in cancer. However, the mechanisms of action and functional utility in colorectal cancer (CRC) have not been fully elucidated. Here we describe the functional role and potential mechanism of TINCR (terminal differentiation-induced non-coding RNA) in CRC. Firstly, TINCR was selected using sequencing analyses and the starBase database. Cell Counting Kit-8, scratch wound heal...
Source: Pathology Research and Practice - September 4, 2019 Category: Pathology Source Type: research

Shp2 expression is upregulated in cervical cancer, and Shp2 contributes to cell growth and migration and reduces sensitivity to cisplatin in cervical cancer cells
In conclusion, Shp2 is involved in the occurrence and development of cervical cancer and may confer cisplatin resistance in cervical cancer. Shp2 blockade may be a new strategy for cervical cancer treatment. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 4, 2019 Category: Pathology Source Type: research

NOTCH Signaling Pathway and Non-coding RNAs in Cancer
Publication date: Available online 3 September 2019Source: Pathology - Research and PracticeAuthor(s): Jing Guo, Ping Li, Xiaomin Liu, Yanli LiAbstractMalignant tumors, known as cancer, seriously threaten human life and health. Cancer has the characteristics of abnormal cell differentiation, proliferation, invasion and metastasis. As a result, cancer often accompanied by poor prognosis and a lower survival rate. Notch signaling pathway is a highly conserved system in many multicellular organisms, and which has been proved to play a biological role in many cancers. In recent years, increasing evidence has shown that non-cod...
Source: Pathology Research and Practice - September 4, 2019 Category: Pathology Source Type: research

The application of antigen receptor gene rearrangement of BIOMED-2 in the pathologic diagnosis of 348 cases with non-Hodgkin lymphoma in a single institution in Southwest of China
Publication date: Available online 29 August 2019Source: Pathology - Research and PracticeAuthor(s): Xueni Liu, Hong He, Yuanxin Li, Ying Huang, Gang Li, Qiubo Yu, Wenwen Li, Dan LiAbstractObjectiveTo explore the clinical value of immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangement in the diagnosis of non-Hodgkin lymphoma.MethodsUsing the standardized BIOMED-2 multiplex PCR strategy to detect IgH, IgK and TCR in 272 cases of mature B-cell lymphoma, 55 cases of mature T-cell lymphoma, 21 cases of extranodal NK/ T-cell lymphoma, nasal type, and 20 cases of lymphoid tissue reactive hyperplasia.ResultsAmong all ma...
Source: Pathology Research and Practice - August 30, 2019 Category: Pathology Source Type: research

Small-cell carcinoma-associated ovarian mucinous carcinoma: a case report and literature review
Publication date: Available online 27 August 2019Source: Pathology - Research and PracticeAuthor(s): Jie Wei, Yingmei Wang, Peifeng Li, Linni Fan, Mingyang Li, Zhe WangAbstractNeuroendocrine neoplasm-associated ovarian mucinous carcinoma occurs extremely rarely. Here, we report an ovarian composite tumor consisting of small-cell carcinoma and mucinous carcinoma in a 51-year-old woman presented with abdominal distention. Ultrasonography revealed the presence of a complex irregular cystic solid mass. Microscopic findings showed pulmonary-type small-cell carcinoma-associated, intestinal-type ovarian mucinous carcinoma-with po...
Source: Pathology Research and Practice - August 28, 2019 Category: Pathology Source Type: research

The Relationship of Former Board Members of the German Society of Pathology to National Socialism: A Prosopographic Study
This study reaches the conclusion that the DGP executive boards and board members of the Federal Republic of Germany had much closer ties to the National Socialist Party than the DGP executive boards during the Third Reich did. It is precisely this finding that confirms the historical, political, and social relevance of this research project dedicated to reappraising this era in history. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 28, 2019 Category: Pathology Source Type: research

Dietary fat, cholesterol, and cholic acid affect the histopathologic severity of nonalcoholic steatohepatitis in Sprague-Dawley rats
Publication date: Available online 26 August 2019Source: Pathology - Research and PracticeAuthor(s): Ayumi Fukuda, Marin Sasao, Eri Asakawa, Sumire Narita, Mei Hisano, Kazuhito Suruga, Mayuko Ichimura, Koichi Tsuneyama, Kazunari Tanaka, Katsuhisa OmagariAbstractUnderstanding of the pathogenesis of nonalcoholic steatohepatitis (NASH)-associated fibrosis has been hampered by the lack of a comprehensive and physiological small animal model of NASH with fibrosis. Feeding a high-fat and high-cholesterol (HFC) diet supplemented with cholic acid to rats is known to replicate human NASH pathology, and it induces fibrosis earlier t...
Source: Pathology Research and Practice - August 27, 2019 Category: Pathology Source Type: research

Salivary Duct carcinoma: A case report of oncocytic variant with possible treatment implications and review of literature
Publication date: Available online 24 August 2019Source: Pathology - Research and PracticeAuthor(s): Radhika Sekhri, Shweta Agarwal (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2019 Category: Pathology Source Type: research

Upregulation of the long non-coding RNA FAM83H-AS1 in gastric cancer and its clinical significance
ConclusionOur results indicated that FAM83H-AS1 may function as an oncogene in gastric cancer and could be used as a prognosis predictor or diagnostic biomarker in gastric cancer. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2019 Category: Pathology Source Type: research

Apolipoprotein E is a predictive marker for assessing non-small cell lung cancer patients with lymph node metastasis
ConclusionsAPOE is a useful marker for assessing NSCLC patients with lymph node metastasis. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2019 Category: Pathology Source Type: research

Targeting Aurora Kinase B Attenuates Chemoresistance in Glioblastoma via a Synergistic Manner with Temozolomide
ConclusionElevated AURKB expression was strongly correlated to TMZ resistant acquisition and poor prognosis, furthermore, targeting AURKB would be a potential therapeutic target for GBM patients. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 24, 2019 Category: Pathology Source Type: research

Modulation of the endogenous Annexin A1 in a cigarette smoke cessation model: potential therapeutic target in reversing the damage caused by smoking?
ConclusionOur results showed that cigarette abstinence promoted partial recovery of the inflammatory process. The attenuation of the inflammatory profile may be associated with the overexpression of AnxA1 protein. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 24, 2019 Category: Pathology Source Type: research

Long Noncoding RNA PANDA Promotes Esophageal Squamous Carcinoma Cell Progress by Dissociating from NF-YA but Interact with SAFA
Publication date: Available online 22 August 2019Source: Pathology - Research and PracticeAuthor(s): Weihong Shi, Qian Wang, Yonghua Bian, Yanxin Fan, Yang Zhou, Tingting Feng, Zhouxiao Li, Xiufeng CaoAbstractEsophageal squamous cell carcinoma (ESCC) is one of the major global health problems, especially in Asia. Long non-coding RNAs (lncRNAs) have been increasingly identified and characterized in almost every aspect of biology, especially in cancer biology. This research desires to explore the regulatory mechanism of lncRNA PANDA (PANDA) on ESCC process. Quantitative real-time PCR (qRT-PCR) was carried out to detect the P...
Source: Pathology Research and Practice - August 23, 2019 Category: Pathology Source Type: research

Differences in intraosseous and extraosseous post-chemotherapy regression of Ewing sarcomas and their influence on prognosis
ConclusionsOn average, regression of ES seems to be worse in the extraosseous tumor compartment following preoperative chemotherapy. Moreover, extraosseous tumor regression may have a stronger prognostic influence on event-free survival than intraosseous regression. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 23, 2019 Category: Pathology Source Type: research

Lobular neoplasia and invasive lobular breast cancer: Inter-observer agreement for histological grading and subclassification
This study assessed the inter-observer agreement of histological grading in a series of ILBC and LN.54 cases (36x ILBC, 18x LN) were evaluated by 17 observers. 3978 classification calls on various histological features, including nuclear grade, proliferative activity (Ki67 immunohistochemistry, categorical scoring), histological grade and pleomorphism were obtained. Pairwise Cohen’s kappa values were calculated and compared between various features and different observer subsets with variable histomorphological experience.In ILBC, pairwise inter-observer agreement for histological grade ranged from poor to almost per...
Source: Pathology Research and Practice - August 21, 2019 Category: Pathology Source Type: research

Galectin-3 may serve as a marker for poor prognosis in colorectal cancer: A meta-analysis
Publication date: Available online 20 August 2019Source: Pathology - Research and PracticeAuthor(s): Chengyan Wang, Xiaoling Zhou, Luping Ma, Yanhua Zhuang, Yuanfeng Wei, Lu Zhang, Shan Jin, Weihua Liang, Xihua Shen, Changtao Li, Yinghong Wang, Lijuan PangAbstractGalectin-3 has an important function in the development of tumors. The purpose of this meta-analysis was to explore the relationships between the expression of galectin-3 on clinicopathological features and prognosis of colorectal cancer (CRC). A comprehensive literature search was used to identify eligible studies, and Stata software was conducted using in this m...
Source: Pathology Research and Practice - August 21, 2019 Category: Pathology Source Type: research

Editorial Board
Publication date: September 2019Source: Pathology - Research and Practice, Volume 215, Issue 9Author(s): (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 21, 2019 Category: Pathology Source Type: research

Thyroid-1 Transcription factor Expression in Salivary Gland Tumors
Publication date: Available online 19 August 2019Source: Pathology - Research and PracticeAuthor(s): Juliana Mançano Melhado Brod, Patricia Lourenção, Flávia Pedreira Pereira, Icléia Siqueira Barreto, Marcelo Sperandio, Vera C. Araújo, Andresa B. Soares, Ana Cláudia Garcia Rosa (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 20, 2019 Category: Pathology Source Type: research

Multiple Colonic and Ileal Perforations due to Unsuspected Intestinal Amoebiasis – Case Report and Review
Publication date: Available online 19 August 2019Source: Pathology - Research and PracticeAuthor(s): Hui Wang, Rani KanthanAbstractAmoebiasis, caused by the intestinal protozoan Entamoeba histolytica, though a relatively common parasitic disease in the tropical and subtropical regions, is uncommon in the developed countries. In these countries, as amoebic colitis shares similar clinical symptoms and endoscopic features with inflammatory bowel disease (IBD), these cases can be easily unrecognized and misdiagnosed.In this case report, we discuss the case of an adult patient with invasive intestinal amoebiasis, who was initia...
Source: Pathology Research and Practice - August 20, 2019 Category: Pathology Source Type: research

Indentification of breast cancer subtypes sensitive to HCQ-induced autophagy inhibition
ConclusionTo conclude, basal-like breast cancer represented by SUM-190 cells may be most sensitive to HCQ induced autophagy inhibition and the mechanism might be relative to Ras/Raf/ERK signaling pathway. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 20, 2019 Category: Pathology Source Type: research

MiR-1307 influences the chemotherapeutic sensitivity in ovarian cancer cells through the regulation of the CIC transcriptional repressor
ConclusionsOur data suggested that miR-1307 may be involved in the resistance of ovarian cancer to chemotherapy drugs via regulation of CIC, and should be further explored as a potential therapeutic target. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 20, 2019 Category: Pathology Source Type: research

Wuda granule, a traditional Chinese herbal medicine, ameliorates postoperative ileus by anti-inflammatory action
ConclusionsWDG treatment ameliorates the impaired gastrointestinal motility in the rat model of POI through inhibiting the inflammatory response of mesentery. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 20, 2019 Category: Pathology Source Type: research

MiR-188-5p and MiR-141-3p Influence Prognosis of Bladder Cancer and Promote Bladder Cancer Synergistically
Publication date: Available online 17 August 2019Source: Pathology - Research and PracticeAuthor(s): X.X. Yang, P. WangAbstractMicroRNA (miRNA) plays a significant role in suppressing the occurrence and development of tumor by inhibiting the translation of target proteins. Although previous researches have verified many miRNAs’ functions in bladder cancer (BC), the function of miR-188-5p and miR-141-3p in BC still remains unknown. Our experiment manifested that miR-188-5p and miR-141-3p were highly expressed in BC tissues and cells, which indicated a poor prognosis. In vitro functional assays suggested that down-regu...
Source: Pathology Research and Practice - August 18, 2019 Category: Pathology Source Type: research

Esophageal carcinoma cuniculatum: systematic review of the literature and report of two cases
ConclusionCC shows an indolent clinical behavior, with a low recurrence rate after radical surgery. The diagnosis of this rare tumor is typically made after surgery. An aggressive approach is required with curative intents. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 18, 2019 Category: Pathology Source Type: research

miR-182 contributes to cell adhesion-mediated drug resistance in multiple myeloma via targeting PDCD4
Publication date: Available online 17 August 2019Source: Pathology - Research and PracticeAuthor(s): Yaxun Wu, Xinghua Zhu, Rong Shen, Jieyu Huang, Xiaohong Xu, Song HeAbstractmiR-182 is a well-described oncogenic miRNA playing a crucial role in the development of many malignancies. However, the role of miR-182 in multiple myeloma (MM) remains unclear. Here, we demonstrate that adhesion of H929 and MM.1S cells to fibronectin could induce miR-182 expression and decrease PDCD4 expression. Furthermore, miR-182 was found to negatively regulate PDCD4 expression in H929 and MM.1S cells. In addition, PDCD4 down-regulation was req...
Source: Pathology Research and Practice - August 18, 2019 Category: Pathology Source Type: research

Clinicopathological and prognostic significance of TINCR in caner: a meta-analysis
ConclusionIn this study, we found that over-expression of TINCR may influence the tumor size and contribute to the poor prognosis of cancer. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 18, 2019 Category: Pathology Source Type: research

MiR-1193 was sponged by LINC00963 and inhibited cutaneous squamous cell carcinoma progression by targeting SOX4
In conclusion, our study firstly revealed the LINC00963/miR-1193/SOX4 axis in CSCC, indicating miR-1193 as a promising biological target in CSCC progression. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 17, 2019 Category: Pathology Source Type: research