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A possible new morphological variant of mantle cell lymphoma with plasma-cell type Castleman disease-like features
Publication date: Available online 18 September 2017 Source:Pathology - Research and Practice Author(s): Takuro Igawa, Rika Omote, Hiaki Sato, Kohei Taniguchi, Katsuya Miyatani, Tadashi Yoshino, Yasuharu Sato Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by overexpression of cyclin D1 resulting from t(11;14)(q13;q32) translocation. Herein, we report 3 cases of MCL with features of plasma cell-type Castleman disease (CD). The 3 patients were all men, ranging from 51 to 74 years in age, and they all presented with systemic lymphadenopathy with anemia, hypoalbuminemia, elevated serum levels of C-r...
Source: Pathology Research and Practice - September 20, 2017 Category: Pathology Source Type: research

A preliminary study on fetal lung injury in a rat model of acute pancreatitis in pregnancy
In this study, fetal lung injury as well as maternal pancreas and placenta injuries occurred in a time-dependent manner. The levels of serum amylase, lipase and TNF-α were markedly increased in maternal rats, and the levels of surfactant proteins A, B, C and D in fetal lungs were significantly decreased in the fetal lungs of the AP group. Ultrastructure injuries and the dysregulated synthesis and secretion of pulmonary surfactant proteins were observed in the AP group. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 20, 2017 Category: Pathology Source Type: research

Involvement of Bmi-1 gene in the development of gastrointestinal stromal tumor by regulating p16Ink4A/p14ARF gene expressions: an in vivo and in vitro study
Conclusions These collection of data indicated that the down-regulated Bmi-1 might inhibit the proliferation, invasion, and migration of GIST cells and can be subsequently linked to the incidence and developing a prognosis of GIST. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 20, 2017 Category: Pathology Source Type: research

The diagnostic role of plasma circulating precursors of miRNA-944 and miRNA-3662 for non-small cell lung cancer detection
Conclusion Circulating pri-miRNA-944 and 3662 can improve non-invasive NSCLC detection of operable stages of SCC and AC. miRNA precursors could be considered as novel potential lung cancer biomarkers. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 20, 2017 Category: Pathology Source Type: research

Identification of P4HA1 as a prognostic biomarker for high-grade gliomas
Conclusions P4HA1 was upregulated in gliomas. High expression of P4HA1 was correlated with the malignancy of gliomas and could serve as a prognostic indicator for patients with high-grade gliomas. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 20, 2017 Category: Pathology Source Type: research

PD-L1 expression in HNPCC-associated colorectal cancer
Conclusion A subset of HNPCC-associated colorectal cancers in this study clearly showed PD-L1 expression of tumor epithelia and immune cells, therefore, the detection of PD-L1 status is useful. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 19, 2017 Category: Pathology Source Type: research

Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells
In this study, we investigated apoptosis induced by EGCG and the underlying molecular mechanisms in human esophageal squamous cell carcinoma cells. The growth-inhibitory effects of EGCG on esophageal cancer cell (Eca109 and Ec9706) were detected by MTT. Using flow cytometry, we determined the cellular apoptosis, bcl-2, bax and caspase-3 protein expression in Eca109 and Ec9706 cells following treatment with EGCG for 24h. After treatment of Eca109/ABCG2 (an esophageal cancer multidrug resistance cell line) cells with adriamycin (ADM) combined with EGCG for 24h, the cellular apoptosis, mitochondrial membrane potential, ADM co...
Source: Pathology Research and Practice - September 13, 2017 Category: Pathology Source Type: research

Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma
Publication date: Available online 12 September 2017 Source:Pathology - Research and Practice Author(s): Takeharu Imai, Naohide Oue, Yuji Yamamoto, Ryuichi Asai, Naohiro Uraoka, Kazuhiro Sentani, Kazuhiro Yoshida, Wataru Yasui Esophageal squamous cell carcinoma (ESCC) is one of the most common human cancers. We previously reported that KIFC1 is involved in gastric cancer pathogenesis and that KIFC1 plays an important role in gastric cancer spheroid colony formation. However, the significance of KIFC1 in ESCC has not been examined. In the present study, we analyzed the expression and distribution of KIFC1 in 132 ESCC cases...
Source: Pathology Research and Practice - September 13, 2017 Category: Pathology Source Type: research

DIP2C expression in breast cancer and its clinical significance
Conclusion our data revealed DIP2C expression level decreased in breast cancer, especially in basal-like and HER-2 subtypes, and could be a valuable target for diagnosis on specific subtype of breast cancer. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 13, 2017 Category: Pathology Source Type: research

The down-regulation of TAPP2 inhibits the migration of esophageal squamous cell carcinoma and predicts favorable outcome
Publication date: Available online 12 September 2017 Source:Pathology - Research and Practice Author(s): Fang Liu, Fei Ye, Zongyu Guan, Yi Zhou, Fengjun Ji, Qing Zhang, Jianping Zhang, Tianyi Zhang, Songhua Lu Tandem PH domain-containing proteins TAPP1 and TAPP2 are adaptor proteins that specifically bind to phosphatidylinositol-3,4-bisphosphate, or PI(3,4)P2, a product of phosphoinositide 3-kinases (PI3K). Although PI3K enzymes have multiple functions in cell biology, including cell migration, the functions of PI (3, 4) P2 and its binding proteins are not well understood. Previously studies found that TAPP2 is highly exp...
Source: Pathology Research and Practice - September 13, 2017 Category: Pathology Source Type: research

Downregulation of FOXP3 inhibits cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma
Publication date: Available online 8 September 2017 Source:Pathology - Research and Practice Author(s): Chun Li, Liwei Sun, Rui Jiang, Peng Wang, Haogang Xue, Yudong Zhan, Xiaodong Gai Our study aimed to investigate the biological role of FOXP3 expression in human lung adenocarcinoma (LAD) tissues and evaluate its involvement in cell proliferation and chemosensitivity to cisplatin in LAD cells. Paraffin-embedded tissues from 50 LAD patients were collected to detect FOXP3 and Ki-67 expression using immunohistochemistry (IHC). Downregulation of FOXP3 in A549 cells was performed using siRNA transfection. Real-time PCR or wes...
Source: Pathology Research and Practice - September 9, 2017 Category: Pathology Source Type: research

Upregulation of uc.189 in patients with esophageal squamous cell carcinoma and its clinicopathologic value
This study was to identify the prognostic value of uc.189 expression in esophageal squamous cell carcinomas (ESCC). Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of uc.189 in matched cancerous tissues and adjacent noncancerous tissues from 152 patients with ESCC. The correlation of uc.189 with clinicopathological features and prognosis were also analyzed. The expression of uc.189 was significantly higher in human ESCC compared with the adjacent noncancerous tissues (122/152, 80.3%, p<0.01), and the high level of uc.189 expression was significantly correlated with ...
Source: Pathology Research and Practice - September 8, 2017 Category: Pathology Source Type: research

Histiocytoid cardiomyopathy and ventricular noncompaction presenting as sudden death in an adult male
We report the case of a 45-year-old man with an increased heart weight and involvement of both ventricles by HCM and VNC cardiomyopathy. Besides, multiple foci of myocardial disorganization were detected. He died suddenly while hiking. The association of both processes HCM and VNC was an unexpected finding at autopsy. The death was linked to functional abnormalities of the cardiac histiocytoid cells, and it was favored by a state of abnormal development of the heart. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 8, 2017 Category: Pathology Source Type: research

AEG-1 mRNA expression in non-small cell lung cancer is associated with increased tumor angiogenesis
Publication date: Available online 7 September 2017 Source:Pathology - Research and Practice Author(s): Zhihong Ma, Yingrong Chen, Shunli Dong, Xuting Xu, Jin Liu, Pengtao Song, Caihua Yu, Licheng Dai Astrocyte-elevated gene-1 (AEG-1) is implicated in the oncogenesis and angiogenesis of various types of human malignant disease. However, the angiogenesis roles of AEG-1 in non-small cell lung cancer (NSCLC) remain to be further elucidated. In the present study, the expression level of AEG-1 mRNA in seven human lung cell lines and 89 paired tissue samples (tumor tissues (TTs) and pair-matched normal adjacent tissues (PMNATs)...
Source: Pathology Research and Practice - September 8, 2017 Category: Pathology Source Type: research

TIMP-3 mRNA expression levels positively correlates with levels of miR-21 in in situ BC and negatively in PR positive invasive BC
Conclusion These data suggest that signaling pathways involved in formation and progression of BCs in groups formed according to invasiveness might be different. Our findings propose that TIMP-3 mRNA expression levels could be significant prognostic parameter, but within specific BC subtypes. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 7, 2017 Category: Pathology Source Type: research

Current insight in the localized insulin-derived amyloidosis (LIDA): clinico-pathological characteristics and differential diagnosis
Conclusion The identification of amyloid material and immunoreactivity with anti-insulin antibodies are key diagnostic features of LIDA. Although several clinical and animal studies were made in recent years, the lesion is still under-diagnosed and underreported. The clinical suspicion and knowledge of the lesion play a crucial role for the accurate diagnosis of LIDA. Surgical excision of the lesion can dramatically decrease insulin requirement and improve glycemic control. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 2, 2017 Category: Pathology Source Type: research

Molecular Characterization of a Series of Solitary Fibrous Tumors, including Immunohistochemical expression of STAT6 and NATB2-STAT6 Fusion Transcripts, using Reverse Transcriptase(RT) –Polymerase Chain Reaction(PCR) Technique: An Indian Experience
This study reinforces high sensitivity and specificity of NAB2-STAT6 fusion and its correlation with strong and diffuse IHC expression of STAT6 in a SFT, irrespective of its occurrence in various body sites and its histopathologic types. NAB2ex4-STAT6ex2 and NAB2ex7-STAT6ex2 fusions were relatively more frequently observed in our patients. Atypical and malignant SFTs, together, were more frequently associated with relatively aggressive clinical outcomes. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 27, 2017 Category: Pathology Source Type: research

p38MAPK family isoform p38 α and activating transcription factor 2 are associated with the malignant phenotypes and poor prognosis of patients with ovarian adenocarcinoma
This study was to identify the biomarkers for the malignancy and poor prognosis in patients with ovarian cancer. The protein expression of p38MAPK family isoform p38α (p38α) and activating transcription factor 2 (ATF2) was measured in 120 ovarian serous adenocarcinomas and 34 normal fallopian tubes using immunohistochemistry. Stable OV-90 cells expressing p38α and ATF2 inhibitor were established using shRNA lentivirus. Cell proliferation, invasion, and migration were analyzed in vitro. Tumor growth and chemosensitivity were investigated in xenograft tumor models. The percentage of positive p38α and ...
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

miR-155 targets Est-1 and induces ulcerative colitis via the IL-23/17/6-mediated Th17 pathway
Conclusion miR-155 seems to target Est-1 and induces UC via the IL-23/17/6-mediated Th17 pathway. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Correlation between HBV protein preS2 and tumor markers of hepatocellular carcinoma
Conclusion The expression of preS2 protein relates closely to HCC markers AFP and GPC3. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Immunohistochemical analysis of NKX2.2, ETV4, and BCOR in a large series of genetically confirmed Ewing sarcoma family of tumors
In conclusion, NKX2.2, ETV4 and BCOR IHC may be helpful in daily practice for distinguishing ESFT from CIC or BCOR-associated sarcomas, especially in hospitals without access to molecular assays. In addition, the combination of strong CD99 membranous positivity and nuclear NKX2.2 positivity seems to be very reliable for ESFT diagnosis in an appropriate clinicoradiological setting. So far no antibody is entirely specific for ESFT diagnosis, and the IHC or molecular results in round cell tumors of bone may be strongly influenced by decalcification processes. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Melanotic MiT family translocation neoplasms: Expanding the clinical and molecular spectrum of this unique entity of tumors
We report 2 rare cases of melanotic translocation renal neoplasms. The first is a melanotic TFE3 translocation renal cancer with an indolent clinical course, occurring in a patient more than 3-decades older than the usual average age in which such tumors have been described. The other case is, to our knowledge, the first reported melanotic TFEB translocation cancer of the kidney. Both cases exhibit the same H&E morphology as previously reported in melanotic translocation renal cancers and label accordingly with HMB45 and Melan-A. While the TFE3 melanotic tumor lacked any evidence of renal tubular differentiation, t...
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Prognostic relevance of tripartite motif containing 24 expression in colorectal cancer
In conclusion, our study suggests that TRIM24 may play a role in colorectal carcinogens and serve as a potential prognostic marker of human colorectal cancer. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Modulation of Galectin-3 and Galectin 9 in gastric mucosa of patients with chronic gastritis and positive Helicobacter pylori infection.
CONCLUSION Up modulation of Gal-3 expression was associated with H. pylori infection and down modulation of Gal-9 with the inflammatory process of chronic gastritis. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Acquisition of histologic diversity contributes to not only invasiveness but also lymph node metastasis in early gastric cancer
Conclusions We demonstrated that lymphatic invasion was the most important and powerful parameter for LNM in early gastric cancers. In addition, tumor invasiveness into the muscularis mucosae was accompanied by tumor histologic diversity. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Insulin-like growth factor binding protein-1 (IGFBP-1) upregulated by Helicobacter pylori and is associated with gastric cancer cells migration
In this study, we assessed the expression and release of IGFBP-1 from gastric cancer cells with H. pylori 26695 infection and the biological functions of IGFBP-1 in gastric cancer cells. The results showed that the expression and release of IGFBP-1 were increased in gastric cancer cells (MGC-803, BGC-823, SGC-7901) infected with H. pylori 26695. In addition, the upregulation of IGFBP-1 was dose-dependent in BGC-823 cells infected with H. pylori 26695 but not time-dependent. The upregulation of IGFBP-1 got to peak at 12h after H. pylori 26695 infection and then decreased over time. Subsequently, we measured its functions by...
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Expression of STIM1 is associated with tumor aggressiveness and poor prognosis in breast cancer
In this study, we investigate the correlation between STIM1 expressions with clinicopathologic features and prognosis quantified by disease-free survival (DFS) and overall survival (OS). To assess STIM1 expression, we conducted immunohistochemistry assays using breast cancer tissues encompassing a total of 165 breast cancer cases with detailed follow-up data and 40 cases of matched samples including cancer and adjacent normal tissues. STIM1 expression was present in 66.1% (109/165) of breast cancer cases which was significantly higher than adjacent non-tumor tissues. Larger tumors, lymphnode metastasis and negative estroge...
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Autophagy Analysis in Oral Carcinogenesis
Conclusion The levels of autophagy increased during the process of oral carcinogenesis and are correlated with poorer behavior of the leukoplakias. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 6, 2017 Category: Pathology Source Type: research

Evaluation of expression of genes CADM1, TWIST1 and CDH1 by immunohistochemestry in melanocytic lesions
Conclusion These findings allow us to conclude that the immunohistochemical expression of CADM1 has the potential to contribute as an auxiliary tool to the differential diagnosis between nevi and melanomas. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 2, 2017 Category: Pathology Source Type: research

Thyroid Transcription Factor-1 promotes lymph node metastasis by inducing lymphangiogenesis in ovarian carcinoma
Conclusions These findings indicated the occasional expression of TTF-1 immunoreactivity of ovarian carcinomas should be considered in the evaluation of neoplasms of unknown primary origin and TTF-1 might be involved in lymph node metastasis of ovarian carcinomas in the presence of lymphangiogenesis. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 2, 2017 Category: Pathology Source Type: research

Exploration of the pathways and interaction network involved in bladder cancer cell line with knockdown of Opa interacting protein 5
Conclusions OIP5 interaction network might function as an oncogene in BC progression based on aberrant inflammatory responses. Our study might provide valuable information for investigation of tumorigenesis mechanism in BC. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 2, 2017 Category: Pathology Source Type: research

Cytological and histological changes in the urothelium produced by electromotive drug administration (EMDA) and by the combination of intravescical hyperthermia and chemotherapy (thermochemotherapy)
Publication date: Available online 1 August 2017 Source:Pathology - Research and Practice Author(s): Francesco Pierconti, Patrizia Straccia, Sacco Emilio, Pier Francesco Bassi, Ivana De Pascalis, Rita C. Marques, Metka Volavsek, Luigi M. Larocca, Antonio Lopez-Beltran The treatment of non muscle-invasive bladder cancer (NMIBC) encompasses a range of different procedures. Electromotive drug administration (EMDA) and chemo-hyperthermia (C-HT; Synergo) represent a minimally-invasive methods of intravesical instillation of therapeutic agents as mitomycin C (MMC). We selected patients with high grade NMIBC, BCG non responder, ...
Source: Pathology Research and Practice - August 2, 2017 Category: Pathology Source Type: research

Expression and clinicopathological significance of hematopoietic pre-B cell leukemia transcription factor-interacting protein in cervical carcinoma
This study investigated the correlations of HPIP expression with clinicopathological factors and prognosis of cervical carcinoma patients. Expression of HPIP was detected in CC from 167 patients along with 45 corresponding normal cervical specimens by immunohistochemistry. HPIP immunoreactivity was overexpressed in CC cases compared with that in normal endometrium (P < 0.05). High HPIP expression was positively correlated with FIGO stage, histological grade, lymph node metastasis and recurrence (P < 0.05). Patients with high HPIP expression exhibited significantly poorer overall survival (OS) and disease-free...
Source: Pathology Research and Practice - August 2, 2017 Category: Pathology Source Type: research

Grb7 is over-expressed in cervical cancer and facilitate invasion and inhibit apoptosis in cervical cancer cells
The objective of this study was to investigate the expression of Grb7 and its clinicopathological significance in cervical cancer. Utilising immunohistochemical staining, we examined the expression of Grb7 in 120 cases of human cervical cancer tissue and 10 cases of adjacent non-cancerous cervical tissue. The positive rate of Grb7 protein expression was 34.2%, which was significantly higher than that in adjacent non-cancerous cervical tissue (0%, p<0.05). The expression of Grb7 was found to be correlated with age, tumor size, serosal invasion, differentiated degree, tumor stage, early or advanced stage and lymph nod...
Source: Pathology Research and Practice - July 27, 2017 Category: Pathology Source Type: research

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) in a young female athlete at 36 weeks gestation: a case report
Publication date: Available online 25 July 2017 Source:Pathology - Research and Practice Author(s): Hae Yoon Grace Choung, Monika Vyas, Daniel Jacoby, Brian West A 26year old east African professional athlete presented to the obstetric clinic for a routine visit at 36 weeks gestation. She had a history of Right Ventricular Outflow Tract − Ventricular Tachycardia (RVOT-VT) with an episode of cardiac arrest in the past, and had been treated with ablation 4 years earlier. Her current visit was uneventful, her pregnancy progressing normally. Following the visit she went to a local restaurant where she suffered a cardiac...
Source: Pathology Research and Practice - July 26, 2017 Category: Pathology Source Type: research

Pancreatic Heterotropia in wall of Extra-hepatic Choledochal Cysts: A Retrospective Analysis of Thirteen of such cases from North India
Conclusions HP rests in the wall of CC though rare; their coexistence with peribiliary glands may possibly indicate their common embryonic origin. As a common site of inflammation, HP rest may be one of the common causes of CC. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - July 26, 2017 Category: Pathology Source Type: research

Prognostic role of Nectin-4 expression in luminal B (HER2 negative) breast cancer
Publication date: Available online 24 July 2017 Source:Pathology - Research and Practice Author(s): Jasmina Rajc, Damir Gugić, Irena Fröhlich, Ksenija Marjanović, Boris Dumenčić Nectins are Ca2+-independent immunoglobulin (Ig) superfamily proteins that participate in the organization of epithelial and endothelial junctions and regulate several cellular activities including the entry of some viruses. Nectin-4 has recently been shown as a metastasis-associated protein in several cancers. In the following study, we have evaluated the expression of Nectin-4 inthe luminal B HER2 negative subtype breast cancer. The stu...
Source: Pathology Research and Practice - July 25, 2017 Category: Pathology Source Type: research

Nuclear maspin expression: a biomarker for budding assessment in colorectal cancer specimens
Conclusion For the colorectal carcinomas, the infiltrative aspect at macroscopic evaluation and nuclear maspin in the buds might be used as indicators of risk for lymph node metastases. Maspin nuclear expression in the buds may be helpful for a proper budding assessment and may serve as a negative prognostic factor. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - July 25, 2017 Category: Pathology Source Type: research

Forkhead box protein A2, a pioneer factor for hepatogenesis, is involved in the expression of hepatic phenotype of alpha-fetoprotein-producing adenocarcinoma
Publication date: Available online 23 July 2017 Source:Pathology - Research and Practice Author(s): Nobuhisa Yamamura, Kazunori Fugo, Takashi Kishimoto Alpha-fetoprotein (AFP)-producing adenocarcinoma is a high-malignant variant of adenocarcinoma with a hepatic or fetal-intestinal phenotype. The number of cases of AFP-producing adenocarcinomas is increasing, but the molecular mechanism underlying the aberrant production of AFP is unclear. Here we sought to assess the role of Forkhead box A (FoxA)2, which is a pioneer transcription factor in the differentiation of hepatoblasts. FoxA2 expression was investigated in five cas...
Source: Pathology Research and Practice - July 24, 2017 Category: Pathology Source Type: research

Clinicopathologic and molecular characterization of mammary analogue secretory carcinoma of salivary gland origin
Conclusion Our clinicopathological data are in keeping with previous studies; in most cases, MASC is a low-grade malignancy with overall favorable prognosis. In rare cases, however, MASC with high-grade transformation may behave aggressively, and these patients could benefit from targeted biological treatment using tyrosine kinase inhibitors. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - July 24, 2017 Category: Pathology Source Type: research

Granulomas within renal epithelial neoplasms in patients with sarcoidosis: A causal association?
Publication date: Available online 23 July 2017 Source:Pathology - Research and Practice Author(s): Nasma K. Majeed, Andres M. Acosta, Andre Kajdacsy-Balla, Suman Setty, Nathan A. Aardsma Sarcoidosis is a chronic granulomatous disease that can involve virtually every organ system, but most commonly presents as lung, skin, or lymph node disease. Although kidney involvement is usually clinically silent, granulomatous interstitial nephritis − the hallmark of renal sarcoidosis − can lead to functional impairment and organ failure. Also, recent studies have suggested an association between sarcoidosis and an increa...
Source: Pathology Research and Practice - July 24, 2017 Category: Pathology Source Type: research

Analysis of CD15, CD57 and HIF-1 α in biopsies of patients with peri-implantitis
Publication date: Available online 23 July 2017 Source:Pathology - Research and Practice Author(s): Márcia Fernandes de Araújo, Renata Margarida Etchebehere, Marcelo Luiz Ribeiro de Melo, Marcela Beghini, Viviane Oliveira Severino, Eliângela de Castro Côbo, Denise Bertulucci Rocha Rodrigues, Sanívia Aparecida de Lima Pereira Peri-implantitis is an infectious disease characterized by inflammation of the tissues surrounding the implant, bleeding on probing with or without suppuration, and bone loss. Peri-implant lesions contain a leukocyte infiltrate of plasma cells, lymphocytes, macrophages...
Source: Pathology Research and Practice - July 24, 2017 Category: Pathology Source Type: research

Mast cells in calcific aortic stenosis
This study is aimed at examining the presence of CD117 − positive mast cells in CAS. In 56 examined calcified aortic valves excised by cardiac surgery, mast cells were constantly present as a part of the polymorphous cellular infiltrate; in individual cases, their numbers were 1–90 (median 24). The numbers were significantly higher in the congenitally malformed/bicuspid valves (median 40) than in the tricuspid ones (median 20). In valves with presence of metaplastic bone, mast cells were significantly more numerous (median 42) than in those without metaplasia (median 20). In 12 normal aortic valves obtained at ...
Source: Pathology Research and Practice - July 24, 2017 Category: Pathology Source Type: research

Low SIRT3 expression contributes to tumor progression, development and poor prognosis in human pancreatic carcinoma
Publication date: Available online 23 July 2017 Source:Pathology - Research and Practice Author(s): Shanshan Huang, Xiong Chen, Jiawei Zheng, Yufang Huang, Li Song, Yin Yin, Jianping Xiong SIRT3, an important mitochondrial protein, may act as either an oncogene or tumor suppressor depending on the tumor-type. The aim of this study was to investigate the expression of SIRT3 in pancreatic carcinoma (PC) and its clinical association in PC patients. Immunohistochemistry was adopted to investigate the expression of SIRT3 in cancer and corrresponding adjacent non-cancer tissues across 79 patients with PC. The log-rank test and ...
Source: Pathology Research and Practice - July 24, 2017 Category: Pathology Source Type: research

Clinicopathological and immunohistochemical analysis of epithelial-lined (true) cysts of the adrenal gland with proposal of a new histogenetic categorization
Publication date: Available online 21 July 2017 Source:Pathology - Research and Practice Author(s): Łukasz Koperski, Paweł Pihowicz, Benedykt Szczepankiewicz, Łukasz Fus, Agata Cyran, Magdalena Bogdańska, Barbara Górnicka Epithelial- lined (true) cysts are rare lesions and until now the only information we had about their histogenesis was based on the analysis of a few cases. We retrospectively reviewed 8 cases of cysts with a true epithelial lining (confirmed immunohistochemically). The pathological findings and immunohistochemical analysis of the epithelial linings allowed for categorization of the cysts into...
Source: Pathology Research and Practice - July 22, 2017 Category: Pathology Source Type: research

Alpha subunit in clinically non-functioning pituitary adenomas: an immunohistochemical study
Publication date: Available online 16 July 2017 Source:Pathology - Research and Practice Author(s): Michael Solarski, Fabio Rotondo, Luis V. Syro, Michael D. Cusimano, Kalman Kovacs Pituitary adenomas may be classified as either functioning or non-functioning, depending on whether excess hormone secretion can be clinically identified. Of the six hormones produced in the anterior pituitary, TSH, FSH and LH are known as glycoproteins and contain two subunits (α and β). While α-subunit is identical within all of them, each β-subunit is unique and biologically specific. Independently, the α- and &b...
Source: Pathology Research and Practice - July 17, 2017 Category: Pathology Source Type: research

Tissue Hemostasis is Shifted Toward Thrombogenesis in the Psoriatic Plaques
Conclusions A local procoagulable state found in psoriatic plaques suggests a significant role of local tissue hemostasis in pathogenesis of the disease. These findings indicate another potential target for a therapeutic approach in patients with psoriasis, although further research would help elucidate the exact mechanisms. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - July 16, 2017 Category: Pathology Source Type: research

Upregulation of Caprin1 Expression is Associated with Poor Prognosis in Hepatocellular Carcinoma
In conclusion, high Caprin1 expression independently predicts a poor outcome for patients with HCC, supporting that Caprin1 may be a promising novel HCC prognostic factor. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - July 16, 2017 Category: Pathology Source Type: research

Congenital undifferentiated sarcoma associated to BCOR-CCNB3 gene fusion
We report the unusual case of a congenital BCOR-CCNB3 retroperitoneal sarcoma in a female born at 34th gestational week, which was diagnosed in necropsy after 21h of life. Immunohistochemical analysis showed diffuse expression of CD99 and CCNB3. SNPa showed two focal segmentary deletions at 5q34 and 22q11.23, the latter harboring among others the SMARCB1/INI1 tumor suppressor gene. Immunohistochemistry confirmed loss of INI1 in tumor cells, which has not been previously reported in this type of undifferentiated sarcomas. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - July 15, 2017 Category: Pathology Source Type: research

PKC- δ attenuates the cancer stem cell among squamous cell carcinoma cells through down-regulating p63
In conclusion, PKC-δ played as a protective role in SCC partly by down-regulating p63, leading to the suppression of SCC cell proliferation, attenuation of the activity and expression of CSCs in SCC cells. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - July 15, 2017 Category: Pathology Source Type: research