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Pathobiology of HER 2 positive small invasive (T1a,b) breast cancer: “A wolf in sheep’s clothing”
Publication date: Available online 9 October 2017 Source:Pathology - Research and Practice Author(s): Joško Bezić, Ivana Šamija Projić, Petar Projić, Kristina Meljanac Salopek, Piero Marin Živković, Joško Božić, Snježana Tomić Small invasive breast cancers (cancers with maximum diameter <1cm, T1a,b) become more prevalent form of breast cancer as a result of the introduction of breast cancer mammographic screening programs. Although associated with an excellent prognosis, T1a,b breast cancers are heterogeneous group of tumors with prognostically unfavorable subset of cases, primarily th...
Source: Pathology Research and Practice - October 14, 2017 Category: Pathology Source Type: research

Circulating microRNA-339-5p and -21 in plasma as an early detection predictors of lung adenocarcinoma
Conclusion Plasma miR-339-5p or miR-21 could serve as a potential biomarker for diagnosis of LA, however, the combination of miR-339-5p and miR-21 was more efficient for LA detection. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - October 14, 2017 Category: Pathology Source Type: research

Overexpression of microRNA-495 improves the intestinal mucosal barrier function by targeting STAT3 via inhibition of the JAK/STAT3 signaling pathway in a mouse model of ulcerative colitis
Publication date: Available online 12 October 2017 Source:Pathology - Research and Practice Author(s): Xian-Qun Chu, Jing Wang, Guang-Xiang Chen, Guan-Qi Zhang, De-Yong Zhang, Yong-Yan Cai We aim to investigate the role of microRNA-495 (miR-495) in the intestinal mucosal barrier by indirectly targeting signal transducer and activator of transcription 3 (STAT3) through the Janus kinase-signal transducer and activator of transcription (JAK)/STAT3 signaling pathway in a mouse model of ulcerative colitis (UC). BALB/c mice were selected for establishing a mice model of UC, and intestinal tissues of normal and UC mice were coll...
Source: Pathology Research and Practice - October 13, 2017 Category: Pathology Source Type: research

Over expression of HIF1 α is associated with inactivation of both LimD1 and VHL in renal cell carcinoma: clinical importance
In this study, the expression of LimD1, VHL and HIF1α was analyzed in primary renal cell carcinoma (RCC) samples to understand their association with development of the disease. For this purpose, immunohistochemical expression analysis of LimD1, VHL and HIF1α was performed along with proliferation marker PCNA in 32 primary RCC samples in different subtypes at different clinical stages of Indian patients (year: 2014–2016). Significant decrease (P<0.05) in LimD1 and VHL expression was observed in different subtypes of RCC and in early invasive lesions. High nuclear expression of HIF1α was seen ...
Source: Pathology Research and Practice - October 11, 2017 Category: Pathology Source Type: research

Aberrant promoter methylation of the PAQR3 gene is associated with prostate cancer
Publication date: Available online 10 October 2017 Source:Pathology - Research and Practice Author(s): Kowit Lounglaithong, Andrey Bychkov, Pichet Sampatanukul Methylation markers are promising tools for diagnosis, prognosis and targeted treatment of cancer. In prostate carcinoma, aberrant promoter hypermethylation occurs earlier in the disease course and more consistently than recurrent somatic mutations. PAQR3, a tumor suppressor gene, was recently found to be downregulated in prostate cancer cell lines. We hypothesized that promoter methylation could be responsible for PAQR3 silencing in prostate cancer tissues. We aim...
Source: Pathology Research and Practice - October 11, 2017 Category: Pathology Source Type: research

Down-regulation of miR-26a-5p in hepatocellular carcinoma: a qRT-PCR and bioinformatics study
Conclusion Down-regulated miR-26a-5p was closely correlated with the status of metastasis and the progression of HCC. MiR-26a-5p might play protective roles by targeting diverse genes and pathways. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - October 11, 2017 Category: Pathology Source Type: research

The correlation between XIAP gene polymorphisms and esophageal squamous cell carcinoma susceptibility and prognosis in a Chinese population
Conclusion The present study demonstrates that XIAP rs8371 and rs9856 are associated with susceptibility to ESCC, and rs8371 polymorphisms might serve as an indicator for improved clinical efficacy and prognosis of ESCC patients. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - October 10, 2017 Category: Pathology Source Type: research

PATHOBIOLOGY OF HER 2 POSITIVE SMALL INVASIVE (T1a,b) BREAST CANCER: A WOLF IN SHEEP'S CLOTHING
Publication date: Available online 9 October 2017 Source:Pathology - Research and Practice Author(s): Joško Bezić, Ivana Šamija Projić, Petar Projić, Kristina Meljanac Salopek, Piero Marin Živković, Joško Božić, Snježana Tomić Small invasive breast cancers (cancers with maximum diameter <1cm, T1a,b) become more prevalent form of breast cancer as a result of the introduction of breast cancer mammographic screening programs. Although associated with an excellent prognosis, T1a,b breast cancers are heterogeneous group of tumors with prognostically unfavorable subset of cases, primarily th...
Source: Pathology Research and Practice - October 10, 2017 Category: Pathology Source Type: research

Combined Detection of Insulin-Like Growth Factor-Binding Protein 7 Promoter Methylation Improves the Diagnostic Efficacy of AFP in Hepatitis B Virus-associated Hepatocellular Carcinoma
This study quantitatively assessed serum insulin-like growth factor-binding protein 7 (IGFBP7) promoter methylation in hepatocellular carcinoma (HCC), and explored its clinical value. A total of 80 patients with hepatitis B virus-associated HCC, 35 patients with chronic hepatitis B (CHB), and 20 healthy controls (HC) were enrolled. MethyLight was used to quantitatively assess the methylation levels of serum IGFBP7 promoter. A logistic regression model was established for the combined evaluation of AFP and serum IGFBP7 promoter methylation. The results showed that mean methylation levels of serum IGFBP7 promoter were signif...
Source: Pathology Research and Practice - October 10, 2017 Category: Pathology Source Type: research

DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma
In this study, we gene expression profiled (GEP) shDNMT1-treated germinal center B-cell-like DLBCL (GCB-DLBCL)-derived cell line (i.e. HT) compared with non-silencing shRNA (control shRNA)-treated HT cells. Independent gene set enrichment analysis (GSEA) performed using GEPs of shRNA-treated HT cells and primary GCB-DLBCL cases derived from two publicly-available datasets (i.e. GSE10846 and GSE31312) produced three separate lists of enriched gene sets for each gene sets collection from Molecular Signatures Database (MSigDB). Subsequent Venn analysis identified 268, 145 and six consensus gene sets from analyzing gene sets i...
Source: Pathology Research and Practice - October 10, 2017 Category: Pathology Source Type: research

miRNA Genetic Variants: as Potential Diagnostic Biomarkers For Oral Cancer
Publication date: Available online 10 October 2017 Source:Pathology - Research and Practice Author(s): Divya Tandon, Jayant Dewangan, Sonal Srivastava, Vivek Kumar Garg, Srikanta Kumar Rath MicroRNAs (miRNAs) comprise a novel class of small, non-coding endogenous RNAs that have a role in the plethora of regulatory activities by directing their target mRNAs for degradation or translational repression. Single nucleotide polymorphisms (SNPs) in miRNA genes can lead to alteration in mRNA expression, resulting in serious consequences. Detection of miRNA-polymorphisms can potentially improve diagnosis, treatment, prognosis in p...
Source: Pathology Research and Practice - October 10, 2017 Category: Pathology Source Type: research

Comparative Assessment of three Methods to Analyze MGMT Methylation Status in a Series of 350 Gliomas and Gangliogliomas
This study demonstrated that qMSP is an effective and rapid detection method for routine use in pathology laboratories for the identification of MGMT promoter methylation. A combination of IHC and qMSP assays can provide high sensitivity and specificity for the prediction of MGMT status. A few cases that tested negative with PSQ did harbor MGMT promoter methylation, as confirmed by qMSP and sequencing, and this subgroup of patients may benefit from temozolomide. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - October 10, 2017 Category: Pathology Source Type: research

Correlation of lysosome-associated protein transmembrane-4 β gene overexpression with the malignant phenotypes of hepatocellular carcinoma
In conclusion, our results indicated that LAPTM4B plays an important role in the promotion of hepatocarcinogenesis and cancer progression and may serve as a biomarker for the diagnosis and monitoring of HCC. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - October 8, 2017 Category: Pathology Source Type: research

A TERT-CLPTM1 locus polymorphism (rs401681) is associated with EGFR mutation in non-small cell lung cancer
We examined the clinicopathological and prognostic value of rs401681 variants in lung cancer. The relationship between rs401681 variants and telomere length was analyzed in 134 non-small cell lung cancers (NSCLCs). The rs401681 polymorphism had the following genotype frequencies: C/C in 52.2% of the samples, C/T in 30.6%, and T/T in 17.2%. The T allele showed a strong correlation with EGFR mutation (p=0.037). Telomeres in the tumor samples were 3.26-fold longer, on average, than telomeres in matched normal samples (SD=0.48), and there were no differences in telomere length according to rs401681 polymorphism. Smoking was as...
Source: Pathology Research and Practice - October 8, 2017 Category: Pathology Source Type: research

Knockdown of PINCH-1 protein sensitizes the Estrogen positive breast cancer cells to chemotherapy induced apoptosis
Conclusion The results suggest that PINCH-1 may be playing an important role in etiopathogenesis of both subtypes breast cancer. However, enhanced apoptosis observed only in estrogen positive and not in estrogen negative cells upon PINCH-1 knockdown point towards participation of some other protein with redundant functions in the later subtype which needs to be investigated. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 30, 2017 Category: Pathology Source Type: research

Investigation of BRAF V600E detection approaches in papillary thyroid carcinoma
Conclusion We may draw the conclusion that detection of BRAF V600E mutation by immunohistochemistry is highly sensitive and specific. Immunohistochemical detection of the mutated BRAF V600E protein in PTC may facilitate mutational analysis in the clinical setting. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 30, 2017 Category: Pathology Source Type: research

PPP1CC is associated with astrocyte and microglia proliferation after traumatic spinal cord injury in rats
In this study, an acute spinal cord contusion injury model in adult rats was established to investigate the potential role of PPP1CC during the pathological process of SCI. The palpable expression increase of PPP1CC after SCI was found by western blot and immunohistochemistry staining. Double immunofluorescence staining showed that PPP1CC expression mainly increased in astrocytes and microglia, as well as PPP1CC and proliferating cell nuclear antigen (PCNA) co-localized in astrocytes and microglia. Furthermore, PCNA expression also elevated after SCI in a similar manner as PPP1CC. In vitro, PPP1CC and PCNA expression in pr...
Source: Pathology Research and Practice - September 29, 2017 Category: Pathology Source Type: research

Infracentimetric parathyroid cysts in hyperparathyroidemia
In conclusion, heterogeneous E-cadherin expression in parathyroid cells may only indirectly related to cyst formation while CD56 and CD10 seem not to relate at all. The relevance of nuclear clumps and Azzopardi phenomenon as well as of the presence of disperse monocyte/macrophage-type cells for the parathyroiditis lesions remains to be further investigated. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 29, 2017 Category: Pathology Source Type: research

EGFR immunohistochemistry as biomarker for antibody-based therapy of squamous NSCLC – experience from the first ring trial of the German Quality Assurance Initiative for Pathology (QuIP®)
Conclusions The first nationwide ring test for determination of EGFR IHC expression in sqNSCLC could be successfully performed in a very tight time frame. By this, the national pathology community was prepared to incorporate this marker in the panel of predictive cancer tests in a quality assessed manner and to initiate and accompany future studies on EGFR pathway pathology. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 29, 2017 Category: Pathology Source Type: research

The overexpression and predictive significance of MMP-12 in Esophageal Squamous Cell Carcinoma
This study was undertaken to investigate the role of MMP-12 in esophageal squamous cell carcinoma (ESCC). We analyzed the protein expression of MMP-12 and its association with clinicopatholigical parameters, as well as survival analysis. MMP-12 was highly expressed in tumor cells comparing with normal epithelial cells. The high expression of MMP-12 was significantly correlated with tumor grade and stage, nodal metastasis and poor survival of ESCC. Cox multivariate analysis revealed that MMP-12 was an independent prognostic factor in ESCC. Our results suggest that MMP-12 might act as a potential target for the development o...
Source: Pathology Research and Practice - September 29, 2017 Category: Pathology Source Type: research

3D modelling of radical prostatectomy specimens: developing a method to quantify tumor morphometry for prostate cancer risk prediction
Publication date: Available online 27 September 2017 Source:Pathology - Research and Practice Author(s): Marcus C. Hovens, Kevin Lo, Michael Kerger, John Pedersen, Timothy Nottle, Natalie Kurganovs, Andrew Ryan, Justin S. Peters, Daniel Moon, Anthony J. Costello, Niall M. Corcoran, Matthew K.H. Hong Prostate cancer displays a wide spectrum of clinical behaviour from biological indolence to rapidly lethal disease, but we remain unable to accurately predict an individual tumor’s future clinical course at an early curable stage. Beyond basic dimensions and volume calculations, tumor morphometry is an area that has rece...
Source: Pathology Research and Practice - September 28, 2017 Category: Pathology Source Type: research

MiR-375: A Prospective Regulator in Medullary Thyroid Cancer Based on Microarray Data and Bioinformatics Analyses
Conclusion The higher expression level of miR-375 might play a pivotal role in the tumorigenesis of MTC via targeting multiple key pathways, especially PI3K/Akt pathway. However, the exact molecular mechanism of miR-375 needs to be verified with in-depth investigation in the future. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 28, 2017 Category: Pathology Source Type: research

The expression level of miR-203 in patients with gastric cancer and its clinical significance
Conclusion Our data validate an important clinical significance of miR-203 in gastric cancer, and reveal that it might be a potential prognostic factor for gastric cancer. Large- scale and long-term follow-up studies are needed to confirm the significance of miR-203 in gastric cancer. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 28, 2017 Category: Pathology Source Type: research

The relationship between EGFR mutation status and clinic-pathologic features in pulmonary adenocarcinoma
Publication date: Available online 21 September 2017 Source:Pathology - Research and Practice Author(s): Huiyan Deng, Junying Liu, Xiaojin Duan, Yueping Liu To detect the relationship of the epidermal growth factor receptor (EGFR) mutation status and the clinicopathologic features. Six hundred thirty-three patients with pathologically confirmed lung adenocarcinoma who underwent lung cancer resection surgery at the Fourth Hospital of Hebei Medical University between April 2012 and April 2015 were selected for the study. The 32 types of mutations in exons 18–21 of the EGFR gene were detected. The total EGFR mutation r...
Source: Pathology Research and Practice - September 22, 2017 Category: Pathology Source Type: research

A possible new morphological variant of mantle cell lymphoma with plasma-cell type Castleman disease-like features
Publication date: Available online 18 September 2017 Source:Pathology - Research and Practice Author(s): Takuro Igawa, Rika Omote, Hiaki Sato, Kohei Taniguchi, Katsuya Miyatani, Tadashi Yoshino, Yasuharu Sato Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by overexpression of cyclin D1 resulting from t(11;14)(q13;q32) translocation. Herein, we report 3 cases of MCL with features of plasma cell-type Castleman disease (CD). The 3 patients were all men, ranging from 51 to 74 years in age, and they all presented with systemic lymphadenopathy with anemia, hypoalbuminemia, elevated serum levels of C-r...
Source: Pathology Research and Practice - September 20, 2017 Category: Pathology Source Type: research

A preliminary study on fetal lung injury in a rat model of acute pancreatitis in pregnancy
In this study, fetal lung injury as well as maternal pancreas and placenta injuries occurred in a time-dependent manner. The levels of serum amylase, lipase and TNF-α were markedly increased in maternal rats, and the levels of surfactant proteins A, B, C and D in fetal lungs were significantly decreased in the fetal lungs of the AP group. Ultrastructure injuries and the dysregulated synthesis and secretion of pulmonary surfactant proteins were observed in the AP group. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 20, 2017 Category: Pathology Source Type: research

Involvement of Bmi-1 gene in the development of gastrointestinal stromal tumor by regulating p16Ink4A/p14ARF gene expressions: an in vivo and in vitro study
Conclusions These collection of data indicated that the down-regulated Bmi-1 might inhibit the proliferation, invasion, and migration of GIST cells and can be subsequently linked to the incidence and developing a prognosis of GIST. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 20, 2017 Category: Pathology Source Type: research

The diagnostic role of plasma circulating precursors of miRNA-944 and miRNA-3662 for non-small cell lung cancer detection
Conclusion Circulating pri-miRNA-944 and 3662 can improve non-invasive NSCLC detection of operable stages of SCC and AC. miRNA precursors could be considered as novel potential lung cancer biomarkers. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 20, 2017 Category: Pathology Source Type: research

Identification of P4HA1 as a prognostic biomarker for high-grade gliomas
Conclusions P4HA1 was upregulated in gliomas. High expression of P4HA1 was correlated with the malignancy of gliomas and could serve as a prognostic indicator for patients with high-grade gliomas. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 20, 2017 Category: Pathology Source Type: research

PD-L1 expression in HNPCC-associated colorectal cancer
Conclusion A subset of HNPCC-associated colorectal cancers in this study clearly showed PD-L1 expression of tumor epithelia and immune cells, therefore, the detection of PD-L1 status is useful. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 19, 2017 Category: Pathology Source Type: research

Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells
In this study, we investigated apoptosis induced by EGCG and the underlying molecular mechanisms in human esophageal squamous cell carcinoma cells. The growth-inhibitory effects of EGCG on esophageal cancer cell (Eca109 and Ec9706) were detected by MTT. Using flow cytometry, we determined the cellular apoptosis, bcl-2, bax and caspase-3 protein expression in Eca109 and Ec9706 cells following treatment with EGCG for 24h. After treatment of Eca109/ABCG2 (an esophageal cancer multidrug resistance cell line) cells with adriamycin (ADM) combined with EGCG for 24h, the cellular apoptosis, mitochondrial membrane potential, ADM co...
Source: Pathology Research and Practice - September 13, 2017 Category: Pathology Source Type: research

Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma
Publication date: Available online 12 September 2017 Source:Pathology - Research and Practice Author(s): Takeharu Imai, Naohide Oue, Yuji Yamamoto, Ryuichi Asai, Naohiro Uraoka, Kazuhiro Sentani, Kazuhiro Yoshida, Wataru Yasui Esophageal squamous cell carcinoma (ESCC) is one of the most common human cancers. We previously reported that KIFC1 is involved in gastric cancer pathogenesis and that KIFC1 plays an important role in gastric cancer spheroid colony formation. However, the significance of KIFC1 in ESCC has not been examined. In the present study, we analyzed the expression and distribution of KIFC1 in 132 ESCC cases...
Source: Pathology Research and Practice - September 13, 2017 Category: Pathology Source Type: research

DIP2C expression in breast cancer and its clinical significance
Conclusion our data revealed DIP2C expression level decreased in breast cancer, especially in basal-like and HER-2 subtypes, and could be a valuable target for diagnosis on specific subtype of breast cancer. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 13, 2017 Category: Pathology Source Type: research

The down-regulation of TAPP2 inhibits the migration of esophageal squamous cell carcinoma and predicts favorable outcome
Publication date: Available online 12 September 2017 Source:Pathology - Research and Practice Author(s): Fang Liu, Fei Ye, Zongyu Guan, Yi Zhou, Fengjun Ji, Qing Zhang, Jianping Zhang, Tianyi Zhang, Songhua Lu Tandem PH domain-containing proteins TAPP1 and TAPP2 are adaptor proteins that specifically bind to phosphatidylinositol-3,4-bisphosphate, or PI(3,4)P2, a product of phosphoinositide 3-kinases (PI3K). Although PI3K enzymes have multiple functions in cell biology, including cell migration, the functions of PI (3, 4) P2 and its binding proteins are not well understood. Previously studies found that TAPP2 is highly exp...
Source: Pathology Research and Practice - September 13, 2017 Category: Pathology Source Type: research

Downregulation of FOXP3 inhibits cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma
Publication date: Available online 8 September 2017 Source:Pathology - Research and Practice Author(s): Chun Li, Liwei Sun, Rui Jiang, Peng Wang, Haogang Xue, Yudong Zhan, Xiaodong Gai Our study aimed to investigate the biological role of FOXP3 expression in human lung adenocarcinoma (LAD) tissues and evaluate its involvement in cell proliferation and chemosensitivity to cisplatin in LAD cells. Paraffin-embedded tissues from 50 LAD patients were collected to detect FOXP3 and Ki-67 expression using immunohistochemistry (IHC). Downregulation of FOXP3 in A549 cells was performed using siRNA transfection. Real-time PCR or wes...
Source: Pathology Research and Practice - September 9, 2017 Category: Pathology Source Type: research

Upregulation of uc.189 in patients with esophageal squamous cell carcinoma and its clinicopathologic value
This study was to identify the prognostic value of uc.189 expression in esophageal squamous cell carcinomas (ESCC). Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of uc.189 in matched cancerous tissues and adjacent noncancerous tissues from 152 patients with ESCC. The correlation of uc.189 with clinicopathological features and prognosis were also analyzed. The expression of uc.189 was significantly higher in human ESCC compared with the adjacent noncancerous tissues (122/152, 80.3%, p<0.01), and the high level of uc.189 expression was significantly correlated with ...
Source: Pathology Research and Practice - September 8, 2017 Category: Pathology Source Type: research

Histiocytoid cardiomyopathy and ventricular noncompaction presenting as sudden death in an adult male
We report the case of a 45-year-old man with an increased heart weight and involvement of both ventricles by HCM and VNC cardiomyopathy. Besides, multiple foci of myocardial disorganization were detected. He died suddenly while hiking. The association of both processes HCM and VNC was an unexpected finding at autopsy. The death was linked to functional abnormalities of the cardiac histiocytoid cells, and it was favored by a state of abnormal development of the heart. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 8, 2017 Category: Pathology Source Type: research

AEG-1 mRNA expression in non-small cell lung cancer is associated with increased tumor angiogenesis
Publication date: Available online 7 September 2017 Source:Pathology - Research and Practice Author(s): Zhihong Ma, Yingrong Chen, Shunli Dong, Xuting Xu, Jin Liu, Pengtao Song, Caihua Yu, Licheng Dai Astrocyte-elevated gene-1 (AEG-1) is implicated in the oncogenesis and angiogenesis of various types of human malignant disease. However, the angiogenesis roles of AEG-1 in non-small cell lung cancer (NSCLC) remain to be further elucidated. In the present study, the expression level of AEG-1 mRNA in seven human lung cell lines and 89 paired tissue samples (tumor tissues (TTs) and pair-matched normal adjacent tissues (PMNATs)...
Source: Pathology Research and Practice - September 8, 2017 Category: Pathology Source Type: research

TIMP-3 mRNA expression levels positively correlates with levels of miR-21 in in situ BC and negatively in PR positive invasive BC
Conclusion These data suggest that signaling pathways involved in formation and progression of BCs in groups formed according to invasiveness might be different. Our findings propose that TIMP-3 mRNA expression levels could be significant prognostic parameter, but within specific BC subtypes. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 7, 2017 Category: Pathology Source Type: research

Current insight in the localized insulin-derived amyloidosis (LIDA): clinico-pathological characteristics and differential diagnosis
Conclusion The identification of amyloid material and immunoreactivity with anti-insulin antibodies are key diagnostic features of LIDA. Although several clinical and animal studies were made in recent years, the lesion is still under-diagnosed and underreported. The clinical suspicion and knowledge of the lesion play a crucial role for the accurate diagnosis of LIDA. Surgical excision of the lesion can dramatically decrease insulin requirement and improve glycemic control. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - September 2, 2017 Category: Pathology Source Type: research

Molecular Characterization of a Series of Solitary Fibrous Tumors, including Immunohistochemical expression of STAT6 and NATB2-STAT6 Fusion Transcripts, using Reverse Transcriptase(RT) –Polymerase Chain Reaction(PCR) Technique: An Indian Experience
This study reinforces high sensitivity and specificity of NAB2-STAT6 fusion and its correlation with strong and diffuse IHC expression of STAT6 in a SFT, irrespective of its occurrence in various body sites and its histopathologic types. NAB2ex4-STAT6ex2 and NAB2ex7-STAT6ex2 fusions were relatively more frequently observed in our patients. Atypical and malignant SFTs, together, were more frequently associated with relatively aggressive clinical outcomes. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 27, 2017 Category: Pathology Source Type: research

p38MAPK family isoform p38 α and activating transcription factor 2 are associated with the malignant phenotypes and poor prognosis of patients with ovarian adenocarcinoma
This study was to identify the biomarkers for the malignancy and poor prognosis in patients with ovarian cancer. The protein expression of p38MAPK family isoform p38α (p38α) and activating transcription factor 2 (ATF2) was measured in 120 ovarian serous adenocarcinomas and 34 normal fallopian tubes using immunohistochemistry. Stable OV-90 cells expressing p38α and ATF2 inhibitor were established using shRNA lentivirus. Cell proliferation, invasion, and migration were analyzed in vitro. Tumor growth and chemosensitivity were investigated in xenograft tumor models. The percentage of positive p38α and ...
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

miR-155 targets Est-1 and induces ulcerative colitis via the IL-23/17/6-mediated Th17 pathway
Conclusion miR-155 seems to target Est-1 and induces UC via the IL-23/17/6-mediated Th17 pathway. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Correlation between HBV protein preS2 and tumor markers of hepatocellular carcinoma
Conclusion The expression of preS2 protein relates closely to HCC markers AFP and GPC3. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Immunohistochemical analysis of NKX2.2, ETV4, and BCOR in a large series of genetically confirmed Ewing sarcoma family of tumors
In conclusion, NKX2.2, ETV4 and BCOR IHC may be helpful in daily practice for distinguishing ESFT from CIC or BCOR-associated sarcomas, especially in hospitals without access to molecular assays. In addition, the combination of strong CD99 membranous positivity and nuclear NKX2.2 positivity seems to be very reliable for ESFT diagnosis in an appropriate clinicoradiological setting. So far no antibody is entirely specific for ESFT diagnosis, and the IHC or molecular results in round cell tumors of bone may be strongly influenced by decalcification processes. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Melanotic MiT family translocation neoplasms: Expanding the clinical and molecular spectrum of this unique entity of tumors
We report 2 rare cases of melanotic translocation renal neoplasms. The first is a melanotic TFE3 translocation renal cancer with an indolent clinical course, occurring in a patient more than 3-decades older than the usual average age in which such tumors have been described. The other case is, to our knowledge, the first reported melanotic TFEB translocation cancer of the kidney. Both cases exhibit the same H&E morphology as previously reported in melanotic translocation renal cancers and label accordingly with HMB45 and Melan-A. While the TFE3 melanotic tumor lacked any evidence of renal tubular differentiation, t...
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Prognostic relevance of tripartite motif containing 24 expression in colorectal cancer
In conclusion, our study suggests that TRIM24 may play a role in colorectal carcinogens and serve as a potential prognostic marker of human colorectal cancer. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Modulation of Galectin-3 and Galectin 9 in gastric mucosa of patients with chronic gastritis and positive Helicobacter pylori infection.
CONCLUSION Up modulation of Gal-3 expression was associated with H. pylori infection and down modulation of Gal-9 with the inflammatory process of chronic gastritis. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Acquisition of histologic diversity contributes to not only invasiveness but also lymph node metastasis in early gastric cancer
Conclusions We demonstrated that lymphatic invasion was the most important and powerful parameter for LNM in early gastric cancers. In addition, tumor invasiveness into the muscularis mucosae was accompanied by tumor histologic diversity. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research

Insulin-like growth factor binding protein-1 (IGFBP-1) upregulated by Helicobacter pylori and is associated with gastric cancer cells migration
In this study, we assessed the expression and release of IGFBP-1 from gastric cancer cells with H. pylori 26695 infection and the biological functions of IGFBP-1 in gastric cancer cells. The results showed that the expression and release of IGFBP-1 were increased in gastric cancer cells (MGC-803, BGC-823, SGC-7901) infected with H. pylori 26695. In addition, the upregulation of IGFBP-1 was dose-dependent in BGC-823 cells infected with H. pylori 26695 but not time-dependent. The upregulation of IGFBP-1 got to peak at 12h after H. pylori 26695 infection and then decreased over time. Subsequently, we measured its functions by...
Source: Pathology Research and Practice - August 26, 2017 Category: Pathology Source Type: research