Carl August Krauspe (1895-1983)—Founder and Honorary Member of the "European Society of Pathology" and "Politically Reliable" National Socialist
Publication date: Available online 5 December 2018Source: Pathology - Research and PracticeAuthor(s): Dominik Gross, Christina Gräf, Hendrik Uhlendahl, Mathias Schmidt, Jens WestemeierSummaryThe name of the Hamburg pathologist Carl August Krauspe (1895-1983) is closely linked to the history of the "European Society of Pathology" (ESP) and the "German Pathological Society" (DGP): He was one of the founding fathers of the ESP, became its vice president, and was appointed an honorary member in 1983. From 1953 to 1962 he also served as secretary of the DGP and editor of the association's journal. In 19...
Source: Pathology Research and Practice - December 6, 2018 Category: Pathology Source Type: research

Association of PD-L1 gene rs4143815 C>G polymorphism and human cancer susceptibility: a systematic review and meta-analysis
Publication date: Available online 6 December 2018Source: Pathology - Research and PracticeAuthor(s): Ju Zou, Daichao Wu, Tao Li, Xianwen Wang, Yan Liu, Sijie TanAbstractProgrammed death ligand 1(PD-L1) mediated immune escape play important roles in the development of cancer. The gene polymorphism of PD-L1, in particular rs4143815 C > G, has been associated with the cancer risks, but with conflicting results. Therefore, this meta-analysis was aimed to assess the association between rs4143815 C > G and cancer susceptibility. A systematic literature search was performed to select the studies...
Source: Pathology Research and Practice - December 6, 2018 Category: Pathology Source Type: research

SOX7 methylation is an independent prognostic factor in myelodysplastic syndromes
ConclusionsOur findings demonstrated that SOX7 methylation conferred adverse prognosis in MDS patients and was associated with leukemia progression. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - December 6, 2018 Category: Pathology Source Type: research

Clinicopathological and prognostic significance of aberrant G Protein-Couple Receptor 110 (GPR110) expression in gastric cancer
ConclusionsOur study revealed that high expression of GPR110 predicts the poor prognosis of GC patients, and GPTR110 may function as a potential biomarker for the diagnosis of GC. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - December 6, 2018 Category: Pathology Source Type: research

Inhibition of constructed SEC3-ES lentiviral vector to proliferation, migration of hela cells
Publication date: Available online 1 December 2018Source: Pathology - Research and PracticeAuthor(s): Min Yang, Min Wang, Xianping Li, Yixin Xie, Xiaomeng Xia, Jingjing Tian, Kan Zhang, Fang Chen, Huan Song, Zhihui Dong, Aiguo TangAbstractAimTo construct a lentiviral vector with endostatin (ES) and staphylococcal enterotoxin C3(SEC3) gene, and investigate its capacities of inhibition on proliferation and migration of Hela cells.MethodsBy inserting ES and SEC3 gene into the plasmid and then transfect 293 T cell, the co-expressed (SEC3-ES) vector were constructed. A series of experiments in vitro were carried out to d...
Source: Pathology Research and Practice - December 2, 2018 Category: Pathology Source Type: research

Spondin-2 is a novel diagnostic biomarker for laryngeal squamous cell carcinoma
In conclusion, spondin-2 might be a novel therapeutic target and prognostic biomarker for LSCC patients. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - November 30, 2018 Category: Pathology Source Type: research

Colonic Ewing Sarcoma/PNET associated with liver metastases: a systematic review and case report
Publication date: Available online 29 November 2018Source: Pathology - Research and PracticeAuthor(s): Pietro Parcesepe, Guido Giordano, Caterina Zanella, Jacopo Giuliani, Filippo Greco, Andrea Bonetti, Massimo Pancione, Erminia Manfrin, Enrico Molinari, Tiziana Pia Latiano, Mario Rosario D’Andrea, Matteo Fassan, Nunzio Olivieri, Andrea RemoAbstractEwing Sarcoma is a highly lethal undifferentiated tumor of bone. ES is a small round cell tumor with etiological and characteristic chromosomal translocations between TET/FET (TLS/FUS, EWSR1, and TAF15) and ETS (E26 transformation-specific) family genes. Generally, therape...
Source: Pathology Research and Practice - November 30, 2018 Category: Pathology Source Type: research

The deregulation of miR-133b is associated with poor prognosis in bladder cancer
Publication date: Available online 24 November 2018Source: Pathology - Research and PracticeAuthor(s): Zhenfeng Shi, Aihemaiti Kadeer, Mopei Wang, Bin Wen, Min Li, Jinxing Huang, Yang Gao, Enwei Liu, Donghong Liu, Deyong Jia, Chengyuan LiangAbstractBackgroundMicroRNAs (miRNAs) are single-stranded, endogenous, non-coding RNAs that are increased or decreased in almost all cancer types, and they paly crucial roles in the tumorigenesis as well as development.Materials and methods90 patients diagnosed with bladder cancer were enrolled in the present study. The bladder cancer tissues or adjacent normal tissues were obtained from...
Source: Pathology Research and Practice - November 25, 2018 Category: Pathology Source Type: research

Intratumoral heterogeneity of esophageal squamous cell carcinoma and its clinical significance
In conclusion, findings of this study showed that ZNF750, EP300, MTOR and KMT2D heterogeneously expressed in ESCC. High expression of ZNF750 related to a better outcome,while EP300 and MTOR related to a poor prognosis. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - November 25, 2018 Category: Pathology Source Type: research

The role of oxidative stress in the biology of melanoma: a systematic review
Publication date: Available online 24 November 2018Source: Pathology - Research and PracticeAuthor(s): Serafinella Patrizia Cannavò, Alessandro Tonacci, Lucrezia Bertino, Casciaro Marco, Borgia Francesco, Sebastiano GangemiAbstractMelanoma is the most aggressive skin tumour, which incidence is rising fast over the year. The metastatic stage of disease is extremely difficult to treat and the mortality rate is still high. Emerging evidence suggested that oxidative stress (OS) is involved in the pathophysiological pathways of several chronic diseases and in the transformation and progression of many common cancers, inc...
Source: Pathology Research and Practice - November 25, 2018 Category: Pathology Source Type: research

Knockdown of lncRNA SNHG7 inhibited cell proliferation and migration in bladder cancer through activating Wnt/β-catenin pathway
In this study, we discovered that the expression levels of SNHG7 were significantly increased in bladder cancer tissues and cell lines. Patients with high expression level of SNHG7 suffered from poor prognosis. Additionally, knockdown of SNHG7 induced declined cell viability, proliferation as well as G0/G1 cell cycle arrest. Furthermore, we found that cell migratory ability was markedly reduced after silencing SNHG7. Next, we verified that knockdown of SNHG7 reduced the protein level of β-catenin and thus decreased the level of its downstream targets including c-myc, cyclin D1 and E-cadherin, implying that SNHG7 might...
Source: Pathology Research and Practice - November 25, 2018 Category: Pathology Source Type: research

Immune checkpoint blockade resistance-related B2M hotspot mutations in microsatellite-unstable colorectal carcinoma
Publication date: Available online 24 November 2018Source: Pathology - Research and PracticeAuthor(s): Su Yeon Yeon, Seung-Hyun Jung, Yun Sol Jo, Eun Ji Choi, Min Sung Kim, Yeun-Jun Chung, Sug Hyung LeeAbstractβ2-microglobulin (B2M), a component of major histocompatibility complex class I, plays an important role in host immune reaction to tumor, and inactivation of B2M is known to contribute to resistance to immune checkpoint blockade (ICB) treatment. To further characterize the B2M alterations in tumors, we analyzed B2M hotspot mutations in 2765 benign and malignant tumor tissues by Sanger sequencing and found B2M m...
Source: Pathology Research and Practice - November 25, 2018 Category: Pathology Source Type: research

Correlation between EZH2 and CEP55 and lung adenocarcinoma prognosis
ConclusionTaken together, these results indicate that changes in EZH2 expression lead to changes in CEP55 expression in lung adenocarcinoma, and these changes are associated with its prognosis. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - November 25, 2018 Category: Pathology Source Type: research

Editorial Board
Publication date: December 2018Source: Pathology - Research and Practice, Volume 214, Issue 12Author(s): (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - November 23, 2018 Category: Pathology Source Type: research

“… a life broken in two” Walter Pagel (1898–1983)—Famous pathologist and victim of Nazi Germany
Publication date: Available online 2 November 2018Source: Pathology - Research and PracticeAuthor(s): Dominik Gross, Stephanie Kaiser, Janina SziranyiAbstractThere is no doubt that Walter Pagel (1898–1983) is one of the most outstanding figures in the history of pathology. Not only his fundamental research on tuberculosis and various other fields of pathology but also his historicomedical publications set international standards and earned him numerous honors throughout the scientific world.Far less known is the fact that Pagel, as a German Jew, was one of the victims of the “Third Reich”: He was dismisse...
Source: Pathology Research and Practice - November 17, 2018 Category: Pathology Source Type: research

Prognostic Value of Pathologic Complete Response and the Alteration of Breast Cancer Immunohistochemical Biomarkers after Neoadjuvant Chemotherapy
Publication date: Available online 17 November 2018Source: Pathology - Research and PracticeAuthor(s): Li MaAbstractNeoadjuvant chemotherapy(NCT) has become the standard treatment for breast cancer. The information about the tumor’s sensitivity to chemotherapy and prognostic significance based on response to therapy can be provided after individualized neoadjuvant treatment. The biomarkers are key factors in the decision-making process regarding treatment as well as important prognostic indicators. Studies have shown that patients who achieve pathological complete response(pCR) after NCT have a better prognosis. For ...
Source: Pathology Research and Practice - November 17, 2018 Category: Pathology Source Type: research

Pathologic analyses of peritoneal nodules in gastric cancer patients during surgery—A single cancer center experience with diagnostic pitfalls
ConclusionsPeritoneal biopsies in patients with GC were mostly carcinoma, followed by chronic inflammation with fibrosis and papillary mesothelial cell proliferation. Deeper sections or intradepartmental consultations were helpful to reduce false negative diagnosis on FS. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - November 16, 2018 Category: Pathology Source Type: research

MET is overexpressed in microsatellite instability-high gastric carcinoma
ConclusionMET overexpression was observed in 15% of MSI-H gastric carcinomas and was associated with high level expression of PD-L1. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - November 14, 2018 Category: Pathology Source Type: research

The diagnostic and prognostic significance of long non-coding RNA CRNDE in pan-cancer based on TCGA, GEO and comprehensive meta–analysis
ConclusionCRNDE could be a potential biomarker for cancer diagnosis and prognosis. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - November 14, 2018 Category: Pathology Source Type: research

Over-expression of S100B protein as a serum marker of brain metastasis in non-small cell lung cancer and its prognostic value
This study aimed to investigate the role of S100B in NSCLC brain metastasis. The results showed that serum S100B correlated significantly with NSCLC brain metastasis (P 
Source: Pathology Research and Practice - November 14, 2018 Category: Pathology Source Type: research

Relationship between long non-coding RNAs and Alzheimer’s disease: a systematic review
Publication date: Available online 13 November 2018Source: Pathology - Research and PracticeAuthor(s): Lijuan Chen, XiaoBing Guo, Zhengtao Li, Yongsheng HeAbstractAlzheimer disease (AD), is a typical progressive and destructive neurodegenerative disease. It is the leading cause of senile dementia that is mainly represented as neurocognitive symptoms, including progressive memory impairment, cognitive disorder, personality change and language barrier, etc. The pathogeny and nosogenesis of AD have not been clearly explained. AD is characterized by extracellular senile plaques (SP) formed by beta amyloid (Aβ) deposition ...
Source: Pathology Research and Practice - November 14, 2018 Category: Pathology Source Type: research

CAV1 polymorphisms rs1049334, rs1049337, rs7804372 might be the potential risk in tumorigenicity of urinary cancer: a systematic review and meta-analysis
Publication date: Available online 13 November 2018Source: Pathology - Research and PracticeAuthor(s): Song fan, Jialin Meng, Li Zhang, Xiansheng Zhang, Chaozhao LiangAbstractBackgroundAs an integral membrane, Caveolin-1 (CAV1), is a pivotal component to make up the caveolae protein. It has been demonstrated to influence tumorigenicity, including bladder, colon, liver, stomach, breast and lung cancer. Several publications had illustrated the relationship of between CAV1 polymorphism and urinary cancer, but the results were not consistent. We performed a comprehensive meta-analysis to explore the associations and remove the...
Source: Pathology Research and Practice - November 14, 2018 Category: Pathology Source Type: research

MiR-876-5p regulates proliferation, migration and apoptosis of cervical cancer cells through targeting KPNA4
Publication date: Available online 11 November 2018Source: Pathology - Research and PracticeAuthor(s): Hongwei Lei, Jingbin Shi, Yun Teng, Chenghui Song, Lijuan Zou, Fuxiu Ye, Haichen ZhangAbstractMicroRNAs (miRNAs) play fundamental roles in the genesis and progression of various cancers. MiR-876-5p has demonstrated to be a tumor suppressor in several types of tumors. However, little is known about the expression pattern and biological roles of miR-876-5p in cervical cancer (CC). In present study, we assessed the expression level of miR-876-5p in cervical cancer tissues and normal tissues as well as in four cervical cancer...
Source: Pathology Research and Practice - November 12, 2018 Category: Pathology Source Type: research

Genome-wide characterization of aberrant DNA methylation patterns and the potential clinical implications in patients with endometrial cancer
Publication date: Available online 11 November 2018Source: Pathology - Research and PracticeAuthor(s): Yao Wang, Dandan Liu, Xin Jin, Hongwei Song, Ge LouAbstractAberrant DNA methylation has been implicated in the development of the majority of human cancers. However, the association of aberrant DNA methylation with the clinical characteristics of uterine corpus endometrial carcinoma (UCEC) has not been fully explored. We performed an integrative analysis in order to examine the genome-wide DNA methylation profile and the gene expression profile of 432 UCEC samples and 46 normal tissue samples. A total of 793 differentiall...
Source: Pathology Research and Practice - November 12, 2018 Category: Pathology Source Type: research

CD151 promotes proliferation and migration of SK-NEP-1 cells via the GSK-3β/P21/cyclinD signaling pathway
In this study, CD151 protein and mRNA levels were examined by western blot and RT-PCR. The proliferation of SK-NEP-1 cells was examined by CCK8 assay and the migration of SK-NEP-1 cells was detected with wound healing assay. Furthermore, p-GSK3β protein, GSK3β protein, p21protein and CyclinD protein were examined by western blot to verify whether CD151 could regulate the Wilms’tumor progression via the GSK-3β/P21/cyclinD signaling pathway. The RT-PCR and western blot results showed that CD151 protein was upregulated in Wilms’tumor cells compared with the control. The results by CCK8 assay and wou...
Source: Pathology Research and Practice - November 11, 2018 Category: Pathology Source Type: research

Immunohistochemical analysis of vocal cord polyps applying markers of squamous cell carcinogenesis
CONCLUSION: Only polyps that present with simple hyperplasia as the greatest mucosal change can be considered as benign formations.Pathohistologically detected atypia in polypoid changes of vocal cords, confirmed by molecular atypia with an increase of SC carcinogenesis markers, suggest their inclusion in studies of laryngeal carcinogenesis.Our results suggest that in problematic cases IHC analysis could be of interest in detection of biological aggressiveness in polypoid laryngeal tissue and beneficiary for polyp patients’ follow-up.Further research of laryngeal carcinogenesis markers and their meaning in fibrovascu...
Source: Pathology Research and Practice - November 11, 2018 Category: Pathology Source Type: research

Prognostic value of small nuclear RNAs (snRNAs) for digestive tract pan- adenocarcinomas identified by RNA sequencing data
Publication date: Available online 10 November 2018Source: Pathology - Research and PracticeAuthor(s): Xin-gan Qin, Jiang-hui Zeng, Peng Lin, Wei-jia Mo, Qing Li, Zhen-bo Feng, Dian-zhong Luo, Hong Yang, Gang Chen, Jing-jing ZengAbstractMalignant tumors of the digestive tract include esophageal, gastric, and colorectal carcinomas, which all have high global mortality rates. A clinical role for small nuclear RNA (snRNA), a type of small non-coding RNA, has not yet been documented for digestive tract pan-adenocarcinomas. Therefore, the aim of the study was to identify differentially expressed snRNAs and to explore their prog...
Source: Pathology Research and Practice - November 11, 2018 Category: Pathology Source Type: research

Clinical and Prognostic Value of Chaperonin Containing T-complex 1 Subunit 3 in Hepatocellular Carcinoma: A Study Based on Microarray and RNA-sequencing with 4272 cases
Publication date: Available online 10 November 2018Source: Pathology - Research and PracticeAuthor(s): Jiayin Hou, Huayu Wu, Rongquan He, Peng Lin, Yiwu Dang, Gang ChenAbstractLiver cancer is one of the few tumors with a steadily increasing morbidity and mortality; hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. We combined the expression profiles of Chaperonin Containing T-complex 1 Subunit 3 (CCT3) in HCC tissues based on microarray and RNA-sequencing data. The CCT3 expression levels were extracted and examined based on 421 samples from The Cancer Genome Atlas (TCGA) (HCC, n =&thins...
Source: Pathology Research and Practice - November 11, 2018 Category: Pathology Source Type: research

EBV as a potential risk factor for hepatobiliary system cancer: a meta-analysis with 918 cases
Publication date: Available online 2 November 2018Source: Pathology - Research and PracticeAuthor(s): Zu-xuan Chen, Xiao-tong Peng, Lin Tan, Gao-qiang Zhai, Gang Chen, Ting-qing Gan, Jian-jun LiAbstractObjectivesHepatobiliary system cancer, which includes hepatocellular carcinoma (HCC), cholangiocarcinoma, and gallbladder carcinoma, has an increase of incidence and mortality due to various risk factors. Epstein-Barr virus (EBV) is associated with various types of lymphomas and carcinomas, which is also acknowledged as the first-discovered human tumor virus. Despite this, there is no systematic analysis about the relationsh...
Source: Pathology Research and Practice - November 3, 2018 Category: Pathology Source Type: research

Ultrastructural immunolocalization of telomerase and hyaluronate in migrating keratinocytes in a case of oro-pharyngeal squamous cancer
Publication date: Available online 2 November 2018Source: Pathology - Research and PracticeAuthor(s): Lorenzo AlibardiAbstractThe ultrastructural immunolocalization of telomerase and hyaluronate has been studied in a case of oropharyngeal squamous carcinoma. Immunofluorescence shows that telomerase immunolabeling is present in the cytoplasm and in nuclei of some keratinocytes during their migration into the underlying connective tissue. The electron microscope shows that the nuclear localization of telomerase mainly occurs in the large nucleoli and in likely Cajal bodies, the sites of assembling and maturation of proteins ...
Source: Pathology Research and Practice - November 3, 2018 Category: Pathology Source Type: research

“… a life broken in two” Walter Pagel (1898–1983) – Famous Pathologist and Victim of Nazi Germany
Publication date: Available online 2 November 2018Source: Pathology - Research and PracticeAuthor(s): Dominik Gross, Stephanie Kaiser, Janina SziranyiAbstractThere is no doubt that Walter Pagel (1898–1983) is one of the most outstanding figures in the history of pathology. Not only his fundamental research on tuberculosis and various other fields of pathology but also his historicomedical publications set international standards and earned him numerous honors throughout the scientific world.Far less known is the fact that Pagel, as a German Jew, was one of the victims of the “Third Reich”: He was dismisse...
Source: Pathology Research and Practice - November 3, 2018 Category: Pathology Source Type: research

Impact of the 2018 ASCO/CAP HER2 guidelines update for HER2 testing by FISH in breast cancer
Publication date: Available online 2 November 2018Source: Pathology - Research and PracticeAuthor(s): Bin Xu, Jianguo Shen, Wenhao Guo, Wenhe Zhao, Yiyu Zhuang, Linbo WangAbstractRecently, the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) updated the guidelines on HER2 testing for invasive breast cancer. Little is known about the impact of the guidelines update. We aimed to study the impact of the 2018 ASCO/CAP HER2 testing guidelines update. We compared the HER2 FISH results interpreted by 2013 and 2018 ASCO/CAP guidelines in 331 cases of invasive breast cancers. We also analyzed the pa...
Source: Pathology Research and Practice - November 3, 2018 Category: Pathology Source Type: research

Distinct prognostic roles of S100 mRNA expression in gastric cancer
ConclusionsAlthough the results should be further testified in clinical studies, our findings offer new insights into the contribution of S100 members to GC progression and might promote development of S100 targeted reagents for treating GC. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - November 3, 2018 Category: Pathology Source Type: research

Primary Aneurysmal Bone Cyst of the Mandibular Condyle with USP6-CDH11 Fusion
Publication date: Available online 2 November 2018Source: Pathology - Research and PracticeAuthor(s): Patricia J. Brooks, Jeffrey W. Chadwick, Marco Caminiti, Brendan Dickson, Iona LeongAbstractPrimary aneurysmal bone cyst (ABC) is a cystic bone neoplasm characterized by disease-defining gene fusions involving the USP6/Tre2 gene. The literature describing gnathic ABC is limited. This case report describes a 27-year-old man presenting with a long-standing left-sided facial asymmetry. Multi-detector computed tomography imaging demonstrated a large expansile lesion positioned within the left condylar head. The lesion was biop...
Source: Pathology Research and Practice - November 3, 2018 Category: Pathology Source Type: research

Expression and significance of CD47, PD1 and PDL1 in T-cell acute lymphoblastic lymphoma/leukemia
Publication date: Available online 2 November 2018Source: Pathology - Research and PracticeAuthor(s): Kun Yang, Jing Xu, Qinghang Liu, Jing Li, Yanfeng XiAbstractAlthough dose intensification strategies achieve a favorable prognosis for pediatric patients of T-lmphoblastic lymphoma/leukemia (T-LBL/ALL), numerous side effects have been followed. Molecular targeted therapies will be needed to optimize the current treatment strategy for T-LBL/ALL. The aim of this study was to analyse expression and significance of CD47, PD1 and PDL1 in. T-LBL/ALL. We performed immunohistochemistry staining and real time fluorescence q...
Source: Pathology Research and Practice - November 3, 2018 Category: Pathology Source Type: research

Regulation between two alternative splicing isoforms ZNF148FL and ZNF148ΔN, and their roles in the apoptosis and invasion of colorectal cancer
Publication date: Available online 3 November 2018Source: Pathology - Research and PracticeAuthor(s): Yuee Liu, Wei Huang, Xianhua Gao, Fei KuangAbstractObjectiveTo investigate the effect of two alternative splicing isoforms of zinc finger protein (ZNF) 148 gene on the invasion and metastasis of human colorectal cancer (CRC) cells and their related mechanisms.MethodsQuantitative RT-PCR assays were used to detect the expression of twoZNF148 alternative splicing isoforms in SW480 cells. ZNF148FL-siRNA, ZNF148FL-over express vector, ZNF148ΔN-siRNA, and ZNF148ΔN-over express vector were introduced into SW480 cells....
Source: Pathology Research and Practice - November 3, 2018 Category: Pathology Source Type: research

Comprehensive Analysis of Tumor Immune Infiltration Associated with Endogenous Competitive RNA Networks in Lung Adenocarcinoma
Publication date: Available online 29 October 2018Source: Pathology - Research and PracticeAuthor(s): Boyang Wei, Wei Kong, Xiaoyang Mou, Shuaiqun WangAbstractCancer immunotherapy has achieved unprecedented success in the treatment of cancer. However, different patients have different responses to immunotherapy. More and more studies have shown that tumor immune heterogeneity has an important influence on the prognosis of cancer. Therefore, understanding the clinical impact of tumor immune infiltration and the regulatory mechanism of RNA molecules is crucial for exploring the pathogenesis of lung adenocarcinoma (LUAD) and ...
Source: Pathology Research and Practice - October 30, 2018 Category: Pathology Source Type: research

Peritoneal washing is an adequate source for somatic BRCA1/2 mutation testing in ovarian malignancies
Publication date: Available online 28 October 2018Source: Pathology - Research and PracticeAuthor(s): Miguel Barquín, Constanza Maximiano, Clara Pérez-Barrios, Estela Sanchez-Herrero, María Soriano, Marta Colmena, Manuel García-Espantaleón, Eva Tejerina González, Lourdes Gutierrez, Antonio Carlos Sánchez Ruiz, María Torrente, Mariano Provencio, Atocha RomeroAbstractGenetic screening for BRCA mutations should be offered to all women diagnosed with epithelial ovarian, fallopian tube, and/or peritoneal cancers given the implications for treatment options and cancer risk ...
Source: Pathology Research and Practice - October 29, 2018 Category: Pathology Source Type: research

miR-218 inhibits gastric tumorigenesis through regulating Bmi-1/Akt signaling pathway
ConclusionsmiR-218 inhibits the proliferation, invasion and migration of gastric cancer cells through modulating EMT process and the expression of MMPs via Bmi-1/Akt signaling pathway. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - October 29, 2018 Category: Pathology Source Type: research

Loss of BMP-10 is correlated with poor survival in ovarian cancer
ConclusionLow BMP-10 expression was associated with poor prognosis and progression of ovarian cancer. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - October 29, 2018 Category: Pathology Source Type: research

Magnesium isoglycyrrhizinate alleviates liver injury in obese rats with acute necrotizing pancreatitis
ConclusionObesity aggravated ANP-induced liver injury via oxidative stress and inflammatory reactions. MgIg alleviated oxidative stress and decreased the inflammatory reaction, protecting the liver against the AHI induced by ANP in obese rats. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - October 29, 2018 Category: Pathology Source Type: research

The evaluation of inflammatory, anti-inflammatory and regulatory factors contributing to the pathogenesis of COPD in airways
In this study, lung tissue specimens obtained from 33 COPD patients and 49 control patients were analysed. Tissue samples were examined by hematoxylin and eosin staining. Immunoreactive cells positive for interleukin (IL)-1α (IL-1α), IL-4, IL-6, IL-7, IL-8, IL-10, IL-12, and tumour necrosis factor-α (TNF-α) were detected by an immunohistochemistry (IHC) method.ResultsWe evaluated overall higher numbers of IL-7, IL-8 and IL-10 (mostly from few (0/+) to almost abundance (++++)) and overall less numbers of IL-1α and IL-6 (mostly from no positive (0) to numerous to abundance (+++/++++)) immunoreac...
Source: Pathology Research and Practice - October 29, 2018 Category: Pathology Source Type: research

Structural biology of intraepithelial neuroendocrine cells in the larynx: Literature review
Publication date: Available online 24 October 2018Source: Pathology - Research and PracticeAuthor(s): Asterios Triantafyllou, Kenneth O. Devaney, Jennifer L. Hunt, Alessandra Rinaldo, Alfio FerlitoAbstractCurrent knowledge of laryngeal neuroendocrine cells in man and other vertebrates is reviewed. Particular attention is paid to differences in the distribution of neuroendocrine cells between squamous and respiratory laryngeal mucosa, foetal versus post-natal spatial arrangements, relation to the laryngeal cavity and nerve fibres, and immunoreactivities of these cells. Methodological deficiencies and gaps in knowledge are o...
Source: Pathology Research and Practice - October 25, 2018 Category: Pathology Source Type: research

High expression of immunity-related GTPase family M protein in glioma promotes cell proliferation and autophagy protein expression
In this study, we found that 47 glioma specimens had more IRGM expression than 11 non-cancerous brain tissues with immunohistochemistry. IRGM was also up-regulated in human glioma cell lines U87, U251 and A172 and so on compared with immortalized astrocytes. Importantly, overexpression of IRGM significantly increased the cell colonies formation, cell proliferation and Akt activation (Thr308 and Ser473 sites) than matched control. On another hand, all of IRGM, autophagy marker LC3II and autophagy adaptor p62 gradually increased after starvation 2 and 4 hours. Furthermore, western blot and immunofluorescence results s...
Source: Pathology Research and Practice - October 25, 2018 Category: Pathology Source Type: research

The prognostic role of Tumor associated glycoprotein 72 (TAG-72) in stage II and III colorectal adenocarcinoma
Publication date: Available online 24 October 2018Source: Pathology - Research and PracticeAuthor(s): Junhun Cho, Kyoung-Mee Kim, Hee Cheol Kim, Woo Yong Lee, Won ki Kang, Young Suk Park, Sang Yun HaABSTRACTTumor associated glycoprotein 72 (TAG-72) is a membrane-bound glycoprotein complex that is overexpressed in many adenocarcinomas. Recently, monoclonal antibody targeting TAG72, minretumomab, have been introduced as a potential therapeutic target in colorectal cancers (CRC) as well as breast and lung cancers. However, the detailed expression profile of TAG72 and its prognostic effect in CRC are not clear yet. We investig...
Source: Pathology Research and Practice - October 25, 2018 Category: Pathology Source Type: research

The pretreatment lymphocyte to monocyte ratio predicts clinical outcome for patients with urological cancers: A meta-analysis
ConclusionThe high pretreatment LMR was associated with favorable prognosis, and could be a potential prognostic biomarker in patients with UCs. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - October 25, 2018 Category: Pathology Source Type: research

Actin related protein 3 (ARP3) promotes apoptosis of intestinal epithelial cells in ulcerative colitis
In conclusion, our data indicates that ARP3 might promote the apoptosis of IECs in UC, revealing a potential molecular target for treating UC. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - October 25, 2018 Category: Pathology Source Type: research

The epithelial-mesenchymal transition induces aggressivity of mucinous cystic neoplasm of the pancreas with neuroendocrine component: an immunohistochemistry study
ConclusionsThese cases highlight the unusually aggressive behavior of pancreatic MCN with invasive carcinomas that share mixed exo- and endocrine components and show epithelial-mesenchymal transition. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - October 24, 2018 Category: Pathology Source Type: research

Comparison between digital image analysis and visual assessment of immunohistochemical HER2 expression in breast cancer
ConclusionWe conclude that DIA is an accurate method to reduce the number of HER2 equivocal cases without affecting the sensitivity of the HER2 assessment. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - October 24, 2018 Category: Pathology Source Type: research

Clinicopathologic analysis of 10 cases of pulmonary colloid adenocarcinoma and prognostic implication of invasive micropapillary component
ConclusionColloid adenocarcinoma is a rare variant of lung adenocarcinoma with distinct clinicopathologic characteristics. The frequently seen ciliated tumor cells may suggest that this tumor might originate from a metaplastic process. Majority had indolent clinical course but presence of stromal invasion or micropapillary pattern may reflect aggressive behavior of colloid adenocarcinoma and may indicate poor prognosis. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - October 24, 2018 Category: Pathology Source Type: research