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Metastasis-associated protein 1 (MTA1) in gastric cancer tissues is positively associated with poorer prognosis
Conclusion MTA1 immunopositivity was significantly associated with progression of gastric cancer, and may be helpful in gastric cancer prognosis. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - February 22, 2018 Category: Pathology Source Type: research

MicroRNA-30d/JAG1 axis modulates pulmonary fibrosis through Notch signaling pathway
Publication date: Available online 21 February 2018 Source:Pathology - Research and Practice Author(s): Silin Zhao, Xuefei Xiao, Shuang Sun, Da Li, Wei Wang, Yan Fu, Fuyuan Fan Pulmonary fibrosis (PF) is a fibroproliferative disease which can finally end up fatal lung failure. PF is characterized by abnormal proliferation of fibroblast, dysregulated fibroblast differentiation to myofibroblast and disorganized collagen and extracellular matrix (ECM) production, deposition and degradation. JAG1/Notch signaling has been reported to play a key role in tissue fibrosis including PF. Herein, we confirmed the abnormal upregulatio...
Source: Pathology Research and Practice - February 22, 2018 Category: Pathology Source Type: research

Detection of the DICER1 hotspot mutation alongside immunohistochemical analysis may provide a better diagnostic measure for ovarian Sertoli-Leydig cell
Conclusion The clinical presentation of SLCTs can be both varied and complex. Pathological examination is imperative for both diagnostic and prognostic grading. Immunohistochemical stain of α-inhibin, FOXL2, and calretinin and genetic testing for DICER1 mutations will be more potent for differential diagnosis. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - February 22, 2018 Category: Pathology Source Type: research

Indoleamine 2, 3-dioxygenase and B7-H1 expressions as prognostic and follow-up markers in human pancreatic carcinoma
This study was to test hypotheses that indoleamine 2, 3-dioxygenase and B7-H1 expressions can be used as prognostic markers in human pancreatic carcinoma (PC). Ninety-five patients were recruited who had undergone radical surgical resection for PC. IDO and B7-H1 expressions in PC tissue specimens were evaluated by immunohistochemistry (IHC) techniques. The clinical and pathological features of these specimens were analyzed. IDO positive, B7-H1 positive, and combined IDO/B7-H1 positive tumors exhibited significant correlations with lymphocytic infiltration, perineural invasion, TNM status, and pathologic grade (p <...
Source: Pathology Research and Practice - February 22, 2018 Category: Pathology Source Type: research

Local delievery of thalidomide to inhibit neointima formation in rat model with artery injury
Conclusions Thalidomide, which is a specific VEGF inhibitor, significantly inhibited neointimal hyperplasia and vascular restenosis after balloon injury to the carotid artery in rats, thus potentially providing a novel method for the prevention and treatment of restenosis, especially in-stent restenosis. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - February 22, 2018 Category: Pathology Source Type: research

Brain-derived neurotrophic factor induces angiogenin secretion and nuclear translocation in human umbilical vein endothelial cells
In conclusion, angiogenin contributes to angiogenesis induced by BDNF. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - February 22, 2018 Category: Pathology Source Type: research

Protective effects of Schisandrin on high glucose-induced changes of RhoA and eNOS activity in human umbilical vein endothelial cells
Publication date: Available online 21 February 2018 Source:Pathology - Research and Practice Author(s): Rong-Jin Zhang, Hui-Yao Hao, Qing-Juan Liu, Hong-Ye Zuo, Ying-Na Chang, Zhong-Ji Zhi, Peng-Peng Guo, Yong-Mei Hao Schisandrin, derived from the Chinese medicinal herb Schisandra chinensis, has been found to confer protective effects on circulation systems. But the underlying molecular mechanisms remain unclear. The aim of this study was to investigate the effects of a high level of glucose on RhoA and eNOS activity in human umbilical vein endothelial cells(HUVECs) and how Schisandrin plays a role in mediating these effe...
Source: Pathology Research and Practice - February 22, 2018 Category: Pathology Source Type: research

Bex1 attenuates neuronal apoptosis in rat intracerebral hemorrhage model
In this study, the roles of Bex1 were explored in the pathophysiology of ICH. Western blot, immunohistochemistry, and immunofluorescence showed that obvious up-regulation of Bex1 in neurons adjacent to the hematoma after ICH. Furthermore, the increase of Bex1 expression was accompanied by the enhanced expression of Bax and active caspase-3, and decreased expression of B-cell lymphoma 2 (Bcl-2) following ICH. The in vitro study using Bex1 siRNA transfection in hemin-exposed PC12 cells suggested that Bex1 exerted anti-apoptotic function. Therefore, Bex1 may play the neuronal anti-apoptosis role following ICH, implying a nove...
Source: Pathology Research and Practice - February 22, 2018 Category: Pathology Source Type: research

Intradepartmental Consultations in Surgical Pathology: Review of a Standardized Process and Factors Influencing Consultation Rates and Practices in an Academic and Community Hospital Setting
Publication date: Available online 21 February 2018 Source:Pathology - Research and Practice Author(s): Emily A. Goebel, Helen Ettler, Joanna C. Walsh Intradepartmental consultations (ICs) are important for quality assurance (QA) and ensuring diagnostic accuracy in surgical pathology. Few studies have reviewed pathologist factors that influence IC rates. Our study reviews IC data and factors that influence both formal (written) and informal (verbal) consultation practices among pathologists in academic and community hospital settings. Formal IC records from the academic hospital were collected and academic and community p...
Source: Pathology Research and Practice - February 22, 2018 Category: Pathology Source Type: research

The degree of overlap between the follicular dendritic cell meshwork and tumor cells in mantle cell lymphoma is associated with prognosis
This study concerning mantle cell lymphoma (MCL) investigated retrospectively an association between patient prognosis and the percentage of the total number of lymphoma cells found in the follicular dendritic cell (FDC) meshwork, that is, the degree of overlap of lymphoma cells. Two hundred and nine MCL patients were apportioned to grades I–III, in which the CD21-positive FDC meshwork covered ≤50%, 51%-89%, and ≥90% of the tumor area, respectively. Significant differences among the grades (all, P < 0.01) were found in the following: duration of disease (from onset of clinical manifestation to diagno...
Source: Pathology Research and Practice - February 22, 2018 Category: Pathology Source Type: research

Expressional analysis of APLNR, an essential gene for cancer immunotherapy, in colon and prostate cancers
Publication date: Available online 22 February 2018 Source:Pathology - Research and Practice Author(s): Nam Jin Yoo, Min Sung Kim, Ju Hwa Lee, Chang Hyeok An, Sug Hyung Lee (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - February 22, 2018 Category: Pathology Source Type: research

Role of upregulated miR-136-5p in lung adenocarcinoma: a study of 1242 samples utilizing bioinformatics analysis
Conclusion MiR-136-5p is overexpressed in lung adenocarcinoma and is involved in the molecular mechanism of lung adenocarcinoma via suppressing the expressions of downstream targets, especially claudin-18, sialophorin and syndecan 2 that participate in cell adhesion. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - February 22, 2018 Category: Pathology Source Type: research

Targeted next-generation-sequencing for reliable detection of targetable rearrangements in lung adenocarcinoma —A single center retrospective study
Publication date: Available online 16 February 2018 Source:Pathology - Research and Practice Author(s): Nadezda P. Velizheva, Markus P. Rechsteiner, Nadejda Valtcheva, Sandra Nicole Freiberger, Christine E. Wong, Bart Vrugt, Qing Zhong, Ulrich Wagner, Holger Moch, Sven Hillinger, Isabelle Schmitt-Opitz, Alex Soltermann, Peter J. Wild, Verena Tischler Oncogenic rearrangements leading to targetable gene fusions are well-established cancer driver events in lung adenocarcinoma. Accurate and reliable detection of these gene fusions is crucial to select the appropriate targeted therapy for each patient. We compared the targeted...
Source: Pathology Research and Practice - February 17, 2018 Category: Pathology Source Type: research

Clinicopathological analysis of Large Cell Lung Carcinomas definitely diagnosed according to the New World Health Organization Criteria
Conclusion The clinicopathological characteristics of 17 cases of stringently diagnosed LCC were retrospectively analyzed. LCC in our study showed aggressive behavior with high recurrence and metastasis and poor prognosis. Chemotherapy was only predictive factor that is significantly associated with the prognosis of the patients. Future studies based on a larger series and long term follow-up are still needed to characterize it further. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - February 15, 2018 Category: Pathology Source Type: research

Prognostic significance of epithelial-mesenchymal transition phenotypes in upper urinary tract urothelial carcinoma
Publication date: Available online 14 February 2018 Source:Pathology - Research and Practice Author(s): Junhun Cho, Sang Yun Ha, Seok-Hyung Kim, Hyun Hwan Sung, Ghee Young Kwon Epithelial-mesenchymal transition (EMT) is a process which epithelial cells gain mesenchymal phenotype such as motility and invasiveness. We investigated the role of EMT in upper urinary tract urothelial carcinoma (UTUC). The patient cohort included 93 cases of UTUC treated with radical nephroureterectomy. Tissue microarrays were constructed from formalin-fixed paraffin-embedded tissue blocks. Immunohistochemical staining was performed for E-cadher...
Source: Pathology Research and Practice - February 15, 2018 Category: Pathology Source Type: research

Loss of p27kip1 expression is associated with poor prognosis in patients with taxane-treated breast cancer
Conclusions Low p27kip1 expression may be useful to predict overall survival in patients with breast cancer who are treated with taxane. Evaluation of p27kip1 expression may provide further prognostic information beyond traditional prognostic biomarkers and an understanding of the mechanisms that impart resistance against chemotherapy. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - February 15, 2018 Category: Pathology Source Type: research

VEGFR-2 as a novel predictor of survival in gastric cancer: a systematic review and meta-analysis 

Conclusions VEGFR-2 overexpression is a promising negative prognosis predictor for patients with gastric cancer. The prognosis significance of VEGFR-3 still need further study. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - February 15, 2018 Category: Pathology Source Type: research

MiR-1260b promotes the migration and invasion in non-small cell lung cancer via targeting PTPRK
Conclusions These results suggested that miR-1260b may play an important role in NSCLC metastasis progression and could serve as a putative target for diagnosis and treatment of NSCLC. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - February 15, 2018 Category: Pathology Source Type: research

The clinical value of HPV E6/E7 and STAT3 mRNA detection in cervical cancer screening
Conclusions 1. The expression of HPV E6/E7 and STAT3 mRNA confirmed using FISH assay is expected to be a new method and molecular marker for cervical lesions screening. Survivin mRNA was excluded due to its poor performance. 2. HPV E6/E7, STAT3, and STAT3 +HR-HPV assays could be new approaches for cervical cancer screening and ASCUS triage, and the efficiency of combined screening program was better than that of a separate one. 3. HPV E6/E7 + STAT3 regimen is expected to be a diagnostic strategy for cervical lesions. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - February 12, 2018 Category: Pathology Source Type: research

Overexpression of YAP1 in EGFR mutant lung adenocarcinoma prior to tyrosine kinase inhibitor therapy is associated with poor survival
In this study, we demonstrated a prognostic role of YAP1 in EGFR mutant LADC and efficacy of EGFR TKI therapy. A total of 63 patients, including 41 with paired lung cancer specimens before and after EGFR TKI therapy and 22 with non-paired lung cancer specimens prior to EGFR TKI, were enrolled for examination. Expression of YAP1 protein was evaluated using immunohistochemistry. Fifteen paired cases (36.6%) with high nuclear YAP1 expression were detected in the pre-EGFR TKI LADC group and 21 paired cases (52.5%) after treatment with EGFR TKI. Nuclear YAP1 expression was significantly upregulated after EGFR TKI therapy (P =...
Source: Pathology Research and Practice - February 4, 2018 Category: Pathology Source Type: research

The Diagnostic and Prognostic Significance of Long Noncoding RNAs Expression in Thyroid Cancer: A Systematic Review and Meta-Analysis
Conclusions In summary, our meta-analysis suggested that lncRNAs could function as potential diagnostic markers for TC and predict the LNM. In addition, the systematic review elaborated that lncRNAs might be as prognostic indicators in TC. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - February 2, 2018 Category: Pathology Source Type: research

Immunohistochemical evaluation of H3K27 trimethylation in malignant peripheral nerve sheath tumors
Publication date: Available online 31 January 2018 Source:Pathology - Research and Practice Author(s): Hiroshi Otsuka, Kenichi Kohashi, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yuichi Yamada, Hidetaka Yamamoto, Yasuharu Nakashima, Yoshinao Oda The histological definitive diagnosis of malignant peripheral nerve sheath tumor (MPNST) is quite difficult because the morphological features are not specific and no useful immunohistochemical marker has been identified. Loss-of-function mutations in EED or SUZ12, which encode the core subunit of polycomb repressive complex 2 (PRC2), were reported in MPNSTs, and the mutations were...
Source: Pathology Research and Practice - February 1, 2018 Category: Pathology Source Type: research

Downregulation of SETD8 by MiR-382 is involved in glioma progression
Conclusion These data indicated that oncogenic SETD8 was regulated by miR-382 and involved glioma progression, .revealing new therapeutic targets for glioma cancer. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - February 1, 2018 Category: Pathology Source Type: research

Investigation of relationship between precursor of miRNA-944 and its mature form in lung squamous-cell carcinoma - the diagnostic value
Conclusion We assumed that pri-miRNA-944 and miRNA-944 may be involved in early squamous-type differentiation of lung tumors. Moreover, analysis of both markers provided high diagnostic accuracy for SCC detection. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - January 26, 2018 Category: Pathology Source Type: research

Overexpression of CTNNB1: Clinical implication in Chinese de novo acute myeloid leukemia
Publication date: Available online 9 January 2018 Source:Pathology - Research and Practice Author(s): Xi-xi Li, Hong Guo, Jing-dong Zhou, De-hong Wu, Ji-chun Ma, Xiang-mei Wen, Wei Zhang, Zi-jun Xu, Jiang Lin, Jun Qian CTNNB1 expression has been identified in numerous solid tumors. The present study was designed to determine CTNNB1 expression and its clinical significance in Chinese de novo acute myeloid leukemia (AML) patients. Real-time quantitative PCR was carried out to detect the pattern of CTNNB1 expression in 140 AML patients and 46 controls. The level of CTNNB1 transcript in AML patients was significantly up-regul...
Source: Pathology Research and Practice - January 10, 2018 Category: Pathology Source Type: research

MiR-21-5p, miR-34a, and human telomerase RNA component as surrogate markers for cervical cancer progression
Conclusions MiR-21-5p upregulation, miR-34a downregulation, and hTERC amplification were associated with the aggressive progression of CC, which suggests that miR-21-5p, miR-34a and hTERC might serve as surrogate markers for CC progression and potential molecular targets for blockage of the development of CC. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - January 10, 2018 Category: Pathology Source Type: research

MiR-449a suppresses cell migration and invasion by targeting PLAGL2 in breast cancer
Conclusion We demonstrate the miR-449a tumor suppressor role in breast cancer cell migration and invasion via targeting PLAGL2. These findings suggesting that miR-449a/PLAGL2 could serve as a therapeutic strategy for targeting breast cancer. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - January 6, 2018 Category: Pathology Source Type: research

Whole-exome sequencing of chondroid hamartoma of lung identified no driver mutations
Publication date: Available online 2 January 2018 Source:Pathology - Research and Practice Author(s): Su Hye Choi, Hyeon-Chun Park, Min Sung Kim, Yeun-Jun Chung, Sug Hyung Lee (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - January 3, 2018 Category: Pathology Source Type: research

Tumor Budding and Poorly-differentiated Cluster in Prognostication in Stage II Colon Cancer
Publication date: Available online 2 January 2018 Source:Pathology - Research and Practice Author(s): Victor Wai Kwan Lee, Kui Fat Chan Comparison between tumor budding (TB) and poorly-differentiated clusters (PDC) for prognostication in Stage II colon cancer was not extensively studied in literature. In this retrospective study, we assessed TB (according to the consensus statement in 2016) and PDC in 135 Stage II colon adenocarcinoma resection specimens. Counting of TB and PDC was performed on H&E slides. High-grade TB (Bd3 (>=10 tumor buds in 0.785 mm2)) and high-grade PDC (Grade 3 (>=10)) were f...
Source: Pathology Research and Practice - January 3, 2018 Category: Pathology Source Type: research

Analysis of the Proliferative Activity in Lung Adenocarcinomas with Specific Driver Mutations
Publication date: Available online 2 January 2018 Source:Pathology - Research and Practice Author(s): Mark Kriegsmann, Alexander Harms, Daniel Kazdal, Sebastian Fischer, Albrecht Stenzinger, Jonas Leichsenring, Roland Penzel, Rémi Longuespée, Katharina Kriegsmann, Thomas Muley, Seyer Safi, Arne Warth In the last decade it became evident that many lung adenocarcinomas (ADC) harbor key genetic alterations such as KRAS, EGFR or BRAF mutations as well as rearrangements of ROS1 or ALK that drive these tumors. In the present study we investigated whether different driver mutations of ADC result in different prolif...
Source: Pathology Research and Practice - January 3, 2018 Category: Pathology Source Type: research

Clinical value of survivin and its underlying mechanism in ovarian cancer: A bioinformatics study based on GEO and TCGA data mining
Conclusion Survivin (BIRC5) expression might become a specific but low-sensitivity biomarker in ovarian cancer patients, and its presence indicated poor prognosis and worse TNM stages. This protein might function as an oncoprotein by influencing specific pathways involving the 50 genes identified herein. Additional studies are needed to confirm these results. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - January 3, 2018 Category: Pathology Source Type: research

Hyalinizing Clear Cell Carcinoma of Salivary Glands: A Retrospective Study Focused on Uncommon Morphology, Immunohistochemistry, and Detection of Gene Fusion Using Fluorescence In Situ Hybridization
Publication date: Available online 3 January 2018 Source:Pathology - Research and Practice Author(s): Yi-nuo Zhao, Xiao Wang, Fen-hua Liang, Wen-jie Zhang, Xiang-tao Song (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - January 3, 2018 Category: Pathology Source Type: research

Genomic Analysis Reveals Distinct Subtypes in Two Rare Cases of Primary Ovarian Lymphoma
This report describes detailed clinical, histopathological, and imaging findings, along with the review of literature of primary diffuse large B-cell lymphoma (DLBCL) arising from an ovary. In addition we describe findings of targeted capture panel sequencing on both tumors and identify the major genetic mutations that are recurrently mutated in pan-cancers. Compared to the genomic mutation features of major subtypes of DLBCL, we distinguish that each POL belongs to distinctive subtypes, GCB (germinal center B-cell type) DLBCL and ABC (activated B-cell type) DLBCL, respectively. The findings from the genomic analysis may h...
Source: Pathology Research and Practice - January 3, 2018 Category: Pathology Source Type: research

Wnt/ β-catenin signal alteration and its diagnostic utility in basal cell adenoma and histologically similar tumors of the salivary gland
Publication date: Available online 3 January 2018 Source:Pathology - Research and Practice Author(s): Masanobu Sato, Hidetaka Yamamoto, Yui Hatanaka, Toshimitsu Nishijima, Rina Jiromaru, Ryuji Yasumatsu, Kenichi Taguchi, Muneyuki Masuda, Takashi Nakagawa, Yoshinao Oda Differential diagnosis among basal cell adenoma (BCA), basal cell adenocarcinoma (BCAC), adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) of the salivary gland can be challenging due to their similar histological appearance. Although frequent nuclear β-catenin expression and CTNNB1 mutations have been reported in BCA, further details of the W...
Source: Pathology Research and Practice - January 3, 2018 Category: Pathology Source Type: research

Up-regulated Expression of SNHG6 Predicts Poor Prognosis in Colorectal Cancer
Publication date: Available online 3 January 2018 Source:Pathology - Research and Practice Author(s): Min Li, Zehua Bian, Surui Yao, Jia Zhang, Guoying Jin, Xue Wang, Yuan Yin, Zhaohui Huang Long non-coding RNAs (lncRNAs) have been shown to play important roles in tumor formation and development. Small nucleolar RNA host gene 6 (SNHG6) is a recently identified cancer-related lncRNA, and its role in colorectal cancer (CRC) remains to be explored. The aim of this study was to evaluate the expression and function of SNHG6 in CRC. The expression of SNHG6 was detected by real time quantitative RT-PCR (qRT-PCR) in 74 CRC tissue...
Source: Pathology Research and Practice - January 3, 2018 Category: Pathology Source Type: research

High-expressed CKS2 is associated with hepatocellular carcinoma cell proliferation though down-regulating PTEN
Conclusion These findings indicated that CKS2 play a role in tumor activation and serve as a useful potential target for the treatment of HCC. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - December 31, 2017 Category: Pathology Source Type: research

CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation, invasion and apoptosis
Conclusions CIP2A is overexpressed in endometrioid adenocarcinoma and CIP2A promotes the malignant growth and invasion,decrease apoptosis in entometrioid adenocarcinoma cell lines. These results validate that CIP2A plays an important role in the carcinogenesis of endometrioid adenocarcinoma and establishes CIP2A as a clinically relevant oncoprotein and may presents a promising therapeutic target for cancer treatment. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - December 22, 2017 Category: Pathology Source Type: research

Mutational intratumoral heterogeneity of a putative tumor suppressor gene RARRES3 in colorectal cancers
Publication date: Available online 21 December 2017 Source:Pathology - Research and Practice Author(s): Ju Hwa Lee, Chang Hyeok An, Nam Jin Yoo, Sug Hyung Lee (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - December 22, 2017 Category: Pathology Source Type: research

Accentuated p53 staining in usual type vulvar dysplasia —A potential diagnostic pitfall
In conclusion, DVIN is difficult to diagnose due to potential histologic overlap with UVIN, especially the warty, or keratinizing, subtype. Accentuated WT p53 in absence of concurrent p16 staining may lead to misdiagnosis of DVIN, especially in small biopsy samples. P16/p53 staining should be performed in tandem with strict adherence to patterns considered positive, as patients with UVIN have significantly less risk of progression. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - December 16, 2017 Category: Pathology Source Type: research

Impact of DNA repair, folate and glutathione gene polymorphisms on risk of non small cell lung cancer
Publication date: Available online 21 November 2017 Source:Pathology - Research and Practice Author(s): Cristina Pérez-Ramírez, Marisa Cañadas-Garre, Ahmed Alnatsha, Eduardo Villar, Juan Ramón Delgado, Miguel Ángel Calleja-Hernández, María José Faus-Dáder Lung cancer, particularly non-small cell lung cancer (NSCLC) subtype, is the leading cause of cancer-related death related worldwide. Numerous gene polymorphisms in DNA repair, folate and glutathione pathways have been associated with susceptibility of NSCLC. We conducted this study to evaluate the effects of...
Source: Pathology Research and Practice - December 16, 2017 Category: Pathology Source Type: research

Small Round Cell Myofibroblastoma of the Oral Cavity: a Tumor Mimicking Embryonal Rhabdomyosarcoma
Publication date: Available online 14 December 2017 Source:Pathology - Research and Practice Author(s): Gaetano Magro, Giuseppe Angelico, Alberto Righi, Lucia Salvatorelli (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - December 15, 2017 Category: Pathology Source Type: research

Immunohistochemical comparative analysis of GFAP, MAP – 2, NOGO – A, OLIG – 2 and WT – 1 expression in WHO 2016 classified neuroepithelial tumours and their prognostic value
Publication date: Available online 14 December 2017 Source:Pathology - Research and Practice Author(s): David Emanuel Schwab, Guilherme Lepski, Christian Borchers, Katrin Trautmann, Frank Paulsen, Jens Schittenhelm Immunohistochemistry is routinely used in differential diagnosis of tumours of the central nervous system (CNS). The latest 2016 WHO 2016 revision now includes molecular data such as IDH mutation and 1p/19q codeletion thus restructuring glioma classification. Direct comparative information between commonly used immunohistochemical markers for glial tumours GFAP, MAP − 2, NOGO − A, OLIG − 2 and...
Source: Pathology Research and Practice - December 15, 2017 Category: Pathology Source Type: research

Frequent methylation of DAB2, a Wnt pathway antagonist, in oral and oropharyngeal squamous cell carcinomas
Conclusions Our findings corroborate that DAB2 is a frequent target of epigenetic silencing in oral carcinomas and may be potentially used for tumor detection. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - December 15, 2017 Category: Pathology Source Type: research

Clinicopathological features of low-grade malignant endolymphatic sac tumors
CONCLUSIONS Low-grade malignant ELSTs occur most frequently on the left side, with a female preponderance. The disease progressed slowly, with no death, and but relapse in two patients in this series. These tumors are often misdiagnosed. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - December 15, 2017 Category: Pathology Source Type: research

SATB2 is a supportive marker for the differentiation of a primary mucinous tumor of the ovary and an ovarian metastasis of a low-grade appendiceal mucinous neoplasm (LAMN): A series of seven cases
This report supports SATB2 as an additional diagnostic marker for the diagnosis of an ovarian manifestation of LAMN. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - December 15, 2017 Category: Pathology Source Type: research

Gallic acid modulates phenotypic behavior and gene expression in oral squamous cell carcinoma cells by interfering with leptin pathway
Publication date: Available online 10 December 2017 Source:Pathology - Research and Practice Author(s): Eliane Macedo Sobrinho Santos, Rogério Gonçalves da Rocha, Hércules Otacílio Santos, Talita Antunes Guimarães, Carlos Alberto de Carvalho Fraga, Luiz Henrique da Silveira, Paulo Ricardo Batista, Paulo Sérgio Lopes de Oliveira, Geraldo Aclécio Melo, Sérgio Henrique Santos, Alfredo Maurício Batista de Paula, André Luiz Sena Guimarães, Lucyana Conceição Farias Gallic acid is a polyphenolic compost appointed to interfere with neoplast...
Source: Pathology Research and Practice - December 10, 2017 Category: Pathology Source Type: research

Expression profiles of Annexin A1, formylated peptide receptors and cyclooxigenase-2 in gastroesophageal inflammations and neoplasias
Publication date: Available online 7 December 2017 Source:Pathology - Research and Practice Author(s): Rodolfo T.C. Takaoka, Nathália D. Sertório, Lara P.J. Magalini, Leandro M. Do Santos, Helena R. Souza, Melina M. Iyomasa-Pilon, Lucas Possebon, Sara S. Costa, Ana P. Girol The anti−inflammatory protein Annexin−A1 (ANXA1) is associated to tumor invasion process and its actions can be mediated by formylated peptides receptors (FPRs). Therefore, we evaluated the expression and correlation of ANXA1, FPR and cyclooxygenase−2 (COX−2) enzyme in esophageal and stomach inflammations and neopl...
Source: Pathology Research and Practice - December 8, 2017 Category: Pathology Source Type: research

Cyclin D1 expression by histiocytes may mimic cyclin D1-positive proliferation centres of chronic lymphocytic leukaemia/small lymphocytic lymphoma
Conclusions The cyclin D1-positive CLL/SLL cells in this study were mostly histiocytes. The expression of cyclin D1 by histiocytes may mimic cyclin D1+ CLL/SLL; thus, the recognition of cyclin D1 expression by non-lymphoid cells in lymphoma is important. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - December 7, 2017 Category: Pathology Source Type: research

Accentuated p53 Staining in Usual Type Vulvar Dysplasia – A Potential Diagnostic Pitfall
In conclusion, DVIN is difficult to diagnose due to potential histologic overlap with UVIN, especially the warty, or keratinizing, subtype. Accentuated WT p53 in absence of concurrent p16 staining may lead to misdiagnosis of DVIN, especially in small biopsy samples. P16/p53 staining should be performed in tandem with strict adherence to patterns considered positive, as patients with UVIN have significantly less risk of progression. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - December 7, 2017 Category: Pathology Source Type: research

High expression of GRK3 is associated with favorable prognosis in pancreatic ductal adenocarcinoma
Conclusions Our data suggested that expression of GRK3 was down-regulated in PDAC and was an independent prognostic factor. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - December 7, 2017 Category: Pathology Source Type: research