Critical role of exosome, exosomal non-coding RNAs and non-coding RNAs in head and neck cancer angiogenesis
Pathol Res Pract. 2024 Mar 7;256:155238. doi: 10.1016/j.prp.2024.155238. Online ahead of print.ABSTRACTHead and neck cancer (HNC) refers to the epithelial malignancies of the upper aerodigestive tract. HNCs have a constant yet slow-growing rate with an unsatisfactory overall survival rate globally. The development of new blood vessels from existing blood conduits is regarded as angiogenesis, which is implicated in the growth, progression, and metastasis of cancer. Aberrant angiogenesis is a known contributor to human cancer progression. Representing a promising therapeutic target, the blockade of angiogenesis aids in the r...
Source: Pathology, Research and Practice - March 17, 2024 Category: Pathology Authors: Saade Abdalkareem Jasim Sulieman Ibraheem Shelash Al-Hawary Irwanjot Kaur Irfan Ahmad Ahmed Hjazi Iliya Petkov Saad Hayif Jasim Ali Ahmed Huseen Redhee Mahmood Hasen Shuhata Alubiady Ahmed Muzahem Al-Ani Source Type: research

Pollutants to pathogens: The role of heavy metals in modulating TGF- β signaling and lung cancer risk
Pathol Res Pract. 2024 Mar 11;256:155260. doi: 10.1016/j.prp.2024.155260. Online ahead of print.ABSTRACTLung cancer is a malignant tumor that develops in the lungs due to the uncontrolled growth of aberrant cells. Heavy metals, such as arsenic, cadmium, mercury, and lead, are metallic elements characterized by their high atomic weights and densities. Anthropogenic activities, such as industrial operations and pollution, have the potential to discharge heavy metals into the environment, hence presenting hazards to ecosystems and human well-being. The TGF-β signalling pathways have a crucial function in controlling several ...
Source: Pathology, Research and Practice - March 17, 2024 Category: Pathology Authors: Asif Ahmad Bhat Ehssan Moglad Pooja Bansal Harpreet Kaur Mahamedha Deorari Riya Thapa Waleed Hassan Almalki Imran Kazmi Sami I Alzarea Neelima Kukreti Haider Ali Source Type: research

Endobronchial solitary fibrous tumors: An enigma for diagnosis
This report underscores the importance of careful histological and immunohistochemical evaluation in understanding and appropriately stratifying the risk associated with polypoid lesions.PMID:38492357 | DOI:10.1016/j.prp.2024.155240 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 16, 2024 Category: Pathology Authors: F átima Ramalhosa Federica Pezzuto Francesco Fortarezza Gianluca Canu Davide Biondini Eleonora Faccioli Roberta Polverosi Chiara Giraudo Fiorella Calabrese Source Type: research

Deciphering the role of MicroRNAs in diabetic nephropathy: Regulatory mechanisms and molecular insights
Pathol Res Pract. 2024 Mar 4;256:155237. doi: 10.1016/j.prp.2024.155237. Online ahead of print.ABSTRACTA serious consequence of diabetes mellitus, diabetic nephropathy (DN) which causes gradual damage to the kidneys. Dietary changes, blood pressure control, glucose control, and hyperlipidemia are all important components of DN management. New research, however, points to microRNAs (miRNAs) as having a pivotal role in DN pathogenesis. Miniature non-coding RNA molecules such as miRNAs control gene expression and impact several biological processes. The canonical and non-canonical routes of miRNA biogenesis are discussed in t...
Source: Pathology, Research and Practice - March 16, 2024 Category: Pathology Authors: Nourhan M Abdelmaksoud Tohada M Al-Noshokaty Rehab Abdelhamid Nourhan Abdellatif Abdallah Mansour Reem Mohamed Asmaa Hamouda Mohamed Nada Abd Elatif Khalil Sara Sobhy Abdelhamid Alaa Mohsen Heba Abdelaal Ahmed Tawfik Shereen Saeid Elshaer Source Type: research

Interleukin-22 inhibits cardiac fibrosis by regulating fibroblast metabolic reprogramming in myocardial infarction
In this study, we aimed to investigate the role of Interleukin-22 (IL-22) in myocardial fibrosis following myocardial infarction (MI) and to explore the underlying metabolic mechanisms. Here we analyzed the single-cell sequencing data and found that the level of aerobic glycolysis was significantly higher in cardiac fibrosis in MI patient, which we validated through in vivo experiments. Utilizing MI mouse model, these experiments revealed decreased serum IL-22 levels and increased levels of AngII and TGF-β1. However, treatment with exogenous IL-22 reversed these changes, reduced infarct size, and fibrosis. In vitro experi...
Source: Pathology, Research and Practice - March 16, 2024 Category: Pathology Authors: Fang Liu Yueqi Chen Demeng Qin Cheng Qian Source Type: research

LncRNAs associated with lymph node metastasis in thyroid cancer based on TCGA database
CONCLUSION: These lncRNAs may play crucial roles in the development and progression of thyroid cancer and could serve as potential markers for predicting tumor metastasis, clinical stage, and patient prognosis.PMID:38492360 | DOI:10.1016/j.prp.2024.155255 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 16, 2024 Category: Pathology Authors: Ruijing Liu Wen Liu Jingli Xue Beibei Jiang YuQing Wei Yiqiang Yin Peifeng Li Source Type: research

Disorganized adrenocortical zonational structure in COVID-19 patients: Implications of critical illness duration
Pathol Res Pract. 2024 Mar 12;256:155251. doi: 10.1016/j.prp.2024.155251. Online ahead of print.ABSTRACTAberrant adrenal function has been frequently reported in COVID-19 patients, but histopathological evidence remains limited. This retrospective autopsy study aims to scrutinize the impact of COVID-19 duration on adrenocortical zonational architecture and peripheral corticosteroid reactivity. The adrenal glands procured from 15 long intensive care unit (ICU)-stay COVID-19 patients, 9 short ICU-stay COVID-19 patients, and 20 matched controls. Subjects who had received glucocorticoid treatment prior to sampling were exclude...
Source: Pathology, Research and Practice - March 15, 2024 Category: Pathology Authors: Tian-Zi Wen Wen-Juan Fu Shi-Qi Xiao Shuai Wang Tian-Ran Li Xin-Yu Chen He-Yuan Chen Jie Luo Xiu-Wu Bian Xiao-Hong Yao Source Type: research

Uncommon diagnosis of multinodular goiter - isolated extrapulmonary manifestation of sarcoidosis in thyroid gland (scientific case reports)
CONCLUSION: Sarcoidosis is considered a rare granulomatous multi-locular, systemic disease of not completely known etiopathogenesis with substantial heterogeneity. In most cases, it is associated with the lung, but which can become manifest in various organs. Frequently, extrapulmonary manifestations are usually detected as histological findings by coincidence, which require further investigation to find out additional manifestations as well as to exclude florid infection or other granulomatous processes (clarifying competently differential diagnosis). Therapy is only indicated in symptomatic organ manifestations, taking i...
Source: Pathology, Research and Practice - March 15, 2024 Category: Pathology Authors: Marcel Neumann Frank Meyer Tatiana Oksentyuk Polyakova Udo Barth D örthe Jechorek Roland S Croner Manuela Petersen Source Type: research

Cancer stem cells: The important role of CD markers, Signaling pathways, and MicroRNAs
Pathol Res Pract. 2024 Feb 28;256:155227. doi: 10.1016/j.prp.2024.155227. Online ahead of print.ABSTRACTFor the first time, a subset of small cancer cells identified in acute myeloid leukemia has been termed Cancer Stem Cells (CSCs). These cells are notorious for their robust proliferation, self-renewal abilities, significant tumor-forming potential, spread, and resistance to treatments. CSCs are a global concern, as it found in numerous types of cancer, posing a real-world challenge today. Our review encompasses research on key CSC markers, signaling pathways, and MicroRNA in three types of cancer: breast, colon, and live...
Source: Pathology, Research and Practice - March 15, 2024 Category: Pathology Authors: Amir Gholamzad Niloofar Khakpour Elaheh Mohandesi Khosroshahi Saba Asadi Zeinab Khazaei Koohpar Arash Matinahmadi Ali Jebali Mohsen Rashidi Mehrdad Hashemi Farzaneh Hasani Sadi Mehrdad Gholamzad Source Type: research

Disorganized adrenocortical zonational structure in COVID-19 patients: Implications of critical illness duration
Pathol Res Pract. 2024 Mar 12;256:155251. doi: 10.1016/j.prp.2024.155251. Online ahead of print.ABSTRACTAberrant adrenal function has been frequently reported in COVID-19 patients, but histopathological evidence remains limited. This retrospective autopsy study aims to scrutinize the impact of COVID-19 duration on adrenocortical zonational architecture and peripheral corticosteroid reactivity. The adrenal glands procured from 15 long intensive care unit (ICU)-stay COVID-19 patients, 9 short ICU-stay COVID-19 patients, and 20 matched controls. Subjects who had received glucocorticoid treatment prior to sampling were exclude...
Source: Pathology, Research and Practice - March 15, 2024 Category: Pathology Authors: Tian-Zi Wen Wen-Juan Fu Shi-Qi Xiao Shuai Wang Tian-Ran Li Xin-Yu Chen He-Yuan Chen Jie Luo Xiu-Wu Bian Xiao-Hong Yao Source Type: research

Uncommon diagnosis of multinodular goiter - isolated extrapulmonary manifestation of sarcoidosis in thyroid gland (scientific case reports)
CONCLUSION: Sarcoidosis is considered a rare granulomatous multi-locular, systemic disease of not completely known etiopathogenesis with substantial heterogeneity. In most cases, it is associated with the lung, but which can become manifest in various organs. Frequently, extrapulmonary manifestations are usually detected as histological findings by coincidence, which require further investigation to find out additional manifestations as well as to exclude florid infection or other granulomatous processes (clarifying competently differential diagnosis). Therapy is only indicated in symptomatic organ manifestations, taking i...
Source: Pathology, Research and Practice - March 15, 2024 Category: Pathology Authors: Marcel Neumann Frank Meyer Tatiana Oksentyuk Polyakova Udo Barth D örthe Jechorek Roland S Croner Manuela Petersen Source Type: research

Cancer stem cells: The important role of CD markers, Signaling pathways, and MicroRNAs
Pathol Res Pract. 2024 Feb 28;256:155227. doi: 10.1016/j.prp.2024.155227. Online ahead of print.ABSTRACTFor the first time, a subset of small cancer cells identified in acute myeloid leukemia has been termed Cancer Stem Cells (CSCs). These cells are notorious for their robust proliferation, self-renewal abilities, significant tumor-forming potential, spread, and resistance to treatments. CSCs are a global concern, as it found in numerous types of cancer, posing a real-world challenge today. Our review encompasses research on key CSC markers, signaling pathways, and MicroRNA in three types of cancer: breast, colon, and live...
Source: Pathology, Research and Practice - March 15, 2024 Category: Pathology Authors: Amir Gholamzad Niloofar Khakpour Elaheh Mohandesi Khosroshahi Saba Asadi Zeinab Khazaei Koohpar Arash Matinahmadi Ali Jebali Mohsen Rashidi Mehrdad Hashemi Farzaneh Hasani Sadi Mehrdad Gholamzad Source Type: research

A comprehensive review of lncRNA CRNDE in cancer progression and pathology, with a specific glance at the epithelial-mesenchymal transition (EMT) process
Pathol Res Pract. 2024 Feb 27;256:155229. doi: 10.1016/j.prp.2024.155229. Online ahead of print.ABSTRACTIt has been suggested that the long non-coding RNAs (lncRNAs), such as colorectal neoplasia differentially expressed (CRNDE), may contribute to the formation of human cancer. It is yet unknown, though, what therapeutic significance CRNDE expression has for different forms of cancer. CRNDE has recently been proposed as a possible diagnostic biomarker and prognostic pred for excellent specificity and sensitivity in cancer tissues and plasma. To provide the groundwork for potential future therapeutic uses of CRNDE, we brief...
Source: Pathology, Research and Practice - March 14, 2024 Category: Pathology Authors: Saade Abdalkareem Jasim Sulieman Ibraheem Shelash Al-Hawary Ahmed Hjazi Irfan Ahmad Irwanjot Kaur Wesam R Kadhum Adnan Taan Alkhafaji Pallavi Ghildiyal Mohammed Abed Jawad Salim B Alsaadi Source Type: research

Expression of IZUMO2 in colorectal cancer in association with clinicopathological features
In this study, we aimed to elucidate the expression of the IZUMO2 protein in colorectal cancer, with a focus on the clinicopathological features. Sixty-four colorectal cancer tissue specimens were immunohistochemically stained using specific antibodies against IZUMO2. IZUMO2 immunoreactivity was detected at the invasion front in 30 of the 64 colorectal cancer samples. Kaplan-Meier analysis demonstrated that patients with IZUMO2 immunoreactivity had a relatively shorter overall and progression-free survival (log-rank test, P = 0.046 and 0.019, respectively). IZUMO2 immunoreactivity served as an independent factor predictive...
Source: Pathology, Research and Practice - March 14, 2024 Category: Pathology Authors: Toshiya Higashi Hirokatsu Hayashi Yuki Hanamatsu Chiemi Saigo Nobuhisa Matsuhashi Tamotsu Takeuchi Source Type: research

A comprehensive review of lncRNA CRNDE in cancer progression and pathology, with a specific glance at the epithelial-mesenchymal transition (EMT) process
Pathol Res Pract. 2024 Feb 27;256:155229. doi: 10.1016/j.prp.2024.155229. Online ahead of print.ABSTRACTIt has been suggested that the long non-coding RNAs (lncRNAs), such as colorectal neoplasia differentially expressed (CRNDE), may contribute to the formation of human cancer. It is yet unknown, though, what therapeutic significance CRNDE expression has for different forms of cancer. CRNDE has recently been proposed as a possible diagnostic biomarker and prognostic pred for excellent specificity and sensitivity in cancer tissues and plasma. To provide the groundwork for potential future therapeutic uses of CRNDE, we brief...
Source: Pathology, Research and Practice - March 14, 2024 Category: Pathology Authors: Saade Abdalkareem Jasim Sulieman Ibraheem Shelash Al-Hawary Ahmed Hjazi Irfan Ahmad Irwanjot Kaur Wesam R Kadhum Adnan Taan Alkhafaji Pallavi Ghildiyal Mohammed Abed Jawad Salim B Alsaadi Source Type: research