Terminal deoxynucleotidyl transferase expression in different subtypes of childhood B-cell acute lymphoblastic leukemia
Pathol Res Pract. 2024 Apr 2;256:155287. doi: 10.1016/j.prp.2024.155287. Online ahead of print.ABSTRACTThe lack of expression of terminal deoxynucleotidyl transferase (TdT) is frequently associated with KMT2A-rearranged subtype of pediatric acute lymphoblastic leukemia (ALL). However, this association has not been investigated extensively in the Asian population. A retrospective analysis of TdT expression in pediatric B-cell ALL (B-ALL) was performed in patients treated using the Taiwan Pediatric Oncology Group (TPOG) ALL 2002 and 2013 protocols. Among the 331 patients with B-ALL, 12 patients showed TdT negativity at initi...
Source: Pathology, Research and Practice - April 5, 2024 Category: Pathology Authors: Chih-Hsiang Yu Ying-Hui Su Shiann-Tarng Jou Meng-Yao Lu Chien-Yu Lin Kai-Hsin Lin Hsiu-Hao Chang Shu-Wei Chou Ya-Hui Huang Dong-Tsamn Lin Shu-Wha Lin Hsuan-Yu Chen Ya-Hsuan Chang Yung-Li Yang Source Type: research
Identification of miR-125a and miR-106b signature as a potential diagnostic biomarker in breast cancer tissues
Pathol Res Pract. 2024 Mar 27;256:155277. doi: 10.1016/j.prp.2024.155277. Online ahead of print.ABSTRACTMicroRNAs (miRNAs) have essential roles in the etiology of breast cancer and are regarded as possible markers in this malignancy. In order to find new markers for breast cancer, the current study has measured expression level of four miRNAs, namely miR-125a, miR-106b, miR-96 and miR-92a-3p in the paired breast samples. Expression levels of miR-125a and miR-106b were higher in tumoral tissues compared with control tissues (Expression ratios (95% CI) = 4.01 (1.96-8.19) and 3.9 (1.95-7.81); P values = 0.0005 and 0.0003, res...
Source: Pathology, Research and Practice - April 5, 2024 Category: Pathology Authors: Soudeh Ghafouri-Fard Bashdar Mahmud Hussen Solat Eslami Source Type: research
Terminal deoxynucleotidyl transferase expression in different subtypes of childhood B-cell acute lymphoblastic leukemia
Pathol Res Pract. 2024 Apr 2;256:155287. doi: 10.1016/j.prp.2024.155287. Online ahead of print.ABSTRACTThe lack of expression of terminal deoxynucleotidyl transferase (TdT) is frequently associated with KMT2A-rearranged subtype of pediatric acute lymphoblastic leukemia (ALL). However, this association has not been investigated extensively in the Asian population. A retrospective analysis of TdT expression in pediatric B-cell ALL (B-ALL) was performed in patients treated using the Taiwan Pediatric Oncology Group (TPOG) ALL 2002 and 2013 protocols. Among the 331 patients with B-ALL, 12 patients showed TdT negativity at initi...
Source: Pathology, Research and Practice - April 5, 2024 Category: Pathology Authors: Chih-Hsiang Yu Ying-Hui Su Shiann-Tarng Jou Meng-Yao Lu Chien-Yu Lin Kai-Hsin Lin Hsiu-Hao Chang Shu-Wei Chou Ya-Hui Huang Dong-Tsamn Lin Shu-Wha Lin Hsuan-Yu Chen Ya-Hsuan Chang Yung-Li Yang Source Type: research
Identification of miR-125a and miR-106b signature as a potential diagnostic biomarker in breast cancer tissues
Pathol Res Pract. 2024 Mar 27;256:155277. doi: 10.1016/j.prp.2024.155277. Online ahead of print.ABSTRACTMicroRNAs (miRNAs) have essential roles in the etiology of breast cancer and are regarded as possible markers in this malignancy. In order to find new markers for breast cancer, the current study has measured expression level of four miRNAs, namely miR-125a, miR-106b, miR-96 and miR-92a-3p in the paired breast samples. Expression levels of miR-125a and miR-106b were higher in tumoral tissues compared with control tissues (Expression ratios (95% CI) = 4.01 (1.96-8.19) and 3.9 (1.95-7.81); P values = 0.0005 and 0.0003, res...
Source: Pathology, Research and Practice - April 5, 2024 Category: Pathology Authors: Soudeh Ghafouri-Fard Bashdar Mahmud Hussen Solat Eslami Source Type: research
Terminal deoxynucleotidyl transferase expression in different subtypes of childhood B-cell acute lymphoblastic leukemia
Pathol Res Pract. 2024 Apr 2;256:155287. doi: 10.1016/j.prp.2024.155287. Online ahead of print.ABSTRACTThe lack of expression of terminal deoxynucleotidyl transferase (TdT) is frequently associated with KMT2A-rearranged subtype of pediatric acute lymphoblastic leukemia (ALL). However, this association has not been investigated extensively in the Asian population. A retrospective analysis of TdT expression in pediatric B-cell ALL (B-ALL) was performed in patients treated using the Taiwan Pediatric Oncology Group (TPOG) ALL 2002 and 2013 protocols. Among the 331 patients with B-ALL, 12 patients showed TdT negativity at initi...
Source: Pathology, Research and Practice - April 5, 2024 Category: Pathology Authors: Chih-Hsiang Yu Ying-Hui Su Shiann-Tarng Jou Meng-Yao Lu Chien-Yu Lin Kai-Hsin Lin Hsiu-Hao Chang Shu-Wei Chou Ya-Hui Huang Dong-Tsamn Lin Shu-Wha Lin Hsuan-Yu Chen Ya-Hsuan Chang Yung-Li Yang Source Type: research
Identification of miR-125a and miR-106b signature as a potential diagnostic biomarker in breast cancer tissues
Pathol Res Pract. 2024 Mar 27;256:155277. doi: 10.1016/j.prp.2024.155277. Online ahead of print.ABSTRACTMicroRNAs (miRNAs) have essential roles in the etiology of breast cancer and are regarded as possible markers in this malignancy. In order to find new markers for breast cancer, the current study has measured expression level of four miRNAs, namely miR-125a, miR-106b, miR-96 and miR-92a-3p in the paired breast samples. Expression levels of miR-125a and miR-106b were higher in tumoral tissues compared with control tissues (Expression ratios (95% CI) = 4.01 (1.96-8.19) and 3.9 (1.95-7.81); P values = 0.0005 and 0.0003, res...
Source: Pathology, Research and Practice - April 5, 2024 Category: Pathology Authors: Soudeh Ghafouri-Fard Bashdar Mahmud Hussen Solat Eslami Source Type: research
Terminal deoxynucleotidyl transferase expression in different subtypes of childhood B-cell acute lymphoblastic leukemia
Pathol Res Pract. 2024 Apr 2;256:155287. doi: 10.1016/j.prp.2024.155287. Online ahead of print.ABSTRACTThe lack of expression of terminal deoxynucleotidyl transferase (TdT) is frequently associated with KMT2A-rearranged subtype of pediatric acute lymphoblastic leukemia (ALL). However, this association has not been investigated extensively in the Asian population. A retrospective analysis of TdT expression in pediatric B-cell ALL (B-ALL) was performed in patients treated using the Taiwan Pediatric Oncology Group (TPOG) ALL 2002 and 2013 protocols. Among the 331 patients with B-ALL, 12 patients showed TdT negativity at initi...
Source: Pathology, Research and Practice - April 5, 2024 Category: Pathology Authors: Chih-Hsiang Yu Ying-Hui Su Shiann-Tarng Jou Meng-Yao Lu Chien-Yu Lin Kai-Hsin Lin Hsiu-Hao Chang Shu-Wei Chou Ya-Hui Huang Dong-Tsamn Lin Shu-Wha Lin Hsuan-Yu Chen Ya-Hsuan Chang Yung-Li Yang Source Type: research
Identification of miR-125a and miR-106b signature as a potential diagnostic biomarker in breast cancer tissues
Pathol Res Pract. 2024 Mar 27;256:155277. doi: 10.1016/j.prp.2024.155277. Online ahead of print.ABSTRACTMicroRNAs (miRNAs) have essential roles in the etiology of breast cancer and are regarded as possible markers in this malignancy. In order to find new markers for breast cancer, the current study has measured expression level of four miRNAs, namely miR-125a, miR-106b, miR-96 and miR-92a-3p in the paired breast samples. Expression levels of miR-125a and miR-106b were higher in tumoral tissues compared with control tissues (Expression ratios (95% CI) = 4.01 (1.96-8.19) and 3.9 (1.95-7.81); P values = 0.0005 and 0.0003, res...
Source: Pathology, Research and Practice - April 5, 2024 Category: Pathology Authors: Soudeh Ghafouri-Fard Bashdar Mahmud Hussen Solat Eslami Source Type: research
PSMA2 promotes glioma proliferation and migration via EMT
CONCLUSION: Our study provides evidence supporting the role of PSMA2 as a regulatory factor in EMT and suggests its potential as a prognostic biomarker for glioma progression.PMID:38574629 | DOI:10.1016/j.prp.2024.155278 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 4, 2024 Category: Pathology Authors: Yujun Zhang Zijin Xiang Le Chen Xingyan Deng Huaizheng Liu Xiangdong Peng Source Type: research
Exosome miR-101-3p derived from bone marrow mesenchymal stem cells promotes radiotherapy sensitivity in non-small cell lung cancer by regulating DNA damage repair and autophagy levels through EZH2
CONCLUSION: Exosomal miR-101-3p derived from BMSCs can inhibit DNA damage repair, promote autophagy, enhance the radiosensitivity of NSCLC, and inhibit the progression of NSCLC by inhibiting EZH2.PMID:38574630 | DOI:10.1016/j.prp.2024.155271 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 4, 2024 Category: Pathology Authors: Hongwen Sun Runying Zhu Xijing Guo Peizhu Zhao Rui Zhang Zhongquan Zhao Hua Zhou Source Type: research
PSMA2 promotes glioma proliferation and migration via EMT
CONCLUSION: Our study provides evidence supporting the role of PSMA2 as a regulatory factor in EMT and suggests its potential as a prognostic biomarker for glioma progression.PMID:38574629 | DOI:10.1016/j.prp.2024.155278 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 4, 2024 Category: Pathology Authors: Yujun Zhang Zijin Xiang Le Chen Xingyan Deng Huaizheng Liu Xiangdong Peng Source Type: research
Exosome miR-101-3p derived from bone marrow mesenchymal stem cells promotes radiotherapy sensitivity in non-small cell lung cancer by regulating DNA damage repair and autophagy levels through EZH2
CONCLUSION: Exosomal miR-101-3p derived from BMSCs can inhibit DNA damage repair, promote autophagy, enhance the radiosensitivity of NSCLC, and inhibit the progression of NSCLC by inhibiting EZH2.PMID:38574630 | DOI:10.1016/j.prp.2024.155271 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 4, 2024 Category: Pathology Authors: Hongwen Sun Runying Zhu Xijing Guo Peizhu Zhao Rui Zhang Zhongquan Zhao Hua Zhou Source Type: research
Primary mucinous adenocarcinoma of the urethra: A contemporary clinicopathologic analysis of 17 patients
Pathol Res Pract. 2024 Mar 28;256:155273. doi: 10.1016/j.prp.2024.155273. Online ahead of print.ABSTRACTMucinous adenocarcinoma of the urethra is rare. Here we performed a contemporary clinicopathologic analysis of this entity in both male and female patients. All cases with secondary tumors involving the urethra were excluded. Clinicopathologic parameters and follow up was obtained. Seventeen patients were included in the study, 9/17 (53 %) male and 8/17 (47 %) female. The mean patient age was 68 years (range: 53-88 years). The majority (11/17, 65 %) of patients were African American, with an even greater incidence (7/8, ...
Source: Pathology, Research and Practice - April 2, 2024 Category: Pathology Authors: Alaaeddin Alrohaibani Adeboye O Osunkoya Source Type: research
Primary mucinous adenocarcinoma of the urethra: A contemporary clinicopathologic analysis of 17 patients
Pathol Res Pract. 2024 Mar 28;256:155273. doi: 10.1016/j.prp.2024.155273. Online ahead of print.ABSTRACTMucinous adenocarcinoma of the urethra is rare. Here we performed a contemporary clinicopathologic analysis of this entity in both male and female patients. All cases with secondary tumors involving the urethra were excluded. Clinicopathologic parameters and follow up was obtained. Seventeen patients were included in the study, 9/17 (53 %) male and 8/17 (47 %) female. The mean patient age was 68 years (range: 53-88 years). The majority (11/17, 65 %) of patients were African American, with an even greater incidence (7/8, ...
Source: Pathology, Research and Practice - April 2, 2024 Category: Pathology Authors: Alaaeddin Alrohaibani Adeboye O Osunkoya Source Type: research
Exploiting the immune system in hepatic tumor targeting: Unleashing the potential of drugs, natural products, and nanoparticles
Pathol Res Pract. 2024 Mar 19;256:155266. doi: 10.1016/j.prp.2024.155266. Online ahead of print.ABSTRACTHepatic tumors present a formidable challenge in cancer therapeutics, necessitating the exploration of novel treatment strategies. In recent years, targeting the immune system has attracted interest to augment existing therapeutic efficacy. The immune system in hepatic tumors includes numerous cells with diverse actions. CD8+ T lymphocytes, T helper 1 (Th1) CD4+ T lymphocytes, alternative M1 macrophages, and natural killer (NK) cells provide the antitumor immunity. However, Foxp3+ regulatory CD4+ T cells (Tregs), M2-like...
Source: Pathology, Research and Practice - March 30, 2024 Category: Pathology Authors: Chou-Yi Hsu Mohammed Ahmed Mustafa Ashwani Kumar Atreyi Pramanik Rajiv Sharma Faraj Mohammed Israa Abed Jawad Imad Jasim Mohammed Mohammad Y Alshahrani Noor Alhuda Mohammad Ali Khalil Ali Turki Shnishil Munther Kadhim Abosaoda Source Type: research
