Progress in long non-coding RNAs as prognostic factors of papillary thyroid carcinoma
The objective of this review is to provide a comprehensive summary of the biological functions of lncRNAs in PTC, identify prognosis-relevant lncRNAs, and explore their potential mechanisms in drug resistance to BRAF kinase inhibitors, tumor dedifferentiation, and lymph node metastasis. By doing so, this review aims to offer valuable references for both basic research and the prediction of PTC prognosis.PMID:38461693 | DOI:10.1016/j.prp.2024.155230 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 10, 2024 Category: Pathology Authors: Hao-Nan Zhu Dong-Liang Song Si-Nan Zhang Zhao-Jie Zheng Xing-Yu Chen Xin Jin Source Type: research

Morphologic features of prostate cancer-encased native vessels: An image analysis study
CONCLUSIONS: Similar to the 2000 study, increased media thickness and hypercellularity of vessels encased by PC were evident compared to controls. Borderline grade-dependent increased vessel cellularity changes were seen, suggesting a possible role in PC progression; the predictive value of these changes for outcome is uncertain. Whether the etiology of changes reflects locally increased intravascular pressure of vessels within tumor should be investigated.PMID:38461692 | DOI:10.1016/j.prp.2024.155239 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 10, 2024 Category: Pathology Authors: Cristina Fernandez Gonzalez De La Vega Savannah Duenweg Pragya Jain Sarah I Rubenstein Samuel Bobholz Michael J Barrett Peter S LaViolette Kenneth A Iczkowski Source Type: research

Progress in long non-coding RNAs as prognostic factors of papillary thyroid carcinoma
The objective of this review is to provide a comprehensive summary of the biological functions of lncRNAs in PTC, identify prognosis-relevant lncRNAs, and explore their potential mechanisms in drug resistance to BRAF kinase inhibitors, tumor dedifferentiation, and lymph node metastasis. By doing so, this review aims to offer valuable references for both basic research and the prediction of PTC prognosis.PMID:38461693 | DOI:10.1016/j.prp.2024.155230 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 10, 2024 Category: Pathology Authors: Hao-Nan Zhu Dong-Liang Song Si-Nan Zhang Zhao-Jie Zheng Xing-Yu Chen Xin Jin Source Type: research

Laparoscopic retroperitoneal lymphadenectomy for ovarian mixed germ cell tumor in a patient with situs inversus totalis; reporting the first case worldwide with literature review and in silico analysis
CONCLUSION: SIT may be associated with malignant ovarian germ cell tumors. Surgical intervention could be done laparoscopically.PMID:38460244 | DOI:10.1016/j.prp.2024.155228 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 9, 2024 Category: Pathology Authors: Ahmed Shoukry Hafez Mohammed Mamdouh Asar Sayed Farid Ahmed Abdelsamad Nadia M Hamdy Source Type: research

miRNAs Role in Wilms tumor pathogenesis: Signaling pathways interplay
Pathol Res Pract. 2024 Mar 5;256:155254. doi: 10.1016/j.prp.2024.155254. Online ahead of print.ABSTRACTWilms' tumors (WTs) are the most common type of kidney tumor in children, and a negative outlook is generally associated with widespread anaplastic. MicroRNAs (miRNAs) are crucial in the development of WT by regulating the expression of specific genes. There is an increasing amount of research that connects the dysregulation of miRNAs to the development of various renal illnesses. The conditions encompassed are renal fibrosis, renal cancers, and chronic and polycystic kidney disease. Dysregulation of several important miR...
Source: Pathology, Research and Practice - March 9, 2024 Category: Pathology Authors: Jaber Alfaifi Source Type: research

Two effective factors in cancer: Investigating the effect of ncRNAs in cancer and also the effect of nanotherapy in its treatment
This article explores two critical factors influencing cancer: ncRNAs and nanotherapy. The role of ncRNAs, including microRNAs and long non-coding RNAs, in cancer pathogenesis, progression, and treatment resistance is elucidated. Additionally, the potential of nanotherapy, leveraging nanoscale materials for targeted drug delivery and enhanced therapeutic efficacy, is investigated. By comprehensively analyzing the molecular mechanisms underlying ncRNA dysregulation and the promise of nanotherapy in cancer treatment, this article aims to provide valuable insights into novel therapeutic strategies for combating cancer.PMID:38...
Source: Pathology, Research and Practice - March 8, 2024 Category: Pathology Authors: Raed Obaid Saleh Hariadi Yuseran Sofiene Mansouri Anaheed Hussein Kareem Maha Noori Shakir Mohammed Qasim Alasheqi Nabiyeva Naima Akhmedovna Sheraliyeva Intizor Dilmurodovna Ahmed Alawadi Ali Alsalamy Source Type: research

Two effective factors in cancer: Investigating the effect of ncRNAs in cancer and also the effect of nanotherapy in its treatment
This article explores two critical factors influencing cancer: ncRNAs and nanotherapy. The role of ncRNAs, including microRNAs and long non-coding RNAs, in cancer pathogenesis, progression, and treatment resistance is elucidated. Additionally, the potential of nanotherapy, leveraging nanoscale materials for targeted drug delivery and enhanced therapeutic efficacy, is investigated. By comprehensively analyzing the molecular mechanisms underlying ncRNA dysregulation and the promise of nanotherapy in cancer treatment, this article aims to provide valuable insights into novel therapeutic strategies for combating cancer.PMID:38...
Source: Pathology, Research and Practice - March 8, 2024 Category: Pathology Authors: Raed Obaid Saleh Hariadi Yuseran Sofiene Mansouri Anaheed Hussein Kareem Maha Noori Shakir Mohammed Qasim Alasheqi Nabiyeva Naima Akhmedovna Sheraliyeva Intizor Dilmurodovna Ahmed Alawadi Ali Alsalamy Source Type: research

Cadherin-17 (CDH17) expression in human cancer: A tissue microarray study on 18,131 tumors
This study was to comprehensively determine the expression of CDH17 in cancer and to further assess the diagnostic utility of CDH17 immunohistochemistry (IHC). A tissue microarray containing 14,948 interpretable samples from 150 different tumor types and subtypes as well as 76 different normal tissue types was analyzed by IHC. In normal tissues, a membranous CDH17 staining was predominantly seen in the epithelium of the intestine and pancreatic excretory ducts. In tumors, 53 of 150 analyzed categories showed CDH17 positivity including 26 categories with at least one strongly positive case. CDH17 positivity was most common ...
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: Frank Jacobsen Ramesh Pushpadevan Florian Viehweger Morton Freytag Ria Schlichter Natalia Gorbokon Franziska B üscheck Andreas M Luebke Devita Putri Martina Kluth Claudia Hube-Magg Andrea Hinsch Doris H öflmayer Christoph Fraune Christian Bernreuther Pa Source Type: research

The mechanisms behind the dual role of long non-coding RNA (lncRNA) metastasis suppressor-1 in human tumors: Shedding light on the molecular mechanisms
This article provides an overview of the pathological effects of lncRNA MTSS1 dysregulation in cancer. In order to facilitate the development of MTSS1-based therapeutic targeting, we also shed light on the current understanding of MTS1.PMID:38452581 | DOI:10.1016/j.prp.2024.155189 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: Bekhzod Abdullaev Hashem O Alsaab Ahmed Hjazi Adnan Taan Alkhafaji Ahmed Hussien Alawadi Hamza Fadhel Hamzah Source Type: research

Emerging role of tumor suppressing microRNAs as therapeutics in managing non-small cell lung cancer
Pathol Res Pract. 2024 Feb 23;256:155222. doi: 10.1016/j.prp.2024.155222. Online ahead of print.ABSTRACTLung cancer (LC) is the second leading cause of death across the globe after breast cancer. There are two types of LC viz. small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC accounts for approximately 85% of all LC cases. NSCLC affects smokers and people who do not smoke and mainly arises in bronchi and peripheral lungs tissue. LC is often characterized by the alterations of key genes such as EGFR, Wnt/β-catenin signaling, ALK, MET, K-Ras and p53 and downstream signaling pathways associated with...
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: Shubham Singh Sangeeta Saxena Himani Sharma Keshav Raj Paudel Amlan Chakraborty Ronan MacLoughlin Brian G Oliver Gaurav Gupta Poonam Negi Sachin Kumar Singh Kamal Dua Source Type: research

SIRT7: A potential prognostic marker and therapeutic target in gallbladder cancer
In this study, we aimed to investigate the role of SIRT7, a member of the sirtuin family, in GBC and its potential as a prognostic marker and therapeutic target. Through immunohistochemistry analysis of GBC tissue samples, we observed elevated levels of SIRT7, which were correlated with worse clinicopathological parameters and shorter overall survival in GBC patients. Additionally, through cellular and animal experiments, we have discovered that interfering with SIRT7 can effectively suppress the proliferation, migration, and invasive capabilities of GBC cells. Conversely, overexpressing SIRT7 yields the opposite outcome. ...
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: Bo Xu Xiaojing Cai Guohao Cai Guoyu Huang Source Type: research

Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis
Pathol Res Pract. 2024 Feb 23;256:155224. doi: 10.1016/j.prp.2024.155224. Online ahead of print.ABSTRACTSepsis, a potentially fatal illness caused by an improper host response to infection, remains a serious problem in the world of healthcare. In recent years, the role of ncRNA has emerged as a pivotal aspect in the intricate landscape of cellular regulation. The exploration of ncRNA-mediated regulatory networks reveals their profound influence on key molecular pathways orchestrating pyroptotic responses during septic conditions. Through a comprehensive analysis of current literature, we navigate the diverse classes of ncR...
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: Asif Ahmad Bhat Yassine Riadi Muhammad Afzal Pooja Bansal Harpreet Kaur Mahamedha Deorari Haider Ali Moyad Shahwan Waleed Hassan Almalki Imran Kazmi Sami I Alzarea Hairsh Dureja Sachin Kumar Singh Kamal Dua Gaurav Gupta Source Type: research

Beyond the genome: MALAT1's role in advancing urologic cancer care
Pathol Res Pract. 2024 Feb 28;256:155226. doi: 10.1016/j.prp.2024.155226. Online ahead of print.ABSTRACTUrologic cancers (UCs), which include bladder, kidney, and prostate tumors, account for almost a quarter of all malignancies. Long non-coding RNAs (lncRNAs) are tissue-specific RNAs that influence cell growth, death, and division. LncRNAs are dysregulated in UCs, and their abnormal expression may allow them to be used in cancer detection, outlook, and therapy. With the identification of several novel lncRNAs and significant exploration of their functions in various illnesses, particularly cancer, the study of lncRNAs has...
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: Mohd Imran None Abida Lina Eltaib Muhammad Irfan Siddique Mehnaz Kamal Syed Mohammed Basheeruddin Asdaq Neelam Singla Marwan Al-Hajeili Fatemah Abdulaziz Alhakami Ahmed Farhan AlQarni Altaf A Abdulkhaliq Ali A Rabaan Source Type: research

Prognostic value of genome-wide methylation in acute-on-chronic hepatitis B liver failure
CONCLUSIONS: Genome methylation level can be a good biomarker in predicting the severity and prognosis of ACHBLF.PMID:38452586 | DOI:10.1016/j.prp.2024.155232 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: Haiming Li Shuai Gao Jieru Yang Ying Zhang None Xuefei Yuchen Fan Kai Wang Source Type: research

Harnessing the supremacy of MEG3 LncRNA to defeat gastrointestinal malignancies
Pathol Res Pract. 2024 Feb 23;256:155223. doi: 10.1016/j.prp.2024.155223. Online ahead of print.ABSTRACTEvidence suggests that long non-coding RNAs (lncRNAs) play a pivotal role in the carcinogenesis and progression of various human malignancies including gastrointestinal malignancies. This comprehensive review reports the functions and mechanisms of the lncRNA maternally expressed gene 3 (MEG3) involved in gastrointestinal malignancies. It summarizes its roles in mediating the regulation of cellular proliferation, apoptosis, migration, invasiveness, epithelial-to-mesenchymal transition, and drug resistance in several gast...
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: H H Rashwan A M Taher H A Hassan A A Awaji C J Kiriacos R A Assal R A Youness Source Type: research