Uncommon diagnosis of multinodular goiter - isolated extrapulmonary manifestation of sarcoidosis in thyroid gland (scientific case reports)
CONCLUSION: Sarcoidosis is considered a rare granulomatous multi-locular, systemic disease of not completely known etiopathogenesis with substantial heterogeneity. In most cases, it is associated with the lung, but which can become manifest in various organs. Frequently, extrapulmonary manifestations are usually detected as histological findings by coincidence, which require further investigation to find out additional manifestations as well as to exclude florid infection or other granulomatous processes (clarifying competently differential diagnosis). Therapy is only indicated in symptomatic organ manifestations, taking i...
Source: Pathology, Research and Practice - March 15, 2024 Category: Pathology Authors: Marcel Neumann Frank Meyer Tatiana Oksentyuk Polyakova Udo Barth D örthe Jechorek Roland S Croner Manuela Petersen Source Type: research
Cancer stem cells: The important role of CD markers, Signaling pathways, and MicroRNAs
Pathol Res Pract. 2024 Feb 28;256:155227. doi: 10.1016/j.prp.2024.155227. Online ahead of print.ABSTRACTFor the first time, a subset of small cancer cells identified in acute myeloid leukemia has been termed Cancer Stem Cells (CSCs). These cells are notorious for their robust proliferation, self-renewal abilities, significant tumor-forming potential, spread, and resistance to treatments. CSCs are a global concern, as it found in numerous types of cancer, posing a real-world challenge today. Our review encompasses research on key CSC markers, signaling pathways, and MicroRNA in three types of cancer: breast, colon, and live...
Source: Pathology, Research and Practice - March 15, 2024 Category: Pathology Authors: Amir Gholamzad Niloofar Khakpour Elaheh Mohandesi Khosroshahi Saba Asadi Zeinab Khazaei Koohpar Arash Matinahmadi Ali Jebali Mohsen Rashidi Mehrdad Hashemi Farzaneh Hasani Sadi Mehrdad Gholamzad Source Type: research
A comprehensive review of lncRNA CRNDE in cancer progression and pathology, with a specific glance at the epithelial-mesenchymal transition (EMT) process
Pathol Res Pract. 2024 Feb 27;256:155229. doi: 10.1016/j.prp.2024.155229. Online ahead of print.ABSTRACTIt has been suggested that the long non-coding RNAs (lncRNAs), such as colorectal neoplasia differentially expressed (CRNDE), may contribute to the formation of human cancer. It is yet unknown, though, what therapeutic significance CRNDE expression has for different forms of cancer. CRNDE has recently been proposed as a possible diagnostic biomarker and prognostic pred for excellent specificity and sensitivity in cancer tissues and plasma. To provide the groundwork for potential future therapeutic uses of CRNDE, we brief...
Source: Pathology, Research and Practice - March 14, 2024 Category: Pathology Authors: Saade Abdalkareem Jasim Sulieman Ibraheem Shelash Al-Hawary Ahmed Hjazi Irfan Ahmad Irwanjot Kaur Wesam R Kadhum Adnan Taan Alkhafaji Pallavi Ghildiyal Mohammed Abed Jawad Salim B Alsaadi Source Type: research
Expression of IZUMO2 in colorectal cancer in association with clinicopathological features
In this study, we aimed to elucidate the expression of the IZUMO2 protein in colorectal cancer, with a focus on the clinicopathological features. Sixty-four colorectal cancer tissue specimens were immunohistochemically stained using specific antibodies against IZUMO2. IZUMO2 immunoreactivity was detected at the invasion front in 30 of the 64 colorectal cancer samples. Kaplan-Meier analysis demonstrated that patients with IZUMO2 immunoreactivity had a relatively shorter overall and progression-free survival (log-rank test, P = 0.046 and 0.019, respectively). IZUMO2 immunoreactivity served as an independent factor predictive...
Source: Pathology, Research and Practice - March 14, 2024 Category: Pathology Authors: Toshiya Higashi Hirokatsu Hayashi Yuki Hanamatsu Chiemi Saigo Nobuhisa Matsuhashi Tamotsu Takeuchi Source Type: research
A comprehensive review of lncRNA CRNDE in cancer progression and pathology, with a specific glance at the epithelial-mesenchymal transition (EMT) process
Pathol Res Pract. 2024 Feb 27;256:155229. doi: 10.1016/j.prp.2024.155229. Online ahead of print.ABSTRACTIt has been suggested that the long non-coding RNAs (lncRNAs), such as colorectal neoplasia differentially expressed (CRNDE), may contribute to the formation of human cancer. It is yet unknown, though, what therapeutic significance CRNDE expression has for different forms of cancer. CRNDE has recently been proposed as a possible diagnostic biomarker and prognostic pred for excellent specificity and sensitivity in cancer tissues and plasma. To provide the groundwork for potential future therapeutic uses of CRNDE, we brief...
Source: Pathology, Research and Practice - March 14, 2024 Category: Pathology Authors: Saade Abdalkareem Jasim Sulieman Ibraheem Shelash Al-Hawary Ahmed Hjazi Irfan Ahmad Irwanjot Kaur Wesam R Kadhum Adnan Taan Alkhafaji Pallavi Ghildiyal Mohammed Abed Jawad Salim B Alsaadi Source Type: research
Expression of IZUMO2 in colorectal cancer in association with clinicopathological features
In this study, we aimed to elucidate the expression of the IZUMO2 protein in colorectal cancer, with a focus on the clinicopathological features. Sixty-four colorectal cancer tissue specimens were immunohistochemically stained using specific antibodies against IZUMO2. IZUMO2 immunoreactivity was detected at the invasion front in 30 of the 64 colorectal cancer samples. Kaplan-Meier analysis demonstrated that patients with IZUMO2 immunoreactivity had a relatively shorter overall and progression-free survival (log-rank test, P = 0.046 and 0.019, respectively). IZUMO2 immunoreactivity served as an independent factor predictive...
Source: Pathology, Research and Practice - March 14, 2024 Category: Pathology Authors: Toshiya Higashi Hirokatsu Hayashi Yuki Hanamatsu Chiemi Saigo Nobuhisa Matsuhashi Tamotsu Takeuchi Source Type: research
LncRNAs in necroptosis: Deciphering their role in cancer pathogenesis and therapy
Pathol Res Pract. 2024 Mar 5;256:155252. doi: 10.1016/j.prp.2024.155252. Online ahead of print.ABSTRACTNecroptosis, a controlled type of cell death that is different from apoptosis, has become a key figure in the aetiology of cancer and offers a possible target for treatment. A growing number of biological activities, including necroptosis, have been linked to long noncoding RNAs (lncRNAs), a varied family of RNA molecules with limited capacity to code for proteins. The complex interactions between LncRNAs and important molecular effectors of necroptosis, including mixed lineage kinase domain-like pseudokinase (MLKL) and r...
Source: Pathology, Research and Practice - March 13, 2024 Category: Pathology Authors: Rahamat Unissa Syed S Afsar Nayla Ahmed Mohammed Aboshouk Sadeem Salem Alanzi Rania Abdeen Hussain Abdalla Amna Abakar Suleiman Khalifa Jerlyn Apatan Enrera Nancy Mohammad Elafandy Randa Abdeen Husien Abdalla Omar Hafiz Haj Ali G Satheesh Kumar Maali D Al Source Type: research
Peripheral T cell lymphoma initially presenting in lung biopsies: A diagnostic challenge
CONCLUSIONS: Pulmonary involvement by PTCL is rare with dismal outcome. Aggressive clinical course and several clinicopathologic clues, albeit unspecific, may alert the pathologists of the possibilities of pulmonary PTCLs.PMID:38471291 | DOI:10.1016/j.prp.2024.155234 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 12, 2024 Category: Pathology Authors: Lu He Xianzheng Gao Fanqing Meng Jieyu Chen Qianyun Shi Linyue Zhao Jun Yang Qiang Zhou Hongyan Wu Wencai Li Zhiwen Li Source Type: research
Peripheral T cell lymphoma initially presenting in lung biopsies: A diagnostic challenge
CONCLUSIONS: Pulmonary involvement by PTCL is rare with dismal outcome. Aggressive clinical course and several clinicopathologic clues, albeit unspecific, may alert the pathologists of the possibilities of pulmonary PTCLs.PMID:38471291 | DOI:10.1016/j.prp.2024.155234 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 12, 2024 Category: Pathology Authors: Lu He Xianzheng Gao Fanqing Meng Jieyu Chen Qianyun Shi Linyue Zhao Jun Yang Qiang Zhou Hongyan Wu Wencai Li Zhiwen Li Source Type: research
Morphologic features of prostate cancer-encased native vessels: An image analysis study
CONCLUSIONS: Similar to the 2000 study, increased media thickness and hypercellularity of vessels encased by PC were evident compared to controls. Borderline grade-dependent increased vessel cellularity changes were seen, suggesting a possible role in PC progression; the predictive value of these changes for outcome is uncertain. Whether the etiology of changes reflects locally increased intravascular pressure of vessels within tumor should be investigated.PMID:38461692 | DOI:10.1016/j.prp.2024.155239 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 10, 2024 Category: Pathology Authors: Cristina Fernandez Gonzalez De La Vega Savannah Duenweg Pragya Jain Sarah I Rubenstein Samuel Bobholz Michael J Barrett Peter S LaViolette Kenneth A Iczkowski Source Type: research
Progress in long non-coding RNAs as prognostic factors of papillary thyroid carcinoma
The objective of this review is to provide a comprehensive summary of the biological functions of lncRNAs in PTC, identify prognosis-relevant lncRNAs, and explore their potential mechanisms in drug resistance to BRAF kinase inhibitors, tumor dedifferentiation, and lymph node metastasis. By doing so, this review aims to offer valuable references for both basic research and the prediction of PTC prognosis.PMID:38461693 | DOI:10.1016/j.prp.2024.155230 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 10, 2024 Category: Pathology Authors: Hao-Nan Zhu Dong-Liang Song Si-Nan Zhang Zhao-Jie Zheng Xing-Yu Chen Xin Jin Source Type: research
Morphologic features of prostate cancer-encased native vessels: An image analysis study
CONCLUSIONS: Similar to the 2000 study, increased media thickness and hypercellularity of vessels encased by PC were evident compared to controls. Borderline grade-dependent increased vessel cellularity changes were seen, suggesting a possible role in PC progression; the predictive value of these changes for outcome is uncertain. Whether the etiology of changes reflects locally increased intravascular pressure of vessels within tumor should be investigated.PMID:38461692 | DOI:10.1016/j.prp.2024.155239 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 10, 2024 Category: Pathology Authors: Cristina Fernandez Gonzalez De La Vega Savannah Duenweg Pragya Jain Sarah I Rubenstein Samuel Bobholz Michael J Barrett Peter S LaViolette Kenneth A Iczkowski Source Type: research
Progress in long non-coding RNAs as prognostic factors of papillary thyroid carcinoma
The objective of this review is to provide a comprehensive summary of the biological functions of lncRNAs in PTC, identify prognosis-relevant lncRNAs, and explore their potential mechanisms in drug resistance to BRAF kinase inhibitors, tumor dedifferentiation, and lymph node metastasis. By doing so, this review aims to offer valuable references for both basic research and the prediction of PTC prognosis.PMID:38461693 | DOI:10.1016/j.prp.2024.155230 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 10, 2024 Category: Pathology Authors: Hao-Nan Zhu Dong-Liang Song Si-Nan Zhang Zhao-Jie Zheng Xing-Yu Chen Xin Jin Source Type: research
Morphologic features of prostate cancer-encased native vessels: An image analysis study
CONCLUSIONS: Similar to the 2000 study, increased media thickness and hypercellularity of vessels encased by PC were evident compared to controls. Borderline grade-dependent increased vessel cellularity changes were seen, suggesting a possible role in PC progression; the predictive value of these changes for outcome is uncertain. Whether the etiology of changes reflects locally increased intravascular pressure of vessels within tumor should be investigated.PMID:38461692 | DOI:10.1016/j.prp.2024.155239 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 10, 2024 Category: Pathology Authors: Cristina Fernandez Gonzalez De La Vega Savannah Duenweg Pragya Jain Sarah I Rubenstein Samuel Bobholz Michael J Barrett Peter S LaViolette Kenneth A Iczkowski Source Type: research
Progress in long non-coding RNAs as prognostic factors of papillary thyroid carcinoma
The objective of this review is to provide a comprehensive summary of the biological functions of lncRNAs in PTC, identify prognosis-relevant lncRNAs, and explore their potential mechanisms in drug resistance to BRAF kinase inhibitors, tumor dedifferentiation, and lymph node metastasis. By doing so, this review aims to offer valuable references for both basic research and the prediction of PTC prognosis.PMID:38461693 | DOI:10.1016/j.prp.2024.155230 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 10, 2024 Category: Pathology Authors: Hao-Nan Zhu Dong-Liang Song Si-Nan Zhang Zhao-Jie Zheng Xing-Yu Chen Xin Jin Source Type: research
