Biomarker discovery and validation for gastrointestinal tumors: A comprehensive review of colorectal, gastric, and liver cancers
Pathol Res Pract. 2024 Feb 16;255:155216. doi: 10.1016/j.prp.2024.155216. Online ahead of print.ABSTRACTGastrointestinal (GI) malignancies, encompassing gastric, hepatic, colonic, and rectal cancers, are prevalent forms of cancer globally and contribute substantially to cancer-related mortality. Although there have been improvements in methods for diagnosing and treating GI cancers, the chances of survival for these types of cancers are still extremely low. According to the World Cancer Research International Fund's most recent figures, stomach cancer was responsible for roughly one million deaths worldwide in 2020. This e...
Source: Pathology, Research and Practice - February 24, 2024 Category: Pathology Authors: Zaki H Hakami Source Type: research
Pyroptosis-related non-coding RNAs emerging players in atherosclerosis pathology
Pathol Res Pract. 2024 Feb 16;255:155219. doi: 10.1016/j.prp.2024.155219. Online ahead of print.ABSTRACTGlobally, atherosclerosis a persistent inflammatory condition of the artery walls continues to be the primary cause of cardiovascular illness and death. The ncRNAs are important regulators of important signalling pathways that affect pyroptosis and the inflammatory environment in atherosclerotic plaques. Comprehending the complex interaction between pyroptosis and non-coding RNAs (ncRNAs) offers fresh perspectives on putative therapeutic targets for ameliorating cardiovascular problems linked to atherosclerosis. The disc...
Source: Pathology, Research and Practice - February 24, 2024 Category: Pathology Authors: Weam M A Khojali Nasrin E Khalifa Farhan Alshammari S Afsar Nayla Ahmed Mohammed Aboshouk Amna Abakar Suleiman Khalifa Jerlyn Apatan Enrera Nancy Mohammad Elafandy Randa Abdeen Husien Abdalla Omar Hafiz Haj Ali Rahamat Unissa Syed Potnuri Nagaraju Source Type: research
Biomarker discovery and validation for gastrointestinal tumors: A comprehensive review of colorectal, gastric, and liver cancers
Pathol Res Pract. 2024 Feb 16;255:155216. doi: 10.1016/j.prp.2024.155216. Online ahead of print.ABSTRACTGastrointestinal (GI) malignancies, encompassing gastric, hepatic, colonic, and rectal cancers, are prevalent forms of cancer globally and contribute substantially to cancer-related mortality. Although there have been improvements in methods for diagnosing and treating GI cancers, the chances of survival for these types of cancers are still extremely low. According to the World Cancer Research International Fund's most recent figures, stomach cancer was responsible for roughly one million deaths worldwide in 2020. This e...
Source: Pathology, Research and Practice - February 24, 2024 Category: Pathology Authors: Zaki H Hakami Source Type: research
Pyroptosis-related non-coding RNAs emerging players in atherosclerosis pathology
Pathol Res Pract. 2024 Feb 16;255:155219. doi: 10.1016/j.prp.2024.155219. Online ahead of print.ABSTRACTGlobally, atherosclerosis a persistent inflammatory condition of the artery walls continues to be the primary cause of cardiovascular illness and death. The ncRNAs are important regulators of important signalling pathways that affect pyroptosis and the inflammatory environment in atherosclerotic plaques. Comprehending the complex interaction between pyroptosis and non-coding RNAs (ncRNAs) offers fresh perspectives on putative therapeutic targets for ameliorating cardiovascular problems linked to atherosclerosis. The disc...
Source: Pathology, Research and Practice - February 24, 2024 Category: Pathology Authors: Weam M A Khojali Nasrin E Khalifa Farhan Alshammari S Afsar Nayla Ahmed Mohammed Aboshouk Amna Abakar Suleiman Khalifa Jerlyn Apatan Enrera Nancy Mohammad Elafandy Randa Abdeen Husien Abdalla Omar Hafiz Haj Ali Rahamat Unissa Syed Potnuri Nagaraju Source Type: research
Biomarker discovery and validation for gastrointestinal tumors: A comprehensive review of colorectal, gastric, and liver cancers
Pathol Res Pract. 2024 Feb 16;255:155216. doi: 10.1016/j.prp.2024.155216. Online ahead of print.ABSTRACTGastrointestinal (GI) malignancies, encompassing gastric, hepatic, colonic, and rectal cancers, are prevalent forms of cancer globally and contribute substantially to cancer-related mortality. Although there have been improvements in methods for diagnosing and treating GI cancers, the chances of survival for these types of cancers are still extremely low. According to the World Cancer Research International Fund's most recent figures, stomach cancer was responsible for roughly one million deaths worldwide in 2020. This e...
Source: Pathology, Research and Practice - February 24, 2024 Category: Pathology Authors: Zaki H Hakami Source Type: research
Histopathologic and immunophenotypic characterization of patient-derived pediatric malignant hepatocellular tumor xenografts (PDXs)
Pathol Res Pract. 2024 Feb 1;255:155163. doi: 10.1016/j.prp.2024.155163. Online ahead of print.ABSTRACTAdvances in targeted therapies for pediatric hepatocellular tumors have been limited due to a paucity of clinically relevant models. Establishment and validation of intrahepatic patient-derived xenograft (PDX) models would help bridging this gap. The aim of this study is to compare the histomorphologic and immunophenotypic fidelity of patient tumors and their corresponding intrahepatic PDX models. Murine PDX models were established by intrahepatic implantation of patient tumors. Pathology slides from both patients and the...
Source: Pathology, Research and Practice - February 23, 2024 Category: Pathology Authors: Kalyani R Patel Andres F Espinoza Martin Urbicain Roma H Patel Angela Major Stephen F Sarabia Dolores Lopez-Terrada Sanjeev A Vasudevan Sarah E Woodfield Source Type: research
Detection of EGFR T790M mutation using liquid biopsy for non-small cell lung cancer: Utility of droplet digital polymerase chain reaction vs. cobas real-time polymerase chain reaction
CONCLUSION: Using ddPCR to follow up the cobas assay yielded more cases (38% of total) with a T790M mutation. A cut-off value of FA ≥0.1% identified patients who responded as well to osimertinib as those identified by cobas assay. This sequential approach should detect additional patients who might benefit from osimertinib treatment.PMID:38394807 | DOI:10.1016/j.prp.2024.155213 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 23, 2024 Category: Pathology Authors: Nicha Zungsontiporn Pongsakorn Ouwongprayoon Piyaporn Boonsirikamchai Nophol Leelayuwatanakul Chanida Vinayanuwattikun Kantika Moonai Ekkachai Khongkhaduead Paul Scott Thorner Shanop Shuangshoti Chinachote Teerapakpinyo Source Type: research
Solitary fibrous tumor occurring at unusual sites: A clinico-pathological series of 31 cases with emphasis on its wide morphological spectrum
Pathol Res Pract. 2024 Feb 12;255:155207. doi: 10.1016/j.prp.2024.155207. Online ahead of print.ABSTRACTSolitary fibrous tumor (SFT) is a relatively rare mesenchymal fibroblastic tumor occurring most commonly in adults with no gender predilection. Although the pathological diagnosis of SFT is usually straightforward, some difficulties may occasionally arise mainly due to the wide morphological spectrum exhibited by this tumor. In the present paper we aimed to evaluate the unusual clinicopathological features in a series of 31 SFTs arising from parenchymal organs, superficial soft tissues and deep soft tissues. Our results ...
Source: Pathology, Research and Practice - February 23, 2024 Category: Pathology Authors: Giuseppe Angelico Lucia Salvatorelli Giada Maria Vecchio Manuel Mazzucchelli Giovanni Nunzio Rosano Simone Poidomani Gaetano Giuseppe Magro Source Type: research
The immutable relevance of myeloid sarcomas: Clinicopathological study of fourteen cases
Pathol Res Pract. 2024 Jan 28;255:155176. doi: 10.1016/j.prp.2024.155176. Online ahead of print.ABSTRACTAn extramedullary myeloid tumor or chloroma is an infrequent manifestation of a myeloid neoplasm. It is considered an equivalent to an acute myeloid leukemia. It is confirmed through biopsy, where infiltrating neoplastic myeloid cells distort the parenchyma. A total of twenty-nine cases were diagnosed as MS between 198 and 2023. Upon re-evaluation, only fourteen cases fulfilled the criteria for MS. The most common differential diagnosis were lymphomas, leukemic infiltration, and extramedullary hematopoiesis. Few were iso...
Source: Pathology, Research and Practice - February 23, 2024 Category: Pathology Authors: J Lizardo-Thiebaud Maria Avila-Hernandez Emilio Delgado-de la Mora Jesus Daniel Montante-Montes de Oca Source Type: research
Circulating miRNAs and lncRNAs serve as biomarkers for early colorectal cancer diagnosis
CONCLUSION: MicroRNA (miRNA) and long noncoding RNAs (lncRNAs) have recently emerged as detectable entities in the blood of cancer patients, playing crucial roles in diagnosing various malignancies. However, their specific relevance in the diagnosis of colorectal cancer (CRC) remains underexplored. This study aimed to investigate miRNA and lncRNA profiles in the plasma fraction of human blood to discern significant differences in content and expression levels between CRC patients and healthy individuals. Our cohort comprised 30 CRC patients and 30 healthy controls, with no statistically significant differences (p < 0.05...
Source: Pathology, Research and Practice - February 20, 2024 Category: Pathology Authors: Ehsan Lotfi Azam Kholghi Fereshteh Golab Ali Mohammadi Mahmood Barati Source Type: research
Circulating miRNAs and lncRNAs serve as biomarkers for early colorectal cancer diagnosis
CONCLUSION: MicroRNA (miRNA) and long noncoding RNAs (lncRNAs) have recently emerged as detectable entities in the blood of cancer patients, playing crucial roles in diagnosing various malignancies. However, their specific relevance in the diagnosis of colorectal cancer (CRC) remains underexplored. This study aimed to investigate miRNA and lncRNA profiles in the plasma fraction of human blood to discern significant differences in content and expression levels between CRC patients and healthy individuals. Our cohort comprised 30 CRC patients and 30 healthy controls, with no statistically significant differences (p < 0.05...
Source: Pathology, Research and Practice - February 20, 2024 Category: Pathology Authors: Ehsan Lotfi Azam Kholghi Fereshteh Golab Ali Mohammadi Mahmood Barati Source Type: research
Circulating miRNAs and lncRNAs serve as biomarkers for early colorectal cancer diagnosis
CONCLUSION: MicroRNA (miRNA) and long noncoding RNAs (lncRNAs) have recently emerged as detectable entities in the blood of cancer patients, playing crucial roles in diagnosing various malignancies. However, their specific relevance in the diagnosis of colorectal cancer (CRC) remains underexplored. This study aimed to investigate miRNA and lncRNA profiles in the plasma fraction of human blood to discern significant differences in content and expression levels between CRC patients and healthy individuals. Our cohort comprised 30 CRC patients and 30 healthy controls, with no statistically significant differences (p < 0.05...
Source: Pathology, Research and Practice - February 20, 2024 Category: Pathology Authors: Ehsan Lotfi Azam Kholghi Fereshteh Golab Ali Mohammadi Mahmood Barati Source Type: research
Circulating miRNAs and lncRNAs serve as biomarkers for early colorectal cancer diagnosis
CONCLUSION: MicroRNA (miRNA) and long noncoding RNAs (lncRNAs) have recently emerged as detectable entities in the blood of cancer patients, playing crucial roles in diagnosing various malignancies. However, their specific relevance in the diagnosis of colorectal cancer (CRC) remains underexplored. This study aimed to investigate miRNA and lncRNA profiles in the plasma fraction of human blood to discern significant differences in content and expression levels between CRC patients and healthy individuals. Our cohort comprised 30 CRC patients and 30 healthy controls, with no statistically significant differences (p < 0.05...
Source: Pathology, Research and Practice - February 20, 2024 Category: Pathology Authors: Ehsan Lotfi Azam Kholghi Fereshteh Golab Ali Mohammadi Mahmood Barati Source Type: research
Tumor-stroma ratio in preoperative biopsies and matched surgical specimens in oral squamous cell carcinoma: Concordance and impact on recurrence-free and overall survival
Pathol Res Pract. 2024 Feb 16;255:155211. doi: 10.1016/j.prp.2024.155211. Online ahead of print.ABSTRACTStroma-richness is commonly associated with decreased survival times as well as advanced tumor stages in various malignant tumors. A previous study on laryngeal squamous cell carcinomas showed very good agreement for tumor-stroma ratio assessment between pre-treatment biopsies and resection specimens. We therefore aimed to determine whether similar results could be shown for oral squamous cell carcinomas. 107 preoperative biopsies and matched surgical specimens were obtained from the histological archive, dating from 201...
Source: Pathology, Research and Practice - February 18, 2024 Category: Pathology Authors: Juliana Knief Katrin Herber Adrian Muenscher Christoph Thorns Nikolaus Moeckelmann Source Type: research
The potential role and mechanism of circRNAs in Ferroptosis: A comprehensive review
This study explores the regulatory roles of circRNAs in ferroptosis and their potential in diseases such as cancer, neurological disorders, and cardiovascular diseases. By investigating the relationship between circRNAs and ferroptosis, this research provides new insights into the diagnosis, treatment, and prognosis of ferroptosis-related diseases. Furthermore, the therapeutic implications of targeting circRNAs in cancer treatment and the modulation of ferroptosis pathways demonstrate the potential of circRNAs as diagnostic markers and therapeutic targets. Overall, understanding the involvement of circRNAs in regulating fe...
Source: Pathology, Research and Practice - February 18, 2024 Category: Pathology Authors: Javad Arabpour Kimia Rezaei Javad Yaghmoorian Khojini Shokufeh Razi Mohammad Javad Hayati Seyed Mohammad Gheibihayat Source Type: research
