Detection of EGFR T790M mutation using liquid biopsy for non-small cell lung cancer: Utility of droplet digital polymerase chain reaction vs. cobas real-time polymerase chain reaction

CONCLUSION: Using ddPCR to follow up the cobas assay yielded more cases (38% of total) with a T790M mutation. A cut-off value of FA ≥0.1% identified patients who responded as well to osimertinib as those identified by cobas assay. This sequential approach should detect additional patients who might benefit from osimertinib treatment.PMID:38394807 | DOI:10.1016/j.prp.2024.155213

Source: Pathology, Research and Practice - February 23, 2024 Category: Pathology Authors: Nicha Zungsontiporn Pongsakorn Ouwongprayoon Piyaporn Boonsirikamchai Nophol Leelayuwatanakul Chanida Vinayanuwattikun Kantika Moonai Ekkachai Khongkhaduead Paul Scott Thorner Shanop Shuangshoti Chinachote Teerapakpinyo Source Type: research