Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis
In conclusion, our study demonstrated that LINC00675 is an oncogenic lncRNA that enhances the malignancy of AML by upregulating CDK6 expression through miR-6809 sponging, providing a new perspective and feasible target for the diagnosis and treatment of AML.PMID:38422911 | DOI:10.1016/j.prp.2024.155221 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Xinyi Long Huinan Jiang Zhuogang Liu Jing Liu Rong Hu Source Type: research
Prediction of the binding location between the nuclear inhibitor of DNA binding and differentiation 2 (ID2) and HSPA5
Pathol Res Pract. 2024 Feb 17;255:155217. doi: 10.1016/j.prp.2024.155217. Online ahead of print.ABSTRACTGlucose-regulated protein 78 (GRP78), also termed HSPA5, was widely studied in cancer. It was recently approved that GRP78 has nuclear localization potential that sheds light on its role in cancer development. The inhibitor of DNA binding and differentiation 2 (ID2) is the nuclear component that associates with GRP78. The interaction between these two proteins is not understood clearly. In the current study, the binding pattern of GRP78/ID2 is predicted using computational methods. Protein-protein docking is used along w...
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Abdo A Elfiky Source Type: research
Donors risk assessment in transplantation: From the guidelines to their real-world application
Pathol Res Pract. 2024 Feb 12;255:155210. doi: 10.1016/j.prp.2024.155210. Online ahead of print.ABSTRACTTransplantation of an organ from a donor carries an unavoidable risk of tumor transmission. The need to extend the donor pool increases the use of organs from donors with malignancies and potential disease transmission is a constant tension influencing donor suitability decisions. Current classification systems for the assessment of donor malignancy transmission risk have evolved from reports of potential transmission events in recipients to national donation and transplant surveillance agencies. Although the risk of mal...
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Deborah Malvi Francesco Vasuri Elisa Albertini Maurizio Carbone Luca Novelli Claudia Mescoli Massimo Cardillo Fabio Pagni Antonia D'Errico Albino Eccher Source Type: research
The utility of FISH analysis in the diagnosis of BCOR-rearranged sarcomas
CONCLUSIONS: Our study indicates that BCOR FISH analysis using an IVD probe, may be useful to detect the presence of a BCOR rearrangement, including both translocations and inversions; however, negative results, in some cases, can occur.PMID:38422910 | DOI:10.1016/j.prp.2024.155209 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Stefania Cocchi Marco Gambarotti Gabriella Gamberi Giovanna Magagnoli Margherita Maioli Monica Stevanin Federica Samperi Alberto Righi Stefania Benini Source Type: research
Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis
In conclusion, our study demonstrated that LINC00675 is an oncogenic lncRNA that enhances the malignancy of AML by upregulating CDK6 expression through miR-6809 sponging, providing a new perspective and feasible target for the diagnosis and treatment of AML.PMID:38422911 | DOI:10.1016/j.prp.2024.155221 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Xinyi Long Huinan Jiang Zhuogang Liu Jing Liu Rong Hu Source Type: research
Prediction of the binding location between the nuclear inhibitor of DNA binding and differentiation 2 (ID2) and HSPA5
Pathol Res Pract. 2024 Feb 17;255:155217. doi: 10.1016/j.prp.2024.155217. Online ahead of print.ABSTRACTGlucose-regulated protein 78 (GRP78), also termed HSPA5, was widely studied in cancer. It was recently approved that GRP78 has nuclear localization potential that sheds light on its role in cancer development. The inhibitor of DNA binding and differentiation 2 (ID2) is the nuclear component that associates with GRP78. The interaction between these two proteins is not understood clearly. In the current study, the binding pattern of GRP78/ID2 is predicted using computational methods. Protein-protein docking is used along w...
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Abdo A Elfiky Source Type: research
Donors risk assessment in transplantation: From the guidelines to their real-world application
Pathol Res Pract. 2024 Feb 12;255:155210. doi: 10.1016/j.prp.2024.155210. Online ahead of print.ABSTRACTTransplantation of an organ from a donor carries an unavoidable risk of tumor transmission. The need to extend the donor pool increases the use of organs from donors with malignancies and potential disease transmission is a constant tension influencing donor suitability decisions. Current classification systems for the assessment of donor malignancy transmission risk have evolved from reports of potential transmission events in recipients to national donation and transplant surveillance agencies. Although the risk of mal...
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Deborah Malvi Francesco Vasuri Elisa Albertini Maurizio Carbone Luca Novelli Claudia Mescoli Massimo Cardillo Fabio Pagni Antonia D'Errico Albino Eccher Source Type: research
The utility of FISH analysis in the diagnosis of BCOR-rearranged sarcomas
CONCLUSIONS: Our study indicates that BCOR FISH analysis using an IVD probe, may be useful to detect the presence of a BCOR rearrangement, including both translocations and inversions; however, negative results, in some cases, can occur.PMID:38422910 | DOI:10.1016/j.prp.2024.155209 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Stefania Cocchi Marco Gambarotti Gabriella Gamberi Giovanna Magagnoli Margherita Maioli Monica Stevanin Federica Samperi Alberto Righi Stefania Benini Source Type: research
Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis
In conclusion, our study demonstrated that LINC00675 is an oncogenic lncRNA that enhances the malignancy of AML by upregulating CDK6 expression through miR-6809 sponging, providing a new perspective and feasible target for the diagnosis and treatment of AML.PMID:38422911 | DOI:10.1016/j.prp.2024.155221 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Xinyi Long Huinan Jiang Zhuogang Liu Jing Liu Rong Hu Source Type: research
Prediction of the binding location between the nuclear inhibitor of DNA binding and differentiation 2 (ID2) and HSPA5
Pathol Res Pract. 2024 Feb 17;255:155217. doi: 10.1016/j.prp.2024.155217. Online ahead of print.ABSTRACTGlucose-regulated protein 78 (GRP78), also termed HSPA5, was widely studied in cancer. It was recently approved that GRP78 has nuclear localization potential that sheds light on its role in cancer development. The inhibitor of DNA binding and differentiation 2 (ID2) is the nuclear component that associates with GRP78. The interaction between these two proteins is not understood clearly. In the current study, the binding pattern of GRP78/ID2 is predicted using computational methods. Protein-protein docking is used along w...
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Abdo A Elfiky Source Type: research
Studying the correlation of inflammatory cytokines to COVID-19 disease
In conclusion, IL-6, TNF-α, and IP-10 are associated with the pathogenicity of COVID-19, furthermore, vaccination could help to control severity of the disease.PMID:38412656 | DOI:10.1016/j.prp.2024.155215 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 27, 2024 Category: Pathology Authors: Nuha A Alkhattabi Hajer M Alharbi Mohammad A Basabrain Maryam H Al-Zahrani Rana A Alghamdi Husam Joharjy Reham Khalifa Nesrin I Tarbiah Source Type: research
The priority of mesenchymal stem cells treated with melatonin in ameliorating thyroid impairment induced by amiodarone. Thorough look on the apoptotic pathway
Pathol Res Pract. 2024 Feb 17;255:155212. doi: 10.1016/j.prp.2024.155212. Online ahead of print.ABSTRACTAmiodarone treatment has been associated with thyroid alterations. This work was planned to consider therapeutic outcome of MSCs versus MSCs treated with melatonin in minimizing amiodarone -induced deviations in thyroid. We handed-down 50 male Wistar rats, then distributed them into 5 groups; I, II, III, IV, V; control, sham control, amiodarone treated, amiodarone and MSCs treated, and amiodarone, MSCs and melatonin treated groups respectively. Light microscopic examination; levels of T3, T4 and TSH, Oxidative/antioxidat...
Source: Pathology, Research and Practice - February 27, 2024 Category: Pathology Authors: Ehab A A El-Shaarawy Soheir H Ahmed Mogeda M Nasrallah Ali K Mousa Shereen Abdel Fattah Source Type: research
Studying the correlation of inflammatory cytokines to COVID-19 disease
In conclusion, IL-6, TNF-α, and IP-10 are associated with the pathogenicity of COVID-19, furthermore, vaccination could help to control severity of the disease.PMID:38412656 | DOI:10.1016/j.prp.2024.155215 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 27, 2024 Category: Pathology Authors: Nuha A Alkhattabi Hajer M Alharbi Mohammad A Basabrain Maryam H Al-Zahrani Rana A Alghamdi Husam Joharjy Reham Khalifa Nesrin I Tarbiah Source Type: research
The priority of mesenchymal stem cells treated with melatonin in ameliorating thyroid impairment induced by amiodarone. Thorough look on the apoptotic pathway
Pathol Res Pract. 2024 Feb 17;255:155212. doi: 10.1016/j.prp.2024.155212. Online ahead of print.ABSTRACTAmiodarone treatment has been associated with thyroid alterations. This work was planned to consider therapeutic outcome of MSCs versus MSCs treated with melatonin in minimizing amiodarone -induced deviations in thyroid. We handed-down 50 male Wistar rats, then distributed them into 5 groups; I, II, III, IV, V; control, sham control, amiodarone treated, amiodarone and MSCs treated, and amiodarone, MSCs and melatonin treated groups respectively. Light microscopic examination; levels of T3, T4 and TSH, Oxidative/antioxidat...
Source: Pathology, Research and Practice - February 27, 2024 Category: Pathology Authors: Ehab A A El-Shaarawy Soheir H Ahmed Mogeda M Nasrallah Ali K Mousa Shereen Abdel Fattah Source Type: research
Pyroptosis-related non-coding RNAs emerging players in atherosclerosis pathology
Pathol Res Pract. 2024 Feb 16;255:155219. doi: 10.1016/j.prp.2024.155219. Online ahead of print.ABSTRACTGlobally, atherosclerosis a persistent inflammatory condition of the artery walls continues to be the primary cause of cardiovascular illness and death. The ncRNAs are important regulators of important signalling pathways that affect pyroptosis and the inflammatory environment in atherosclerotic plaques. Comprehending the complex interaction between pyroptosis and non-coding RNAs (ncRNAs) offers fresh perspectives on putative therapeutic targets for ameliorating cardiovascular problems linked to atherosclerosis. The disc...
Source: Pathology, Research and Practice - February 24, 2024 Category: Pathology Authors: Weam M A Khojali Nasrin E Khalifa Farhan Alshammari S Afsar Nayla Ahmed Mohammed Aboshouk Amna Abakar Suleiman Khalifa Jerlyn Apatan Enrera Nancy Mohammad Elafandy Randa Abdeen Husien Abdalla Omar Hafiz Haj Ali Rahamat Unissa Syed Potnuri Nagaraju Source Type: research
