Modulation of ferroptosis by non ‑coding RNAs in cancers: Potential biomarkers for cancer diagnose and therapy
Pathol Res Pract. 2023 Dec 22;253:155042. doi: 10.1016/j.prp.2023.155042. Online ahead of print.ABSTRACTFerroptosis is a recently discovered cell programmed death. Extensive researches have indicated that ferroptosis plays an essential role in tumorigenesis, development, migration and chemotherapy drugs resistance, which makes it become a new target for tumor therapy. Non-coding RNAs (ncRNAs) are considered to control a wide range of cellular processes by modulating gene expression. Recent studies have indicated that ncRNAs regulate the process of ferroptosis via various pathway to affect the development of cancer. However...
Source: Pathology, Research and Practice - January 7, 2024 Category: Pathology Authors: Huifang Gong Zheng Li Zhimin Wu Gaojian Lian Zehong Su Source Type: research
miRNAs as modulators of neuroinflammation and excitotoxicity: Implications for stroke therapeutics
Pathol Res Pract. 2024 Jan 5;253:155093. doi: 10.1016/j.prp.2024.155093. Online ahead of print.ABSTRACTStroke is a widespread neurological disorder associated with physical disabilities, mortality, and economic burden. In recent decades, substantial progress has been achieved in reducing the impact of this public health problem. However, further understanding of the pathophysiology of stroke and the underlying genetic pathways is required. The pathological mechanisms of stroke comprise multifaceted molecular cascades regulated by various microRNAs (miRNAs). An increasing number of studies have highlighted the role of miRNA...
Source: Pathology, Research and Practice - January 7, 2024 Category: Pathology Authors: Mohammed S Elballal Osama A Mohammed Mohamed Bakr Zaki Ahmed I Abulsoud Manar Mohammed El Tabaa Ola Elazazy Mai A Abd-Elmawla Walaa A El-Dakroury Sherif S Abdel Mageed Ahmed A Rashad Nourhan M Abdelmaksoud Mahmoud A Elrebehy Yousra Nomier Mustafa Ahmed Ab Source Type: research
Modulation of ferroptosis by non ‑coding RNAs in cancers: Potential biomarkers for cancer diagnose and therapy
Pathol Res Pract. 2023 Dec 22;253:155042. doi: 10.1016/j.prp.2023.155042. Online ahead of print.ABSTRACTFerroptosis is a recently discovered cell programmed death. Extensive researches have indicated that ferroptosis plays an essential role in tumorigenesis, development, migration and chemotherapy drugs resistance, which makes it become a new target for tumor therapy. Non-coding RNAs (ncRNAs) are considered to control a wide range of cellular processes by modulating gene expression. Recent studies have indicated that ncRNAs regulate the process of ferroptosis via various pathway to affect the development of cancer. However...
Source: Pathology, Research and Practice - January 7, 2024 Category: Pathology Authors: Huifang Gong Zheng Li Zhimin Wu Gaojian Lian Zehong Su Source Type: research
Clear cell renal cell carcinoma with syncytial giant cells: Not that rare
In this study, the clinical and pathological data of 16 ccRCC cases with SGCs were retrospectively reviewed. The incidence of SGCs in pathological stages pT3 and above (12.1%, 8/66) was significantly higher than that in pT1 and pT2 (2.6%, 8/306) (P = 0.002). The incidence of SGCs in the WHO/ISUP nuclear grade 3 or 4 ccRCC (12.4%, 14/113) was significantly higher than that in grade 1 or 2 (0.8%, 2/259) (P < 0.001). Two forms of SGCs were observed, some exhibited nuclear pyknosis and degeneration. Of the 16 cases, eight cases were accompanied by necrosis and seven cases had lymphovascular invasion. Both SGCs and mononucle...
Source: Pathology, Research and Practice - January 6, 2024 Category: Pathology Authors: Wenjia Sun Junqiu Yue Lifang Fan Source Type: research
Unraveling the impact of melatonin treatment: Oxidative stress, metabolic responses, and morphological changes in HuH7.5 hepatocellular carcinoma cells
Pathol Res Pract. 2023 Dec 21;253:155056. doi: 10.1016/j.prp.2023.155056. Online ahead of print.ABSTRACTIn addition to its highly aggressive nature and late diagnosis, hepatocellular carcinoma (HCC) does not respond effectively to available chemotherapeutic agents. The search is on for an ideal and effective compound with low cost and minimal side effects that can be used as an adjunct to chemotherapeutic regimens. One of the mechanisms involved in the pathology of HCC is the oxidative stress, which plays a critical role in tumor survival and dissemination. Our group has already demonstrated the antitumor potential of mela...
Source: Pathology, Research and Practice - January 6, 2024 Category: Pathology Authors: Juliana M B de Morais Ellen M S Cruz Virg ínia M Concato Milena C de Souza Yasmin M Santos D ébora H Quadreli Fabr ício S R Inoue Francielle B Ferreira Glaura S A Fernandes Danielle L Bid óia Rayanne R B Machado Luiz Gustavo A Chuffa Wander R Pavanell Source Type: research
Immunohistochemical expression of cytochrome P4A11 (CYP4A11), carbonic anhydrase 9 (CAIX) and Ki67 in renal cell carcinoma; diagnostic relevance and relations to clinicopathological parameters
CONCLUSIONS: CYP4A11 and CAIX can be used as diagnostic markers to differentiate clear cell RCC from other subtypes. CYP4A11 is more diagnostically accurate and specific than CAIX. High expression of CYP4A11, low CAIX expression and high ki67 labeling index were related to features of aggressive tumor behavior.PMID:38183818 | DOI:10.1016/j.prp.2023.155070 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - January 6, 2024 Category: Pathology Authors: Hoda Khalid Elfakharany Hussein Mohamed Ghoraba Khairia Abdullraheem Gaweesh Aliaa Atef Shams Eldeen Asmaa Mustafa Eid Source Type: research
Evaluation of cell proliferation marker CDC-7 in salivary adenoid cystic carcinoma
CONCLUSION: The biological behavior of AdCC can be predicated from the expression of CDC-7.PMID:38183819 | DOI:10.1016/j.prp.2024.155098 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - January 6, 2024 Category: Pathology Authors: Rawda Elsherbiny Mona Hany Emile Mona Mohsen Abdo Ibrahim Lawahez El M Ismail Source Type: research
The emerging role of miRNAs in myocardial infarction: From molecular signatures to therapeutic targets
Pathol Res Pract. 2024 Jan 3;253:155087. doi: 10.1016/j.prp.2023.155087. Online ahead of print.ABSTRACTGlobally, myocardial infarction (MI) and other cardiovascular illnesses have long been considered the top killers. Heart failure and mortality are the results of myocardial apoptosis, cardiomyocyte fibrosis, and cardiomyocyte hypertrophy, all of which are caused by MI. MicroRNAs (miRNAs) play a crucial regulatory function in the progression and advancement of heart disease following an MI. By consolidating the existing data on miRNAs, our aim is to gain a more comprehensive understanding of their role in the pathological ...
Source: Pathology, Research and Practice - January 6, 2024 Category: Pathology Authors: Osama A Mohammed Mushabab Alghamdi Jaber Alfaifi Mohannad Mohammad S Alamri Abdullah M Al-Shahrani Muffarah Hamid Alharthi Abdullah M Alshahrani Abdullah Hassan Alhalafi Masoud I E Adam Emad Bahashwan AbdulElah Al Jarallah AlQahtani Waad Fuad BinAfif Must Source Type: research
Palisading adenocarcinoma. Case report on a newly recognized tumor in the salivary glands
Pathol Res Pract. 2024 Jan 5;253:155088. doi: 10.1016/j.prp.2023.155088. Online ahead of print.ABSTRACTA palisading adenocarcinoma arising in the left submandibular salivary gland in a 65-year old woman is presented here. This tumor has been identified only very recently and its recognition as a true entity in the list of salivary gland tumors is still pending. Its distinct clinical-pathological context includes a predilection for women, sublingual or submandibular gland involvement, low-grade cytology with pseudo-neuroendocrine features, and sharp immunohistochemical expression.PMID:38183821 | DOI:10.1016/j.prp.2023.15508...
Source: Pathology, Research and Practice - January 6, 2024 Category: Pathology Authors: Claudia Manini Claudia Provenza Adolfo Suriani Alberto Montemagno Riccardo Vergano Jos é I López Source Type: research
Unveiling the regulatory role of miRNAs in stroke pathophysiology and diagnosis
Pathol Res Pract. 2024 Jan 3;253:155085. doi: 10.1016/j.prp.2023.155085. Online ahead of print.ABSTRACTStroke, a major global cause of mortality, leads to a range of problems for those who survive. Besides its brutal events, stroke also tends to have a characteristic of recurrence, making it a complex disease involving intricate regulatory networks. One of the major cellular regulators is the non-coding RNAs (ncRNA), specifically microRNAs (miRNAs), thus the possible functions of miRNAs in the pathogenesis of stroke are discussed as well as the possibility of using miRNA-based therapeutic approaches. Firstly, the molecular...
Source: Pathology, Research and Practice - January 6, 2024 Category: Pathology Authors: Mustafa Ahmed Abdel-Reheim Yousra Nomier Mohamed Bakr Zaki Ahmed I Abulsoud Osama A Mohammed Ahmed A Rashad Mamdouh A Oraby Mohammed S Elballal Manar Mohammed El Tabaa Ola Elazazy Mai A Abd-Elmawla Walaa A El-Dakroury Sherif S Abdel Mageed Nourhan M Abdel Source Type: research
Primary melanoma of the nipple: Report of 10 cases including coexistence with Paget's disease
Pathol Res Pract. 2023 Dec 22;253:155058. doi: 10.1016/j.prp.2023.155058. Online ahead of print.ABSTRACTPrimary melanoma of the nipple (PMN) is exceedingly rare, with only single cases reported to date. We identified 10 patients with PMN: 5 females, 5 males, median age 55.5 years (range 29-66) at diagnosis of melanoma in situ (4 cases) or invasive melanoma (6 cases, Breslow depth 0.2 mm to 3.5 mm). Follow-up was available for all 10 patients (median 19 months, range 1-183). Nine patients had no evidence of disease; one patient died of disease (13.5 months) after presenting with a nodal metastasis. One case was exceptional,...
Source: Pathology, Research and Practice - January 5, 2024 Category: Pathology Authors: Carina A Dehner Emma F Johnson Margot S Peters Ruifeng Ray Guo Source Type: research
Aggressive renal cell carcinoma with biphasic papillary and solid clear cell features harboring IDH2 (R172M) mutation
Pathol Res Pract. 2024 Jan 3;253:155090. doi: 10.1016/j.prp.2024.155090. Online ahead of print.ABSTRACTRenal cell carcinoma (RCC) is fundamentally a metabolic disease, and RCC associated with mutation of the Krebs cycle enzyme genes include fumarate hydratase-deficient and succinate dehydrogenase-deficient RCC. Most recently, the mutation of isocitrate dehydrogenase 2 (IDH2) has been suggested as the third Krebs cycle enzyme alteration to be associated with oncometabolite-induced RCC tumorigenesis. Herein, we report the second case of RCC harboring an IDH2 (R127M) mutation identified by targeted next-generation sequencing ...
Source: Pathology, Research and Practice - January 5, 2024 Category: Pathology Authors: Ming Zhao Yan Xia Wei Wang Source Type: research
Clinical and pathological correlation of P < sup > 53 < /sup > expression in oral cancers
Pathol Res Pract. 2023 Dec 29;253:155071. doi: 10.1016/j.prp.2023.155071. Online ahead of print.ABSTRACTIn our study, we aimed to evaluate the overexpression of P53 in 155 oral squamous cell carcinomas and to correlate with various clinicopathological features like depth of invasion, lymph nodal involvement, and margin status, which affect the local recurrence and prognosis. This cross-sectional study included 155 oral squamous cell carcinoma patients who underwent surgical resection of primary and nodal disease. The histopathological and clinical features were noted. Immunohistochemical expression was reported, and other ...
Source: Pathology, Research and Practice - January 5, 2024 Category: Pathology Authors: Bellala Ravishankar Bellala Venkata Madhavi Akash Kalagara Srija Bodepudi Sriharsha Harnadh P Josephine Bindu Venkateswar Rao Pydi Bellala Prithvi Raj Gopireddy Nitya Bellala Rishik Source Type: research
Testicular/paratesticular mesothelial tumours: Uncommon histopathologic entities in a very complex anatomical site
Pathol Res Pract. 2023 Dec 30;253:155069. doi: 10.1016/j.prp.2023.155069. Online ahead of print.ABSTRACTMesothelial tumours of the testicular/paratesticular region are uncommon, poorly characterised and difficult-to-diagnose lesions. They encompass entirely benign proliferations (adenomatoid tumour) and malignant, very aggressive tumours (mesothelioma) whose morphological features can be overlapping, highly variable and confounding. Moreover, testicular/paratesticular mesothelial tumours comprise relatively new entities with indolent behaviour (well-differentiated papillary mesothelial tumour) as well as tumours which cann...
Source: Pathology, Research and Practice - January 5, 2024 Category: Pathology Authors: Francesca Pagliuca Stefano Luc à Marco De Sio Davide Arcaniolo Gaetano Facchini Marco De Martino Francesco Esposito Ferdinando DE Vita Paolo Chieffi Renato Franco Source Type: research
Clinical and pathological correlation of P < sup > 53 < /sup > expression in oral cancers
Pathol Res Pract. 2023 Dec 29;253:155071. doi: 10.1016/j.prp.2023.155071. Online ahead of print.ABSTRACTIn our study, we aimed to evaluate the overexpression of P53 in 155 oral squamous cell carcinomas and to correlate with various clinicopathological features like depth of invasion, lymph nodal involvement, and margin status, which affect the local recurrence and prognosis. This cross-sectional study included 155 oral squamous cell carcinoma patients who underwent surgical resection of primary and nodal disease. The histopathological and clinical features were noted. Immunohistochemical expression was reported, and other ...
Source: Pathology, Research and Practice - January 5, 2024 Category: Pathology Authors: Bellala Ravishankar Bellala Venkata Madhavi Akash Kalagara Srija Bodepudi Sriharsha Harnadh P Josephine Bindu Venkateswar Rao Pydi Bellala Prithvi Raj Gopireddy Nitya Bellala Rishik Source Type: research
