Tumor-stroma ratio in preoperative biopsies and matched surgical specimens in oral squamous cell carcinoma: Concordance and impact on recurrence-free and overall survival
Pathol Res Pract. 2024 Feb 16;255:155211. doi: 10.1016/j.prp.2024.155211. Online ahead of print.ABSTRACTStroma-richness is commonly associated with decreased survival times as well as advanced tumor stages in various malignant tumors. A previous study on laryngeal squamous cell carcinomas showed very good agreement for tumor-stroma ratio assessment between pre-treatment biopsies and resection specimens. We therefore aimed to determine whether similar results could be shown for oral squamous cell carcinomas. 107 preoperative biopsies and matched surgical specimens were obtained from the histological archive, dating from 201...
Source: Pathology, Research and Practice - February 18, 2024 Category: Pathology Authors: Juliana Knief Katrin Herber Adrian Muenscher Christoph Thorns Nikolaus Moeckelmann Source Type: research
The potential role and mechanism of circRNAs in Ferroptosis: A comprehensive review
This study explores the regulatory roles of circRNAs in ferroptosis and their potential in diseases such as cancer, neurological disorders, and cardiovascular diseases. By investigating the relationship between circRNAs and ferroptosis, this research provides new insights into the diagnosis, treatment, and prognosis of ferroptosis-related diseases. Furthermore, the therapeutic implications of targeting circRNAs in cancer treatment and the modulation of ferroptosis pathways demonstrate the potential of circRNAs as diagnostic markers and therapeutic targets. Overall, understanding the involvement of circRNAs in regulating fe...
Source: Pathology, Research and Practice - February 18, 2024 Category: Pathology Authors: Javad Arabpour Kimia Rezaei Javad Yaghmoorian Khojini Shokufeh Razi Mohammad Javad Hayati Seyed Mohammad Gheibihayat Source Type: research
Transcription factor RELA promotes hepatocellular carcinoma progression by promoting the transcription of m6A modulator METTL3
CONCLUSION: RELA promotes the transcription of METTL3 by binding to METTL3 promoter region, thus promoting the malignancy of HCC cells. This study suggests NF-κB signaling contributes the dysregulation of m6A modification in HCC tumorigenesis.PMID:38367599 | DOI:10.1016/j.prp.2024.155168 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 17, 2024 Category: Pathology Authors: Jianguo Wu Weixing Wang Yongbin Zheng Wenhong Deng Jiasheng Liu Source Type: research
TIGIT: A potential immunotherapy target for gynecological cancers
Pathol Res Pract. 2024 Feb 7;255:155202. doi: 10.1016/j.prp.2024.155202. Online ahead of print.ABSTRACTGynecological cancer represents a significant global health challenge, and conventional treatment modalities have demonstrated limited efficacy. However, recent investigations into immune checkpoint pathways have unveiled promising opportunities for enhancing the prognosis of patients with cancer. Among these pathways, TIGIT has surfaced as a compelling candidate owing to its capacity to augment the immune function of NK and T cells through blockade, thereby yielding improved anti-tumor effects and prolonged patient survi...
Source: Pathology, Research and Practice - February 17, 2024 Category: Pathology Authors: Siyue Jiang Wenhua Wang Yongxiu Yang Source Type: research
Hepatic granulomas following liver transplantation: A retrospective survey, and analysis of possible microbiological etiology
CONCLUSION: Our study confirmed that granulomas are frequently seen in liver allograft biopsy specimens, and most often localized in the parenchyma, occurring in the first post-transplant period in patients with AILD, and often seen simultaneously with episodes of ACR. Neither a specific microbiological etiological agent nor a consistent microbiome was detected in any case.PMID:38367601 | DOI:10.1016/j.prp.2024.155201 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 17, 2024 Category: Pathology Authors: Anisoara Iordache Kurt Fuursted Charlotte Vestrup Rift Allan Rasmussen Gro Linno Willemoe Jane Preuss Hasselby Source Type: research
Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cellular functions modulated by endothelial cells in pancreatic cancer cells under hypoxic conditions
CONCLUSION: These results suggest that LPA receptor-mediated signaling plays an important role in the modulation of pancreatic cancer cell functions by endothelial cells under hypoxic conditions.PMID:38367602 | DOI:10.1016/j.prp.2024.155192 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 17, 2024 Category: Pathology Authors: Miwa Takai Narumi Yashiro Koki Hara Yuka Amano Mao Yamamoto Toshifumi Tsujiuchi Source Type: research
Transcription factor RELA promotes hepatocellular carcinoma progression by promoting the transcription of m6A modulator METTL3
CONCLUSION: RELA promotes the transcription of METTL3 by binding to METTL3 promoter region, thus promoting the malignancy of HCC cells. This study suggests NF-κB signaling contributes the dysregulation of m6A modification in HCC tumorigenesis.PMID:38367599 | DOI:10.1016/j.prp.2024.155168 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 17, 2024 Category: Pathology Authors: Jianguo Wu Weixing Wang Yongbin Zheng Wenhong Deng Jiasheng Liu Source Type: research
TIGIT: A potential immunotherapy target for gynecological cancers
Pathol Res Pract. 2024 Feb 7;255:155202. doi: 10.1016/j.prp.2024.155202. Online ahead of print.ABSTRACTGynecological cancer represents a significant global health challenge, and conventional treatment modalities have demonstrated limited efficacy. However, recent investigations into immune checkpoint pathways have unveiled promising opportunities for enhancing the prognosis of patients with cancer. Among these pathways, TIGIT has surfaced as a compelling candidate owing to its capacity to augment the immune function of NK and T cells through blockade, thereby yielding improved anti-tumor effects and prolonged patient survi...
Source: Pathology, Research and Practice - February 17, 2024 Category: Pathology Authors: Siyue Jiang Wenhua Wang Yongxiu Yang Source Type: research
Hepatic granulomas following liver transplantation: A retrospective survey, and analysis of possible microbiological etiology
CONCLUSION: Our study confirmed that granulomas are frequently seen in liver allograft biopsy specimens, and most often localized in the parenchyma, occurring in the first post-transplant period in patients with AILD, and often seen simultaneously with episodes of ACR. Neither a specific microbiological etiological agent nor a consistent microbiome was detected in any case.PMID:38367601 | DOI:10.1016/j.prp.2024.155201 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 17, 2024 Category: Pathology Authors: Anisoara Iordache Kurt Fuursted Charlotte Vestrup Rift Allan Rasmussen Gro Linno Willemoe Jane Preuss Hasselby Source Type: research
Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cellular functions modulated by endothelial cells in pancreatic cancer cells under hypoxic conditions
CONCLUSION: These results suggest that LPA receptor-mediated signaling plays an important role in the modulation of pancreatic cancer cell functions by endothelial cells under hypoxic conditions.PMID:38367602 | DOI:10.1016/j.prp.2024.155192 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 17, 2024 Category: Pathology Authors: Miwa Takai Narumi Yashiro Koki Hara Yuka Amano Mao Yamamoto Toshifumi Tsujiuchi Source Type: research
The hidden threat: Environmental toxins and their effects on gut microbiota
Pathol Res Pract. 2024 Jan 28;255:155173. doi: 10.1016/j.prp.2024.155173. Online ahead of print.ABSTRACTThe human gut microbiota (GM), which consists of a complex and diverse ecosystem of bacteria, plays a vital role in overall wellness. However, the delicate balance of this intricate system is being compromised by the widespread presence of environmental toxins. The intricate connection between contaminants in the environment and human well-being has garnered significant attention in recent times. Although many environmental pollutants and their toxicity have been identified and studied in laboratory settings and animal m...
Source: Pathology, Research and Practice - February 16, 2024 Category: Pathology Authors: Gautam Bhardwaj Yassine Riadi Muhammad Afzal Pooja Bansal Harpreet Kaur Mahamedha Deorari Rajiv Kumar Tonk Waleed Hassan Almalki Imran Kazmi Sami I Alzarea Neelima Kukreti Lakshmi Thangavelu Shakir Saleem Source Type: research
Integrated bioinformatics approaches and expression assays identified new markers in pituitary adenomas
In conclusion, this study offers information about deregulation of bioinformatically identified genes in PA tumors and indicates that further studies in this field is needed to understand the involved molecular mechanisms.PMID:38364650 | DOI:10.1016/j.prp.2024.155193 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 16, 2024 Category: Pathology Authors: Parisa Esmaeili Motlagh Elena Jamali Nastaran Karimi Solat Eslami Guive Sharifi Soudeh Ghafouri-Fard Source Type: research
Immunohistochemical and molecular pattern of p53 in epithelial ovarian cancers negative for germline BRCA1/2 variants
We describe TP53 mutation results in relationship to the immunohistochemical pattern of p53 expression in a series of EOCs negative for BRCA1 and BRCA2 germline mutations. In addition, we also investigated STIC presence and "p53 signature" in fallopian tube sampling of these EOCs. Our results demonstrate that TP53 alterations are frequent and early events in sporadic EOCs including also low-grade carcinomas. Also in this series, STIC is associated with an abnormal p53 pattern in fallopian tubes of high-grade EOCs. In summary, TP53 aberrations are the most frequent and early molecular events in EOC carcinogenesis independen...
Source: Pathology, Research and Practice - February 16, 2024 Category: Pathology Authors: Susanna Ronchi Sofia Facchi Eleonora Di Lauro Laura Libera Ileana Wanda Carnevali Francesca Zefiro Elena Alexandrova Francesca Rizzo Fausto Sessa Maria Grazia Tibiletti Source Type: research
IL-33 immunohistochemical pattern of expression in neoplastic and nonneoplastic peripheral lung tissues of stage 1 o 2 lung adenocarcinoma
Pathol Res Pract. 2024 Feb 13;255:155208. doi: 10.1016/j.prp.2024.155208. Online ahead of print.ABSTRACTIL-33 is a multifaceted cytokine, plays a pivotal role in various biological processes, making it a subject of extensive research and intrigue in the field of immunology. This cytokine acts as a key regulator, effectively putting the brakes on proinflammatory nuclear factor-kappa B (NF-κB), thereby modulating chromatin compaction by promoting nucleosome-to-nucleosome interactions. IL-33's influence extends to the realm of innate and acquired immunity through its binding to the membrane-bound ST2 molecule (ST2L) of the I...
Source: Pathology, Research and Practice - February 15, 2024 Category: Pathology Authors: Marco Casciaro Sebastiano Gangemi Gaetano Caramori Francesco Nucera Giovanni Tuccari Antonio Ieni Source Type: research
IL-33 immunohistochemical pattern of expression in neoplastic and nonneoplastic peripheral lung tissues of stage 1 o 2 lung adenocarcinoma
Pathol Res Pract. 2024 Feb 13;255:155208. doi: 10.1016/j.prp.2024.155208. Online ahead of print.ABSTRACTIL-33 is a multifaceted cytokine, plays a pivotal role in various biological processes, making it a subject of extensive research and intrigue in the field of immunology. This cytokine acts as a key regulator, effectively putting the brakes on proinflammatory nuclear factor-kappa B (NF-κB), thereby modulating chromatin compaction by promoting nucleosome-to-nucleosome interactions. IL-33's influence extends to the realm of innate and acquired immunity through its binding to the membrane-bound ST2 molecule (ST2L) of the I...
Source: Pathology, Research and Practice - February 15, 2024 Category: Pathology Authors: Marco Casciaro Sebastiano Gangemi Gaetano Caramori Francesco Nucera Giovanni Tuccari Antonio Ieni Source Type: research
