Immunohistochemical and molecular pattern of p53 in epithelial ovarian cancers negative for germline BRCA1/2 variants

We describe TP53 mutation results in relationship to the immunohistochemical pattern of p53 expression in a series of EOCs negative for BRCA1 and BRCA2 germline mutations. In addition, we also investigated STIC presence and "p53 signature" in fallopian tube sampling of these EOCs. Our results demonstrate that TP53 alterations are frequent and early events in sporadic EOCs including also low-grade carcinomas. Also in this series, STIC is associated with an abnormal p53 pattern in fallopian tubes of high-grade EOCs. In summary, TP53 aberrations are the most frequent and early molecular events in EOC carcinogenesis independently from BRCA mutation status.PMID:38364651 | DOI:10.1016/j.prp.2024.155183

Source: Pathology, Research and Practice - February 16, 2024 Category: Pathology Authors: Susanna Ronchi Sofia Facchi Eleonora Di Lauro Laura Libera Ileana Wanda Carnevali Francesca Zefiro Elena Alexandrova Francesca Rizzo Fausto Sessa Maria Grazia Tibiletti Source Type: research