Noncoding RNAs in hepatitis: Unraveling the apoptotic pathways
Pathol Res Pract. 2024 Jan 28;255:155170. doi: 10.1016/j.prp.2024.155170. Online ahead of print.ABSTRACTHepatitis is a worldwide health issue that causes inflammation of the liver and is frequently brought on by viral infections, specifically those caused by the hepatitis B and C viruses. Although the pathophysiological causes of hepatitis are complex, recent research indicates that noncoding RNAs (ncRNAs) play a crucial role in regulating apoptosis, an essential process for maintaining liver homeostasis and advancing the illness. Noncoding RNAs have been linked to several biological processes, including apoptosis. These R...
Source: Pathology, Research and Practice - February 7, 2024 Category: Pathology Authors: Khalid Saad Alharbi Source Type: research
Comparative analysis of ARID1A mutations with mRNA levels and protein expression in gastric carcinoma
Pathol Res Pract. 2024 Jan 10;255:155063. doi: 10.1016/j.prp.2023.155063. Online ahead of print.ABSTRACTThe ARID1A gene is pivotal in chromatin remodeling and genomic integrity and is frequently mutated in various cancer types. ARID1A mutation is the second most frequently mutated tumor suppressor gene and has been suggested as a predictor of immunotherapeutic responsiveness in gastric carcinoma (GC). Despite its significance, the relationship among ARID1A somatic mutations, RNA expression levels, and protein expression remains unclear, particularly in GC. For this purpose, we performed comparative study in two cohorts. Co...
Source: Pathology, Research and Practice - February 7, 2024 Category: Pathology Authors: Inwoo Hwang Yunjoo Cho So Young Kang Deok Geun Kim Soomin Ahn Jeeyun Lee Kyoung-Mee Kim Source Type: research
Reduced expression of Ankyrin-G and E-cadherin in duodenal mucosal biopsy of subjects with celiac disease
Pathol Res Pract. 2024 Jan 22;255:155164. doi: 10.1016/j.prp.2024.155164. Online ahead of print.ABSTRACTConfirmatory diagnosis of celiac disease (CD) include histopathology of duodenal biopsy and tissue trans-glutaminase-IgA. Identification of tissue-specific histological markers is warranted to improve the diagnosis. A genetic study in CD identified the association of ankyrin-G that connects E-cadherin with β2-spectrin in epithelial cells of the duodenal tissue. We attempted to investigate the differential expression of ankyrin-G, E-cadherin and β2-spectrin in duodenal biopsy of CD subjects compared to non-CD controls. ...
Source: Pathology, Research and Practice - February 7, 2024 Category: Pathology Authors: Nidhi Sharma Vikram Narang Ajit Sood Vandana Midha Sabyasachi Senapati Source Type: research
Perineural differentiation in neurotized nevi
CONCLUSION: Perineural differentiation is not uncommon and immunohistochemically observed in all nevi with a relatively large component of neurotization. To prevent misdiagnosing desmoplastic melanoma and overtreating patients, it is crucial to be aware of perineuromatous nevi.PMID:38324967 | DOI:10.1016/j.prp.2024.155184 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 7, 2024 Category: Pathology Authors: Cem Leblebici Beste Noyan Mod Merve Cin Burcu Özcan Source Type: research
Beyond typical histology of BAP1-inactivated melanocytoma
Pathol Res Pract. 2024 Jan 24:155162. doi: 10.1016/j.prp.2024.155162. Online ahead of print.ABSTRACTBAP1-inactivated melanocytoma (BIM) is a novel subgroup of melanocytic neoplasm listed in the 5th edition of WHO classification of skin tumor. BIM is characterized by two molecular alterations, including a mitogenic driver mutation (usually BRAF gene) and the loss of function of BAP1, a tumor suppressor gene located on chromosome 3p21, which encodes for BRCA1-associated protein (BAP1). The latter represents a nuclear-localized deubiquitinase involved in several cellular processes including cell cycle regulation, chromatin re...
Source: Pathology, Research and Practice - February 7, 2024 Category: Pathology Authors: Michele Donati Dmitry V Kazakov Source Type: research
Deciphering the functional landscape and therapeutic implications of noncoding RNAs in the TGF- β signaling pathway in colorectal cancer: A comprehensive review
In conclusion, this review offers a comprehensive overview of the intricate interplay between ncRNAs and the TGF-β signaling pathway in CRC. By unraveling the functional significance of these regulatory elements, we gain valuable insights into the molecular landscape of CRC, paving the way for the development of novel and targeted therapeutic interventions aimed at modulating the TGF-β signaling cascade through the manipulation of ncRNAs.PMID:38320438 | DOI:10.1016/j.prp.2024.155158 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 6, 2024 Category: Pathology Authors: Mohamed J Saadh Omer Qutaiba B Allela Zahraa Jasim Sattay Rafil Adnan Hussein Al Zuhairi Hijaz Ahmad Gaber E Eldesoky Mohaned Adil Mohammed Shnain Ali Source Type: research
Overcoming chemoresistance and radio resistance in prostate cancer: The emergent role of non-coding RNAs
Pathol Res Pract. 2024 Feb 1;255:155179. doi: 10.1016/j.prp.2024.155179. Online ahead of print.ABSTRACTProstate cancer (PCa) continues to be a major health concern worldwide, with its resistance to chemotherapy and radiation therapy presenting major hurdles in successful treatment. While patients with localized prostate cancer generally have a good survival rate, those with metastatic prostate cancer often face a grim prognosis, even with aggressive treatments using various methods. The high mortality rate in severe cases is largely due to the lack of treatment options that can offer lasting results, especially considering...
Source: Pathology, Research and Practice - February 6, 2024 Category: Pathology Authors: Muhammad Sarfraz None Abida Lina Eltaib Syed Mohammed Basheeruddin Asdaq Arbi Guetat A Khuzaim Alzahrani Shatha Sulaiman Alanazi Shams Aaghaz Neelam Singla Mohd Imran Source Type: research
Unlocking the secrets: Volatile Organic Compounds (VOCs) and their devastating effects on lung cancer
Pathol Res Pract. 2024 Jan 26;255:155157. doi: 10.1016/j.prp.2024.155157. Online ahead of print.ABSTRACTLung cancer (LCs) is still a serious health problem globally, with many incidences attributed to environmental triggers such as Volatile Organic Compounds (VOCs). VOCs are a broad class of compounds that can be released via various sources, including industrial operations, automobile emissions, and indoor air pollution. VOC exposure has been linked to an elevated risk of lung cancer via multiple routes. These chemicals can be chemically converted into hazardous intermediate molecules, resulting in DNA damage and genetic ...
Source: Pathology, Research and Practice - February 6, 2024 Category: Pathology Authors: Md Sadique Hussain Gaurav Gupta Riya Mishra Neeraj Patel Saurabh Gupta Sami I Alzarea Imran Kazmi Popat Kumbhar John Disouza Harish Dureja Neelima Kukreti Sachin Kumar Singh Kamal Dua Source Type: research
Unlocking β-cell restoration: The crucial role of PDX1 in diabetes therapy
Pathol Res Pract. 2024 Feb;254:155131. doi: 10.1016/j.prp.2024.155131. Epub 2024 Jan 20.ABSTRACTDiabetes has been a significant healthcare problem worldwide for a considerable period. The primary objective of diabetic treatment plans is to control the symptoms associated with the pathology. To effectively combat diabetes, it is crucial to comprehend the disease's etiology, essential factors, and the relevant processes involving β-cells. The development of the pancreas, maturation, and maintenance of β-cells, and their role in regular insulin function are all regulated by PDX1. Therefore, understanding the regulation of P...
Source: Pathology, Research and Practice - February 3, 2024 Category: Pathology Authors: Deepali Siwan Mukesh Nandave Ritu Gilhotra Waleed Hassan Almalki Gaurav Gupta Rupesh K Gautam Source Type: research
Long non-coding RNA (lncRNA) PVT1 in drug resistance of cancers: Focus on pathological mechanisms
Pathol Res Pract. 2024 Feb;254:155119. doi: 10.1016/j.prp.2024.155119. Epub 2024 Jan 11.ABSTRACTAccording to estimates, cancer will be the leading cause of death globally in 2022, accounting for 9.6 million deaths. At present, the three main therapeutic modalities utilized to treat cancer are radiation therapy, chemotherapy, and surgery. However, during treatment, tumor cells resistant to chemotherapy may arise. Drug resistance remains a major oppose since it often leads to therapeutic failure. Furthermore, the term "acquired drug resistance" describes the situation where tumor cells already display drug resistance before ...
Source: Pathology, Research and Practice - February 3, 2024 Category: Pathology Authors: Saade Abdalkareem Jasim Ali A Majeed Herlina Uinarni Mohammed Alshuhri Abdullah Ali Alzahrani Abeer A Ibrahim Ahmed Alawadi Noor K Abed Al-Abadi Yasser Fakri Mustafa Batool Ali Ahmed Source Type: research
The biological function of miR-128-2 in hepatocellular carcinoma and its molecular mechanism functioning
CONCLUSION: The serum level of miR-128-2 in cases with HCC was obviously increased, which was related to the malignant progression of HCC. Due to the reasonable sensitivity and specificity, miR-128-2 might be as a new and effective marker for the diagnosis of HCC.PMID:38309020 | DOI:10.1016/j.prp.2024.155178 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 3, 2024 Category: Pathology Authors: Jingzhe Jin Mingcheng Ren Source Type: research
Unravelling the role of long non-coding RNAs in modulating the Hedgehog pathway in cancer
Pathol Res Pract. 2024 Feb;254:155156. doi: 10.1016/j.prp.2024.155156. Epub 2024 Jan 26.ABSTRACTCancer is a multifactorial pathological condition characterized by uncontrolled cellular proliferation, genomic instability, and evasion of regulatory mechanisms. It arises from the accumulation of genetic mutations confer selective growth advantages, leading to malignant transformation and tumor formation. The intricate interplay between LncRNAs and the Hedgehog pathway has emerged as a captivating frontier in cancer research. The Hedgehog pathway, known for its fundamental roles in embryonic development and tissue homeostasis,...
Source: Pathology, Research and Practice - February 3, 2024 Category: Pathology Authors: Shailendra Singh Chandel Anurag Mishra Gaurav Dubey Ravindra Pal Singh Mithilesh Singh Mohit Agarwal Himmat Singh Chawra Neelima Kukreti Source Type: research
Prognostic role of PD-L1 expression in head and neck squamous cell carcinoma: An institutional experience from India
CONCLUSION: PD-L1 expression is more likely to be seen in conventional HNSCC histomorphology. PD-L1 expression is a predictor of better prognosis in HNSCC.PMID:38306860 | DOI:10.1016/j.prp.2024.155133 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 2, 2024 Category: Pathology Authors: Pooja Sharma Kala Naveen Thapliyal Bhawna Pant Nitin Sharma Hari Shankar Pandey Source Type: research
Germinal centres within tumour positive sentinel lymph nodes are positively associated with tumour infiltrating lymphocytes and tertiary lymphoid structures in breast cancer
CONCLUSION: This study suggests GCs measured within SLNpos might be useful indicators of the humoral anti-tumour immune response in breast cancer. Future studies are needed investigating underlying biological mechanisms and prognostic value of GCs in SLNs.PMID:38306861 | DOI:10.1016/j.prp.2024.155171 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 2, 2024 Category: Pathology Authors: Sabine Dieleman Loes F S Kooreman Sander M J van Kuijk Axel Zur Hausen Marjolein L Smidt Heike I Grabsch Source Type: research
Functions of Sialyltransferases in gynecological malignancies: A systematic review
CONCLUSION: ST6Gal-I gene expression occurs at a high speed in ovarian, cervix, endometrial, and breast cancers, leading to metastasis to distant cells, cell destruction, cell invasion, and reduced patient survival.PMID:38306862 | DOI:10.1016/j.prp.2024.155159 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 2, 2024 Category: Pathology Authors: Siyuan Sun Zhenying Yang Mehrsa Majdaeen Alaba Tolulope Agbele Razzagh Abedi-Firouzjah Source Type: research
