Beyond the genome: MALAT1's role in advancing urologic cancer care
Pathol Res Pract. 2024 Feb 28;256:155226. doi: 10.1016/j.prp.2024.155226. Online ahead of print.ABSTRACTUrologic cancers (UCs), which include bladder, kidney, and prostate tumors, account for almost a quarter of all malignancies. Long non-coding RNAs (lncRNAs) are tissue-specific RNAs that influence cell growth, death, and division. LncRNAs are dysregulated in UCs, and their abnormal expression may allow them to be used in cancer detection, outlook, and therapy. With the identification of several novel lncRNAs and significant exploration of their functions in various illnesses, particularly cancer, the study of lncRNAs has...
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: Mohd Imran None Abida Lina Eltaib Muhammad Irfan Siddique Mehnaz Kamal Syed Mohammed Basheeruddin Asdaq Neelam Singla Marwan Al-Hajeili Fatemah Abdulaziz Alhakami Ahmed Farhan AlQarni Altaf A Abdulkhaliq Ali A Rabaan Source Type: research
Prognostic value of genome-wide methylation in acute-on-chronic hepatitis B liver failure
CONCLUSIONS: Genome methylation level can be a good biomarker in predicting the severity and prognosis of ACHBLF.PMID:38452586 | DOI:10.1016/j.prp.2024.155232 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: Haiming Li Shuai Gao Jieru Yang Ying Zhang None Xuefei Yuchen Fan Kai Wang Source Type: research
Harnessing the supremacy of MEG3 LncRNA to defeat gastrointestinal malignancies
Pathol Res Pract. 2024 Feb 23;256:155223. doi: 10.1016/j.prp.2024.155223. Online ahead of print.ABSTRACTEvidence suggests that long non-coding RNAs (lncRNAs) play a pivotal role in the carcinogenesis and progression of various human malignancies including gastrointestinal malignancies. This comprehensive review reports the functions and mechanisms of the lncRNA maternally expressed gene 3 (MEG3) involved in gastrointestinal malignancies. It summarizes its roles in mediating the regulation of cellular proliferation, apoptosis, migration, invasiveness, epithelial-to-mesenchymal transition, and drug resistance in several gast...
Source: Pathology, Research and Practice - March 7, 2024 Category: Pathology Authors: H H Rashwan A M Taher H A Hassan A A Awaji C J Kiriacos R A Assal R A Youness Source Type: research
The detailed histopathological characteristics of ovarian fibroma compared with thecoma, granulosa cell tumor, and sclerosing stromal tumor
CONCLUSION: Ovarian fibromas can present some maybe unexpected features rather frequently, such as cystic degeneration, hyaline plaques, prominent vascularity, increased cellularity, and some mitotic activity, thus their presence should not always prompt to an alternative diagnosis.PMID:38447489 | DOI:10.1016/j.prp.2024.155236 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 6, 2024 Category: Pathology Authors: Mousa Mobarki Alexandra Papoudou-Bai Shaqraa Musawi Michel P éoc'h Georgia Karpathiou Source Type: research
Noncoding RNAs as therapeutic targets in autophagy-related diabetic cardiomyopathy
Pathol Res Pract. 2024 Feb 28;256:155225. doi: 10.1016/j.prp.2024.155225. Online ahead of print.ABSTRACTDiabetic cardiomyopathy, a multifaceted complication of diabetes mellitus, remains a major challenge in clinical management due to its intricate pathophysiology. Emerging evidence underscores the pivotal role of autophagy dysregulation in the progression of diabetic cardiomyopathy, providing a novel avenue for therapeutic intervention. Noncoding RNAs (ncRNAs), a diverse class of regulatory molecules, have recently emerged as promising candidates for targeted therapeutic strategies. The exploration of various classes of n...
Source: Pathology, Research and Practice - March 5, 2024 Category: Pathology Authors: Mohammed Khaled Bin Break Rahamat Unissa Syed Weiam Hussein Saad Alqarni Sami M Magam Muhammad Nawaz Sameer Shaikh Ahmed Al Otaibi Najat Masood Kareem M Younes Source Type: research
Noncoding RNAs as therapeutic targets in autophagy-related diabetic cardiomyopathy
Pathol Res Pract. 2024 Feb 28;256:155225. doi: 10.1016/j.prp.2024.155225. Online ahead of print.ABSTRACTDiabetic cardiomyopathy, a multifaceted complication of diabetes mellitus, remains a major challenge in clinical management due to its intricate pathophysiology. Emerging evidence underscores the pivotal role of autophagy dysregulation in the progression of diabetic cardiomyopathy, providing a novel avenue for therapeutic intervention. Noncoding RNAs (ncRNAs), a diverse class of regulatory molecules, have recently emerged as promising candidates for targeted therapeutic strategies. The exploration of various classes of n...
Source: Pathology, Research and Practice - March 5, 2024 Category: Pathology Authors: Mohammed Khaled Bin Break Rahamat Unissa Syed Weiam Hussein Saad Alqarni Sami M Magam Muhammad Nawaz Sameer Shaikh Ahmed Al Otaibi Najat Masood Kareem M Younes Source Type: research
Unraveling IGFBP3-mediated m6A modification in fracture healing
CONCLUSION: The IGFBP3/miR-23a-3p/SMAD5 axis plays a pivotal role in fracture healing, highlighting the relevance of m6A modification. IGFBP3's role in stabilizing miR-23a-3p expression through m6A modification offers a potential therapeutic target for enhancing fracture healing outcomes.PMID:38432050 | DOI:10.1016/j.prp.2024.155220 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 3, 2024 Category: Pathology Authors: Aining Lai Junjian Sun Zhiyuan Dai Long Guo Degang Tao Haitang Li Bin Chen Rong Zhou Source Type: research
Unraveling IGFBP3-mediated m6A modification in fracture healing
CONCLUSION: The IGFBP3/miR-23a-3p/SMAD5 axis plays a pivotal role in fracture healing, highlighting the relevance of m6A modification. IGFBP3's role in stabilizing miR-23a-3p expression through m6A modification offers a potential therapeutic target for enhancing fracture healing outcomes.PMID:38432050 | DOI:10.1016/j.prp.2024.155220 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - March 3, 2024 Category: Pathology Authors: Aining Lai Junjian Sun Zhiyuan Dai Long Guo Degang Tao Haitang Li Bin Chen Rong Zhou Source Type: research
Unlocking the potential of exosomes in cancer research: A paradigm shift in diagnosis, treatment, and prevention
Pathol Res Pract. 2024 Feb 20;255:155214. doi: 10.1016/j.prp.2024.155214. Online ahead of print.ABSTRACTExosomes, which are tiny particles released by cells, have the ability to transport various molecules, including proteins, lipids, and genetic material containing non-coding RNAs (ncRNAs). They are associated with processes like cancer metastasis, immunity, and tissue repair. Clinical trials have shown exosomes to be effective in treating cancer, inflammation, and chronic diseases. Mesenchymal stem cells (MSCs) and dendritic cells (DCs) are common sources of exosome production. Exosomes have therapeutic potential due to ...
Source: Pathology, Research and Practice - March 2, 2024 Category: Pathology Authors: Saloomeh Khoushab Mina Hobabi Aghmiuni Negin Esfandiari Mohammad Reza Roudaki Sarvandani Mohsen Rashidi Afshin Taheriazam Maliheh Entezari Mehrdad Hashemi Source Type: research
Unlocking the potential of exosomes in cancer research: A paradigm shift in diagnosis, treatment, and prevention
Pathol Res Pract. 2024 Feb 20;255:155214. doi: 10.1016/j.prp.2024.155214. Online ahead of print.ABSTRACTExosomes, which are tiny particles released by cells, have the ability to transport various molecules, including proteins, lipids, and genetic material containing non-coding RNAs (ncRNAs). They are associated with processes like cancer metastasis, immunity, and tissue repair. Clinical trials have shown exosomes to be effective in treating cancer, inflammation, and chronic diseases. Mesenchymal stem cells (MSCs) and dendritic cells (DCs) are common sources of exosome production. Exosomes have therapeutic potential due to ...
Source: Pathology, Research and Practice - March 2, 2024 Category: Pathology Authors: Saloomeh Khoushab Mina Hobabi Aghmiuni Negin Esfandiari Mohammad Reza Roudaki Sarvandani Mohsen Rashidi Afshin Taheriazam Maliheh Entezari Mehrdad Hashemi Source Type: research
The utility of FISH analysis in the diagnosis of BCOR-rearranged sarcomas
CONCLUSIONS: Our study indicates that BCOR FISH analysis using an IVD probe, may be useful to detect the presence of a BCOR rearrangement, including both translocations and inversions; however, negative results, in some cases, can occur.PMID:38422910 | DOI:10.1016/j.prp.2024.155209 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Stefania Cocchi Marco Gambarotti Gabriella Gamberi Giovanna Magagnoli Margherita Maioli Monica Stevanin Federica Samperi Alberto Righi Stefania Benini Source Type: research
Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis
In conclusion, our study demonstrated that LINC00675 is an oncogenic lncRNA that enhances the malignancy of AML by upregulating CDK6 expression through miR-6809 sponging, providing a new perspective and feasible target for the diagnosis and treatment of AML.PMID:38422911 | DOI:10.1016/j.prp.2024.155221 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Xinyi Long Huinan Jiang Zhuogang Liu Jing Liu Rong Hu Source Type: research
Prediction of the binding location between the nuclear inhibitor of DNA binding and differentiation 2 (ID2) and HSPA5
Pathol Res Pract. 2024 Feb 17;255:155217. doi: 10.1016/j.prp.2024.155217. Online ahead of print.ABSTRACTGlucose-regulated protein 78 (GRP78), also termed HSPA5, was widely studied in cancer. It was recently approved that GRP78 has nuclear localization potential that sheds light on its role in cancer development. The inhibitor of DNA binding and differentiation 2 (ID2) is the nuclear component that associates with GRP78. The interaction between these two proteins is not understood clearly. In the current study, the binding pattern of GRP78/ID2 is predicted using computational methods. Protein-protein docking is used along w...
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Abdo A Elfiky Source Type: research
Donors risk assessment in transplantation: From the guidelines to their real-world application
Pathol Res Pract. 2024 Feb 12;255:155210. doi: 10.1016/j.prp.2024.155210. Online ahead of print.ABSTRACTTransplantation of an organ from a donor carries an unavoidable risk of tumor transmission. The need to extend the donor pool increases the use of organs from donors with malignancies and potential disease transmission is a constant tension influencing donor suitability decisions. Current classification systems for the assessment of donor malignancy transmission risk have evolved from reports of potential transmission events in recipients to national donation and transplant surveillance agencies. Although the risk of mal...
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Deborah Malvi Francesco Vasuri Elisa Albertini Maurizio Carbone Luca Novelli Claudia Mescoli Massimo Cardillo Fabio Pagni Antonia D'Errico Albino Eccher Source Type: research
The utility of FISH analysis in the diagnosis of BCOR-rearranged sarcomas
CONCLUSIONS: Our study indicates that BCOR FISH analysis using an IVD probe, may be useful to detect the presence of a BCOR rearrangement, including both translocations and inversions; however, negative results, in some cases, can occur.PMID:38422910 | DOI:10.1016/j.prp.2024.155209 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - February 29, 2024 Category: Pathology Authors: Stefania Cocchi Marco Gambarotti Gabriella Gamberi Giovanna Magagnoli Margherita Maioli Monica Stevanin Federica Samperi Alberto Righi Stefania Benini Source Type: research
