Critical role of miR-21/exosomal miR-21 in autophagy pathway

Pathol Res Pract. 2024 Mar 30;257:155275. doi: 10.1016/j.prp.2024.155275. Online ahead of print.ABSTRACTActivation of autophagy, a process of cellular stress response, leads to the breakdown of proteins, organelles, and other parts of the cell in lysosomes, and can be linked to several ailments, such as cancer, neurological diseases, and rare hereditary syndromes. Thus, its regulation is very carefully monitored. Transcriptional and post-translational mechanisms domestically or in whole organisms utilized to control the autophagic activity, have been heavily researched. In modern times, microRNAs (miRNAs) are being considered to have a part in post-translational orchestration of the autophagic activity, with miR-21 as one of the best studied miRNAs, it is often more than expressed in cancer cells. This regulatory RNA is thought to play a major role in a plethora of processes and illnesses including growth, cancer, cardiovascular disease, and inflammation. Different studies have suggested that a few autophagy-oriented genes, such as PTEN, Rab11a, Atg12, SIPA1L2, and ATG5, are all targeted by miR-21, indicating its essential role in the regulation.PMID:38643552 | DOI:10.1016/j.prp.2024.155275

Source: Pathology, Research and Practice - April 21, 2024 Category: Pathology Authors: Mohamed J Saadh Morug Salih Mahdi Omer Qutaiba B Allela Tuqa S Alazzawi Mohammed Ubaid Nodir M Rakhimov Zainab H Athab Pushpamala Ramaiah Lathamangeswari Chinnasamy Fahad Alsaikhan Bagher Farhood Source Type: research