GSE249573 Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies [RNA-seq]

Contributors : Kornelia Polyak ; Marie-Anne Goyette ; Laura StevensSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn a 3D coculture with stroma cells derived from breast cancer patients ’ brain metastasis, HER2+ breast cancer cells were protected from HER2-targeted therapies, particularly the EGFR/HER2 small molecule inhibitor neratinib. To get insight into how this protection arises, a Synthetic Notch (SynNotch) reporter model allowed to study the effect of direct contact betwee n stroma and cancer cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research