The Impact of Dose Rate on the Tumor Microenvironment Using Flattening-Filter-Free Beams
Recently, dose delivery technology has rapidly evolved with flattening filter-free beams (FFF), and the biological effects of high dose rates are a matter of interest. We hypothesized that FFF beams at different dose rates obtained with modern linear accelerators have different effects on the TME. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Melek Tugce Yilmaz, Aysenur Gok, Mustafa Emre Gedik, Aydan Caglayan, Fazli Yagiz Yedekci, Sevtap Aydin Dilsiz, Gurcan Gunaydin, Aytekin Akyol, Pervin Hurmuz Tags: Original Article Source Type: research

Reducing Salivary Toxicity with Adaptive Radiotherapy (ReSTART): A Randomized Controlled Trial comparing conventional IMRT to adaptive IMRT in head and neck Squamous Cell Carcinomas
The utility of Adaptive Radiotherapy (ART) in Head and Neck Squamous Cell Carcinoma (HNSCC) remains to be ascertained. While multiple retrospective and single-arm prospective studies have demonstrated its efficacy in decreasing parotid doses and reducing xerostomia, there is a lack of adequate randomized evidence. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Sarbani Ghosh-Laskar, Shwetabh Sinha, Anuj Kumar, Asesh Samanta, Samarpita Mohanty, Srikant Kale, Faizalam Khan, Shirley Lewis Salins, Vedang Murthy Tags: Original Article Source Type: research

Prehabilitation reduces hospital admissions for patients with advanced lung cancer
(Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Iain Phillips, Abi Walton, Colin Barrie, Melanie Mackean Tags: Letter Source Type: research

Systematic review of hypofractionated radiation therapy for the treatment of oesophageal squamous cell carcinoma and oesophageal adenocarcinoma
There has been limited progress made in improving the suboptimal outcomes delivered by conventionally fractionated radiotherapy (RT) for oesophageal adenocarcinoma (OAC) and squamous cell carcinoma (OSCC). A greater biological effect may be achieved using hypofractionated RT (HFRT), though the toxicity, tolerability and efficacy of this approach in OAC and OSCC is uncertain. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Chandan Sanghera, Dylan McClurg, Christopher M. Jones Tags: Original Article Source Type: research

A Single Institution Review of the Use of Radiation in the Adjuvant and Definitive Management of Keloids
And purpose: Many individuals suffer from keloids that are refractory to standard treatment modalities, including surgical excision alone. Radiation therapy can be used to reduce the risk of recurrent keloids post-operatively, as well as be used as primary treatment for keloids not amenable to surgical resection. The purpose of this study was to review our institutional experience of radiation therapy for keloid management. (Source: Clinical Oncology)
Source: Clinical Oncology - March 18, 2024 Category: Radiology Authors: Jason Fernandes, Donna Liao, Archya Dasgupta, May N. Tsao, Elizabeth A. Barnes Tags: Original Article Source Type: research

Radiomics for clinical decision support in radiation oncology
Radiomics is a promising tool for the development of quantitative biomarkers to support clinical decision-making. It has been shown to improve the prediction of response to treatment and outcome in different settings, particularly in the field of radiation oncology by optimising the dose delivery solutions and reducing the rate of radiation-induced side effects, leading to a fully personalised approach.Despite the promising results offered by radiomics at each of these stages, standardised methodologies, reproducibility and interpretability of results are still lacking, limiting the potential clinical impact of these tools...
Source: Clinical Oncology - March 15, 2024 Category: Radiology Authors: Luca Russo, Charles-Davies Diepriye, Silvia Bottazzi, Evis Sala, Luca Boldrini Source Type: research

A Randomised Phase II Trial to Evaluate the Feasibility of Radiotherapy Dose Escalation, Facilitated by Intensity Modulated Arc Radiotherapy Techniques, in High-Risk Neuroblastoma
AND PURPOSE: For high-risk neuroblastoma, planning target volume coverage is often compromised to respect adjacent kidney tolerance. This trial investigated whether intensity modulated arc radiotherapy techniques (IMAT) could facilitate dose escalation better than conventional techniques. (Source: Clinical Oncology)
Source: Clinical Oncology - March 15, 2024 Category: Radiology Authors: Jennifer E. Gains, Amit Patel, Yen-Ch ’ing Chang, Henry C. Mandeville, Gregory Smyth, Christopher Stacey, James Talbot, Keith Wheatley, Mark N. Gaze Tags: Original Article Source Type: research

How long does contouring really take? Results of the Royal College of Radiologists contouring surveys
The success and safety of modern radiotherapy relies on accurate contouring. Understanding the time taken to complete radiotherapy contours is critical to informing workforce planning and, in the context of a workforce shortfall, advocating for investment in technology and multi-professional skills mix. We aimed to quantify the time taken to delineate target volumes for radical radiotherapy. (Source: Clinical Oncology)
Source: Clinical Oncology - March 15, 2024 Category: Radiology Authors: Emily Montague, Tom Roques, Katie Spencer, Alexander Burnett, Joanna Lourenco, Nicky Thorp Tags: Original Article Source Type: research

North-South Divide: Chemo-Immunotherapy Combination in Head and Neck Squamous Cell Cancer (HNSCC)
(Source: Clinical Oncology)
Source: Clinical Oncology - March 15, 2024 Category: Radiology Authors: Ian S. Boon, Cheng S. Boon, Kenneth Oguejiofor, Shanmugasundaram Ramkumar Tags: Letter Source Type: research

Shared Decision Making in Oncology Care: Translating to clinical practice
(Source: Clinical Oncology)
Source: Clinical Oncology - March 15, 2024 Category: Radiology Authors: Chloe Holden, Alison Keen, Am élie Harle, Ian S. Boon Tags: Letter Source Type: research

Federated learning survival model and potential radiotherapy decision support impact assessment for non-small cell lung cancer using real-world data
The objective of this study was to develop a two-year overall survival model for inoperable stage I-III non-small cell lung cancer (NSCLC) patients using routine radiation oncology data over a federated (distributed) learning network and evaluate the potential of decision support for curative versus palliative radiotherapy. (Source: Clinical Oncology)
Source: Clinical Oncology - March 14, 2024 Category: Radiology Authors: Matthew Field, Shalini Vinod, Geoff P. Delaney, Noel Aherne, Michael Bailey, Martin Carolan, Andre Dekker, Stuart Greenham, Eric Hau, Joerg Lehmann, Joanna Ludbrook, Andrew Miller, Angela Rezo, Jothybasu Selvaraj, Jonathan Sykes, David Thwaites, Lois Holl Tags: Original Article Source Type: research

High-dose-rate brachytherapy monotherapy in patients with localized prostate cancer: Dose modelling and optimization using computer algorithms
The objectives of the study was to optimize the therapy regime variables using two models: Response surface methodology (RSM) and Artificial Neural Network (ANN). (Source: Clinical Oncology)
Source: Clinical Oncology - March 14, 2024 Category: Radiology Authors: Kata Dabic-Stankovic, Katarina Rajkovic, Jovan Stankovic, Goran Marosevic, Goran Kolarevic, Bojan Pavicar Tags: Original Article Source Type: research

Component patterns and survival outcomes in patients with mixed malignant ovarian germ cell tumors: a retrospective cohort study
To evaluate the component patterns and risk stratification in patients with mixed malignant ovarian germ cell tumors (mMOGCT). (Source: Clinical Oncology)
Source: Clinical Oncology - March 14, 2024 Category: Radiology Authors: Sijian Li, Rundong Zhang, Xinyue Zhang, Tianyu Zhang, Dongyan Cao, Yang Xiang, Jiaxin Yang Tags: Original Article Source Type: research

National survey of current follow-up protocols for patients treated for endometrial cancer in the UK
The aim of this study was to establish a baseline of national practice for follow up after treatment for endometrial cancer in the UK. (Source: Clinical Oncology)
Source: Clinical Oncology - March 12, 2024 Category: Radiology Authors: Hersha Patel, Karl Drinkwater, Alexandra Stewart Source Type: research

Volumetric response and survival of patients with bulky idh-mutated grade 3 glioma managed with fet-fdg guided integrated boost imrt.
This study audits volumetric response, survival and functional outcomes in this ‘large volume’ subgroup who undergo intensity modulated radiation therapy (IMRT). (Source: Clinical Oncology)
Source: Clinical Oncology - March 12, 2024 Category: Radiology Authors: D. Mills, P. Horsley, V. Venkatasha, M. Back Tags: Original Article Source Type: research