Tumor cells inhibit the activation of ILC2s through up-regulating PD-1 expression
Immunopharmacol Immunotoxicol. 2024 Apr 28:1-10. doi: 10.1080/08923973.2024.2347315. Online ahead of print.ABSTRACTUp-regulating programmed cell death ligand-1(PD-L1) expressed on tumor cells and tumor-infiltrating myeloid cells interacting with up-regulated programmed cell death-1 (PD-1) expressed on tumor-infiltrating lymphoid cells greatly hinder their tumor-inhibiting effect. It is necessary to explore the deep mechanism of this negative effect, so as to find the potential methods to improve the immunotherapy efficiency. Here, we found that the PD-1 expression in lung cancer-infiltrating type II innate lymphoid cells (...
Source: Immunopharmacology and Immunotoxicology - April 28, 2024 Category: Allergy & Immunology Authors: Chaoyun Yin Yani Pa Guangyu Li Qiang Chen Xizu Wang Xijun He Huangao Zhou Source Type: research
Potential biomarkers for immune monitoring after renal transplantation
Transpl Immunol. 2024 Apr 26:102046. doi: 10.1016/j.trim.2024.102046. Online ahead of print.ABSTRACTRenal transplantation represents the foremost efficacious approach for ameliorating end-stage renal disease. Despite the current state of advanced renal transplantation techniques and the established postoperative immunosuppression strategy, a subset of patients continues to experience immune rejection during both the early and late postoperative phases, ultimately leading to graft loss. Consequently, the identification of immunobiomarkers capable of predicting the onset of immune rejection becomes imperative in order to fac...
Source: Transplant Immunology - April 28, 2024 Category: Transplant Surgery Authors: Xiaoyu Xu Yi Chen Luyue Kong Xianduo Li Dongdong Chen Zhe Yang Jianning Wang Source Type: research
Characterization of the prognostic, diagnostic, and immunological roles of DSCC1 and its genomic alteration and instability in human cancers
In this study, we obtained data on physiological conditions, transcriptional expression, survival prognosis, genomic alteration, genomic instability, enriched pathways, immune infiltration, and immunotherapy from The Cancer Genome Atlas, The Genotype-Tissue Expression, cBioPortal, and other publicly available databases to systematically characterize the oncogenic and immunological roles of DSCC1 in 33 different cancers. We found that DSCC1 expression was upregulated at both mRNA and protein levels in various cancers. Additionally, DSCC1 expression was associated with higher tumor stage and grade in specific cancers. DSCC1 ...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Hailong Liu Zhiwei Cui Rongli Wang Lijun Wang Lihui Wang Feiyan Cheng Rumeng Pan Xinyuan Yang Source Type: research
Predictive Value of Nasal Nitric Oxide for Diagnosing Eosinophilic Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
CONCLUSION: Nasal NO has the potential as a noninvasive diagnostic measure and endotype tool for ECRS.PMID:38679754 | DOI:10.1177/19458924241251387 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 28, 2024 Category: ENT & OMF Authors: Do Hyun Kim Hyesoo Shin Gulnaz Stybayeva Se Hwan Hwang Source Type: research
Characterization of the prognostic, diagnostic, and immunological roles of DSCC1 and its genomic alteration and instability in human cancers
In this study, we obtained data on physiological conditions, transcriptional expression, survival prognosis, genomic alteration, genomic instability, enriched pathways, immune infiltration, and immunotherapy from The Cancer Genome Atlas, The Genotype-Tissue Expression, cBioPortal, and other publicly available databases to systematically characterize the oncogenic and immunological roles of DSCC1 in 33 different cancers. We found that DSCC1 expression was upregulated at both mRNA and protein levels in various cancers. Additionally, DSCC1 expression was associated with higher tumor stage and grade in specific cancers. DSCC1 ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Hailong Liu Zhiwei Cui Rongli Wang Lijun Wang Lihui Wang Feiyan Cheng Rumeng Pan Xinyuan Yang Source Type: research
MAL, a potential immunotherapy target, is associated with poor prognosis in cancer patients
In conclusion, the pan-cancer study indicates that MAL with excellent prognostic value is a potential immunotherapy target in multiple cancers.PMID:38678596 | DOI:10.14715/cmb/2024.70.4.39 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Ruinian Zheng Biao Yao Yongkang Ye Ruijuan Luo Zhiming Wu Xiarong Hu Yinjiao Yuan Xuebing Pan Caixiang Liu Linxuan Huang Yongmei Luo Dan Yang NiYa Shang Yamin Tian Jun Jia Source Type: research
Recent advances in IgG4-related autoimmune pancreatitis
Pathol Res Pract. 2024 Apr 26;257:155331. doi: 10.1016/j.prp.2024.155331. Online ahead of print.ABSTRACTThe incidence of IgG4-related autoimmune pancreatitis (IgG4-AIP) is high in Asia and other countries, and unnecessary treatment is often undertaken due to both missed diagnosis and misdiagnosis in clinical practice. Although IgG4-AIP has attracted increasing attention, the details of IgG4-AIP pathogenesis and systemic immune response, including its relationship to tumor pathogenesis, are still unclear. In recent years, research on serum immunological detection, pathological features, clinical manifestations, diagnosis an...
Source: Pathology, Research and Practice - April 28, 2024 Category: Pathology Authors: Xisheng Yang Haikun Zhou Weidong Wang Chunyu Yan Gang Ji Source Type: research
Development of a topical treatment for tegumentary leishmaniasis using 8-hydroxyquinoline
Eur J Pharm Biopharm. 2024 Apr 26:114306. doi: 10.1016/j.ejpb.2024.114306. Online ahead of print.ABSTRACTIn the context of neglected diseases, tegumentary leishmaniasis (TL) presents an emerging and re-emerging character in the national territory and in the world. The treatment of TL has limitations, such as intravenous administration route, high toxicity, and high treatment costs. Thus, several researchers work on new therapeutic strategies to improve the effectiveness of the treatment of leishmaniasis. In this light, the present study used a topical formulation, containing 8-hydroquinoline (8-HQN), for the treatment of B...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 28, 2024 Category: Drugs & Pharmacology Authors: Naianda Rezende Ribeiro Lucas Magno Oliveira Santos Scarleth Silva Costa Carolina Kei Myasaki Daniela Pagliara Lage Vivian Tamietti Martins Rory Cristiane Fortes De Brito Larissa Chaves Freire Ana Maria Ravena Severino Carvalho Bryan Victor Serafim Brigid Source Type: research
Low-dose metformin suppresses hepatocellular carcinoma metastasis via the AMPK/JNK/IL-8 pathway
CONCLUSION: The results indicate that low-dose metformin can inhibit HCC metastasis by suppressing IL-8 expression. Targeting the AMPK/JNK/IL-8 axis may be a promising treatment strategy for patients with HCC metastasis.PMID:38679570 | DOI:10.1177/03946320241249445 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - April 28, 2024 Category: Allergy & Immunology Authors: Chengwen Zhao Lu Zheng Yuting Ma Yue Zhang Chanjuan Yue Feng Gu Guoping Niu Yongqiang Chen Source Type: research
Heat shock protein-related diagnostic signature and molecular subtypes in ankylosing spondylitis: new pathogenesis insights
Int J Hyperthermia. 2024;41(1):2336149. doi: 10.1080/02656736.2024.2336149. Epub 2024 Apr 28.ABSTRACTHeat shock proteins (HSP) have been associated with a range of persistent inflammatory disorders; however, little research has been conducted on the involvement of HSP in the development of ankylosing spondylitis (AS). The research aims to identify a diagnostic signature based on HSP-related genes and determine the molecular subtypes of AS. We gathered the transcriptional data of patients with AS from the GSE73754 dataset and conducted a literature search for HSP-related genes (HRGs). The logistic regression model was utili...
Source: International Journal of Hyperthermia - April 28, 2024 Category: Internal Medicine Authors: Geqiang Wang Yongji Li Jiaxing Liu Qian Zhang Weixin Cai Xiaodong Li Source Type: research
PD-BAT: A novel approach of pooling basophil donors for expansion of commercial laboratory testing of Chronic Spontaneous Urticaria
In this study, we introduce an innovative approach where multiple potential basophil donors undergo rigorous BAT characterization alongside control samples. By selecting and pooling donors with optimal performance, we significantly enhance the inter-assay reproducibility of the indirect BAT test.PMID:38679364 | DOI:10.1016/j.jim.2024.113679 (Source: Journal of Immunological Methods)
Source: Journal of Immunological Methods - April 28, 2024 Category: Allergy & Immunology Authors: Saintedym Wills Jessica Chavez Ajay Grover Nathanael Beck Michele Romano Christina Bauer Michael Gerspach Michael Schneider Andre Valcour Source Type: research
Collective good and individual choice: Perceptions on COVID-19 vaccine mandate among COVID-19 vaccinated individuals
CONCLUSION: Support for a COVID-19 vaccination mandate is controversial even among vaccinated people. Identifying and understanding cultural and contextual factors that underlie differences in attitudes and beliefs about COVID-19 vaccination mandates is essential to advance dialogue and inform educational health campaigns to increase COVID-19 vaccination rates.PMID:38679513 | DOI:10.1016/j.vaccine.2024.04.052 (Source: Vaccine)
Source: Vaccine - April 28, 2024 Category: Allergy & Immunology Authors: Kaivalya Gudooru Kimberly Nguyen Kathy Le Vyas Sarabu Meredith Hosek Anna Phan Michelle Garza Bertha E Flores Armida Flores Amelie Ramirez Luz M Garcini Source Type: research
Association between Covishield vaccine and menstrual disturbance. Findings from a cross-sectional study among participants of Zero TB cohort in India
CONCLUSION: Menstrual problems were reported by Covishield vaccinees, but they were minor and reversible within three months and do not constitute a ground for vaccine hesitancy. Studies designed to assess causal link taking care to avoid selection bias or confounding are needed.PMID:38679512 | DOI:10.1016/j.vaccine.2024.04.063 (Source: Vaccine)
Source: Vaccine - April 28, 2024 Category: Allergy & Immunology Authors: Kunchok Dorjee Tenzin Namdon Sonam Topgyal Ugen Gyatso Tenzin Tsundue Tashi Dolma Vipan Kumar Dekyi Lhadon Tenzin Yangkyi Tenzin Khachoe Sangyal Dorjee R C Sadoff David Peters Amita Gupta Zorba Paster Richard E Chaisson Dawa Phunkyi Tsetan D Sadutshang Source Type: research
Identification and functional analysis of the hub Ferroptosis-Related gene EZH2 in diabetic kidney disease
CONCLUSION: Overall, our data shouwed that histone H3K27 methyltransferase EZH2 could regulate the renal tubular epithelial cell ferroptosis by suppressing SLC7A11 in DKD, which may serve as a credible reliable indicator for diagnosing DKD and a potential target for treatment.PMID:38678670 | DOI:10.1016/j.intimp.2024.112138 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 28, 2024 Category: Allergy & Immunology Authors: Han Wang Jiajia Wang Qingsen Ran Yan Leng Tiejun Liu Zhuang Xiong Dixin Zou Weipeng Yang Source Type: research
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3
Int Immunopharmacol. 2024 Apr 26;133:112153. doi: 10.1016/j.intimp.2024.112153. Online ahead of print.ABSTRACTLPS induced sepsis is a complex process involving various immune cells and signaling molecules. Dysregulation of macrophage polarization and ROS production contributed to the pathogenesis of sepsis. PGP is a transmembrane transporter responsible for the efflux of a number of drugs and also expressed in murine macrophages. Natural products have been shown to decrease inflammation and expression of efflux transporters. However, no treatment is currently available to treat LPS induced sepsis. Verapamil and Tangeretin ...
Source: International Immunopharmacology - April 28, 2024 Category: Allergy & Immunology Authors: Ayantika Kundu Pratiti Ghosh Biswadev Bishayi Source Type: research
