Autologous platelet-rich plasma for assisted reproduction
CONCLUSIONS: We are uncertain about the effect of intrauterine or intraovarian administration of PRP on outcomes of assisted reproduction technology in infertile women. The pooled results should be interpreted with caution. Only one of the 12 included studies was judged at low risk of bias. Other limitations of the included trials were failure to report live birth, poor reporting of methods, lack of prospective protocol registration, low precision due to the small number of enrolled participants, indirectness due to the specific subpopulations and settings studied, and insufficient or absent safety data.PMID:38682756 | PMC...
Source: Cochrane Database of Systematic Reviews - April 29, 2024 Category: General Medicine Authors: Dennis Vaidakis Michail Papapanou Charalampos S Siristatidis Source Type: research
Antinuclear antibody titration and pattern are helpful in the diagnosis of systemic autoimmune rheumatic diseases
CONCLUSION: ANA-IIF titration of equal or more than 1:320 can be used as the best titration for differentiating between SARDs and non-SARDs in a positive ANA sample. Patients with homogeneous pattern were more likely to be diagnosed with SARDs than other ANA-IIF patterns.PMID:38682845 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - April 29, 2024 Category: Pathology Authors: M S Mohd Razi Y Sugumaran N A Mohd Haniz K Khilmie A H Osmera E J Jauhary A A Wahab Source Type: research
Treatment Options and the Management of Complications in Hydatid Cysts of the Liver in Endemic Regions
CONCLUSION: Surgical treatment should represent the standard procedure since it is safe and effective, ensures complete elimination of the parasite, involves no intraoperative shedding, preserves healthy tissues, and minimizes the risk of long-term recurrence and cavity-related complications.PMID:38684490 | DOI:10.62713/aic.3379 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Yildiray Daduk Ahmet Seker Alper Sozutek Tolga Olmez Kuntay Kaplan Huseyin Dur Gorkem Ozdemir Source Type: research
Probiotics: Shaping the gut immunological responses
World J Gastroenterol. 2024 Apr 21;30(15):2096-2108. doi: 10.3748/wjg.v30.i15.2096.ABSTRACTProbiotics are live microorganisms exerting beneficial effects on the host's health when administered in adequate amounts. Among the most popular and adequately studied probiotics are bacteria from the families Lactobacillaceae, Bifidobacteriaceae and yeasts. Most of them have been shown, both in vitro and in vivo studies of intestinal inflammation models, to provide favorable results by means of improving the gut microbiota composition, promoting the wound healing process and shaping the immunological responses. Chronic intestinal c...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Eirini Filidou Leonidas Kandilogiannakis Anne Shrewsbury George Kolios Katerina Kotzampassi Source Type: research
Ethnopharmacological uses of fauna among the people of central Punjab, Pakistan
This study focuses on investigating the utilization of animal-based traditional medicine by the people of Pakistan, specifically in the Gujranwala area.METHODS: Data collection took place from January to September 2019 through interviews with local communities. Ethnomedicinal applications of animal products were analyzed using several indices, including Relative Frequency of Citation (RFC), Relative Popularity Level (RPL), Folk Use Value (FL), and Relative Occurrence Percentage (ROP).RESULTS: The study identified the use of different body parts of 54 species of animals in treating various diseases and health issues. These ...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Abdul Majid Khan Muhammad Altaf Tanveer Hussain M Haroon Hamed Umaira Safdar Amina Ayub Zaibun-Nisa Memon Adnan Hafiz Sana Ashraf Muhammad Shoaib Amjad Muhammad Majeed Musheerul Hassan Rainer W Bussmann Arshad Mahmood Abbasi Mohamed Al-Yafrsi Hosam O Elan Source Type: research
Polyclonally Derived Alloantigen-Specific T Regulatory Cells Exhibit Target-Specific Suppression and Capture MHC Class II from Dendritic Cells
J Immunol. 2024 Apr 29:ji2300780. doi: 10.4049/jimmunol.2300780. Online ahead of print.ABSTRACTFoxp3+ T regulatory (Treg) cells prevent allograft rejection and graft-versus-host disease. Although polyclonal Tregs have been used both in animal models and in humans, the fine specificity of their suppressive function is poorly defined. We have generated mouse recipient-derived alloantigen-specific Tregs in vitro and explored the fine specificity of their suppressive function and their mechanism of action in vitro and in vivo. In vitro, when alloantigen and peptide Ag were both presented on the same dendritic cell, both respon...
Source: Journal of Immunology - April 29, 2024 Category: Allergy & Immunology Authors: Yoshihiro Oya Yasuyo Tanaka Takuya Nakazawa Ryutaro Matsumura Deborah D Glass Hiroshi Nakajima Ethan M Shevach Source Type: research
A Significant Contribution of the Classical Pathway of Complement in SARS-CoV-2 Neutralization of Convalescent and Vaccinee Sera
In this study, we report that the SARS-CoV-2 neutralization titers of human convalescent sera were relatively consistent across all disease states except for severe COVID-19, which yielded significantly higher neutralization titers. Furthermore, we show that heat inactivation of human serum significantly lowered neutralization activity in a live virus SARS-CoV-2 neutralization assay. Heat inactivation of human convalescent serum was shown to inactivate complement proteins, and the contribution of complement in SARS-CoV-2 neutralization was often >50% of the neutralizing activity of human sera without heat inactivation a...
Source: Journal of Immunology - April 29, 2024 Category: Allergy & Immunology Authors: Patrick Budylowski Serena L L Chau Arinjay Banerjee Furkan Guvenc Reuben Samson Queenie Hu Lindsey Fiddes Laurie Seifried Gary Chao Megan Buchholz Antonio Estacio Patti Lou Cheatley Katerina Pavenski Christopher J Patriquin Yanling Liu Salma Sheikh-Mohame Source Type: research
BHLHE40 Regulates Myeloid Cell Polarization through IL-10-Dependent and -Independent Mechanisms
In this study, we report that BHLHE40 is required in myeloid cells exposed to GM-CSF, an abundant cytokine in the lung, to promote the expression of genes associated with a proinflammatory state and better control of M. tuberculosis infection. Loss of Bhlhe40 expression in murine bone marrow-derived myeloid cells cultured in the presence of GM-CSF results in lower levels of proinflammatory associated signaling molecules IL-1β, IL-6, IL-12, TNF-α, inducible NO synthase, IL-2, KC, and RANTES, as well as higher levels of the anti-inflammatory-associated molecules MCP-1 and IL-10 following exposure to heat-killed M. tubercul...
Source: Journal of Immunology - April 29, 2024 Category: Allergy & Immunology Authors: Skyler V Hendrix Yassin Mreyoud Michael E McNehlan Asya Smirnov Sthefany M Chavez Brian Hie Megan M Chamberland Tara R Bradstreet Ashlee M Webber Darren Kreamalmeyer Reshma Taneja Bryan D Bryson Brian T Edelson Christina L Stallings Source Type: research
Molecular mimic between cardiovascular diseases and microorganism antigens
CONCLUSION: Human actin and HSPs share a high degree of conservation with epitopes from various microorganisms, such as bacteria, fungi and protozoa, suggesting molecular mimicry and cross-reactivity as a mechanism for the development of atherosclerosis, heart disease rheumatic disease, myocarditis and Chagas heart disease. In vitro and in vivo work is needed to demonstrate the results obtained in the In Silico analysis.PMID:38683079 | DOI:10.29262/ram.v71i1.1379 (Source: Atherosclerosis)
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Andr és Sánchez-Caraballo Valentina Garc ía-Solano Sonia Karina Gonz ález-Rangel Valeria Grattz-Lamadrid Marlon Munera-Gomez Source Type: research
Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions
Biomark Res. 2024 Apr 29;12(1):45. doi: 10.1186/s40364-024-00593-x.ABSTRACTCell death is an important part of the life cycle, serving as a foundation for both the orderly development and the maintenance of physiological equilibrium within organisms. This process is fundamental, as it eliminates senescent, impaired, or aberrant cells while also promoting tissue regeneration and immunological responses. A novel paradigm of programmed cell death, known as disulfidptosis, has recently emerged in the scientific circle. Disulfidptosis is defined as the accumulation of cystine by cancer cells with high expression of the solute ca...
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Jinyu Chen Boyuan Ma Yubiao Yang Bitao Wang Jian Hao Xianhu Zhou Source Type: research
A comparison of healthcare utilization and outcomes following skin vs. serum-specific IgE allergy testing
Conclusions: Allergy testing, regardless of the testing method used, is associated with decreases in ED and UR visits at 1-year follow-up. sIgE allergy testing is associated with lower testing cost and fewer allergist/immunologist visits, compared to skin testing.PMID:38682798 | DOI:10.1080/13696998.2024.2349471 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 29, 2024 Category: Health Management Authors: Yang Z Lu Kenny Yat-Choi Kwong Source Type: research
Tissue-specific features of innate lymphoid cells in antiviral defense
Cell Mol Immunol. 2024 Apr 29. doi: 10.1038/s41423-024-01161-x. Online ahead of print.ABSTRACTInnate lymphocytes (ILCs) rapidly respond to and protect against invading pathogens and cancer. ILCs include natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells and include type I, type II, and type III immune cells. While NK cells have been well recognized for their role in antiviral immunity, other ILC subtypes are emerging as players in antiviral defense. Each ILC subset has specialized functions that uniquely impact the antiviral immunity and health of the host depending on the tissue microe...
Source: Cellular and Molecular Immunology - April 29, 2024 Category: Molecular Biology Authors: Sytse J Piersma Source Type: research
Effect of dietary supplementation of plantain herb, lemongrass and their combination on milk yield, immunity, liver enzymes, serum, and milk mineral status in dairy cows
CONCLUSIONS: Both plantain and lemongrass improved dairy cows' DM consumption and milk yield. Plantain and/or lemongrass enhanced the immune system and liver health, but not serum and milk calcium and phosphorus level. Lemongrass and a combination of plantain and lemongrass increased the serum and milk zinc concentrations.PMID:38680813 | PMC:PMC11055577 | DOI:10.5455/javar.2024.k764 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Md Aliar Rahman Md Rahat Ahmad Redoy Rakhi Chowdhury Mohammad Al-Mamun Source Type: research
Potent Immunomodulators Developed from an Unstable Bacterial Metabolite of Vitamin B2 Biosynthesis
We report their water stability, capacity to bind MR1 and traffic it to the cell surface (EC50 17 nM), potent activation (EC50 56 pM) or inhibition (IC50 80 nM) of interacting MAIT cells, and develop compounds with diazirine-alkyne, biotin, or fluorophore labels for studying cellular MR1. Computer modelling casts new light on the molecular mechanism of activation, revealing that activators are first captured in MR1 via pi-interactions and H-bonds, before tighter covalent bonding to Lys43 in MR1. This chemical study advances our molecular understanding of how bacterial metabolites are captured by MR1, influence cell surface...
Source: Angewandte Chemie - April 29, 2024 Category: Chemistry Authors: Jeffrey Y W Mak Ryan J D Rivero Huy N Hoang Xin Yi Lim Jieru Deng Hamish E G McWilliam Jose A Villadangos James McCluskey Alexandra J Corbett David P Fairlie Source Type: research
The two faces of antibiotics: an overview of the effects of antibiotic residues in foodstuffs
Arch Toxicol. 2024 Apr 30. doi: 10.1007/s00204-024-03760-z. Online ahead of print.ABSTRACTAntibiotics, which have been used for many years to treat infections, also play an important role in food contamination with antibiotic residues. There is also unnecessary use of antibiotics, particularly to increase production efficiency. Non-compliance with withdrawal periods and maximum residue limits (MRLs) for antibiotics used in food-producing animals results in undesirable events, such as allergic reactions, teratogenicity, carcinogenicity, changes in the microbiota and, in particular, antibiotic resistance. Therefore, it may b...
Source: Archives of Toxicology - April 29, 2024 Category: Toxicology Authors: Merve G üdül Bacanlı Source Type: research
