Association between ascites Gustave Roussy immune score and the intratumoural microbiome in malignant ascites secondary to hepatocellular carcinoma
CONCLUSIONS: Our present study identified a novel scoring system (aGRIm score) that can predict the survival outcome of patients with malignant ascites secondary to HCC.PMID:38677092 | DOI:10.1016/j.intimp.2024.112097 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 27, 2024 Category: Allergy & Immunology Authors: None ShanTian Yingyun Guo Qingzhi Lan Jiao Li Jiaming Hu Meiqi Qiu Chunxia Guo Weiguo Dong Source Type: research
FLip mutations (L455F + F456L) in newly emerging VOI, JN.1: Its antibody and immune escape
Int Immunopharmacol. 2024 Apr 26;133:112146. doi: 10.1016/j.intimp.2024.112146. Online ahead of print.ABSTRACTDuring the COVID-19 pandemic, one of the biggest challenges was the continuous evolution of SARS-CoV-2 through various mutations. This has resulted in the emergence of several variants and subvariants. The escape mutations are reported as significant mutations in several variants and subvariants responsible for immune, antibody, and nAb escape. It has been reported that FLip mutations (L455F and F456L) in the spike RBD are responsible for immune evasion and antibody escape. Recently, WHO has included a new SARS-CoV...
Source: International Immunopharmacology - April 27, 2024 Category: Allergy & Immunology Authors: Chiranjib Chakraborty Manojit Bhattacharya Source Type: research
An extensive overview of the role of lncRNAs generated from immune cells in the etiology of cancer
Int Immunopharmacol. 2024 Apr 26;133:112063. doi: 10.1016/j.intimp.2024.112063. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) are involved in the control of critical tumor-suppressor and oncogenic pathways in cancer. These types of non-coding RNAs could affect both immune and cancer cells. The thorough analysis of lncRNAs derived from immune cells and the incorporation of new findings significantly advance our understanding of the complex role of lncRNAs in the context of cancer. This work highlights the promise of lncRNAs for translational therapeutic approaches while also establishing a solid foundation fo...
Source: International Immunopharmacology - April 27, 2024 Category: Allergy & Immunology Authors: Hong Luo Hailiang Jing Wei Chen Source Type: research
Immune Checkpoint molecules in solid organ transplantation: a promising way to prevent rejection
Immunol Lett. 2024 Apr 25:106860. doi: 10.1016/j.imlet.2024.106860. Online ahead of print.ABSTRACTImmune checkpoint (IC) molecules modulate immune responses upon antigen presentation; the interaction between different IC molecules will result in the stimulation or, rather, the thwarting of such responses. Tumor cells express increased amounts of inhibitory IC molecules in an attempt to evade immune responses; therapeutic agents have been developed that bind inhibitory IC molecules, restoring tumor-directed immune responses and changing the prognosis of a number of cancers. Stimulation of inhibitory IC molecules could be be...
Source: Immunology Letters - April 27, 2024 Category: Allergy & Immunology Authors: Ilaria Righi Daria Trabattoni Lorenzo Rosso Valentina Vaira Mario Clerici Source Type: research
Induction of Trained Immunity using β-glucan and its protective responses in Nile tilapia, Oreochromis niloticus
Dev Comp Immunol. 2024 Apr 25:105188. doi: 10.1016/j.dci.2024.105188. Online ahead of print.ABSTRACTEmerging and re-emerging diseases in fish cause drastic economic losses in the aquaculture sector. To combat the impact of disease outbreaks and prevent the emergence of infections in culture systems, understanding the advanced strategies for protecting fish against infections is inevitable in fish health research. Therefore, the present study aimed to evaluate the induction of trained immunity and its protective efficacy against Streptococcus agalactiae in tilapia. For this, Nile tilapia and the primary head kidney macropha...
Source: Developmental and Comparative Immunology - April 27, 2024 Category: Allergy & Immunology Authors: David Waikhom Jeena Kezhedath Sooraj Nediyirippil Suresh Megha Kadam Bedekar Tincy Varghese Pani Prasad Kurcheti Rajendran Kooloth Valappil Source Type: research
IUIS 2023: yEFIS workshop on career development and code-switching
Eur J Immunol. 2024 Apr 27:e2451155. doi: 10.1002/eji.202451155. Online ahead of print.NO ABSTRACTPMID:38676471 | DOI:10.1002/eji.202451155 (Source: European Journal of Immunology)
Source: European Journal of Immunology - April 27, 2024 Category: Allergy & Immunology Authors: Rosalie W M Kempkes Christos Nikolaou Myriam Nabhan Nathaniel Edward Bennett Saidu Source Type: research
Cow's milk oral immunotherapy has differentially better long-term adherence than peanut or sesame
Ann Allergy Asthma Immunol. 2024 Apr 25:S1081-1206(24)00241-2. doi: 10.1016/j.anai.2024.04.021. Online ahead of print.NO ABSTRACTPMID:38677475 | DOI:10.1016/j.anai.2024.04.021 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 27, 2024 Category: Allergy & Immunology Authors: Meital Almog Nadira Musallam Roni Wagner Larisa Epov Lisa Kaly Vika Dor Aharon Kessel Source Type: research
IgE deficiency is not associated with hypogammaglobulinemia in a large cohort of military recruits
Ann Allergy Asthma Immunol. 2024 Apr 25:S1081-1206(24)00277-1. doi: 10.1016/j.anai.2024.04.025. Online ahead of print.NO ABSTRACTPMID:38677476 | DOI:10.1016/j.anai.2024.04.025 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 27, 2024 Category: Allergy & Immunology Authors: Thomas Makin Larry Borish Cade M Nylund Jeffrey M Wilson Monica G Lawrence Source Type: research
How could our genetics impact COVID-19 vaccine response?
Expert Rev Clin Immunol. 2024 Apr 27:1-13. doi: 10.1080/1744666X.2024.2346584. Online ahead of print.ABSTRACTINTRODUCTION: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has posed unprecedented global health challenges since its emergence in December 2019. The rapid availability of vaccines has been estimated to save millions of lives, but there is variation in how individuals respond to vaccines, influencing their effectiveness at an individual, and population level.AREAS COVERED: This review focuses on human genetic factors influencing the immune response and effectiveness of vaccines, highlighting the importance...
Source: Expert Review of Clinical Immunology - April 27, 2024 Category: Allergy & Immunology Authors: Keyi Zheng Amanda Y Chong Alexander J Mentzer Source Type: research
Hues of risk: investigating genotoxicity and environmental impacts of azo textile dyes
Environ Sci Pollut Res Int. 2024 Apr 27. doi: 10.1007/s11356-024-33444-1. Online ahead of print.ABSTRACTThe textile industry, with its extensive use of dyes and chemicals, stands out as a significant source of water pollution. Exposure to certain textile dyes, such as azo dyes and their breakdown products like aromatic amines, has been associated with health concerns like skin sensitization, allergic reactions, and even cancer in humans. Annually, the worldwide production of synthetic dyes approximates 7 × 107 tons, of which the textile industry accounts for over 10,000 tons. Inefficient dyeing procedures result in the di...
Source: Environmental Science and Pollution Research International - April 27, 2024 Category: Environmental Health Authors: Karthikeyan Ramamurthy Peter Snega Priya Raghul Murugan Jesu Arockiaraj Source Type: research
Cracking the Code: Investigating the Correlation between Aerobic Vaginitis and Preterm Labor
Medicina (Kaunas). 2024 Apr 18;60(4):648. doi: 10.3390/medicina60040648.ABSTRACTAerobic vaginitis (AV) is a distinct clinical entity characterized by inflammation and abnormal vaginal microflora. Often mistaken for bacterial vaginosis, AV remains relatively unknown and underdiagnosed. AV's understanding is evolving, with some experts suggesting it may primarily be an immunological disorder, the prevalence of which has a range of 7-13% in non-pregnant women and 4.1-8.3% during pregnancy. Pregnancy can affect susceptibility to vaginal infections, leading to adverse outcomes for the woman and the newborn. This review summariz...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Panagiota Zarmakoupi Alexandros Psarris Christina Karasmani Panagiotis Antsaklis Marianna Theodora Michael Syndos Andreas Pampanos Kalliopi I Pappa Ekaterini Domali Nikolaos Thomakos Karolina Akinosoglou Aristotelis Tsiakalos George Daskalakis Source Type: research
Evaluation of Toll-Like Receptor Gene Expressions in Encephalitozoon intestinalis Infection
In conclusion, this study is the f irst report in which the changes in ten different TLR gene expressions were evaluated at different times in MDCK cells stimulated with E.intestinalis and the change in TLR3 gene expression.PMID:38676584 | DOI:10.5578/mb.202498201 (Source: Mikrobiyoloji Bulteni)
Source: Mikrobiyoloji Bulteni - April 27, 2024 Category: Microbiology Authors: Erdi Uzun Ülfet Çetinkaya Source Type: research
Mother's smoking habits affects IL10 methylation but not asthma in Ecuadorian children
ConclusionSmoking habit could be essential as an environmental exposure factor in regulating gene expression in children with asthma. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - April 27, 2024 Category: Genetics & Stem Cells Authors: Cristina Ochoa ‐Avilés,
Angélica Ochoa‐Avilés,
Roque Rivas‐Párraga,
Samuel Escandón,
Talita Dos Santos‐Jesus,
Milca de J. Silva,
Valderiene Leão,
Marco Salinas,
Yosselin Vicuña,
Lucy Baldeón,
María José Molina‐Cando,
Diana M Tags: ORIGINAL ARTICLE Source Type: research
Clinical characteristics, laboratory findings, and tolerance acquisition in infants with cow's milk protein allergy in a private center in Lima, Peru for the period 2021 –2022
ConclusionOur findings provide a foundational framework for future investigations into CMPA diagnosis, tolerance acquisition, and the utilization of hypoallergenic formulas tailored to the unique characteristics of our region. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 27, 2024 Category: Allergy & Immunology Authors: C ésar Galván Calle,
Cecilia Díaz‐Vásquez,
Wilmer Córdova‐Calderón,
Juan Gómez de la Torre,
Edgar Matos‐Benavides,
Crhistian Toribio‐Dionicio Tags: ORIGINAL ARTICLE Source Type: research
Inflammatory Protein Signatures as Predictive Disease-Specific Markers for Non-Alcoholic Steatohepatitis (NASH)
AbstractNon-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic disease worldwide, consisting of a broad spectrum of diseases such as simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatic inflammation plays a key role in the pathophysiology of NAFLD. Inflammatory mediators such as cytokines and chemokines are considered as contributing factors to NAFLD development and progression. In the present study, we aimed to investigate the inflammatory protein signatures as predictive disease-specific markers for non-alcoholic fatty liver disease (NA...
Source: Inflammation - April 27, 2024 Category: Allergy & Immunology Source Type: research
