Validated Anxiety Assessments Among Pediatric Peanut-Allergic Patients on Oral Immunotherapy
: While efficacy, safety, and quality of life measures associated with peanut oral immunotherapy (OIT) have been studied, the relationship between peanut OIT and clinical anxiety has not yet been assessed. The latter is important to help providers and families have an improved shared medical decision discussion around the benefits of initiating OIT. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 2, 2023 Category: Allergy & Immunology Authors: Kelsey Kaman, Meera Dhodapkar, Veronika Shabanova, Sarah McCollum, Jeffrey Factor, Stephanie Leeds Source Type: research

Evaluation of Salivary Alpha-Amylase as a Potential Biomarker of Inhaled Beta-2 Agonist Response
In individuals with asthma, chronic use of short (SABAs) and long-acting beta-2 agonists (LABAs) can lead to loss of bronchoprotection (LOBP) from direct and indirect stimuli.1-3 It is hypothesized that LOBP is the result of beta-2 receptor down-regulation, reduced production or internalization of receptors, and uncoupling from secondary messengers leading to desensitization of beta-2 receptors.4 Assessment of beta-2 receptor activation is a laborious process.5 Therefore, a biomarker that serves as an indirect method of measuring beta-2 receptor activation would facilitate clinical studies on beta-2 agonist-induced LOBP an...
Source: Annals of Allergy, Asthma and Immunology - February 2, 2023 Category: Allergy & Immunology Authors: Andrea A. Pappalardo, Jun Fu, James N. Moy Tags: Letters Source Type: research

Delabeling Penicillin Allergy in a Pediatric Primary Care Clinic
Reported adverse drug reactions to penicillins are common, affecting between 10-20% of the North American population; however, more than 90% of patients with a penicillin allergy label can safely tolerate penicillins 1, 2. Numerous adverse outcomes are associated with labeled penicillin allergy 1, 2. In light of this, appropriate diagnosis and verification of a penicillin allergy label is crucial to achieving optimal health outcomes and has been recommended by the Centers for Disease Control and Prevention, the American College of Allergy, Asthma, and Immunology, and the American Academy of Allergy, Asthma, and Immunology ...
Source: Annals of Allergy, Asthma and Immunology - February 2, 2023 Category: Allergy & Immunology Authors: Timothy G Chow, Gaytri Patel, Mariya Mohammed, Dawn Johnson, David A. Khan Tags: Letters Source Type: research

Real-world experience of pediatric patients treated with Peanut (Arachis hypogaea) Allergen Powder-dnfp
: Peanut (Arachis hypogaea) Allergen Powder-dnfp (PTAH) is the first oral immunotherapy indicated for children aged 4-17 years with peanut allergy. There are limited real-world data on patients treated with PTAH. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Jay Portnoy, Jodi Shroba, Stephen Tilles, Hela Romdhani, Sarah M Donelson, Dominick Latremouille-Viau, Rebecca Bungay, Kathleen Chen, William McCann Tags: Original Article Source Type: research

Jak out of the box –targeting BTK, siglec-8, & Jak1 in food allergy
There has been rapid growth in the field of IgE-mediated food allergy therapeutics, with one FDA-approved therapy in 2020 and several others in various stages of investigation. Oral immunotherapy is the approach with the longest track record of study, and provides desensitization for most individuals undertaking therapy. However, therapy must be maintained for continued clinical protection, and side effects of therapy are frequent. There is a need to improve allergen immunotherapy safety and durability, and to provide a treatment that can target multiple food allergies. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Cecilia Berin Tags: Review Source Type: research

Antibody and T-cell responses to COVID-19 Vaccination in Common Variable Immunodeficiency and Specific Antibody Deficiency
Clinical trials of the mRNA COVID-19 vaccines excluded individuals with primary antibody deficiencies. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Jamie A. Rosenthal, Michelle Premazzi Papa, Marta Sanz, Samuel Nicholes, Carissa Stower, Alberto Bosque, Anjeni Keswani, Richard Amdur, Rebecca M. Lynch, Natalia Soriano-Sarabia, Daniel Ein Tags: Original Article Source Type: research

Yardstick for Managing Cough. Part 2: in Children
Nationwide statistics in the United States and Australia reveal that cough of undifferentiated duration is the most common complaint for which patients of all ages seek medical care in the ambulatory setting. Management of chronic cough is one of the most common reasons for new patient visits to respiratory specialists. Because symptomatic cough is such a common problem and so much has been learned about how to diagnose and treat cough of all durations but especially chronic cough, this 2-part yardstick has been written to review in a practical way the evidence-based guidelines most of which have been developed from high q...
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Anne B. Chang, John J. Oppenheimer, Whitney Dunlap, Jay Lieberman, Richard S. Irwin Tags: Special Series Source Type: research

Further evidence of a type 2 inflammatory signature in chronic obstructive pulmonary disease or emphysema
There is increasing recognition of a type 2 (T2) inflammatory pattern in a subset of patients with COPD and/or emphysema, characterized by blood and airway eosinophilia. The mechanism underlying this is not well established. The recognition that CD125 (IL-5Ra) is expressed on some lung neutrophils as well as eosinophils in patients with asthma led us to speculate that CD125 may also be expressed on lung neutrophils in patients with COPD/emphysema. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Larry Borish, W. Gerald Teague, James T. Patrie, Kristin W. Wavell, Andrew J. Barros, H. Charles Malpass, Monica G. Lawrence Source Type: research

Gell & Coombs: Episode IVb
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Source Type: research

Drug allergy biomarkers
Although the true burden of drug allergy is unknown, several studies indicate that adverse drug reactions occur in up to 6% to 10% of hospitalized patients —20% of which are because of drug allergy—and up to 10% of the general population claims to have penicillin or other drug allergies.1 A plethora of new antibiotics, vaccines, chemotherapy drugs, and, more recently, biologicals and targeted molecular drugs are available and have improved disease treatment options, but drug allergy remains a vexing and unaddressed problem that deprives patients of the best medication for their disease, and when re-exposed, places them...
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Mariana Castells Tags: Editorial Source Type: research

Lupin allergy
Food allergies are on the rise. Common food allergens are well-recognized and have been studied extensively worldwide.1 However, there is a gradual emergence of new food allergens that are not well characterized or studied. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Hana B. Ruran, Lisa M. Bartnikas Tags: Editorial Source Type: research

Cow's milk formula each day may keep milk allergy away
The landscape of food allergy prevention has seen tremendous change over the past few years, with multiple studies supporting early food introduction. The Learning Early About Peanut Allergy study1 focused on a high-risk population for peanut allergy development and found that early peanut introduction resulted in an 81% reduction in the prevalence of peanut allergy at age 5 years. The Enquiring About Tolerance study2 investigated the introduction of 6 allergenic foods (including cow's milk) in a general population of infants from age 3 months and reported a 20% reduction in food allergy to 1 or more foods. (Source: Annals...
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Aikaterini Anagnostou, Julia Upton, Anna Nowak-Wegrzyn Tags: Editorial Source Type: research

Does improved indoor air quality lead to better asthma control?
The use of environmental control as an intervention for respiratory conditions such as asthma is the underlying tenant of the allergy profession. The allergy model goes like this: A patient with a respiratory condition is seen by an allergist who attempts to identify environmental triggers for the condition using a combination of history and allergy testing. Once the likely triggers are identified, the patient is instructed to reduce exposure to them to an extent that is feasible. The hope is that this approach, along with medical management, will lead to reduced symptoms and better disease control. (Source: Annals of Alle...
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Aarti Pandya, Jay Portnoy Tags: Editorial Source Type: research

Information for Readers
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2023 Category: Allergy & Immunology Source Type: research