SARS-CoV2 infection in those on Mepolizumab therapy
Coronavirus disease 2019 (COVID ‐19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 1, continues to cause morbidity and mortality across the world. Expert recommendation is to continue biologic therapy unchanged in severe eosinophilic asthma 2,3 but concern has been expressed as eosinopenia may be a risk factor for worse disease outcomes 4. Here we report the outcomes of four patients from centres in the UK, Italy and North America with COVID-19, whilst receiving treatment with mepolizumab, an anti IL-5 monoclonal antibody, which reduces eosinophils to within the normal range 5. (Source: Anna...
Source: Annals of Allergy, Asthma and Immunology - January 12, 2021 Category: Allergy & Immunology Authors: Adnan Azim, Laura Pini, Zeeshan Khakwani, Santosh Kumar, Peter Howarth Tags: Letters Source Type: research

Quality of Life in Patients with Hereditary Angioedema in Canada
Hereditary angioedema (HAE) is associated with decreased quality of life (QoL), which has typically been measured using a generic non-disease specific questionnaire. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 12, 2021 Category: Allergy & Immunology Authors: Erika Yue Lee, Jane Hsieh, Rozita Borici-Mazi, Teresa Caballero, Amin Kanani, Gina Lacuesta, Christine McCusker, Susan Waserman, Stephen Betschel Source Type: research

From the Pages of Allergy Watch
For this issue of From the Pages of Allergy Watch, I ’ve selected two articles related to COVID and asthma. The first reviewed by Dr Lee from the Nov-Dec Allergy Watch postulates that the ACE2 receptor may be protective in our allergic asthmatic patients and reduce the risk for hospitalization with COVID-19. The next article, reviewed by Dr Mahr, fr om the Sept-Oct Allergy Watch warns about stepping down controllers in pediatric asthma patients during the pandemic. The last article, reviewed by Dr Chipps, examines the role of eNO as a guide to ICS step-down decisions for our asthmatic patients. (Source: Annals of All...
Source: Annals of Allergy, Asthma and Immunology - January 12, 2021 Category: Allergy & Immunology Authors: Stanley M. Fineman, Gerald Lee, Todd Mahr, Bradley E. Chipps Tags: From the Pages of AllergyWatch Source Type: research

Cow ’s Milk Allergy Prevention
Scoping review on IgE-mediated cow ’s milk allergy prevention (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 12, 2021 Category: Allergy & Immunology Authors: Elissa M. Abrams, Scott H. Sicherer Tags: Review Source Type: research

The Evolution of FPIES: From a Diagnosis That Did Not Exist to a Condition in Need of Answers.
CONCLUSIONS: By partnering together, healthcare providers, advocacy organizations and families can continue to advance our understanding and improve care of patients and families living with FPIES. PMID: 33444729 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 11, 2021 Category: Allergy & Immunology Authors: Bartnikas LM, Nowak-Wegrzyn A, Schultz F, Phipatanakul W, Bingemann TA Tags: Ann Allergy Asthma Immunol Source Type: research

The Evolution of FPIES: From a Diagnosis That Did Not Exist to a Condition in Need of Answers
This article catalogs areas of progress and areas for further research. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 11, 2021 Category: Allergy & Immunology Authors: Lisa M. Bartnikas, Anna Nowak-Wegrzyn, Fallon Schultz, Wanda Phipatanakul, Theresa A. Bingemann Tags: Review Source Type: research

The Use of Microarray and Other Multiplex Technologies in the Diagnosis of Allergy
To give an overview and describe strengths/weaknesses of IgE microarray and other multiplex assays that have been developed and are being used for allergy diagnostics. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 11, 2021 Category: Allergy & Immunology Authors: Behnam Keshavarz, Thomas A.E. Platts-Mills, Jeffrey M. Wilson Tags: CME Reviews Source Type: research

Anaphylactic shock after first exposure to star fruit in a bird keeper
Averrhoa carambola – also known as star fruit – is a fruit native to the South Pacific and Southeast Asian countries that was introduced in the western countries in the early 1930s, and has now become a worldwide popular fruit that can be eaten raw in juices, pickles and salads. Star fruit (SF) is rich in vitamins and potassium, and is known for its antioxidant and antimicrobial properties1. Several studies have demonstrated the nephrotoxic and neurotoxic effects of some of its components, especially in those patients who suffer from kidney failure 2-5. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 11, 2021 Category: Allergy & Immunology Authors: Paula Vazquez-Revuelta, Blanca Andr és-López, Borja Bartolomé, Mercè Corominas, Ramon Lleonart Bellfill Tags: Letters Source Type: research

Diagnostic Testing for Galactose-alpha-1,3-galactose (Alpha-gal), United States, 2010-2018.
CONCLUSION: More than 34,000 persons, most presumably symptomatic, have tested positive for IgE antibodies to alpha-gal, suggesting AGS is an increasingly recognized public health problem. The geographic distribution of persons who tested positive is consistent with exposure to Amblyomma americanum ticks. PMID: 33422649 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 7, 2021 Category: Allergy & Immunology Authors: Binder AM, Commins S, Altrich ML, Wachs T, Biggerstaff BJ, Beard CB, Petersen LR, Kersh GJ, Armstrong PA Tags: Ann Allergy Asthma Immunol Source Type: research

Atopic Dermatitis in the Pediatric Population: A Cross-sectional, International, Epidemiologic Study.
Abstract BACKGROUND: Little is known about the current global prevalence of atopic dermatitis (AD) in the pediatric population. OBJECTIVE: To estimate the real-world global prevalence of AD in the pediatric population and by disease severity. METHODS: This international, cross-sectional, web-based survey of children/adolescents (6 months to
Source: Annals of Allergy, Asthma and Immunology - January 6, 2021 Category: Allergy & Immunology Authors: Silverberg JI, Barbarot S, Gadkari A, Simpson EL, Weidinger S, Mina-Osorio P, Rossi AB, Brignoli L, Saba G, Guillemin I, Fenton MC, Auziere S, Eckert L Tags: Ann Allergy Asthma Immunol Source Type: research

Diagnostic Testing for Galactose-alpha-1,3-galactose (Alpha-gal), United States, 2010 –2018
Alpha-gal syndrome (AGS) is an emerging immunoglobulin E (IgE)mediated allergy to galactose-alpha-1,3-galactose (alpha-gal). The geographic distribution and burden of AGS in the United States is unknown. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 6, 2021 Category: Allergy & Immunology Authors: Alison M. Binder, Scott Commins, Michelle L. Altrich, Tyler Wachs, Brad J. Biggerstaff, Charles B. Beard, Lyle R. Petersen, Gilbert J. Kersh, Paige A. Armstrong Source Type: research

Atopic Dermatitis in the Pediatric Population: A Cross-sectional, International, Epidemiologic Study
Little is known about the current global prevalence of atopic dermatitis (AD) in the pediatric population. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 6, 2021 Category: Allergy & Immunology Authors: Jonathan I. Silverberg, Sebastien Barbarot, Abhijit Gadkari, Eric L. Simpson, Stephan Weidinger, Paola Mina-Osorio, Ana B. Rossi, Lysel Brignoli, Grece Saba, Isabelle Guillemin, Miriam C. Fenton, Sebastien Auziere, Laurent Eckert Source Type: research

A randomized trial of subcutaneous allergy immunotherapy in inner-city asthmatic children < 4 years of age.
A randomized trial of subcutaneous allergy immunotherapy in inner-city asthmatic children
Source: Annals of Allergy, Asthma and Immunology - January 5, 2021 Category: Allergy & Immunology Authors: de Vos G, Viswanathan S, Pichardo Y, Nazari R, Jorge Y, Ren Z, Serebrisky D, Rosenstreich D, Wiznia A Tags: Ann Allergy Asthma Immunol Source Type: research

A randomized trial of subcutaneous allergy immunotherapy in inner-city asthmatic children < 4 years of age
Allergic sensitization to environmental allergens in the first years of life is a strong predictor of asthma morbidity in children. Allergy immunotherapy can improve asthma and allergy outcomes, but its efficacy in atopic, inner-city children (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 5, 2021 Category: Allergy & Immunology Authors: Gabriele de Vos, Shankar Viswanathan, Yikania Pichardo, Ramin Nazari, Yurydia Jorge, Zhen Ren, Denise Serebrisky, David Rosenstreich, Andrew Wiznia Source Type: research

Negative Penicillin Skin Testing Induced Anaphylaxis with Concurrent Beta Blocker and Angiotensin-converting Enzyme Inhibitor Use
We present the first case of anaphylaxis following negative skin prick and intradermal tests with penicillin and benzylpenicilloyl polylysine. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 30, 2020 Category: Allergy & Immunology Authors: Phuong Daniels, Maaz Jalil, Chelsea Michaud, Robert Hostoffer Tags: Letters Source Type: research

Real-world evidence: patient views on asthma in respiratory specialist clinics in America
Approximately 30 –50% of patients with moderate/severe asthma have inadequately controlled disease despite adherence to inhaled corticosteroid/long-acting β 2 agonist (ICS/LABA) therapy. Data on prevalence and burden of uncontrolled asthma in specialty settings is lacking. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 30, 2020 Category: Allergy & Immunology Authors: John Oppenheimer, David J. Slade, Beth A. Hahn, Laurie Zografos, Alicia Gilsenan, David Richardson, David McSorley, Robson Lima, Nestor A. Molfino, Carlyne M. Averell Source Type: research

Reported drug allergies among patients with opioid use disorder: Role for allergy evaluation and intervention
Patients with opioid use disorder (OUD) commonly experience infectious complications and challenges surrounding pain management, which contribute to high utilization of the healthcare system.1,2 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 30, 2020 Category: Allergy & Immunology Authors: Lily Li, Bianca Martin, Christin Price, Joji Suzuki, Tanya M. Laidlaw Tags: Letters Source Type: research

Monitoring Neutrophil to Lymphocyte Ratio in COVID-19 Patients Receiving Tocilizumab
The novel coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2, an enveloped non-segmented positive-sense RNA β-coronavirus. The virus can trigger a cascade of biological events that can lead to critical illness. It is urgent to gain an in-depth understanding of the critical activators that foreshadow patients highest risk for mortality.(1) Patients who have received tocilizumab for COVID-19 related cytoki ne storm have had improvements in c-reactive protein (CRP), lymphocytosis, and chest CT findings.(2) There exist a lack of understanding on which patients would benefit from Tocilizumab admin...
Source: Annals of Allergy, Asthma and Immunology - December 29, 2020 Category: Allergy & Immunology Authors: Nicholas L. Hartog, Alan T. Davis, Jeremy W. Prokop, Andrew Walls, Surender Rajasekaran Tags: Letters Source Type: research

Self versus partnered epinephrine autoinjector training, performance differences in an anaphylaxis simulation
Epinephrine, often delivered through an autoinjector, remains the mainstay of treatment for anaphylaxis.1 Delays in epinephrine autoinjector (EAI) administration by caregivers and patients are common.2,3 Access to medication, difficulty recognizing anaphylaxis, and insufficient training contribute to injection delays.3 Fear of harm is an additional factor, notably among parents of children with food allergies, even when they know it could be life-saving.3-5 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 22, 2020 Category: Allergy & Immunology Authors: Ann E. Kaminski, Zhuo Li, Nkechi O. Dike, Alexei Gonzalez-Estrada, Leslie V. Simon Source Type: research

Indoor environmental quality, allergens and surface bio-contamination in tribal homes and schools from Cherokee nation
The prevalence of asthma is relatively high among Native American children (>11% according to CDC), but there are limited studies assessing exposures to asthma triggers in both homes and schools. We assessed the level of surface biocontamination and allergens in tribal homes and schools, and factors that could explain differences. With these analyses, we seek further insights into ways for reducing asthma triggers and improving wellbeing among asthmatic tribal children. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 22, 2020 Category: Allergy & Immunology Authors: Shaughnessy R, Khan S, Haverinen-Shaughnessy U Tags: Letters Source Type: research

Outcomes of 3 Patients with Adenosine Deaminase Deficiency on Long-Term Enzyme Replacement Therapy (ERT)
Adenosine deaminase (ADA) deficiency is an autosomal recessive severe combined immunodeficiency that typically presents within the first year with severe infections. Other features of ADA deficiency include: autoimmunity, myeloid dysplasia, pulmonary disease, neurodevelopmental delay, skeletal dysplasia, hepatic dysfunction, and lymphoma.1 Hematopoietic stem cell transplant (HSCT) and gene therapy (GT) have been successful in the treatment of ADA deficiency.2,3 Enzyme replacement therapy (ERT) has traditionally been used as a bridge to HSCT or GT and not as first-line long-standing treatment. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 21, 2020 Category: Allergy & Immunology Authors: Melissa D. Gans, Larry Bernstein, Jenny Shliozberg, Tatyana Gavrilova, Arye Rubinstein Tags: Letters Source Type: research

Eosinophilic Esophagitis May Persist after Discontinuation of Oral Immunotherapy
Eosinophilic esophagitis (EoE) is a chronic, inflammatory condition perpetuated by allergen exposure.1 Oral immunotherapy (OIT) is an emerging therapy for IgE-mediated food allergy that desensitizes patients to prevent harm from accidental exposure to a trigger food; however, EoE is a potential complication.2 The rate of OIT-induced EoE has been estimated at ∼5%3; although a majority of cases remit after stopping OIT.2 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 16, 2020 Category: Allergy & Immunology Authors: Laura Hamant, Catherine Freeman, Shipra Garg, Benjamin L. Wright, Shauna Schroeder Tags: Letters Source Type: research

Health-related quality of life with tralokinumab in moderate-to-severe atopic dermatitisA phase 2b randomized study
Atopic dermatitis (AD) is a chronic, heterogeneous, inflammatory skin disease resulting from immune dysregulation and skin barrier disruption, leading to chronic inflammation that includes overexpression of type 2 cytokines such as interleukin-13 (IL-13).1-3 The symptoms of AD, including intense and debilitating itch, are associated with pain, sleep disruption, anxiety, and depression, which contribute to a significant burden on health-related quality of life (HRQoL).4-17 As a result, it is important to consider the effects of new treatments for AD on both the physical and mental well-being of patients to ensure they recei...
Source: Annals of Allergy, Asthma and Immunology - December 14, 2020 Category: Allergy & Immunology Authors: Jonathan I. Silverberg, Emma Guttman-Yassky, Melinda Gooderham, Margitta Worm, Stephanie Rippon, Sean O ’Quinn, René van der Merwe, Nana Kragh, Azra Kurbasic, Andreas Wollenberg Source Type: research

Physician Well-being in Allergy and Immunology: Creating a Culture of Wellness
There are 3 domains of physician wellness: the culture of wellness, efficiency of practice, and physician resilience. The culture of wellness encompasses an organization ’s values, environment, and behaviors that foster compassion and growth in its physicians. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 14, 2020 Category: Allergy & Immunology Authors: Theresa A. Bingemann, Susan Laubach Tags: CME Reviews Source Type: research

Advances in cutaneous allergy.
PMID: 33292968 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 11, 2020 Category: Allergy & Immunology Authors: Leung DYM Tags: Ann Allergy Asthma Immunol Source Type: research

Serum insulin-like growth factor-1, asthma, and lung function among British adults
Insulin-like growth factor-1 (IGF-1) plays a key role in the pathogenesis of metabolic syndrome (MS), which is in turn associated with asthma. Whether IGF-1 contributes to asthma causation or asthma severity is largely unknown. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 11, 2020 Category: Allergy & Immunology Authors: Yueh-Ying Han, Qi Yan, Wei Chen, Erick Forno, Juan C. Celed ón Source Type: research

Traditional Chinese Medicine for Food Allergy and Eczema
To summarize the recent evidence of traditional Chinese medicine (TCM) for food allergy and eczema. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 10, 2020 Category: Allergy & Immunology Authors: Zixi Wang, Zhen-Zhen Wang, Jan Geliebter, Raj Tiwari, Xiu-Min Li Tags: Review Source Type: research

Zoonotic coronavirus epidemics: SARS, MERS, and COVID-19
To review the virology, immunology, epidemiology, clinical manifestations, and treatment of the three major zoonotic coronavirus epidemics: severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 10, 2020 Category: Allergy & Immunology Authors: Monica Fung, Iris Otani, Michele Pham, Jennifer Babik Tags: CME Reviews Source Type: research

From the pages of AllergyWatch ®
For this month ’s edition of “From the Pages of AllergyWatch,” I have chosen reviews from interesting articles published in recent AllergyWatch issues. The first, reviewed by Dr Chipps, highlights a study revealing improved outcomes when treatable traits are targeted in adult individuals with asthma. The nex t study reviewed by Dr Lee reported the surprising findings that a quarter of patients with asthma were found to have concomitant laryngeal dysfunction. The final review by Dr Oppenheimer of 15 years of data on biologic use for asthma reported that only approximately 10% of clinicians wrote 30% of t h...
Source: Annals of Allergy, Asthma and Immunology - December 9, 2020 Category: Allergy & Immunology Authors: Stanley M. Fineman, Gerald B. Lee, Bradley E. Chipps, John Oppenheimer Tags: From the Pages of AllergyWatch ® Source Type: research

From the Pages of Allergy Watch
For this month ’s ‘From the pages of Allergy Watch’, I’ve chosen reviews from interesting articles published in recent Allergy Watch issues. The first, reviewed by Dr Chipps, highlights a study showing improved outcomes when treatable traits are targeted in adult asthmatics. The next study reviewed by Dr L ee found the surprising findings that a quarter of asthmatic patients were found to have concomitant laryngeal dysfunction. The final review by Dr Oppenheimer reported data from 15 years of biologic use for asthma that only about 10% of clinicians wrote 30% of the prescriptions. (Source: Annals of...
Source: Annals of Allergy, Asthma and Immunology - December 9, 2020 Category: Allergy & Immunology Authors: Stanley M. Fineman, Gerald Lee, Bradley E. Chipps, John J. Oppenheimer Tags: From the Pages of AllergyWatch Source Type: research

Reflecting on prediction strategies for epidemics
To provide an overview of the literature on respiratory infectious disease epidemic prediction, preparedness, and response (including pharmaceutical and nonpharmaceutical interventions) and their impact on public health, with a focus on respiratory conditions such as asthma. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 8, 2020 Category: Allergy & Immunology Authors: Melike Yildirim, Nicoleta Serban, Jennifer Shih, Pinar Keskinocak Tags: Review Source Type: research

Reflecting on Prediction Strategies for Epidemics: Preparedness and Public Health Response
Provide an overview of the literature on respiratory infectious disease epidemic prediction, preparedness, and response (including pharmaceutical and nonpharmaceutical interventions) and their impact on public health, with a focus on respiratory conditions such as asthma. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 8, 2020 Category: Allergy & Immunology Authors: Melike Yildirim, Nicoleta Serban, Jennifer Shih, Pinar Keskinocak Tags: Review Source Type: research

Enhancing Practice Efficiency: A Key Organizational Strategy to Improve Professional Fulfillment in Allergy and Immunology
To review evidence-based strategies which have been shown to improve professional fulfillment and reduce burnout by enhancing practice efficiency. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 8, 2020 Category: Allergy & Immunology Authors: Hemant P. Sharma Tags: Review Source Type: research

Advances in cutaneous allergy
Atopic dermatitis (AD) has now been well documented to be associated with an important impact on quality of life and is a major driver of not only systemic comorbidities including other allergic diseases (such as asthma and food allergy) but also cardiovascular and autoimmune diseases.1 Sleep disturbance and adverse effects on mental health are common in patients with AD. A major contributor for these events is the skin and resultant systemic immune activation associated with AD.2 Recent studies support the importance of skin barrier dysfunction in driving cutaneous allergy. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 6, 2020 Category: Allergy & Immunology Authors: Donald Y.M. Leung Tags: Editorial Source Type: research

Information for Readers
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 6, 2020 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 6, 2020 Category: Allergy & Immunology Source Type: research

Information for Authors
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 6, 2020 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 6, 2020 Category: Allergy & Immunology Source Type: research

2020 Reviewer Acknowledgment
The editors and staff of the Annals of Allergy, Asthma and Immunology would like to thank the flowing individuals who gave of their time to provide reviews of submitted manuscripts between July 1, 2019 and June 30, 2020. The high-quality manuscript reviews provided by these individuals is essentially to the peer review process so necessary for a journal like ours to provide scientifically sound as well as interesting and engaging articles for our readers. Thanks to each of you for your service. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 6, 2020 Category: Allergy & Immunology Source Type: research

Stiehm's Immune Deficiencies: Inborn Errors of Immunity
This book is a fittingly titled, well-written publication. As a lengthy read, Stiehm's utility proves more to be as a comprehensive and informative reference book and guide for clinicians and any other readers interested in immunodeficiency. Readers will be able to easily navigate this well-organized text that provides outstanding details pertaining to immunodeficiencies and their common presentations, diagnostic approaches, and laboratory evaluations for diseases and a focused discussion on immunodeficiency management. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 4, 2020 Category: Allergy & Immunology Authors: Jessica Beth Perkins Tags: Book Review Source Type: research

The spectrum of allergic ocular diseases-2020.
CONCLUSION: Ocular allergy is frequently encountered by allergists as well as eye-care specialists, and despite progressively increasing incidence, it often remains underdiagnosed and hence untreated. PMID: 33276116 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 1, 2020 Category: Allergy & Immunology Authors: Rodrigues J, Kalangara ME, Vanijcharoenkarn K, Patel N, Hom MM, Wallace DV Tags: Ann Allergy Asthma Immunol Source Type: research

Type 2 Inflammation in the Sputum of Adolescents with Asthma.
PMID: 33276117 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 1, 2020 Category: Allergy & Immunology Authors: Coverstone AM, Boomer JS, Lew D, Bacharier LB, Castro M, Severe Asthma Research Program (SARP) Investigators Tags: Ann Allergy Asthma Immunol Source Type: research

Characterization of Hypereosinophilia in University Health Care Systems.
PMID: 33276118 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 1, 2020 Category: Allergy & Immunology Authors: Li JC, Kahwash B, Ganju A, Ogbogu PU, Mathur SK Tags: Ann Allergy Asthma Immunol Source Type: research

A 6-Step Rapid Desensitization Protocol to Hydroxychloroquine.
PMID: 33276119 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 1, 2020 Category: Allergy & Immunology Authors: Sutton KM, Fernando SL Tags: Ann Allergy Asthma Immunol Source Type: research

Type 2 Inflammation in the Sputum of Adolescents with Asthma
Type 2 (T2) inflammation, which includes cytokines interleukin (IL)-4, -5 and -13, is a major molecular mechanism in asthma pathogenesis. While extensively studied in adults, pediatric-specific data on these pathways in children with asthma are limited1-4. The Severe Asthma Research Program (SARP), a longitudinal cohort study with 7 US clinical sites, enrolled children 6-17 years of age with asthma, who underwent detailed characterization and collection of various biomarkers to understand the molecular mechanisms of the different asthma endotypes. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 1, 2020 Category: Allergy & Immunology Authors: Andrea M. Coverstone, Jonathan S. Boomer, Daphne Lew, Leonard B. Bacharier, Mario Castro, Severe Asthma Research Program (SARP) Investigators Tags: Letters Source Type: research

Characterization of Hypereosinophilia in University Health Care Systems
Hypereosinophilia (HE), defined as peripheral blood eosinophilia ≥1500 cells/μL, is an uncommon finding in clinical practice that may be discovered incidentally or with associated symptoms. HE warrants further investigation as it can portend life-threatening diseases such as malignancy or the eosinophil-associated end-organ damage of hypereosinophilic syndrome s (HES).1 The differential for HE is broad and includes malignancies and secondary causes such as adverse medication reactions, parasitic infections, and eosinophilic granulomatosis with polyangiitis (EGPA). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 1, 2020 Category: Allergy & Immunology Authors: Jennifer C. Li, Basil Kahwash, Akaansha Ganju, Princess U. Ogbogu, Sameer K. Mathur Tags: Letters Source Type: research

A 6-Step Rapid Desensitization Protocol to Hydroxychloroquine
Hydroxychloroquine, a 4-amino-quinolone antimalarial medication, is widely used for the treatment of systemic lupus erythematosus (SLE), discoid lupus erythematosus (DLE), rheumatoid arthritis and related inflammatory conditions. Cutaneous adverse reactions typically develop within 2-33 days and manifest as type IV reactions typically as a maculopapular exanthem (MPE)1. Type 1 reactions resulting in urticaria and anaphylaxis are less commonly reported in the literature2. It is estimated that 10% of patients on hydroxychloroquine will develop a hypersensitivity reaction resulting in its discontinuation3. (Source: Annals of ...
Source: Annals of Allergy, Asthma and Immunology - December 1, 2020 Category: Allergy & Immunology Authors: Kathryn M. Sutton, Suran L. Fernando Tags: Letters Source Type: research

The spectrum of allergic ocular diseases-2020
The purpose of this paper is to review the pathophysiologic mechanisms, differential diagnosis, evaluation and treatment of the various manifestations of ocular allergy, with an especial focus on IgE-mediated disease. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 30, 2020 Category: Allergy & Immunology Authors: Jonathan Rodrigues, Merin E. Kalangara, Kristine Vanijcharoenkarn, Nikki Patel, Milton M. Hom, Dana V. Wallace Tags: Review Source Type: research

The Evolution of Allergy Immunotherapy
The objective of this review is to trace the evolution of the art and science of allergy immunotherapy. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 30, 2020 Category: Allergy & Immunology Authors: Harold S. Nelson Tags: Review Source Type: research

Efficacy of type-2 targeted biologics in patients with asthma and bronchiectasis
Bronchiectasis is characterized by permanent, irreversible dilation of the bronchi due to inflammation and impaired mucus clearance and is associated with significant respiratory impairment. Bronchiectasis shares significant clinical characteristics with severe asthma, and they often coexist.1 Although classically thought of as neutrophilic-predominant inflammation, emerging evidence suggests that the inflammation in bronchiectasis is heterogeneous with a subset of patients having an eosinophil-predominant type 2 inflammatory response. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 30, 2020 Category: Allergy & Immunology Authors: Elizabeth Kudlaty, Gayatri B. Patel, Michelle L. Prickett, Chen Yeh, Anju T. Peters Tags: Letters Source Type: research