Development and Acceptability of a Shared Decision-Making Tool for Commercial Peanut Allergy Therapies
Shared decision making (SDM) is the process through which patients and their medical provider mutually explore therapy goals, risks/benefits, and treatment options regarding medical care. Decision-aids are tools to help with the values clarification process and assess decisional needs and potential decisional conflicts. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 11, 2020 Category: Allergy & Immunology Authors: Matthew Greenhawt, Marcus Shaker, Tonya Winders, Don A. Bukstein, Ray S. Davis, John Oppenheimer, David M. Fleischer, Edwin Kim, Edmond S. Chan, David R. Stukus, Daniel Matlock Source Type: research

Fatal Food Anaphylaxis – registering a rare outcome
Deaths due to food allergy are incredibly rare (1), but it is now understood that food is the most commonly identified trigger of anaphylaxis (2). In the United States, deaths from food anaphylaxis are broadly estimated to occur at a rate of 5-200 cases per year (3). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 11, 2020 Category: Allergy & Immunology Authors: Stacy Dorris Tags: Perspective Source Type: research

Evaluating Drug Fever to Beta Lactam Antibiotics.
PMID: 32044449 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 7, 2020 Category: Allergy & Immunology Authors: Gans MD, Tejera DS, Jerschow E Tags: Ann Allergy Asthma Immunol Source Type: research

Prevalence and natural history of tree nut allergy.
CONCLUSION: Tree nut allergy remains an understudied area of food allergy research with limited region specific studies based on robust food allergy measures in population cohorts with longitudinal follow up. This currently limits our understanding of tree nut allergy prognosis. PMID: 32044450 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 7, 2020 Category: Allergy & Immunology Authors: McWilliam VL, Perrett KP, Dang T, Peters RL Tags: Ann Allergy Asthma Immunol Source Type: research

Key Steps in Vaccine Development.
CONCLUSION: In an era of increasing vaccine hesitancy the need for a better and widespread understanding of how immunization acts to counteract the continuing and changing risks from the pathogenic world is required. This demands a societal responsibility for obligate education on the benefits of vaccination, which as a medical intervention has saved more lives than any other procedure. PMID: 32044451 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 7, 2020 Category: Allergy & Immunology Authors: Stern PL Tags: Ann Allergy Asthma Immunol Source Type: research

Hypereosinophilia with Angioimmunoblastic T cell Lymphoma 1.
PMID: 32044452 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 7, 2020 Category: Allergy & Immunology Authors: Eng V, Kulkarni SK, Kaplan MS, Samant SA, Sheikh J Tags: Ann Allergy Asthma Immunol Source Type: research

Engaging Patient Partners In State of the Art Allergy Care: Finding Balance When Discussing Risk.
CONCLUSION: Communicating risk is complex and validated patient decision aids using visual aids, presenting essential information, using knowledge checks, and incorporating values clarification can reduce decisional conflict and improve decisional self-efficacy. PMID: 32044453 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 7, 2020 Category: Allergy & Immunology Authors: Shaker M, Hsu-Blatman K, M Abrams E Tags: Ann Allergy Asthma Immunol Source Type: research

Doctor, I am allergic to penicillin: Is this dangerous?
PMID: 32044454 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 7, 2020 Category: Allergy & Immunology Authors: Solensky R Tags: Ann Allergy Asthma Immunol Source Type: research

Prevalence and natural history of tree nut allergy
Tree nuts are common causes of food related allergic reactions and anaphylaxis. Resolution of tree nut allergy is thought to be low yet studies of the natural history of tree nut allergy are limited. This review summarizes the available literature regarding tree nut allergy prevalence and natural history, and discusses emerging diagnostic and prognostic developments that will inform clinical management of tree nut allergy. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 7, 2020 Category: Allergy & Immunology Authors: Vicki L. McWilliam, Kirsten P. Perrett, Thanh Dang, Rachel L. Peters Tags: Review Source Type: research

Key Steps in Vaccine Development
This article reviews the main elements that provide for the development of safe and effective vaccines Data Sources: Literature covering target pathogen epidemiology, the key aspects of the functioning immune response underwriting target antigen selection, optimal vaccine formulation, preclinical and clinical trial studies necessary to deliver safe and efficacious immunization. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 7, 2020 Category: Allergy & Immunology Authors: Peter L. Stern Tags: CME Reviews Source Type: research

Evaluating Drug Fever to Beta Lactam Antibiotics
Drug fever is a rare and frequently overlooked reaction to medications. Drug fever is often missed, as fever is commonly miscategorized as infectious, and drug fever is a diagnosis of exclusion. Drug fevers typically occur within days to weeks after starting the culprit medication and cease after stopping the medication.1 Patients are otherwise well with no other symptoms. Many different medications have been implicated in drug fever.1-5 The true incidence of drug fever is unknown, but it is likely underreported. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 7, 2020 Category: Allergy & Immunology Authors: Melissa D. Gans, Denise Sanchez Tejera, Elina Jerschow Tags: Letters Source Type: research

Doctor, I am allergic to penicillin: Is this dangerous?
A 52-year-old female is self-referred for evaluation of penicillin allergy. Her visit is prompted by reading a story in The New York Times1 about the dangers of being mislabeled as penicillin-allergic. Her past medical history is notable only for hypertension which is controlled on lisinopril. She reports receiving penicillin VK in college for Streptococcal pharyngitis and sometimes during the course developing generalized urticaria, without any oropharyngeal, respiratory, cardiovascular or gastrointestinal symptoms. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 7, 2020 Category: Allergy & Immunology Authors: Roland Solensky Tags: Perspective Source Type: research

Hypereosinophilia with Angioimmunoblastic T cell Lymphoma 1
A 58-year-old woman was evaluated for persistent eosinophilia. She had joint pain with effusions for 14 years and was treated for presumptive seronegative rheumatoid arthritis with prednisone and multiple disease-modifying antirheumatic drugs with minimal improvement (timeline in Figure 1). For 2.5 years prior to evaluation, she developed a persistent pruritic rash, chronic cough, and a 20 pound weight loss. She had no atopic history and was not taking any herbal supplements. She did travel to Mexico and the US Virgin Islands within the past 2 years. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 7, 2020 Category: Allergy & Immunology Authors: Victoria Eng, Sameer Kumar Kulkarni, Michael Stuart Kaplan, Shefali Anil Samant, Javed Sheikh Tags: Letters Source Type: research

Engaging Patient Partners In State of the Art Allergy Care: Finding Balance When Discussing Risk
To review risk communication in the context of shared decision making. Data Sources: Articles describing risk communication, shared decision making, and cost-effective healthcare delivery. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 7, 2020 Category: Allergy & Immunology Authors: Marcus Shaker, Karen Hsu-Blatman, Elissa M Abrams Tags: CME Reviews Source Type: research

Exercise-induced Bronchoconstriction in Elite or Endurance Athletes: Pathogenesis and Diagnostic Considerations.
CONCLUSION: A greater awareness of EIB among elite and endurance athletes is needed and a thorough evaluation should be performed if EIB is suspected in this population. We propose an algorithm to aid in this evaluation. Symptoms should not be solely relied upon for diagnosis, but be taken into the context of bronchoprovocative challenges, which should replicate the competitive environment as closely as possible. Further research is needed to validate these tests' predictive values. PMID: 32035936 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 6, 2020 Category: Allergy & Immunology Authors: Atchley TJ, Smith DM Tags: Ann Allergy Asthma Immunol Source Type: research

In-vivo Raman spectroscopy discriminates between FLG loss-of-function carriers vs. wild-type in day 1-4 neonates.
Abstract BACKGROUND: Carriers of loss-of-function mutations in the filaggrin (LoF FLG) gene have less natural moisturising factor (NMF) in their stratum corneum (SC) and an increased risk of atopic dermatitis (AD). NMF can be measured non-invasively by Raman spectroscopy. The use of Raman-derived NMF at birth to screen for FLG genotype could inform targeted AD prevention, but values in neonatal populations are largely unexplored. OBJECTIVE: To examine the associations between Raman-derived neonatal NMF measurements and FLG genotype. METHODS: NMF was measured by Raman Spectroscopy in the SC of the thenar ...
Source: Annals of Allergy, Asthma and Immunology - February 6, 2020 Category: Allergy & Immunology Authors: Chaoimh CN, Nico C, Puppels GJ, Caspers PJ, Wong XFCC, Common JE, Irvine AD, O'B Hourihane J Tags: Ann Allergy Asthma Immunol Source Type: research

In-vivo Raman spectroscopy discriminates between FLG loss-of-function carriers vs. wild-type in day 1-4 neonates
Carriers of loss-of-function mutations in the filaggrin (LoF FLG) gene have less natural moisturising factor (NMF) in their stratum corneum (SC) and an increased risk of atopic dermatitis (AD). NMF can be measured non-invasively by Raman spectroscopy. The use of Raman-derived NMF at birth to screen for FLG genotype could inform targeted AD prevention, but values in neonatal populations are largely unexplored. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 6, 2020 Category: Allergy & Immunology Authors: Carol N í Chaoimh, Claudio Nico, Gerwin J. Puppels, Peter J. Caspers, X.F.Colin C. Wong, John E. Common, Alan D. Irvine, Jonathan O’B. Hourihane Source Type: research

Exercise-induced Bronchoconstriction in Elite or Endurance Athletes: Pathogenesis and Diagnostic Considerations
To review the pathogenesis and evaluation of exercise-induced bronchoconstriction pertaining to the elite or endurance athlete, as well as propose a diagnostic algorithm based on the current literature. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 6, 2020 Category: Allergy & Immunology Authors: Taylor J. Atchley, Derek M. Smith Tags: Review Source Type: research

Anaphylaxis: watch out, it is everywhere now!
PMID: 32029208 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Castells MC Tags: Ann Allergy Asthma Immunol Source Type: research

Anaphylaxis: watch out, it is everywhere now!
Anaphylaxis continues to be underdiagnosed, underreported, and undertreated, and this issue of the Annals of Allergy, Asthma and Immunology provides granularity on some of the key issues: 1) How accurate are the ICD codes that are used to make its diagnosis and what are their limitations? 2) What drugs are the usual and new etiologic suspects and by what mechanisms do they induce anaphylaxis? 3) How do new food allergens such as alpha-gal expand the understanding of reactions to monoclonal antibodies? 4) How common and severe are allergic reactions to dyes and contrast media and which tools are available for their diagnosi...
Source: Annals of Allergy, Asthma and Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Mariana C. Castells Tags: Editorial Source Type: research

Information for Readers
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2020 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2020 Category: Allergy & Immunology Source Type: research

Information for Authors
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2020 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2020 Category: Allergy & Immunology Source Type: research

The Modern Plague of Anti-Vaccine Extremists.
PMID: 32007566 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2020 Category: Allergy & Immunology Authors: Pan RJ Tags: Ann Allergy Asthma Immunol Source Type: research

Comprehensive Assessment of Respiratory Complications in Patients with Common Variable Immunodeficiency.
Abstract BACKGROUND: Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by recurrent upper and lower respiratory tract infections and some non-infectious clinical complications. OBJECTIVE: The current study aimed to provide a detailed evaluation of respiratory presentations and complications in a cohort of Iranian patients with CVID. METHODS: The present retrospective cohort study was conducted on 245 CVID patients who were recorded at the Iranian primary immunodeficiency disorders registry network. Respiratory manifestations were evaluated by reviewing clinical ...
Source: Annals of Allergy, Asthma and Immunology - January 30, 2020 Category: Allergy & Immunology Authors: Moazzami B, Mohayeji Nasrabadi MA, Abolhassani H, Olbrich P, Azizi G, Shirzadi R, Modaresi M, Sohani M, Delavari S, Shahkarami S, Yazdani R, Aghamohammadi A Tags: Ann Allergy Asthma Immunol Source Type: research

Review Article: Unmet needs of children with peanut allergy: aligning the risks and the evidence.
CONCLUSION: There are significant unmet needs in our understanding of peanut allergy; addressing these needs will help to enhance understanding of how to most effectively prevent and treat peanut allergy, as well as educate the food-allergic and nonallergic community regarding current evidence-based practices. PMID: 32007568 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2020 Category: Allergy & Immunology Authors: Chan ES, Dinakar C, Gonzales-Reyes E, Green TD, Gupta R, Jones D, Wang J, Winders T, Greenhawt M Tags: Ann Allergy Asthma Immunol Source Type: research

Epithelia Cell Function and Remodeling in Nasal Polyposis.
CONCLUSIONS: Airway epithelial remodeling in chronic rhinosinusitis is extensive, leading to loss of innate immune function and enhanced proinflammatory potential. The mechanisms driving airway remodeling and its sequelae deserve further attention before restitution of epithelial differentiation can be considered a reasonable therapeutic target. PMID: 32007569 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2020 Category: Allergy & Immunology Authors: Bankova LG, Barrett NA Tags: Ann Allergy Asthma Immunol Source Type: research

Mechanisms and Treatment of Olfactory Dysfunction in Chronic Rhinosinusitis.
PMID: 32007570 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2020 Category: Allergy & Immunology Authors: Mattos JL Tags: Ann Allergy Asthma Immunol Source Type: research

Utilizing Endotypes, Phenotypes, and Inflammatory Markers to Guide Treatment Decisions in Chronic Rhinosinusitis.
CONCLUSION: While significant progress has been made in characterizing endotypes, phenotypes, and biomarkers in CRS, additional studies are needed to determine if and how these factors could assist physicians in providing more individualized clinical care. PMID: 32007571 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2020 Category: Allergy & Immunology Authors: Staudacher AG, Peters AT, Kato A, Stevens WW Tags: Ann Allergy Asthma Immunol Source Type: research

Utilizing Endotypes, Phenotypes, and Inflammatory Markers to Guide Treatment Decisions in Chronic Rhinosinusitis
With the advent of new treatment options for Chronic Rhinosinusitis (CRS) comes the ability for physicians to provide more individualized patient care. Physicians are now tasked with identifying who may be the best candidate for a particular therapy. In this review, existing biomarkers and potentially new methods that could guide treatment choices in CRS patients will be discussed. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2020 Category: Allergy & Immunology Authors: Anna G. Staudacher, Anju T. Peters, Atsushi Kato, Whitney W. Stevens Tags: CME Reviews Source Type: research

Mechanisms and Treatment of Olfactory Dysfunction in Chronic Rhinosinusitis
Chronic Rhinosinusitis (CRS) is one of the most common chronic conditions in North America. CRS patients suffer from discolored nasal drainage, facial pain, difficulty breathing, and decreased sense of smell1. CRS has been shown to impair quality of life (QOL), reduce productivity, and increase the risk of depression and sleep disorders.1 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2020 Category: Allergy & Immunology Authors: Jose L. Mattos Tags: Perspective Source Type: research

The Modern Plague of Anti-Vaccine Extremists
In 2019, the World Health Organization declared vaccine hesitancy a top threat to global health1, and the United States experienced the largest number of measles infections since 1992, almost losing measles elimination status. Vaccine disinformation flourishes on social media, where misleading click-bait conspiracies go viral and families, physicians, and public health advocates are bullied and threatened to silence support for vaccination. As a result, the CDC reported rates of young children not receiving certain vaccinations continues to rise, with states reporting rates as high as 7.7% of kindergarteners granted vaccin...
Source: Annals of Allergy, Asthma and Immunology - January 30, 2020 Category: Allergy & Immunology Authors: Richard J. Pan Tags: Perspective Source Type: research

Review Article: Unmet needs of children with peanut allergy: aligning the risks and the evidence
Peanut allergy is a potentially severe and lifelong allergy, with few effective treatments or preventative measures. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2020 Category: Allergy & Immunology Authors: Edmond S. Chan, Chitra Dinakar, Erika Gonzales-Reyes, Todd D. Green, Ruchi Gupta, Douglas Jones, Julie Wang, Tonya Winders, Matthew Greenhawt Source Type: research

Epithelia Cell Function and Remodeling in Nasal Polyposis
To review the latest discoveries on airway epithelial cell diversity and remodeling in type 2 inflammation, including nasal polyposis. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2020 Category: Allergy & Immunology Authors: Lora G. Bankova, Nora A. Barrett Tags: Review Source Type: research

Comprehensive Assessment of Respiratory Complications in Patients with Common Variable Immunodeficiency
Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by recurrent upper and lower respiratory tract infections and some non-infectious clinical complications. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2020 Category: Allergy & Immunology Authors: Bobak Moazzami, Mohammad Ali Mohayeji Nasrabadi, Hassan Abolhassani, Peter Olbrich, Gholamreza Azizi, Rohola Shirzadi, Mohammadreza Modaresi, Mahsa Sohani, Samaneh Delavari, Sepideh Shahkarami, Reza Yazdani, Asghar Aghamohammadi Source Type: research

Biologic logistics
The use of biologics has breathed new life into asthma management. They have provided truly life-changing improvement for those with atopic dermatitis, chronic idiopathic urticaria, and chronic rhinosinusitis with nasal polyposis. After a biologic has been chosen, the next challenge is making the medication available to the patient. Ongoing changes in medication delivery, such as at-home administration, insurance coverage, and reimbursement, have made prescribing biologics and monitoring these patients a moving target. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 29, 2020 Category: Allergy & Immunology Authors: Jared Darveaux Tags: Perspective Source Type: research

Significantly Increased Threshold Dose After Long-Term Peanut Epicutaneous Immunotherapy and Daily Oral Peanut Intake.
PMID: 32006703 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 29, 2020 Category: Allergy & Immunology Authors: Fink WR, Capucilli PS, Lewis MO, Rooney CB, Brown-Whitehorn TF Tags: Ann Allergy Asthma Immunol Source Type: research

Differences in Management of Peanut Allergy between Allergists and Pediatricians.
PMID: 32006704 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 29, 2020 Category: Allergy & Immunology Authors: Manious M, Atalla J, Erwin E, Stukus D, Mikhail I Tags: Ann Allergy Asthma Immunol Source Type: research

Biologic Logistics: Connecting with your patients on biologics.
PMID: 32006705 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 29, 2020 Category: Allergy & Immunology Authors: Darveaux J Tags: Ann Allergy Asthma Immunol Source Type: research

Biologic Logistics: Connecting with your patients on biologics
The use of biologics has breathed new life into asthma management. They have provided truly life changing improvement for those with atopic dermatitis, chronic idiopathic urticaria, and chronic rhinosinusitis with nasal polyposis. After a biologic has been chosen, the next challenge is making the medication available to the patient. Ongoing changes in medication delivery like at-home administration, insurance coverage, and reimbursement have made prescribing biologics and monitoring these patients a moving target. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 29, 2020 Category: Allergy & Immunology Authors: Jared Darveaux Tags: Perspective Source Type: research

Differences in Management of Peanut Allergy between Allergists and Pediatricians
Peanut allergy (PA) affects 1-2% of the pediatric population, is rarely outgrown and is the leading cause of fatal food allergic reactions1-3. Data suggests that one-half of patients in need of allergy services do not have access to an allergist4. It is unclear how management of PA may differ between allergists and pediatricians. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 29, 2020 Category: Allergy & Immunology Authors: Michelle Manious, Jasmyn Atalla, Elizabeth Erwin, David Stukus, Irene Mikhail Tags: Letters Source Type: research

Significantly Increased Threshold Dose After Long-Term Peanut Epicutaneous Immunotherapy and Daily Oral Peanut Intake
In the last decade, large strides have been made regarding immunotherapy for peanut allergy. While randomized control trials have documented the efficacy and safety of oral immunotherapy (OIT), sublingual immunotherapy (SLIT), and epicutaneous immunotherapy (EPIT), questions remain regarding long-term outcomes, including optimal maintenance dosing and impact on desensitization and sustained unresponsiveness.1,2,3 Herein, we describe a unique case of long-term peanut tolerance following peanut EPIT within the Viaskin ® Peanut Efficacy and Safety (VIPES) study, a double-blind, placebo-controlled trial, and subsequent Ope...
Source: Annals of Allergy, Asthma and Immunology - January 29, 2020 Category: Allergy & Immunology Authors: Whitney Reid Fink, Peter S. Capucilli, Megan O. Lewis, Courtney B. Rooney, Terri F. Brown-Whitehorn Tags: Letters Source Type: research

Psychosocial and neurodevelopmental aspects of food protein –induced enterocolitis syndrome
Food protein –induced enterocolitis syndrome (FPIES) is a non–immunoglobulin E (IgE)-mediated food allergy that presents with severe vomiting and lethargy, with or without diarrhea, within 1 to 4 hours of ingestion of a trigger food antigen.1 In approximately 15% of cases, the reaction may be severe enough t o cause hypotension and shock. Prevalence of FPIES is likely underestimated, with a reported incidence of 0.34% to 0.7% amongst infants.2,3 Although FPIES in adults has been reported, it is typically a disease of young children. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 28, 2020 Category: Allergy & Immunology Authors: Catherine Peterson, Malika Gupta Tags: Letters Source Type: research

Ocular Symptoms Improvement from Intranasal Triamcinolone compared with Placebo and Intranasal Fluticasone Propionate: a meta-analysis.
CONCLUSION: The meta-analysis demonstrated the positive clinical improvements TAA has on total ocular allergy symptoms, especially tearing, in addition to its recognized nasal symptom efficacy in SAR. PMID: 32004698 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 28, 2020 Category: Allergy & Immunology Authors: Bielory L, Gross G, Letierce A, Melas-Melt L, Lucio L Tags: Ann Allergy Asthma Immunol Source Type: research

Psychosocial and Neurodevelopmental Aspects of FPIES.
PMID: 32004699 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 28, 2020 Category: Allergy & Immunology Authors: Peterson C, Gupta M Tags: Ann Allergy Asthma Immunol Source Type: research

Psychosocial and Neurodevelopmental Aspects of FPIES
Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE-mediated food allergy that presents with severe vomiting and lethargy, with or without diarrhea, within 1-4 hours of ingestion of a trigger food antigen1. In about 15% of cases, the reaction may be severe enough to cause hypotension and shock. Prevalence of FPIES is likely underestimated, with a reported incidence of 0.34% to 0.7% amongst infants2,3. Although FPIES in adults has been reported, it is typically a disease of young children. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 28, 2020 Category: Allergy & Immunology Authors: Catherine Peterson, Malika Gupta Tags: Letters Source Type: research

Ocular Symptoms Improvement from Intranasal Triamcinolone compared with Placebo and Intranasal Fluticasone Propionate: a meta-analysis.
Allergic rhinitis is a prevalent disease, which can be classed as seasonal (SAR), or perennial. In addition to nasal symptoms, up to 75% of sufferers experience itching, redness and tearing of the eyes. Intranasal corticosteroids are effective in controlling the allergic nasal symptoms, and there is increasing evidence suggesting they can also relieve some of the allergic ocular symptoms. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 28, 2020 Category: Allergy & Immunology Authors: Leonard Bielory, Gary Gross, Alexia Letierce, Lydie Melas-Melt, Luiz Lucio Source Type: research

Food reactions during avoidance: focus on peanut.
CONCLUSION: Clinicians should continue to discuss avoidance as a viable option for long-term peanut allergy management and empower patients to differentiate relevant situations in which accidental reactions might occur. PMID: 32001367 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 27, 2020 Category: Allergy & Immunology Authors: Capucilli P, Wang KY, Spergel JM Tags: Ann Allergy Asthma Immunol Source Type: research

Food reactions during avoidance: focus on peanut
Peanut allergy has historically been difficult to manage, with most cases persisting into adulthood. Novel therapies for peanut allergy treatment are on the horizon, yet allergists must maintain a robust understanding of the risks and benefits of the current standard of therapy, avoidance diet. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 27, 2020 Category: Allergy & Immunology Authors: Peter Capucilli, Kathleen Y. Wang, Jonathan M. Spergel Tags: Review Source Type: research