Single-step direct drug provocation testing is safe for de-labelling selected “non-low-risk” penicillin allergy labels
Penicillin allergy labels are prevalent, and removal of incorrect labels improves patient outcomes and health economics. Labels may be classified as "low-risk", or "non-lowrisk", the latter chiefly where symptoms suggest IgE-mediated etiology. Traditionally, "non-low-risk" allergy labels are assessed by penicillin skin testing followed by graded multi-step penicillin drug provocation testing (DPT). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 15, 2021 Category: Allergy & Immunology Authors: Jamma Li, Vera Cvetanovski, B. Nursing, Suran Fernando Source Type: research

Increased risk of allergy hospitalization after cesarean delivery: a longitudinal study of 950,000 children
Ann Allergy Asthma Immunol. 2021 Apr 10:S1081-1206(21)00272-6. doi: 10.1016/j.anai.2021.04.009. Online ahead of print.NO ABSTRACTPMID:33848629 | DOI:10.1016/j.anai.2021.04.009 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 13, 2021 Category: Allergy & Immunology Authors: Safiya Soullane Phillipe B égin Antoine Lewin Ga Eun Lee Nathalie Auger Source Type: research

Comparing the NAC and EEU Models of Allergic Rhinitis
Ann Allergy Asthma Immunol. 2021 Apr 10:S1081-1206(21)00275-1. doi: 10.1016/j.anai.2021.04.012. Online ahead of print.NO ABSTRACTPMID:33848630 | DOI:10.1016/j.anai.2021.04.012 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 13, 2021 Category: Allergy & Immunology Authors: Rashi Ramchandani Sophia Linton Lubnaa Hossenbaccus Anne K Ellis Source Type: research

Exploiting Nut Cross Reactivity to Facilitate Real World Treatment of Tree Nut Allergy
Ann Allergy Asthma Immunol. 2021 Apr 10:S1081-1206(21)00273-8. doi: 10.1016/j.anai.2021.04.010. Online ahead of print.NO ABSTRACTPMID:33848631 | DOI:10.1016/j.anai.2021.04.010 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 13, 2021 Category: Allergy & Immunology Authors: Richard L Wasserman Hugh H Windom Daria Lie Deanna M Pence Jean Ly Source Type: research

From the Pages of Allergy Watch (for July-21)
Ann Allergy Asthma Immunol. 2021 Apr 10:S1081-1206(21)00269-6. doi: 10.1016/j.anai.2021.04.006. Online ahead of print.NO ABSTRACTPMID:33848632 | DOI:10.1016/j.anai.2021.04.006 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 13, 2021 Category: Allergy & Immunology Authors: Stanley M Fineman John J Oppenheimer Gerald B Lee Vivian Hernandez-Trujillo Source Type: research

Real-world efficacy and safety of Dupilumab use in the treatment of asthma
Ann Allergy Asthma Immunol. 2021 Apr 10:S1081-1206(21)00274-X. doi: 10.1016/j.anai.2021.04.011. Online ahead of print.NO ABSTRACTPMID:33848633 | DOI:10.1016/j.anai.2021.04.011 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 13, 2021 Category: Allergy & Immunology Authors: Somaira Nowsheen Jared I Darveaux Source Type: research

Increased risk of allergy hospitalization after cesarean delivery: a longitudinal study of 950,000 children
Ann Allergy Asthma Immunol. 2021 Apr 10:S1081-1206(21)00272-6. doi: 10.1016/j.anai.2021.04.009. Online ahead of print.NO ABSTRACTPMID:33848629 | DOI:10.1016/j.anai.2021.04.009 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 13, 2021 Category: Allergy & Immunology Authors: Safiya Soullane Phillipe B égin Antoine Lewin Ga Eun Lee Nathalie Auger Source Type: research

Comparing the NAC and EEU Models of Allergic Rhinitis
Ann Allergy Asthma Immunol. 2021 Apr 10:S1081-1206(21)00275-1. doi: 10.1016/j.anai.2021.04.012. Online ahead of print.NO ABSTRACTPMID:33848630 | DOI:10.1016/j.anai.2021.04.012 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 13, 2021 Category: Allergy & Immunology Authors: Rashi Ramchandani Sophia Linton Lubnaa Hossenbaccus Anne K Ellis Source Type: research

Exploiting Nut Cross Reactivity to Facilitate Real World Treatment of Tree Nut Allergy
Ann Allergy Asthma Immunol. 2021 Apr 10:S1081-1206(21)00273-8. doi: 10.1016/j.anai.2021.04.010. Online ahead of print.NO ABSTRACTPMID:33848631 | DOI:10.1016/j.anai.2021.04.010 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 13, 2021 Category: Allergy & Immunology Authors: Richard L Wasserman Hugh H Windom Daria Lie Deanna M Pence Jean Ly Source Type: research

From the Pages of Allergy Watch (for July-21)
Ann Allergy Asthma Immunol. 2021 Apr 10:S1081-1206(21)00269-6. doi: 10.1016/j.anai.2021.04.006. Online ahead of print.NO ABSTRACTPMID:33848632 | DOI:10.1016/j.anai.2021.04.006 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 13, 2021 Category: Allergy & Immunology Authors: Stanley M Fineman John J Oppenheimer Gerald B Lee Vivian Hernandez-Trujillo Source Type: research

Real-world efficacy and safety of Dupilumab use in the treatment of asthma
Ann Allergy Asthma Immunol. 2021 Apr 10:S1081-1206(21)00274-X. doi: 10.1016/j.anai.2021.04.011. Online ahead of print.NO ABSTRACTPMID:33848633 | DOI:10.1016/j.anai.2021.04.011 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 13, 2021 Category: Allergy & Immunology Authors: Somaira Nowsheen Jared I Darveaux Source Type: research

The future of the allergy Immunology specialty is in our hands
Ann Allergy Asthma Immunol. 2021 Apr 9:S1081-1206(21)00268-4. doi: 10.1016/j.anai.2021.04.005. Online ahead of print.NO ABSTRACTPMID:33845132 | DOI:10.1016/j.anai.2021.04.005 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 12, 2021 Category: Allergy & Immunology Authors: Marie Cavuoto Petrizzo Source Type: research

Anaphylaxis to nimesulide
Ann Allergy Asthma Immunol. 2021 Apr 9:S1081-1206(21)00270-2. doi: 10.1016/j.anai.2021.04.007. Online ahead of print.NO ABSTRACTPMID:33845133 | DOI:10.1016/j.anai.2021.04.007 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 12, 2021 Category: Allergy & Immunology Authors: Marco Dubini Paolo Marraccini Clizia Gagliardi Sara Marelli Federica Rivolta Source Type: research

The future of the allergy Immunology specialty is in our hands
Ann Allergy Asthma Immunol. 2021 Apr 9:S1081-1206(21)00268-4. doi: 10.1016/j.anai.2021.04.005. Online ahead of print.NO ABSTRACTPMID:33845132 | DOI:10.1016/j.anai.2021.04.005 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 12, 2021 Category: Allergy & Immunology Authors: Marie Cavuoto Petrizzo Source Type: research

Anaphylaxis to nimesulide
Ann Allergy Asthma Immunol. 2021 Apr 9:S1081-1206(21)00270-2. doi: 10.1016/j.anai.2021.04.007. Online ahead of print.NO ABSTRACTPMID:33845133 | DOI:10.1016/j.anai.2021.04.007 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 12, 2021 Category: Allergy & Immunology Authors: Marco Dubini Paolo Marraccini Clizia Gagliardi Sara Marelli Federica Rivolta Source Type: research

Peanut oral immunotherapy in a pediatric allergy clinic: patient factors associated with clinical outcomes
Ann Allergy Asthma Immunol. 2021 Apr 8:S1081-1206(21)00266-0. doi: 10.1016/j.anai.2021.04.003. Online ahead of print.ABSTRACTBACKGROUND: Additional information is needed to inform optimal patient selection, expected outcomes, and treatment endpoints for clinical peanut oral immunotherapy (OIT).OBJECTIVE: We analyzed a real-world peanut OIT cohort to provide insight into these questions.METHODS: Records were reviewed for 174 children undergoing peanut OIT at a pediatric allergy clinic. Patient age, peanut skin prick test, peanut-specific IgE (sIgE) results, and inclusion of additional foods in OIT were analyzed for correlat...
Source: Annals of Allergy, Asthma and Immunology - April 11, 2021 Category: Allergy & Immunology Authors: Katharine M Guarnieri Ian F Slack Vanessa Gadoury-L évesque Amy A Eapen Sandra Andorf Michelle B Lierl Source Type: research

Outcome of trimethoprim-sulfamethoxazole (TMP-SMX) challenge in previously reported sulfa antibiotic allergic patients
Ann Allergy Asthma Immunol. 2021 Apr 7:S1081-1206(21)00264-7. doi: 10.1016/j.anai.2021.04.001. Online ahead of print.NO ABSTRACTPMID:33838337 | DOI:10.1016/j.anai.2021.04.001 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 10, 2021 Category: Allergy & Immunology Authors: Hailey A Benesch Vidya L Atluri Bailey Coerver Lahari Rampur Source Type: research

Disproportionality Analysis of Anaphylactic Reactions after Vaccination with mRNA COVID-19 Vaccines in the United States
Ann Allergy Asthma Immunol. 2021 Apr 7:S1081-1206(21)00267-2. doi: 10.1016/j.anai.2021.04.004. Online ahead of print.NO ABSTRACTPMID:33838338 | PMC:PMC8026243 | DOI:10.1016/j.anai.2021.04.004 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 10, 2021 Category: Allergy & Immunology Authors: Guillermo Rodriguez-Nava Goar Egoryan Daniela Patricia Trelles-Garcia Maria Adriana Yanez-Bello Ricardo Murguia-Fuentes Source Type: research

Omalizumab response in patients with asthma by number and type of allergen
CONCLUSION: Overall findings suggest that patients with allergic asthma achieved comparable improvements across distinct outcome measures following omalizumab therapy in a real-world setting, regardless of number and type of allergen sensitizations.PMID:33838339 | DOI:10.1016/j.anai.2021.04.002 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 10, 2021 Category: Allergy & Immunology Authors: Weily Soong Bongin Yoo Hooman Pazwash Cecile T J Holweg Thomas B Casale Source Type: research

Outcome of trimethoprim-sulfamethoxazole (TMP-SMX) challenge in previously reported sulfa antibiotic allergic patients
Ann Allergy Asthma Immunol. 2021 Apr 7:S1081-1206(21)00264-7. doi: 10.1016/j.anai.2021.04.001. Online ahead of print.NO ABSTRACTPMID:33838337 | DOI:10.1016/j.anai.2021.04.001 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 10, 2021 Category: Allergy & Immunology Authors: Hailey A Benesch Vidya L Atluri Bailey Coerver Lahari Rampur Source Type: research

Disproportionality Analysis of Anaphylactic Reactions after Vaccination with mRNA COVID-19 Vaccines in the United States
Ann Allergy Asthma Immunol. 2021 Apr 7:S1081-1206(21)00267-2. doi: 10.1016/j.anai.2021.04.004. Online ahead of print.NO ABSTRACTPMID:33838338 | DOI:10.1016/j.anai.2021.04.004 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 10, 2021 Category: Allergy & Immunology Authors: Guillermo Rodriguez-Nava Goar Egoryan Daniela Patricia Trelles-Garcia Maria Adriana Yanez-Bello Ricardo Murguia-Fuentes Source Type: research

Omalizumab response in patients with asthma by number and type of allergen
CONCLUSION: Overall findings suggest that patients with allergic asthma achieved comparable improvements across distinct outcome measures following omalizumab therapy in a real-world setting, regardless of number and type of allergen sensitizations.PMID:33838339 | DOI:10.1016/j.anai.2021.04.002 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 10, 2021 Category: Allergy & Immunology Authors: Weily Soong Bongin Yoo Hooman Pazwash Cecile T J Holweg Thomas B Casale Source Type: research

From the Pages of Allergy Watch (for July-21)
From the Pages of Allergy Watch – for Annals July 2021 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 10, 2021 Category: Allergy & Immunology Authors: Stanley M. Fineman, John J. Oppenheimer, Gerald B. Lee, Vivian Hernandez-Trujillo Source Type: research

Increased risk of allergy hospitalization after cesarean delivery: a longitudinal study of 950,000 children
Cesarean delivery is increasingly implicated in the development of childhood allergies.1 –3 In newborns, cesarean delivery prevents colonization by maternal vaginal and intestinal flora and is associated with mucosal dysbiosis.4 Mucosal dysbiosis is thought to impair immune tolerance and facilitate allergic sensitization.4,5 However, recent data suggesting that operative vaginal deliv ery is also associated with asthma and allergy challenge this hypothesis.2,6 Operative vaginal delivery does not cause mucosal dysbiosis as fetuses born with forceps or vacuum instrumentation pass through the vagina and are colonized by...
Source: Annals of Allergy, Asthma and Immunology - April 10, 2021 Category: Allergy & Immunology Authors: Safiya Soullane, Phillipe B égin, Antoine Lewin, Ga Eun Lee, Nathalie Auger Source Type: research

Exploiting Nut Cross Reactivity to Facilitate Real World Treatment of Tree Nut Allergy
Oral immunotherapy (OIT) for food allergy has become increasingly common among practicing allergists1. Tree nut allergy accounts for ∼33% of food-induced anaphylaxis fatalities and only 9% outgrow their allergy2,3. Tree nut OIT has been successful4,5, but is burdened by frequent sensitization, as assessed by positive specific IgE (sIgE) or skin prick tests (SPT) to multiple nuts, often without a prior exposure history. Although allergy to each nut could be confirmed or refuted by an oral food challenge (OFC) and OIT performed to each reactive nut, such an approach is not only onerous for patients but each challenge car...
Source: Annals of Allergy, Asthma and Immunology - April 10, 2021 Category: Allergy & Immunology Authors: Richard L. Wasserman, Hugh H. Windom, Daria Lie, Deanna M. Pence, Jean Ly Tags: Letters Source Type: research

Real-world efficacy and safety of Dupilumab use in the treatment of asthma
ACT asthma control test (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 10, 2021 Category: Allergy & Immunology Authors: Somaira Nowsheen, Jared I Darveaux Source Type: research

Comparing the NAC and EEU Models of Allergic Rhinitis
Allergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated hypersensitivity reaction triggered by allergen exposure that causes inflammation of the nasal cavity. Allergens can be seasonal, such as pollens and grasses, or perennial, including house dust mite (HDM) and animal dander. Historically, evaluations of novel AR therapies have been conducted using outpatient studies, whereby participants, having received a certain medication, go about their day-to-day routines during the expected pollen season. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 10, 2021 Category: Allergy & Immunology Authors: Rashi Ramchandani, Sophia Linton, Lubnaa Hossenbaccus, Anne K. Ellis Source Type: research

The future of the allergy Immunology specialty is in our hands
This year's results are in. In 2021, the number of Allergy/Immunology (AI) fellowship applicants per position (APP) was 1.4.1 With the exceptions of a 2018 nadir (1 APP), and 2008 peak (1.7 APP), AI applications have ranged from 1.2-1.5 APP since joining the National Resident Matching Program (NRMP) Specialties Matching Service (SMS) in 2008.1-3 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 9, 2021 Category: Allergy & Immunology Authors: Marie Cavuoto Petrizzo Tags: Letters Source Type: research

Anaphylaxis to nimesulide
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) that specifically inhibits COX-2, the inducible form of the cyclooxygenase enzyme. When administered at high doses, it is also known to inhibit COX-1. Nimesulide (N-(4-Nitro-2-phenoxyphenyl)-methanesulfonamide) has a unique chemical structure among the NSAIDs, and belongs to the sulfonanilide class. It is often used as a reliable alternative for NSAID-sensitive patients, but, to date, the molecular mechanisms that confers its uniqueness have not yet been defined. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 9, 2021 Category: Allergy & Immunology Authors: Marco Dubini, Paolo Marraccini, Clizia Gagliardi, Sara Marelli, Federica Rivolta Tags: Letters Source Type: research

Peanut oral immunotherapy in a pediatric allergy clinic: patient factors associated with clinical outcomes
Additional information is needed to inform optimal patient selection, expected outcomes, and treatment endpoints for clinical peanut oral immunotherapy (OIT). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 8, 2021 Category: Allergy & Immunology Authors: Katharine M. Guarnieri, Ian F. Slack, Vanessa Gadoury-L évesque, Amy A. Eapen, Sandra Andorf, Michelle B. Lierl Source Type: research

Outcome of trimethoprim-sulfamethoxazole (TMP-SMX) challenge in previously reported sulfa antibiotic allergic patients
Sulfa antibiotics are the drug of choice for treatment and prophylaxis of several infections. Unfortunately, about 7% of people exposed to them have adverse reactions ranging from mild rash and nausea, to life-threatening reactions like Stevens-Johnson Syndrome/Toxic Epidermal Necrosis (SJS/TEN)I. Sulfa antibiotics are often avoided in patients with any reported sulfa allergy, irrespective of whether the initial reaction was to an antibiotic or non-antibiotic sulfa drug. This leads to the use of less effective, second-line antibiotics. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 7, 2021 Category: Allergy & Immunology Authors: Hailey A. Benesch, Vidya L. Atluri, Bailey Coerver, Lahari Rampur Tags: Letters Source Type: research

Omalizumab response in patients with asthma by number and type of allergen
The anti-IgE therapy omalizumab improves asthma control and reduces exacerbations in patients with moderate-to-severe allergic asthma. However, it has been suggested that omalizumab should be reserved for highly allergic patients with multiple allergen sensitivities or perennial-only sensitivities. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 7, 2021 Category: Allergy & Immunology Authors: Weily Soong, Bongin Yoo, Hooman Pazwash, Cecile T.J. Holweg, Thomas B. Casale Source Type: research

Disproportionality Analysis of Anaphylactic Reactions after Vaccination with mRNA COVID-19 Vaccines in the United States
One year after the emergence of the novel coronavirus SARS-CoV-2 that causes the coronavirus disease 2019 (COVID-19), the United States Food and Drug Administration (FDA) granted two Emergency Use Authorizations (EUA) for two novel mRNA COVID-19 vaccines. Reports of acute hypersensitivity reactions in the real world after EUA are creating anxiety among potential vaccine recipients and may delay achieving universal vaccination (1). Although the Centers for Disease Control and Prevention (CDC) and the FDA jointly monitor vaccine adverse reactions through a variety of surveillance systems such as the Vaccine Adverse Event Rep...
Source: Annals of Allergy, Asthma and Immunology - April 7, 2021 Category: Allergy & Immunology Authors: Guillermo Rodriguez-Nava, Goar Egoryan, Daniela Patricia Trelles-Garcia, Maria Adriana Yanez-Bello, Ricardo Murguia-Fuentes Tags: Letter Source Type: research

Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00262-3. doi: 10.1016/j.anai.2021.03.030. Online ahead of print.ABSTRACTBACKGROUND: Separating viral-induced wheezers from asthmatics is challenging, and there are no guidelines for children under 6 years of age. Impulse oscillometry is feasible beginning 4-year old children.OBJECTIVE: To explore the use of impulse oscillometry in diagnosing and monitoring asthma in young children and evaluating treatment response to inhaled corticosteroid.METHODS: Forty-two children (median age 5.3 years, range 4.0-7.9 years) with doctor diagnosed asthma and lability in oscillometry wer...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Janne Burman L Pekka Malmberg Sami Remes Tuomas Jartti Anna S Pelkonen Mika J M äkelä Source Type: research

Discontinuation of inhaled corticosteroids in patients with controlled asthma: The DISCO study
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00263-5. doi: 10.1016/j.anai.2021.03.031. Online ahead of print.ABSTRACTBACKGROUND: Although inhaled corticosteroids (ICSs) are the recommended first-line therapy for asthma, determining whether to continue or discontinue ICS treatment in patients with mild asthma remains challenging for clinicians. Several studies have demonstrated that patients with mild-persistent asthma maintained a well-controlled state after ICS withdrawal. However, the long-term outcomes of ICS withdrawal have not yet been determined.OBJECTIVE: We aimed to determine the possible clinical outcomes ...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Jung-Hyun Kim Juhae Jin Seo Young Park So-Young Park Hyo-Jung Kim Min-Hye Kim Hyouk-Soo Kwon Woo-Jung Song Sae-Hoon Kim Heung-Woo Park Yoon-Seok Chang You Sook Cho Young-Joo Cho Sang-Heon Cho Hee-Bom Moon Tae-Bum Kim Source Type: research

Clinical phenotyping of atopic dermatitis using combined itch and lesional severity: A prospective observational study
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00220-9. doi: 10.1016/j.anai.2021.03.019. Online ahead of print.ABSTRACTBACKGROUND: Atopic dermatitis (AD) patients have heterogeneous clinical phenotypes, including different combinations of itch and lesional severity. Little is known about the characteristics and course of these subtypes.OBJECTIVE: To determine the characteristics, associations, burden, and course of AD patients using combined itch and lesional severity.METHODS: A prospective practice-based study was performed using questionnaires and physical examination (n=592). AD subsets were defined using verbal r...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Raj Chovatiya Donald Lei Adnan Ahmed Rajeev Chavda Sylvie Gabriel Jonathan I Silverberg Source Type: research

Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00262-3. doi: 10.1016/j.anai.2021.03.030. Online ahead of print.ABSTRACTBACKGROUND: Separating viral-induced wheezers from asthmatics is challenging, and there are no guidelines for children under 6 years of age. Impulse oscillometry is feasible beginning 4-year old children.OBJECTIVE: To explore the use of impulse oscillometry in diagnosing and monitoring asthma in young children and evaluating treatment response to inhaled corticosteroid.METHODS: Forty-two children (median age 5.3 years, range 4.0-7.9 years) with doctor diagnosed asthma and lability in oscillometry wer...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Janne Burman L Pekka Malmberg Sami Remes Tuomas Jartti Anna S Pelkonen Mika J M äkelä Source Type: research

Discontinuation of inhaled corticosteroids in patients with controlled asthma: The DISCO study
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00263-5. doi: 10.1016/j.anai.2021.03.031. Online ahead of print.ABSTRACTBACKGROUND: Although inhaled corticosteroids (ICSs) are the recommended first-line therapy for asthma, determining whether to continue or discontinue ICS treatment in patients with mild asthma remains challenging for clinicians. Several studies have demonstrated that patients with mild-persistent asthma maintained a well-controlled state after ICS withdrawal. However, the long-term outcomes of ICS withdrawal have not yet been determined.OBJECTIVE: We aimed to determine the possible clinical outcomes ...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Jung-Hyun Kim Juhae Jin Seo Young Park So-Young Park Hyo-Jung Kim Min-Hye Kim Hyouk-Soo Kwon Woo-Jung Song Sae-Hoon Kim Heung-Woo Park Yoon-Seok Chang You Sook Cho Young-Joo Cho Sang-Heon Cho Hee-Bom Moon Tae-Bum Kim Source Type: research

Clinical phenotyping of atopic dermatitis using combined itch and lesional severity: A prospective observational study
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00220-9. doi: 10.1016/j.anai.2021.03.019. Online ahead of print.ABSTRACTBACKGROUND: Atopic dermatitis (AD) patients have heterogeneous clinical phenotypes, including different combinations of itch and lesional severity. Little is known about the characteristics and course of these subtypes.OBJECTIVE: To determine the characteristics, associations, burden, and course of AD patients using combined itch and lesional severity.METHODS: A prospective practice-based study was performed using questionnaires and physical examination (n=592). AD subsets were defined using verbal r...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Raj Chovatiya Donald Lei Adnan Ahmed Rajeev Chavda Sylvie Gabriel Jonathan I Silverberg Source Type: research

Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00262-3. doi: 10.1016/j.anai.2021.03.030. Online ahead of print.ABSTRACTBACKGROUND: Separating viral-induced wheezers from asthmatics is challenging, and there are no guidelines for children under 6 years of age. Impulse oscillometry is feasible beginning 4-year old children.OBJECTIVE: To explore the use of impulse oscillometry in diagnosing and monitoring asthma in young children and evaluating treatment response to inhaled corticosteroid.METHODS: Forty-two children (median age 5.3 years, range 4.0-7.9 years) with doctor diagnosed asthma and lability in oscillometry wer...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Janne Burman L Pekka Malmberg Sami Remes Tuomas Jartti Anna S Pelkonen Mika J M äkelä Source Type: research

Discontinuation of inhaled corticosteroids in patients with controlled asthma: The DISCO study
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00263-5. doi: 10.1016/j.anai.2021.03.031. Online ahead of print.ABSTRACTBACKGROUND: Although inhaled corticosteroids (ICSs) are the recommended first-line therapy for asthma, determining whether to continue or discontinue ICS treatment in patients with mild asthma remains challenging for clinicians. Several studies have demonstrated that patients with mild-persistent asthma maintained a well-controlled state after ICS withdrawal. However, the long-term outcomes of ICS withdrawal have not yet been determined.OBJECTIVE: We aimed to determine the possible clinical outcomes ...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Jung-Hyun Kim Juhae Jin Seo Young Park So-Young Park Hyo-Jung Kim Min-Hye Kim Hyouk-Soo Kwon Woo-Jung Song Sae-Hoon Kim Heung-Woo Park Yoon-Seok Chang You Sook Cho Young-Joo Cho Sang-Heon Cho Hee-Bom Moon Tae-Bum Kim Source Type: research

Clinical phenotyping of atopic dermatitis using combined itch and lesional severity: A prospective observational study
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00220-9. doi: 10.1016/j.anai.2021.03.019. Online ahead of print.ABSTRACTBACKGROUND: Atopic dermatitis (AD) patients have heterogeneous clinical phenotypes, including different combinations of itch and lesional severity. Little is known about the characteristics and course of these subtypes.OBJECTIVE: To determine the characteristics, associations, burden, and course of AD patients using combined itch and lesional severity.METHODS: A prospective practice-based study was performed using questionnaires and physical examination (n=592). AD subsets were defined using verbal r...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Raj Chovatiya Donald Lei Adnan Ahmed Rajeev Chavda Sylvie Gabriel Jonathan I Silverberg Source Type: research

Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00262-3. doi: 10.1016/j.anai.2021.03.030. Online ahead of print.ABSTRACTBACKGROUND: Separating viral-induced wheezers from asthmatics is challenging, and there are no guidelines for children under 6 years of age. Impulse oscillometry is feasible beginning 4-year old children.OBJECTIVE: To explore the use of impulse oscillometry in diagnosing and monitoring asthma in young children and evaluating treatment response to inhaled corticosteroid.METHODS: Forty-two children (median age 5.3 years, range 4.0-7.9 years) with doctor diagnosed asthma and lability in oscillometry wer...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Janne Burman L Pekka Malmberg Sami Remes Tuomas Jartti Anna S Pelkonen Mika J M äkelä Source Type: research

Discontinuation of inhaled corticosteroids in patients with controlled asthma: The DISCO study
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00263-5. doi: 10.1016/j.anai.2021.03.031. Online ahead of print.ABSTRACTBACKGROUND: Although inhaled corticosteroids (ICSs) are the recommended first-line therapy for asthma, determining whether to continue or discontinue ICS treatment in patients with mild asthma remains challenging for clinicians. Several studies have demonstrated that patients with mild-persistent asthma maintained a well-controlled state after ICS withdrawal. However, the long-term outcomes of ICS withdrawal have not yet been determined.OBJECTIVE: We aimed to determine the possible clinical outcomes ...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Jung-Hyun Kim Juhae Jin Seo Young Park So-Young Park Hyo-Jung Kim Min-Hye Kim Hyouk-Soo Kwon Woo-Jung Song Sae-Hoon Kim Heung-Woo Park Yoon-Seok Chang You Sook Cho Young-Joo Cho Sang-Heon Cho Hee-Bom Moon Tae-Bum Kim Source Type: research

Clinical phenotyping of atopic dermatitis using combined itch and lesional severity: A prospective observational study
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00220-9. doi: 10.1016/j.anai.2021.03.019. Online ahead of print.ABSTRACTBACKGROUND: Atopic dermatitis (AD) patients have heterogeneous clinical phenotypes, including different combinations of itch and lesional severity. Little is known about the characteristics and course of these subtypes.OBJECTIVE: To determine the characteristics, associations, burden, and course of AD patients using combined itch and lesional severity.METHODS: A prospective practice-based study was performed using questionnaires and physical examination (n=592). AD subsets were defined using verbal r...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Raj Chovatiya Donald Lei Adnan Ahmed Rajeev Chavda Sylvie Gabriel Jonathan I Silverberg Source Type: research

Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00262-3. doi: 10.1016/j.anai.2021.03.030. Online ahead of print.ABSTRACTBACKGROUND: Separating viral-induced wheezers from asthmatics is challenging, and there are no guidelines for children under 6 years of age. Impulse oscillometry is feasible beginning 4-year old children.OBJECTIVE: To explore the use of impulse oscillometry in diagnosing and monitoring asthma in young children and evaluating treatment response to inhaled corticosteroid.METHODS: Forty-two children (median age 5.3 years, range 4.0-7.9 years) with doctor diagnosed asthma and lability in oscillometry wer...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Janne Burman L Pekka Malmberg Sami Remes Tuomas Jartti Anna S Pelkonen Mika J M äkelä Source Type: research

Discontinuation of inhaled corticosteroids in patients with controlled asthma: The DISCO study
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00263-5. doi: 10.1016/j.anai.2021.03.031. Online ahead of print.ABSTRACTBACKGROUND: Although inhaled corticosteroids (ICSs) are the recommended first-line therapy for asthma, determining whether to continue or discontinue ICS treatment in patients with mild asthma remains challenging for clinicians. Several studies have demonstrated that patients with mild-persistent asthma maintained a well-controlled state after ICS withdrawal. However, the long-term outcomes of ICS withdrawal have not yet been determined.OBJECTIVE: We aimed to determine the possible clinical outcomes ...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Jung-Hyun Kim Juhae Jin Seo Young Park So-Young Park Hyo-Jung Kim Min-Hye Kim Hyouk-Soo Kwon Woo-Jung Song Sae-Hoon Kim Heung-Woo Park Yoon-Seok Chang You Sook Cho Young-Joo Cho Sang-Heon Cho Hee-Bom Moon Tae-Bum Kim Source Type: research

Clinical phenotyping of atopic dermatitis using combined itch and lesional severity: A prospective observational study
Ann Allergy Asthma Immunol. 2021 Apr 2:S1081-1206(21)00220-9. doi: 10.1016/j.anai.2021.03.019. Online ahead of print.ABSTRACTBACKGROUND: Atopic dermatitis (AD) patients have heterogeneous clinical phenotypes, including different combinations of itch and lesional severity. Little is known about the characteristics and course of these subtypes.OBJECTIVE: To determine the characteristics, associations, burden, and course of AD patients using combined itch and lesional severity.METHODS: A prospective practice-based study was performed using questionnaires and physical examination (n=592). AD subsets were defined using verbal r...
Source: Annals of Allergy, Asthma and Immunology - April 5, 2021 Category: Allergy & Immunology Authors: Raj Chovatiya Donald Lei Adnan Ahmed Rajeev Chavda Sylvie Gabriel Jonathan I Silverberg Source Type: research

Common variable immunodeficiency in association with autoimmune encephalitis, collagenous gastritis and colitis
Ann Allergy Asthma Immunol. 2021 Mar 31:S1081-1206(21)00261-1. doi: 10.1016/j.anai.2021.03.028. Online ahead of print.NO ABSTRACTPMID:33812019 | DOI:10.1016/j.anai.2021.03.028 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 3, 2021 Category: Allergy & Immunology Authors: Joshua G Jacob John D E Parratt Christopher J Kiely Suran L Fernando Source Type: research

COVID Fatigue in the Allergy Clinic
Ann Allergy Asthma Immunol. 2021 Mar 31:S1081-1206(21)00259-3. doi: 10.1016/j.anai.2021.03.027. Online ahead of print.NO ABSTRACTPMID:33812020 | DOI:10.1016/j.anai.2021.03.027 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 3, 2021 Category: Allergy & Immunology Authors: Joseph P Forester Sumana C Reddy J Wesley Sublett Marissa R Shams J Allen Meadows Source Type: research