Bruton's tyrosine kinase inhibition for the treatment of allergic disorders
Ann Allergy Asthma Immunol. 2024 Mar 14:S1081-1206(24)00145-5. doi: 10.1016/j.anai.2024.03.002. Online ahead of print.ABSTRACTIgE signaling through its high-affinity receptor FcεRI is central to the pathogenesis of numerous allergic disorders. Oral inhibitors of Bruton's tyrosine kinase (BTKis), which are currently FDA-approved for the treatment of B cell malignancies, broadly inhibit the FcεRI pathway in human mast cells and basophils and therefore may be effective allergen-independent therapies for a variety of allergic diseases. The application of these drugs to the allergy space was previously limited by the low kina...
Source: Annals of Allergy, Asthma and Immunology - March 16, 2024 Category: Allergy & Immunology Authors: Erica V Lin Ragha V Suresh Melanie C Dispenza Source Type: research

Activated non-neuronal cholinergic system correlates with non-type 2 inflammation and exacerbations in severe asthma
Non-neuronal cholinergic system (NNCS) contributes to various inflammatory airway diseases. However, the role of NNCS in severe asthma (SA) remains largely unexplored. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 16, 2024 Category: Allergy & Immunology Authors: Dan Huang, Li Zhang, Ying Liu, Ji Wang, Jie Zhang, Katherine J Baines, Gang Liu, Alan Chen-Yu Hsu, Fang Wang, Zhihong Chen, Brian G. Oliver, Min Xie, Ling Qin, Dan Liu, Huajing Wan, Fengming Luo, Weimin Li, Gang Wang, Peter G. Gibson Tags: Original Article Source Type: research

Clinical Characteristics and Management of Pediatric Egg-Induced Anaphylaxis: A Cross-Sectional Study
Egg is the third most common food allergy in children; however, data on pediatric egg-induced anaphylaxis are sparse. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Connor Prosty, Moniah Alyasin, Sofianne Gabrielli, Ann E Clarke, Judy Morris, Jocelyn Gravel, Rodrick Lim, Edmond S. Chan, Ran D. Goldman, Andrew O'Keefe, Jennifer Gerdts, Derek K. Chu, Julia Upton, Elana Hochstadter, Jocelyn Moisan, Adam Bretholz, Christ Tags: Original Article Source Type: research

Evidence for two clusters among non-eosinophilic asthmatics
Although asthma is often seen as an eosinophilic disease associated with atopy non eosinophilic asthmatics represent a substantial part of asthmatic population. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Halehsadat Nekoee Zahraei, Florence Schleich, Gilles Louis, Sara Gerday, Mare Sabbe, Nicolas Bougard, Fran çoise Guissard, Virginie Paulus, Monique Henket, Benoit Petre, Anne-Françoise Donneau, Renaud Louis Tags: Original Article Source Type: research

Gut microbiome in the first 1000 days and risk for childhood food allergy
To summarize recent data on the association between gut microbiome composition and food allergy (FA) in early childhood and highlight potential host-microbiome interactions that reinforce or abrogate oral tolerance. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Erin C. Davis, Cynthia Monaco, Richard Insel, Kirsi M. J ärvinen Tags: Review Source Type: research

Advancing assessment of asthma control with a composite tool: the Asthma Impairment and Risk Questionnaire
National and international asthma guidelines and reports do not include control tools that combine impairment assessment with exacerbation history in one instrument. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Bradley E. Chipps, Robert S. Zeiger, David A. Beuther, Robert A. Wise, William McCann, Joan Reibman, Maureen George, Ileen Gilbert, James M. Eudicone, Karin S. Coyne, Gale Harding, Kevin R. Murphy Tags: Original Article Source Type: research

Associations between cord blood acetaminophen biomarkers and childhood asthma with and without allergic comorbidities
CONCLUSION: In a prospective birth cohort, cord blood acetaminophen biomarkers were associated with an increased risk of childhood asthma without allergic comorbidities, but were not associated with childhood asthma with allergic comorbidities.PMID:38484838 | DOI:10.1016/j.anai.2024.03.001 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 14, 2024 Category: Allergy & Immunology Authors: Yijun Li Xiumei Hong Aruna Chandran Corinne A Keet Clary B Clish Liming Liang Lisa P Jacobson Xiaobin Wang Christine Ladd-Acosta Source Type: research

Leveraging Learning Systems to Improve Quality and Patient Safety in Allergen Immunotherapy
Ann Allergy Asthma Immunol. 2024 Mar 12:S1081-1206(24)00144-3. doi: 10.1016/j.anai.2024.03.003. Online ahead of print.ABSTRACTAdverse events occur in all fields of medicine including allergy-immunology, where allergen immunotherapy medical errors can result in significant harm. Though difficult to experience, such errors constitute opportunities for improvement. Identification of system vulnerabilities can allow resolution of latent errors before they become active problems. We review key aspects and frameworks of the medical error response, acknowledging the fundamental responsibility of clinical teams to learn from harm....
Source: Annals of Allergy, Asthma and Immunology - March 14, 2024 Category: Allergy & Immunology Authors: Alexandra E Conway Chase Rupprecht Priya Bansal Irene Yuan Ziwei Wang Marcus S Shaker Marylee Verdi Joel Bradley Source Type: research

Associations between cord blood acetaminophen biomarkers and childhood asthma with and without allergic comorbidities
CONCLUSION: In a prospective birth cohort, cord blood acetaminophen biomarkers were associated with an increased risk of childhood asthma without allergic comorbidities, but were not associated with childhood asthma with allergic comorbidities.PMID:38484838 | DOI:10.1016/j.anai.2024.03.001 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 14, 2024 Category: Allergy & Immunology Authors: Yijun Li Xiumei Hong Aruna Chandran Corinne A Keet Clary B Clish Liming Liang Lisa P Jacobson Xiaobin Wang Christine Ladd-Acosta Source Type: research

Leveraging Learning Systems to Improve Quality and Patient Safety in Allergen Immunotherapy
Ann Allergy Asthma Immunol. 2024 Mar 12:S1081-1206(24)00144-3. doi: 10.1016/j.anai.2024.03.003. Online ahead of print.ABSTRACTAdverse events occur in all fields of medicine including allergy-immunology, where allergen immunotherapy medical errors can result in significant harm. Though difficult to experience, such errors constitute opportunities for improvement. Identification of system vulnerabilities can allow resolution of latent errors before they become active problems. We review key aspects and frameworks of the medical error response, acknowledging the fundamental responsibility of clinical teams to learn from harm....
Source: Annals of Allergy, Asthma and Immunology - March 14, 2024 Category: Allergy & Immunology Authors: Alexandra E Conway Chase Rupprecht Priya Bansal Irene Yuan Ziwei Wang Marcus S Shaker Marylee Verdi Joel Bradley Source Type: research

Bruton's tyrosine kinase inhibition for the treatment of allergic disorders
IgE signaling through its high-affinity receptor Fc εRI is central to the pathogenesis of numerous allergic disorders. Oral inhibitors of Bruton's tyrosine kinase (BTKis), which are currently FDA-approved for the treatment of B cell malignancies, broadly inhibit the FcεRI pathway in human mast cells and basophils and therefore may be effective alle rgen-independent therapies for a variety of allergic diseases. The application of these drugs to the allergy space was previously limited by the low kinase selectivity and subsequent toxicities of early-generation compounds. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 14, 2024 Category: Allergy & Immunology Authors: Erica V. Lin, Ragha V. Suresh, Melanie C. Dispenza Tags: Review Source Type: research

Undercooked Wheat Allergy and New Wheat Allergens - A Case Report
Ann Allergy Asthma Immunol. 2024 Mar 11:S1081-1206(24)00148-0. doi: 10.1016/j.anai.2024.03.005. Online ahead of print.NO ABSTRACTPMID:38479710 | DOI:10.1016/j.anai.2024.03.005 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Ana Lu ísa Pinhal Borja Bartolom é Diana Silva Source Type: research

Who are the potential patients for Omalizumab for Food Allergy?
Ann Allergy Asthma Immunol. 2024 Mar 11:S1081-1206(24)00147-9. doi: 10.1016/j.anai.2024.03.006. Online ahead of print.NO ABSTRACTPMID:38479711 | DOI:10.1016/j.anai.2024.03.006 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Hugh A Sampson J Andrew Bird David Fleischer Wayne G Shreffler Jonathan Spergel Source Type: research

Real-world safety experience with Peanut (Arachis hypogaea) Allergen Powder-dnfp in 2,500 peanut-allergic children
Ann Allergy Asthma Immunol. 2024 Mar 11:S1081-1206(24)00142-X. doi: 10.1016/j.anai.2024.02.027. Online ahead of print.NO ABSTRACTPMID:38479712 | DOI:10.1016/j.anai.2024.02.027 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Michele Jara Ekaterina Walker Stephen Tilles Aikaterini Anagnostou Source Type: research

Undercooked Wheat Allergy and New Wheat Allergens - A Case Report
Ann Allergy Asthma Immunol. 2024 Mar 11:S1081-1206(24)00148-0. doi: 10.1016/j.anai.2024.03.005. Online ahead of print.NO ABSTRACTPMID:38479710 | DOI:10.1016/j.anai.2024.03.005 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Ana Lu ísa Pinhal Borja Bartolom é Diana Silva Source Type: research