High anxiety and health-related quality-of-life in families with children with food allergy during COVID-19
Food allergy has a known impact on quality of life (QoL), but this has not been extensively studied during the COVID-19 pandemic. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 17, 2020 Category: Allergy & Immunology Authors: J.L.P. Protudjer, M. Golding, M.R. Salisbury, E.M. Abrams, L.E. Roos Source Type: research

Factors Contributing to Underuse of Epinephrine Autoinjectors in Pediatric Patients with Food Allergy
Epinephrine autoinjectors (EA) are the standard of care for severe food allergic reactions, although they are frequently underused or misused. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 17, 2020 Category: Allergy & Immunology Authors: Brittany Glassberg, Anna Nowak-Wegrzyn, Julie Wang Source Type: research

Lipid-mediated innate lymphoid cell recruitment and activation in AERD
To synthesize investigations into the role of lipid-mediated recruitment and activation of ILC2s in AERD. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 17, 2020 Category: Allergy & Immunology Authors: Kellen J. Cavagnero, Taylor A. Doherty Tags: Review Source Type: research

Gender effects in the association between airway microbiome and asthma.
CONCLUSION: The airway microbiome differed by gender and gender effects exist in the association of airway microbial markers and asthma. Future airway microbiome studies may yield better resolution if the context of specific gender is considered. The airway microbiome is a potential mechanism driving gender differences in asthma. PMID: 32931909 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 12, 2020 Category: Allergy & Immunology Authors: Chen R, Wang L, Koch T, Curtis V, Yin-DeClue H, Handley SA, Shan L, Holtzman MJ, Castro M, Wang L Tags: Ann Allergy Asthma Immunol Source Type: research

Exposomal Research in the Context of Birth Cohorts - What have they taught us?
Abstract OBJECTIVE: Exposome encompasses all human environmental exposures from conception onwards. The impact of environmental exposures is greatest in critical stages of life including fetal and early childhood. Birth cohorts provide a good study setting to assess exposome in the sensitive periods of life. Here, we review birth cohorts with an exposomic approach, their key outcomes and challenges. DATA SOURCES: MEDLINE was searched for birth cohorts that have employed an exposomic approach. Study Selections Relevant studies in English language were selected and reviewed. RESULTS: The outcomes of birth ...
Source: Annals of Allergy, Asthma and Immunology - September 11, 2020 Category: Allergy & Immunology Authors: Baluch N, Gallant M, Ellis AK Tags: Ann Allergy Asthma Immunol Source Type: research

Exposomal Research in the Context of Birth Cohorts - What have they taught us?
Exposome encompasses all human environmental exposures from conception onwards. The impact of environmental exposures is greatest in critical stages of life including fetal and early childhood. Birth cohorts provide a good study setting to assess exposome in the sensitive periods of life. Here, we review birth cohorts with an exposomic approach, their key outcomes and challenges. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 11, 2020 Category: Allergy & Immunology Authors: Narges Baluch, Mallory Gallant, Anne K. Ellis Tags: Review Source Type: research

Gender effects in the association between airway microbiome and asthma
Gender differences are found in asthma susceptibility and severity. Accumulating evidence has linked airway microbiome dysbiosis with asthma and the airway microbial communities are found to be different by gender. However, whether gender modifies the link between airway microbiome and asthma has not been investigated. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 11, 2020 Category: Allergy & Immunology Authors: Renjin Chen, Leran Wang, Tammy Koch, Vanessa Curtis, Huiqing Yin-DeClue, Scott A. Handley, Liang Shan, Michael J. Holtzman, Mario Castro, Leyao Wang Source Type: research

Exhaled nitric oxide measurements are not influenced by anti-eosinophil therapy in asthmatics: a retrospective analysis.
PMID: 32920056 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 10, 2020 Category: Allergy & Immunology Authors: Ramonell RP, Eun-Hyung Lee F, Levy JM, Kuruvilla M Tags: Ann Allergy Asthma Immunol Source Type: research

Exhaled nitric oxide measurements are not influenced by anti-eosinophil therapy in asthmatics: a retrospective analysis
The heterogeneity of even “well-defined” type 2 (T2) asthma is reflected by the absence of uniform response to T2 blockade despite recruitment of subjects with a strong T2 signal. Fractional exhaled nitric oxide (FeNO) is a biomarker elevated in uncontrolled T2-asthma secondary to IL-13 induced nitric oxide synthase expr ession in the airway epithelium. While FeNO is reduced by anti-IgE and anti-IL-4/13 therapies(1-5), it did not change in studies with mepolizumab, suggesting the absence of modulation by anti-eosinophil therapy(6). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 9, 2020 Category: Allergy & Immunology Authors: Richard P. Ramonell, F. Eun-Hyung Lee, Joshua M. Levy, Merin Kuruvilla Tags: Letters Source Type: research

Differentiating characteristics of asthmatic patients in the SARS-CoV2 infection.
te;nchez CS PMID: 32911055 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 7, 2020 Category: Allergy & Immunology Authors: Calderón JL, Martin PB, Rodriguez RG, Cataldi HC, Sánchez CS Tags: Ann Allergy Asthma Immunol Source Type: research

Challenges in Skin Testing for Progestogen Hypersensitivity.
PMID: 32911056 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 7, 2020 Category: Allergy & Immunology Authors: Foer D, Tran LK, Wickner P, Castells M, Marquis KA, Buchheit KM Tags: Ann Allergy Asthma Immunol Source Type: research

Indoor endotoxin, proximity to a major roadway, and severe asthma exacerbations among children in Puerto Rico.
CONCLUSION: Our findings suggest that residential proximity to a major road modifies the estimated effect of endotoxin on severe asthma exacerbations in children. PMID: 32911057 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 7, 2020 Category: Allergy & Immunology Authors: Rosser F, Han YY, Forno E, Acosta-Pérez E, Canino G, Celedón JC Tags: Ann Allergy Asthma Immunol Source Type: research

Novel basophil activation test in diagnosis of povidone anaphylaxis.
PMID: 32911058 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 7, 2020 Category: Allergy & Immunology Authors: Murthee KG, Varese N, Hew M, O'Hehir RE, Zubrinich C Tags: Ann Allergy Asthma Immunol Source Type: research

Trends in U.S. hospitalizations for anaphylaxis among infants and toddlers: 2006-2015.
Abstract BACKGROUND: Anaphylaxis is a potentially fatal acute allergic reaction. Its overall prevalence appears to be rising, but little is known about U.S. hospitalization trends among infants and toddlers. OBJECTIVE: To identify the trends and predictors of hospitalization for anaphylaxis among infants and toddlers. METHODS: We used the nationally representative National Inpatient Sample (NIS), from 2006-2015, to perform an analysis of trends in U.S. hospitalizations for anaphylaxis among infants and toddlers (age
Source: Annals of Allergy, Asthma and Immunology - September 7, 2020 Category: Allergy & Immunology Authors: Robinson LB, Arroyo AC, Faridi MK, Rudders SA, Camargo CA Tags: Ann Allergy Asthma Immunol Source Type: research

Indoor endotoxin, proximity to a major roadway, and severe asthma exacerbations among children in Puerto Rico
Few studies have examined concurrent exposure to household endotoxin and traffic-related air pollution (TRAP) in relation to childhood asthma, yet both factors are associated with asthma outcomes. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 7, 2020 Category: Allergy & Immunology Authors: Franziska Rosser, Yueh-Ying Han, Erick Forno, Edna Acosta-P érez, Glorisa Canino, Juan C. Celedón Tags: Original Article Source Type: research

Trends in U.S. hospitalizations for anaphylaxis among infants and toddlers: 2006-2015
Anaphylaxis is a potentially fatal acute allergic reaction. Its overall prevalence appears to be rising, but little is known about U.S. hospitalization trends among infants and toddlers. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 7, 2020 Category: Allergy & Immunology Authors: Lacey B. Robinson, Anna Chen Arroyo, Mohammad Kamal Faridi, Susan A. Rudders, Carlos A. Camargo Tags: Original Article Source Type: research

Novel basophil activation test in diagnosis of povidone anaphylaxis
Medications generally contain two components: the active ingredient – intended to produce the desired therapeutic effect, and excipients – inactive ingredients added for purposes such as improving absorption and product stability. Although considered inert, excipients may represent occult allergens capable of causing allergic reactions. To date, thirty-eight exc ipients have been described to cause symptoms, with an increasing number of reports documenting type 1 hypersensitivity reactions1. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 7, 2020 Category: Allergy & Immunology Authors: Kavitha Garuna Murthee, Nirupama Varese, Mark Hew, Robyn E. O ’Hehir, Celia Zubrinich Tags: Letters Source Type: research

Challenges in Skin Testing for Progestogen Hypersensitivity
Progestogen hypersensitivity (PH) is an increasingly recognized heterogenous clinical entity that presents as hypersensitivity symptoms associated with the progesterone surge during the luteal phase of the menstrual cycle or following exposure to exogenous progestins1. Diagnosis requires a careful clinical history and assessment to evaluate other potential triggers, and at minimum, compatible symptoms associated with exposure to endogenous or exogenous progestogens. Testing modalities used to support the diagnosis include progesterone skin testing, progesterone challenge, inhibition of ovulation with gonadotropin-releasing...
Source: Annals of Allergy, Asthma and Immunology - September 7, 2020 Category: Allergy & Immunology Authors: Dinah Foer, Lena K. Tran, Paige Wickner, Mariana Castells, Kathleen A. Marquis, Kathleen M. Buchheit Tags: Letters Source Type: research

Differentiating characteristics of asthmatic patients in the SARS-CoV2 infection.
- There are no conflicts for any of the authors of the article. There has no been financial support. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 7, 2020 Category: Allergy & Immunology Authors: Jos é Lemus Calderón, Pedro Beneyto Martin, Raúl Guzmán Rodriguez, Horacio Caligaris Cataldi, Carlos Senent Sánchez Tags: Letters Source Type: research

Descriptive analysis of a simplified approach to low-risk drug hypersensitivity reactions.
CONCLUSION: Performing an open PT (without previous tests) in two steps in patients with low-risk drug reactions is safe. However, every case must be analized individually in terms of risk/benefit ratio. PMID: 32896639 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 4, 2020 Category: Allergy & Immunology Authors: Silva Espinosa DL, Rojas Mejia DV, Ramírez Zuluaga LF, Hernadez MO, Serrano Reyes CD Tags: Ann Allergy Asthma Immunol Source Type: research

Skin Tape Sampling Technique Identifies Proinflammatory Cytokines in Atopic Dermatitis Skin.
CONCLUSION: Using minimally invasive STS analysis we identified cytokine profiles easily sampled in AD lesional skin. The expression of these markers correlated with disease severity and reflected changes in TEWL in lesional skin. These markers suggest new response assessment targets for AD skin. PMID: 32896640 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 4, 2020 Category: Allergy & Immunology Authors: Lyubchenko T, Collins HK, Goleva E, Leung DYM Tags: Ann Allergy Asthma Immunol Source Type: research

Descriptive analysis of a simplified approach to low-risk drug hypersensitivity reactions
Evaluation of drug allergy is intricate because of nonstandardized testing and challenge method variability. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 4, 2020 Category: Allergy & Immunology Authors: Diana lucia silva espinosa, Dolly Vanesa Rojas mejia, Luis Fernado Ram írez Zuluaga, Manuela Olaya Hernadez, Carlos Daniel Serrano Reyes Tags: Original Article Source Type: research

Skin Tape Sampling Technique Identifies Proinflammatory Cytokines in Atopic Dermatitis Skin
Monitoring the effects of biologic therapies in skin diseases will benefit from alternative nonivasive skin sampling techniques to examine immune pathways in diseased tissue early and longitudinally. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 4, 2020 Category: Allergy & Immunology Authors: Taras Lyubchenko, Hannah K. Collins, Elena Goleva, Donald Y.M. Leung Tags: Original Article Source Type: research

Eosinophilic fasciitis in common variable immunodeficiency with hypereosinophilia.
PMID: 32891788 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 3, 2020 Category: Allergy & Immunology Authors: Daniels P, Shilian R, Huq M, Hostoffer R Tags: Ann Allergy Asthma Immunol Source Type: research

Eosinophilic fasciitis in common variable immunodeficiency with hypereosinophilia
We report the first case of CVID associated with eosinophilic fasciitis in the United States in the setting of hypereosinophilia. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - September 2, 2020 Category: Allergy & Immunology Authors: Phuong Daniels, Ryan Shilian, Madiha Huq, Robert Hostoffer Tags: Letters Source Type: research

Children and adolescents with allergy and/or asthma seem to be protected from coronavirus disease 2019.
PMID: 32859351 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 30, 2020 Category: Allergy & Immunology Authors: Ciprandi G, Licari A, Filippelli G, Tosca MA, Marseglia GL Tags: Ann Allergy Asthma Immunol Source Type: research

Authors' response.
, Keet C PMID: 32859352 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 30, 2020 Category: Allergy & Immunology Authors: Authors' response. Tags: Ann Allergy Asthma Immunol Source Type: research

Successful desensitization of a patient with Fabry disease with agalsidase beta (Fabrazyme) anaphylaxis after omalizumab pretreatment
Fabry disease is a rare lysosomal storage X-linked genetic disorder caused by pathogenic variants in the α-galactosidase A gene (α-Gal A) resulting in glycolipid accumulation (mainly globotriaosylceramide or globotriaosylsphingosine) within cell lysosomes. Of note, 2 Fabry disease phenotypes in men include a severe form (1:22,570 men) characterized by a reduction in α-Gal A activity and accumulation of globotriaosylceramide in vascular endothelial cells, cardiomyocytes, smooth muscle cells, and podocytes, resulting in progressive multiorgan failure and premature death and a milder form (1:1390 men) that d...
Source: Annals of Allergy, Asthma and Immunology - August 28, 2020 Category: Allergy & Immunology Authors: Ilona DuBuske, Kristin Schmidlin, Jonathan A. Bernstein Tags: Letters Source Type: research

Successful Desensitization Of A Fabry ’s Patient with Agalsidase-Beta (Fabrazyme™) Anaphylaxis After Omalizumab Pre-Treatment
Fabry disease is a rare lysosomal storage X-linked genetic disorder caused by pathogenic variants in the α-galactosidase A gene (α-Gal A) resulting glycolipid accumulation (mainly globotriaosylceramide or globotriaosylsphingosine) within cell lysosomes. Two Fabry Disease phenotypes in males include a severe form (1:22,570 males) characterized by reduced α-Gal A activity and accumulation of Gb3 in va scular endothelial cells, cardiomyocytes, smooth muscle cells, and podocytes resulting in progressive multi-organ failure and premature death and a milder form (1:1,390 males) that develops later in life assoc...
Source: Annals of Allergy, Asthma and Immunology - August 28, 2020 Category: Allergy & Immunology Authors: Ilona DuBuske, Kristin Schmidlin, Jonathan A. Bernstein Tags: Letters Source Type: research

Delayed hypersensitivity reactions to edoxaban
Edoxaban is the fourth approved Direct Oral AntiCoagulant (DOAC) that has been introduced into the European market (2015), after dabigatran (2008), rivaroxaban (2008) and apixaban (2011). Dabigatran is the only direct thrombin inhibitor, whereas apixaban, edoxaban, and rivaroxaban are factor-Xa inhibitors. In a few years DOACs' use steadily increased in clinical practice for the prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF) [1], as well as for treatment and prevention of recurrent deep vein thrombosis (DVT) and pulmonary embolism (PE)[2]. (Source: Annals of Allerg...
Source: Annals of Allergy, Asthma and Immunology - August 28, 2020 Category: Allergy & Immunology Authors: Laura Franceschini, Giulia Carli, Giancarlo Landini, Daniela Matarrese, Alessandro Farsi Tags: Letters Source Type: research

Children and adolescents with allergy and/or asthma seem to be protected from coronavirus disease 2019
Akenroye et  al1 discussed the use of corticosteroids and biologics in asthma during coronavirus disease 2019 (COVID-19) pandemic. COVID-19 began in the People's Republic of China and rapidly spread worldwide.2 Italy was the first European country involved in the pandemic and the first cluster occurring in Sou th Lombardy. The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), penetrates the host cells binding to the angiotensin-converting enzyme 2 (ACE2) receptors. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 26, 2020 Category: Allergy & Immunology Authors: Giorgio Ciprandi, Amelia Licari, Gaetana Filippelli, Maria Angela Tosca, Gian Luigi Marseglia Tags: Correspondence Source Type: research

Authors' response
We thank Ciprandi et  al1 for their salient points related to our recent article and description of their experiences with Italian patients.2 As they pointed out, children and those with allergy and asthma seem to be at a lower risk of coronavirus disease 2019 (COVID-19) and have milder disease.3,4 Recently, however, a severe complication called multisystem inflammatory syndrome in children, which appears to be associated with COVID-19, has been described in pediatric patients.5 The incidence of this Kawasaki disease–like condition, its causes, and optimal management are still under investigation. (Source: Annal...
Source: Annals of Allergy, Asthma and Immunology - August 26, 2020 Category: Allergy & Immunology Authors: Ayobami T. Akenroye, Robert Wood, Corinne Keet Tags: Correspondence Source Type: research

Information for Readers
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 26, 2020 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 26, 2020 Category: Allergy & Immunology Source Type: research

Information for Authors
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 26, 2020 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 26, 2020 Category: Allergy & Immunology Source Type: research

Association between cognitive function and asthma in adults.
PMID: 32858237 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 25, 2020 Category: Allergy & Immunology Authors: Rhyou HI, Nam YH Tags: Ann Allergy Asthma Immunol Source Type: research

U.S. Public Health Resources for COVID-19 That Are Relevant to Allergy/Immunology.
PMID: 32858238 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 25, 2020 Category: Allergy & Immunology Authors: Hsu J Tags: Ann Allergy Asthma Immunol Source Type: research

Association between cognitive function and asthma in adults
Mild cognitive impairment (MCI) is a transitional state between the cognition of normal aging and mild dementia. People with MCI have an increased risk of developing Alzheimer ’s disease at a rate of 10% to 15% per year or prodrome of dementia.1 Cognitive impairment is a complex chronic condition, and its prevalence increases with age.2 The presence of coexisting chronic conditions such as chronic obstructive pulmonary disease and vision or hearing impairment increases healthcare utilization and contributes to a higher risk of serious health outcomes. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 25, 2020 Category: Allergy & Immunology Authors: Hyo-In Rhyou, Young-Hee Nam Source Type: research

On the surface
To discuss the skin microbiome modulates immunity by interactions between skin immunology with keratinocytes to combat pathogens. Allergic disorders are classified by immunoglobulin E sensitivity and aberrant TH2 cell responses, and an increasing number of studies have described the associations with skin microbiome fluctuations. In this review, we discuss commensal-epidermal homeostasis and its influence on allergic disease. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 24, 2020 Category: Allergy & Immunology Authors: Stanley B. DeVore, Tammy Gonzalez, Michael G. Sherenian, Andrew B. Herr, Gurjit K. Khurana Hershey Tags: CME Review Source Type: research

Food protein –induced allergic proctocolitis may have distinct phenotypes
Food protein –induced allergic proctocolitis (FPIAP) is a non–immunoglobulin E (IgE)-mediated food allergy, which presents with bloody mucoid stool in infants. Although IgE-mediated allergy and sensitizations to offending foods have been described in other non–IgE-mediated food allergies, it has not been i nvestigated in FPIAP. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 24, 2020 Category: Allergy & Immunology Authors: P ınar Gur Cetinkaya, Melike Kahveci, Umit Murat Sahiner, Bulent Enis Sekerel, Ozge Soyer Source Type: research

US public health resources for coronavirus disease 2019 that are relevant to allergy-immunology
US public health responses to emerging infections have involved public health agencies, health care systems, community leaders, and others. This Perspective focuses on providing an overview of the US public health resources (as of August 2020) related to the coronavirus disease 2019 (COVID-19) pandemic that might be most relevant to allergists-immunologists. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 24, 2020 Category: Allergy & Immunology Authors: Joy Hsu Tags: Perspective Source Type: research

On the Surface: Skin Microbial Exposure Contributes to Allergic Disease.
PMID: 32853786 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 24, 2020 Category: Allergy & Immunology Authors: DeVore SB, Gonzalez T, Sherenian MG, Herr AB, Khurana Hershey GK Tags: Ann Allergy Asthma Immunol Source Type: research

Food protein-induced allergic proctocolitis may have distinct phenotypes.
Abstract BACKGROUND: Food protein-induced allergic proctocolitis (FPIAP) is a nonimmunoglobulin E (IgE)-mediated food allergy, which presents with bloody mucoid stool in infants. OBJECTIVE: Although IgE-mediated allergy and sensitizations to offending foods have been described in other non-IgE-mediated food allergies, it has not been investigated in FPIAP. Therefore, we aimed to investigate IgE-mediated allergy and sensitization to offending foods in FPIAP. METHODS: Patients (n=204) were retrospectively recruited and grouped as FPIAP (n=180; FPIAP+/-symptoms of IgE-mediated food hypersensitivity to offen...
Source: Annals of Allergy, Asthma and Immunology - August 24, 2020 Category: Allergy & Immunology Authors: Cetinkaya PG, Kahveci M, Sahiner UM, Sekerel BE, Soyer O Tags: Ann Allergy Asthma Immunol Source Type: research

U.S. Public Health Resources for COVID-19 That Are Relevant to Allergy/Immunology
U.S. public health responses to emerging infections have involved public health agencies, healthcare systems, community leaders, and others. This Perspective will focus on providing an overview of U.S. public health resources (as of August 2020) related to the coronavirus disease 2019 (COVID-19) pandemic that might be most relevant to allergists/immunologists. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 24, 2020 Category: Allergy & Immunology Authors: Joy Hsu Tags: Perspective Source Type: research

Food protein-induced allergic proctocolitis may have distinct phenotypes
Background: Food protein-induced allergic proctocolitis (FPIAP) is a nonimmunoglobulin E (IgE)-mediated food allergy, which presents with bloody mucoid stool in infants.Objective: Although IgE-mediated allergy and sensitizations to offending foods have been described in other non-IgE-mediated food allergies, it has not been investigated in FPIAP. Therefore, we aimed to investigate IgE-mediated allergy and sensitization to offending foods in FPIAP.Methods: Patients (n=204) were retrospectively recruited and grouped as FPIAP (n=180; FPIAP+/-symptoms of IgE-mediated food hypersensitivity to offending and non-offending foods a...
Source: Annals of Allergy, Asthma and Immunology - August 24, 2020 Category: Allergy & Immunology Authors: P ınar Gur Cetinkaya, Melike Kahveci, Umit Murat Sahiner, Bulent Enis Sekerel, Ozge Soyer Tags: Original Article Source Type: research

On the Surface: Skin Microbial Exposure Contributes to Allergic Disease
Allergic disorders, characterized by IgE sensitivity, are steadily rising in prevalence worldwide and significantly impact quality of life in all age groups1. A growing body of literature is revealing that the skin microbiome, the community of bacteria, viruses and fungi present on the skin, plays a significant role in modulating allergic disorders. The microbiome is vital for the development of the immune system and homeostasis. Changes in microbial composition and function, termed dysbiosis, have been linked to alterations in immune responses and to the development of allergic diseases. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 24, 2020 Category: Allergy & Immunology Authors: Stanley B. DeVore, Tammy Gonzalez, Michael G. Sherenian, Andrew B. Herr, Gurjit K. Khurana Hershey Tags: CME Reviews Source Type: research

From the pages of AllergyWatch ®
For this month's edition of “From the Pages of AllergyWatch,” I have chosen reviews of articles of interest to the clinical allergist. The first study found that wheezing infants with atopic sensitization at the time of the first wheezing episode was strongly associated with bronchial reactivity in childhood. The next revi ew, of an article published in the Annals of Allergy, Asthma& Immunology, investigated the complexity of atopic sensitization to foods in children with atopic dermatitis (AD). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 17, 2020 Category: Allergy & Immunology Authors: Stanley M. Fineman, John Oppenheimer, Vivian Hernandez-Trujillo, Bradley E. Chipps Tags: From the pages of AllergyWatch ® Source Type: research

A fatal case of coronavirus disease 2019 in a patient with common variable immunodeficiency
Common variable immunodeficiency (CVID) is a heterogeneous group of primary immunodeficiency syndromes characterized by hypogammaglobulinemia and impaired vaccine responses. Although immunodeficiency is described as a risk factor for coronavirus disease 2019 (COVID-19), limited data are available regarding CVID. Of note, 3 recent reports describe mostly positive outcomes in patients with CVID who were diagnosed as having COVID-19,1-3 with only 1 fatality.3 All these patients had adequate immunoglobulin G (IgG) levels at the time of COVID-19 diagnosis. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 17, 2020 Category: Allergy & Immunology Authors: Jyotsna Mullur, Alberta Wang, Anna Feldweg Tags: Letters Source Type: research

Perceived stress links income loss and urticaria activity during the coronavirus disease 2019 pandemic
The pandemic of coronavirus disease 2019 (COVID-19) has caused substantially adverse effects on health and economy at both individual and societal levels. It was estimated that the worldwide unemployment rate might increase from 4.9% to 5.6% owing to the pandemic.1 Decades of research have accumulated evidence on the adverse impacts of unemployment on poverty-related health outcomes and mental illness, such as stress and anxiety.2 Interestingly, it has been well established that allergic diseases are associated with higher socioeconomic status (SES). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - August 17, 2020 Category: Allergy & Immunology Authors: Minxue Shen, Yangjian Xiao, Yan Yuan, Xiang Chen, Jie Li Tags: Letters Source Type: research