The microbiome of the nose
The human body harbors 10 trillion to 100 trillion microorganisms, vastly outnumbering the quantity of human cells.1 The microbes and their genomes located within a particular area are defined as the microbiome. Microbiomes can be found in all different types of hosts, such as plants, animals, and humans. Research into the human microbiome surged in the late 2000s with the launch of the Human Microbiome Project.1 This project aimed to identify and characterize microorganisms located on environmentally exposed surfaces. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Matthew Rawls, Anne K. Ellis Tags: CME Review Source Type: research

Paraproteinemia and serum protein electrophoresis interpretation
Monoclonal gammopathy may be encountered in an allergist's office during evaluation for primary immunodeficiency, unexplained dermatologic disorders, or acquired forms of angioedema. Serum protein electrophoresis (SPEP) is usually ordered, and an abnormal result should lead to further evaluation until a diagnosis is established or a referral is made to a hematologist or rheumatologist. By definition, monoclonal gammopathy refers to the excessive production of a single immunoglobulin by a clone of plasma cells. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Shailaja Raj, Bhuvana Guha, Cesar Rodriguez, Guha Krishnaswamy Tags: Disease in a Nutshell Source Type: research

The effect of being African American on atopic dermatitis
Atopic Dermatitis is a complex pruritic inflammatory skin disease that is associated with significant impairment of quality of life and high socio-economic burden.1,2 Recent studies reinforce the challenges of managing patients with severe AD as they often suffer from uncontrollable scratching, sleep disturbance, depression and systemic comorbidities.3,4 It is often associated with the atopic march5 and can be complicated by serious infection.6 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Donald Y.M. Leung Tags: Editorial Source Type: research

Erratum
In the abstract, “AK002, a novel Siglec-8 antibody depletes human eosinophils and inhibits anaphylaxis in humanized mice” (Ann Allergy Asthma Immunnol. 2018;121[suppl 1]:D400), on page S20, the authorship byline should read as follows: “B. Youngblood1,*, E. Brock1, R. Falahati1, P. Bryce1, M. Brehm2, J. Leun g1, C. Bebbington1, N. Tomasevic1, 1. San Carlos, CA; 2. Cambridge, MA.” (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Tags: Erratum Source Type: research

Information for Readers
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Source Type: research

Information for Authors
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Source Type: research

Tolerance to poison ivy following vaccine delivery by precipitation
Previous poison ivy vaccines, comprising urushiol in sterile vegetable oils injected subcutaneously, were withdrawn from the market in 1994 for failure to demonstrate statistical efficacy (J.  Slater, personal email communication, March 25, 1999). We had anecdotally found these vaccines to be safe and effective in some patients. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Robert E. Coifman, Catherine F. Yang Tags: Letter Source Type: research

Asthma biologics
Uncontrolled asthma is a significant problem worldwide. It is important to acknowledge that many patients with uncontrolled asthma can be brought under control using medications that have been available now for decades. Unfortunately, nonadherence to regular use of inhaled corticosteroids (ICSs) and long-acting β-agonists (LABAs) is incredibly common, and solving the complex reasons for nonadherence is not straightforward. Recently, 5 injectable asthma biologic medications have become available. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Matthew A. Rank, John J. Oppenheimer Tags: Perspective Source Type: research

Vaccine delivery by precipitation (VDBP) induces tolerance to poison ivy.
PMID: 30578856 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Coifman RE, Yang CF Tags: Ann Allergy Asthma Immunol Source Type: research

The Gut Microbiome in Food Allergy.
CONCLUSION: By advancing research on the microbiome in food allergy, we can further our understanding of food allergy and derive new approaches for its prevention and therapy. PMID: 30578857 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Zhao W, Ho HE, Bunyavanich S Tags: Ann Allergy Asthma Immunol Source Type: research

"Asthma Biologics: Underuse, Overuse, and Best Use?"
"Asthma Biologics: Underuse, Overuse, and Best Use?" Ann Allergy Asthma Immunol. 2018 Dec 19;: Authors: Rank MA, Oppenheimer JJ PMID: 30578858 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Rank MA, Oppenheimer JJ Tags: Ann Allergy Asthma Immunol Source Type: research

Severe uncontrolled eosinophilic asthma, which responded to benralizumab after failure to respond to mepolizumab.
PMID: 30578859 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Kurosawa M, Sutoh E Tags: Ann Allergy Asthma Immunol Source Type: research

Seasonal exacerbation of eosinophilic esophagitis histologic activity in adults and children implicates role of aeroallergens.
PMID: 30578860 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Reed CC, Iglesia EGA, Commins SP, Dellon ES Tags: Ann Allergy Asthma Immunol Source Type: research

The Gut Microbiome in Food Allergy
To review observational human, murine, and interventional trial studies that have examined the gut microbiome in food allergy, and to provide perspective on future investigations in this field. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: William Zhao, Hsi-en Ho, Supinda Bunyavanich Tags: Review Source Type: research

Seasonal exacerbation of eosinophilic esophagitis histologic activity in adults and children implicates role of aeroallergens
Eosinophilic esophagitis (EoE) is a chronic immune/antigen-mediated disorder characterized histologically by eosinophilic-predominant esophageal inflammation and clinically by esophageal dysfunction. The condition is diagnosed when there are at least 15 eosinophils per high-power field (eos/hpf) on esophageal biopsies following the exclusion of alternative etiologies of esophageal eosinophilia.1 –4 EoE contributes significantly to esophageal morbidity and represents the second-leading cause of esophagitis. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Craig C. Reed, Edward G.A. Iglesia, Scott P. Commins, Evan S. Dellon Source Type: research

Severe uncontrolled eosinophilic asthma, which responded to benralizumab after failure to respond to mepolizumab
We present the case of eosinophilic asthma of a 55-year-old female, who was initially diagnosed bronchial asthma by the author in February 2008. The diagnosis was confirmed using the Global Initiative for Asthma guidelines.1 She showed forced expiratory volume in 1 second (FEV1) was 63.9 % of the predicted value with an increase of 12.9 % in FEV1 after 180 μg salbutamol inhaler. She had no history of smoking. She met the American Thoracic Society criteria for a diagnosis of refractory asthma.2 She had non-allergic asthma, diagnosed with serum total IgE level 94 IU/mL and negative results of serum specific IgE for common...
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Motohiro Kurosawa, Eijin Sutoh Source Type: research

Vaccine delivery by precipitation (VDBP) induces tolerance to poison ivy.
Previous poison ivy vaccines, comprising urushiol in sterile vegetable oils injected SQ, were withdrawn in 1994 for failure to demonstrate statistical efficacy (personal communication J.Slater). We ’d found them anecdotally safe and effective in some patients. For highly allergic patients for whom avoidance was not practical we offered immunotherapy with home-made vaccines in accordance with Declaration of Helsinki guidelines for ethical use of "unproven interventions”1. Informed consent w as obtained from all patients. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Robert E. Coifman, Catherine F. Yang Source Type: research

“Asthma Biologics: Underuse, Overuse, and Best Use?”
Uncontrolled asthma is a significant problem worldwide . It is important to acknowledge that many patients with uncontrolled asthma can be brought under control using medications that have been available now for decades. Unfortunately, nonadherence to regular use of ICS/LABA is incredibly common and solving the complex reasons for nonadherence is not straightforward. Recently, we have the addition of 5 injected asthma biologic medications which are intended for patients who are not controlled with ICS/LABA and specific features such as IgE-high (omalizumab), Eosinophils-high (benralizumab, mepolizumab, and reslizumab), and...
Source: Annals of Allergy, Asthma and Immunology - December 19, 2018 Category: Allergy & Immunology Authors: Matthew A. Rank, John J. Oppenheimer Source Type: research

Association of exhaled nitric oxide with ethnicity and sex in rural Georgia youth
Nitric oxide is produced by the human bronchial epithelium1 and is associated with airway eosinophilic inflammation seen in patients with asthma and other airway diseases.2 Airway inflammation is a characteristic of asthma, along with airway hyperresponsiveness and airway obstruction. Inhaled corticosteroids to treat the inflammation are a mainstay of asthma treatment. Measurement of exhaled nitric oxide (eNO) as a biomarker of eosinophilic inflammation is noninvasive, safe, reproducible, and easy to perform; however, the clinical value of measurements has been limited by imprecise reference ranges. (Source: Annals of Alle...
Source: Annals of Allergy, Asthma and Immunology - December 14, 2018 Category: Allergy & Immunology Authors: Brian C. Reed, Jennifer L. Waller, Dennis R. Ownby, Martha S. Tingen Tags: Letter Source Type: research

The Relationship of Exhaled Nitric Oxide with Ethnicity and Gender in Rural Georgia YouthAuthors.
Waller JL, Ownby DR, Tingen MS PMID: 30557616 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 14, 2018 Category: Allergy & Immunology Authors: Authors. Tags: Ann Allergy Asthma Immunol Source Type: research

Associations of urban greenness with asthma and respiratory symptoms in Mexican American children.
PMID: 30557617 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 14, 2018 Category: Allergy & Immunology Authors: Eldeirawi K, Kunzweiler C, Zenk S, Finn P, Nyenhuis S, Rosenberg N, Persky V Tags: Ann Allergy Asthma Immunol Source Type: research

Associations of urban greenness with asthma and respiratory symptoms in Mexican American children
Asthma is one of the most common childhood chronic conditions with approximately 19 million adults and seven million children affected in the United States alone. 1 The etiology of asthma and other allergic conditions is not fully understood, but environmental and lifestyle factors have been implicated in the inception of these conditions. In the United States, the prevalence of asthma and asthma related symptoms is disproportionately high in urban poor neighborhoods.2-4 Although this might be due partly to sociodemographic factors, studies have suggested that urbanization and its detrimental impact on the natural environm...
Source: Annals of Allergy, Asthma and Immunology - December 14, 2018 Category: Allergy & Immunology Authors: Kamal Eldeirawi, Colin Kunzweiler, Shannon Zenk, Patricia Finn, Sharmilee Nyenhuis, Natalya Rosenberg, Victoria Persky Source Type: research

The Relationship of Exhaled Nitric Oxide with Ethnicity and Gender in Rural Georgia YouthAuthors
Nitric oxide is produced by the human bronchial epithelium1 and is associated with airway eosinophilic inflammation seen in asthmatics and other airway diseases.2 Airway inflammation is a characteristic of asthma, along with airway hyper-responsiveness and airway obstruction. Inhaled corticosteroids (ICS) to treat the inflammation are a mainstay of asthma treatment. Measurement of exhaled nitric oxide (eNO) as a biomarker of eosinophilic inflammation is noninvasive, safe, reproducible, and easy to perform; however, the clinical value of measurements has been limited by imprecise reference ranges. (Source: Annals of Allergy...
Source: Annals of Allergy, Asthma and Immunology - December 14, 2018 Category: Allergy & Immunology Authors: Brian C. Reed, Jennifer L. Waller, Dennis R. Ownby, Martha S. Tingen Tags: Letters Source Type: research

The Microbiome in Asthma: Role in pathogenesis, phenotype, and response to treatment
Asthma was first described by Hippocrates as a disease of breathlessness, potentially caused by emotional distress1. The 17th century writings of Sir John Floyer describe bronchial constriction and the concepts of attacks and triggers2. In the 20th century, mounting evidence led to the characterization of asthma as an inflammatory condition2. Asthma symptoms were recognized as narrowing of the airways with distinctive sputum and swelling of the bronchial mucous membranes, triggered by a variety of circumstances or exposures that stimulate immune cells2. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 13, 2018 Category: Allergy & Immunology Authors: Ariangela J. Kozik, Yvonne J. Huang Tags: Review Source Type: research

Modulating the Microbiome: The Future of Allergy Therapeutics?
The incidence of IgE sensitization and associated diseases has been on the rise since the late 19th century reaching epidemic proportions in the current era.1 This increase has occurred over just four generations, a rate that far exceeds the rate at which genetics alone could account for the change. Explaining the cause for this epidemic has proven to be a challenge for epidemiologists, scientists and clinical researchers alike. In 1980, David Strachan proposed the well-known “hygiene hypothesis” which proposed that the increase in hay fever and eczema was a result of the decrease in “opportunity for cros...
Source: Annals of Allergy, Asthma and Immunology - December 13, 2018 Category: Allergy & Immunology Authors: Christina E. Ciaccio Source Type: research

Acute Eosinophilic Pneumonia due to Piperacillin/Tazobactam
Eosinophilic pneumonia (EP) is a rare and severe disease that belongs to the group of pulmonary eosinophilias (PE). There are two clinical presentations: chronic eosinophilic pneumonia (CEP) and acute eosinophilic pneumonia (AEP). In 1989, Allen et al. described the first case of AEP. 1 Many causes of AEP have been described, although the idiopathic form is the most common.3 We herein present a case of AEP probably due to piperacillin/tazobactam (P/T). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 13, 2018 Category: Allergy & Immunology Authors: Ismael Garc ía-Moguel, Irina Bobolea, Maria Carmen Diéguez Pastor, Guillermo López-Arranz Monge, Ruth Barranco Jimenez Tags: Letters Source Type: research

ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitisation in offspring: a systematic review and meta-analysis
In the last two decades allergic diseases have seen a rise worldwide with children suffering the highest burden of the condition(1). Food allergies, eczema and asthma are the most common allergic disorders in children(1-2). The increasing burden of allergic conditions is an important public health concern and understanding how to prevent the development of allergic diseases is a vital area of research. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 13, 2018 Category: Allergy & Immunology Authors: M. Vahdaninia, H. Mackenzie, T. Dean, S. Helps Source Type: research

The microbiome in asthma
To synthesize evidence on the role of microbiota in asthma pathogenesis, phenotype, and treatment outcomes, and to provide perspective on future research directions and challenges. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 12, 2018 Category: Allergy & Immunology Authors: Ariangela J. Kozik, Yvonne J. Huang Tags: Review Article Source Type: research

ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitization in offspring
Allergic diseases have increased worldwide in the last 2 decades, with children suffering the highest burden of the condition. The ω-3 long-chain poly-unsaturated fatty acid (LCPUFA) possesses anti-inflammatory properties that could lead to a reduction in inflammatory mediators in allergies. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 12, 2018 Category: Allergy & Immunology Authors: Mariam Vahdaninia, Healther Mackenzie, Taraneh Dean, Suzannah Helps Tags: Original Article Source Type: research

Modulating the microbiome
The incidence of immunoglobulin (Ig) E sensitization and associated diseases has been on the rise since the late 19th century, reaching epidemic proportions in the current era.1 This increase has occurred over just 4 generations, a rate that far exceeds the rate at which genetics alone could account for the change. Explaining the cause for this epidemic has proved to be a challenge for epidemiologists, scientists, and clinical researchers alike. In 1980, David Strachan proposed the well-known “hygiene hypothesis,” which proposed that the increase in hay fever and eczema was a result of the decrease in “op...
Source: Annals of Allergy, Asthma and Immunology - December 12, 2018 Category: Allergy & Immunology Authors: Christina E. Ciaccio Tags: Perspective Source Type: research

Acute Eosinophilic Pneumonia due to Piperacillin/Tazobactam.
nge G, Jimenez RB PMID: 30552984 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 12, 2018 Category: Allergy & Immunology Authors: García-Moguel I, Bobolea I, Diéguez Pastor MC, López-Arranz Monge G, Jimenez RB Tags: Ann Allergy Asthma Immunol Source Type: research

Modulating the Microbiome: The Future of Allergy Therapeutics?
PMID: 30552985 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 12, 2018 Category: Allergy & Immunology Authors: Ciaccio CE Tags: Ann Allergy Asthma Immunol Source Type: research

The Microbiome in Asthma: Role in pathogenesis, phenotype, and response to treatment.
PMID: 30552986 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 12, 2018 Category: Allergy & Immunology Authors: Kozik AJ, Huang YJ Tags: Ann Allergy Asthma Immunol Source Type: research

ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitisation in offspring: a systematic review and meta-analysis.
ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitisation in offspring: a systematic review and meta-analysis. Ann Allergy Asthma Immunol. 2018 Dec 12;: Authors: Vahdaninia M, Mackenzie H, Dean T, Helps S PMID: 30552987 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 12, 2018 Category: Allergy & Immunology Authors: Vahdaninia M, Mackenzie H, Dean T, Helps S Tags: Ann Allergy Asthma Immunol Source Type: research

The Asthma Controller Step-down Yardstick.
PMID: 30550809 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 11, 2018 Category: Allergy & Immunology Authors: Chipps BE, Bacharier LB, Murphy KR, Lang D, Farrar JR, Rank M, Oppenheimer J, Zeiger RS Tags: Ann Allergy Asthma Immunol Source Type: research

The role of the skin microbiome in atopic dermatitis.
PMID: 30550810 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 11, 2018 Category: Allergy & Immunology Authors: Nakatsuji T, Gallo RL Tags: Ann Allergy Asthma Immunol Source Type: research

The role of the skin microbiome in atopic dermatitis
Atopic dermatitis (AD) is a common inflammatory skin disease associated with significant medical burden, affecting 15-20% of children and 1-3% of adults worldwide.1 The prevalence of AD has increased by 2-3 folds during the past decade in Western countries. While the cause of this increase remains unknown, meta-analyses have indicated that the risk of AD is lower when associated with potentially protective environmental factors during childhood such as three or more siblings, day care, pet ownership and farm residence. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 11, 2018 Category: Allergy & Immunology Authors: Teruaki Nakatsuji, Richard L. Gallo Tags: CME Reviews Source Type: research

The Asthma Controller Step-down Yardstick
Guidelines for asthma recommend a series of treatment steps (Figure 1) as a framework for disease management.1,2 The steps allow individualized adjustments in controller therapy in an upward or downward manner in response to a patient ’s level of asthma control over a period of time. For patients with inadequately controlled asthma, a step-up is recommended.1,2 Strategies for stepping up controller therapy are described in detail in the adult and pediatric Asthma Yardsticks.3,4 For patients whose asthma has been well controlled for at least 3 months (or longer for the highest risk patients), controller treatment may ...
Source: Annals of Allergy, Asthma and Immunology - December 11, 2018 Category: Allergy & Immunology Authors: Bradley E. Chipps, Leonard B. Bacharier, Kevin R. Murphy, David Lang, Judith R. Farrar, Matthew Rank, John Oppenheimer, Robert S. Zeiger Source Type: research

Antibiotic choice and methicillin-resistant Staphylococcus aureus rate in children hospitalized for atopic dermatitis
Systemic antibiotics are commonly used in hospitalized patients with severe atopic dermatitis (AD) exacerbation. However, the antibiotic prescribing patterns are unclear. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 7, 2018 Category: Allergy & Immunology Authors: Vivian Wang, Matthew Keefer, Peck Y. Ong Source Type: research

Antibiotic choice and MRSA rate in children who are hospitalized for atopic dermatitis.
PMID: 30529713 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 7, 2018 Category: Allergy & Immunology Authors: Wang V, Keefer M, Ong PY Tags: Ann Allergy Asthma Immunol Source Type: research

Successful treatment of four types of chronic urticaria with anti-IgE omalizumab in the same patient.
PMID: 30529714 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 7, 2018 Category: Allergy & Immunology Authors: Nettis E, Di Leo E, Calogiuri G, Foti C, Macchia L Tags: Ann Allergy Asthma Immunol Source Type: research

Antibiotic choice and MRSA rate in children who are hospitalized for atopic dermatitis
Atopic dermatitis (AD) is the most common chronic inflammatory skin condition of childhood. It is associated with allergic co-morbities including asthma and allergic rhinitis. AD patients are also affected by sleep deprivation and psychosocial problems. Those with uncontrolled AD may require hospitalization.1 Previous studies have shown that about 70% of children who were treated inpatient for AD exacerbation were given an antibiotic.2,3 However, information on the choice of antibiotics used to treat AD exacerbation is limited. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 7, 2018 Category: Allergy & Immunology Authors: Vivian Wang, Matthew Keefer, Peck Y. Ong Source Type: research

Successful treatment of four types of chronic urticaria with anti-IgE omalizumab in the same patient
Urticaria is a skin disorder that is characterized by the appearance of wheals (hives), angioedema or both1. Chronic urticaria (CU) is defined as wheals (with or without angioedema) that persists for ≥6 weeks, and is further classified into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU)1. In most cases of CU a trigger cannot be identified. These cases are defined as CSU. The term inducible urticaria is used when a specific trigger can be linked to the development of CU. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 7, 2018 Category: Allergy & Immunology Authors: Eustachio Nettis, Elisabetta Di Leo, Gianfranco Calogiuri, Caterina Foti, Luigi Macchia Tags: Letters Source Type: research

When is epinephrine prescribed for anaphylaxis?
Anaphylaxis represents a severe allergic reaction that is rapid in onset and can be fatal 1. Epinephrine is the first-choice medication in the treatment of anaphylaxis, both in the community and in the hospital setting 2. Nonetheless, epinephrine is largely underused 3. The purpose of this study was to examine the reasons that currently motivate professionals to treat anaphylaxis with epinephrine in the Emergency Department (ED) and the prescription of EAI for outpatient use after the allergy workup. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 7, 2018 Category: Allergy & Immunology Authors: Alberto Alvarez-Perea, Margarita Tom ás-Pérez, Beatriz Ameiro, José M. Zubeldia, María L. Baeza Tags: Letters Source Type: research

When is epinephrine prescribed for anaphylaxis?
M, Baeza ML PMID: 30529549 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 6, 2018 Category: Allergy & Immunology Authors: Alvarez-Perea A, Tomás-Pérez M, Ameiro B, Zubeldia JM, Baeza ML Tags: Ann Allergy Asthma Immunol Source Type: research

Urticaria control test might misevaluate disease control in particular patients treated with omalizumab.
İ PMID: 30529015 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 4, 2018 Category: Allergy & Immunology Authors: Türk M, Yılmaz İ Tags: Ann Allergy Asthma Immunol Source Type: research

Urticaria control test might misevaluate disease control in particular patients treated with omalizumab
Since its effectiveness in H1-antihistamine refractory chronic spontaneous urticaria (CSU) was shown, omalizumab has been increasingly used across the world. Omalizumab is licensed at a dose of 300 mg subcutaneously every 4 weeks in Turkey and in the European Union[1, 2]. The urticaria activity, control and response to treatment should be assessed by a reliable and easily applicable tool during this 4 week-interval. Urticaria activity score (UAS) and urticaria control test (UCT) are two well-developed and validated patient reported outcome measures (PRO). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 4, 2018 Category: Allergy & Immunology Authors: Murat T ürk, İnsu Yılmaz Tags: Letters Source Type: research

Challenges in allergy immunology practice: Solutions needed for persistent patient problems.
PMID: 30502819 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 1, 2018 Category: Allergy & Immunology Authors: Marshall GD Tags: Ann Allergy Asthma Immunol Source Type: research