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Annals 80th anniversary: Immunotherapy for food allergy
The 1944 edition of the Annals of Allergy, Asthma& Immunology held the seed of an idea that today, some 80 years later, has come to define the field of food allergy. The article —entitled “Experimental approach to oral treatment of food allergy: Chemistry of food propeptans”—was conducted by Austrian dermatologist Erich Urbach, a war émigré who had escaped Nazi persecution to take up a position at the University of Pennsylvania.1 Alongside detailed chemical explan ations of the hydrolysis of food proteins, the article contained a surprising laboratory finding: guinea pigs who had been “allergenized” to egg wh...
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Brit Trogen, Anna Nowak-Wegrzyn Tags: Editorial Source Type: research

Healthcare Pollution Quiz
The healthcare sector produces 8.5% of US greenhouse gas emissions (GHG) at an estimated annual loss of 388,000 disability-adjusted life years.1 To measure GHGs, life cycle assessment studies use a “cradle to grave” approach, which calculates all emissions that occur during the production, transportation, and use of an item or service.2 Because fossil fuels remain a major source of electricity, energy consumption for heating, cooling, and ventilation are a leading cause of GHGs in healthca re facilities. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Erin L. Reigh Tags: Marginal Zone Source Type: research

Optimizing clinical practice today while pondering an extraordinary immune system
In this issue of the Annals, Theoharides et al1 present a thought-provoking review on an extended scope of practice for the allergist-immunologist of tomorrow. The authors highlighted that although mast cells have traditionally been compartmentalized to a narrow pathway of IgE engagement and release of a limited scope of mediators (eg, histamine and tryptase), in fact these cells are pleiotropic and active across organs systems.1 Mast cell activation mediators are quite diverse and include tumor necrosis factor and mitochondrial DNA acting as an alarmin, chemokines, interleukin-6, interleukin-10, and transforming growth fa...
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Marcus Shaker Tags: Editorial Source Type: research

Balancing benefits and potential harms of stock inhaler policies in schools
In this issue of Annals of Allergy, Asthma& Immunology, Hardy et al1 provide valuable insights into the feasibility and acceptability of common canister policies in schools. Schools with stock inhaler programs may be able to optimize point-of-care access to asthma rescue medications for both children and adults working in educational environments when needed while minimizing costs.2 The authors surveyed both school nurses and administrators, finding that less than 25% of those surveyed reported having stock inhaler programs with even lower adoption in more rural regions. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Alexandra E. Conway, Marylee Verdi, John Oppenheimer, S. Shahzad Mustafa, Marcus Shaker Tags: Editorial Source Type: research

Specific IgE point-of-care testing is evolving
There was a time when an Allergist, often with the collaboration of a local botanical specialist, would venture into his/her local woods and fields collecting pollen from local trees and weeds. Gradually, using percutaneous testing with solutions made from this collected pollen, allergists became aware of plants most likely to cause allergic symptoms. This testing was very specific for local flora. The article by Davies et al1 in this issue of Annals of Allergy, Asthma& Immunology begins to move back toward local testing, but using novel methods. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Charles S. Barnes Tags: Editorial Source Type: research

The paradigm shift in anaphylaxis management cannot occur without changing minds
The paradigm shift in anaphylaxis management was fomented by the recent SARS-CoV-2 global pandemic. These recent uncertain times forced all of us to reconsider if, when, and why we should visit the emergency department or hospital. We suddenly had to weigh the risks of exposure to a potentially deadly virus (particularly before the availability of vaccines) with the necessity for urgent evaluation and treatment of various symptoms and conditions. Within our specialty, this prompted several experts to critically evaluate the evidence surrounding anaphylaxis management and whether our patients truly needed to go to the emerg...
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Andriana La Mantia, David R. Stukus Tags: Editorial Source Type: research

'Tis the season for dupilumab?
Peters et al1 explored the efficacy of dupilumab in reducing asthma exacerbations across seasons in patients with asthma and type 2 inflammation, with and without an allergic phenotype, using post hoc data analysis from the LIBERTY ASTHMA QUEST (NCT02414854) and LIBERTY ASTHMA TRAVERSE (NCT02134028) studies. The investigators concluded that dupilumab similarly reduced severe exacerbations compared with placebo in treated patients independent of season, allergic sensitization, and baseline inhaled corticosteroid dose, supporting the use of dupilumab across seasons for all patients with type 2 asthma. (Source: Annals of Alle...
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Matthew McCulloch, William C. Anderson Tags: Editorial Source Type: research

How does pollution worsen allergies?
There is increasing evidence that pollution contributes to the rise in allergic diseases.1-3 Major pollutant contributors to this trend include particulate matter (PM), greenhouse and other harmful gases, and pollen.1-9 The studies conducted by various research groups have advanced our understanding of mechanisms by which pollution worsens allergies. The PM, in particular, is a complex mixture of components, and exposure to PM has been reported to worsen preexisting allergic disease symptoms.1,3,4 Furthermore, PM2.5, particles with a diameter of less than 2.5 mm, is considered the most harmful because of its ability to tra...
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Myongsoon Sung, Donald Y.M. Leung, Byung Eui Kim Tags: Editorial Source Type: research

Information for Readers
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 1, 2024 Category: Allergy & Immunology Source Type: research

Sex Disparities In Awards Granted by US Allergy/Immunology Societies
Ann Allergy Asthma Immunol. 2024 Mar 29:S1081-1206(24)00204-7. doi: 10.1016/j.anai.2024.03.023. Online ahead of print.NO ABSTRACTPMID:38556076 | DOI:10.1016/j.anai.2024.03.023 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 31, 2024 Category: Allergy & Immunology Authors: Matthew D Viveiros Monica T Kraft Source Type: research

Impact of circulating angiomotin and angiostatin on clinical variables in patients with asthma
Ann Allergy Asthma Immunol. 2024 Mar 29:S1081-1206(24)00207-2. doi: 10.1016/j.anai.2024.03.024. Online ahead of print.NO ABSTRACTPMID:38556077 | DOI:10.1016/j.anai.2024.03.024 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 31, 2024 Category: Allergy & Immunology Authors: Pureun-Haneul Lee MinHyeok An DaYeon Hwang An-Soo Jang Source Type: research

Asthma and allergy screening in elite football athletes: is it worth it?
Ann Allergy Asthma Immunol. 2024 Mar 29:S1081-1206(24)00205-9. doi: 10.1016/j.anai.2024.03.021. Online ahead of print.NO ABSTRACTPMID:38556078 | DOI:10.1016/j.anai.2024.03.021 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 31, 2024 Category: Allergy & Immunology Authors: Diogo Mota Carla Martins Nelson Puga Andr é Moreira Source Type: research

Sex Disparities In Awards Granted by US Allergy/Immunology Societies
Ann Allergy Asthma Immunol. 2024 Mar 29:S1081-1206(24)00204-7. doi: 10.1016/j.anai.2024.03.023. Online ahead of print.NO ABSTRACTPMID:38556076 | DOI:10.1016/j.anai.2024.03.023 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 31, 2024 Category: Allergy & Immunology Authors: Matthew D Viveiros Monica T Kraft Source Type: research