Implementation of the NIAID Peanut Allergy Guidelines
The publication of the Learning Early About Peanut Allergy study in 2015 represented a paradigm shift in the field of food allergy with the finding of an 81% reduction in the incidence of peanut allergy when early introduction of peanut was compared with strict avoidance in high-risk infants.1 In 2017, the National Institute of Allergy and Infectious Disease (NIAID) provided official recommendations for early peanut introduction with the publication of the Addendum Guidelines to the 2010 Guidelines for Diagnosis and Management of Food Allergy in the United States. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Amanda L. Pratt, Jonathan A. Hemler Tags: Letters Source Type: research

Drug allergy in children and adults
This article reviews the latest science and epidemiologic studies related to drug allergy in children and adults to explore possible mechanisms related to female propensity for drug allergy. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Allison Eaddy Norton, Ana Dioun Broyles Tags: Review Source Type: research

Immediate-hypersensitivity reactions to proton pump inhibitors
Proton pump inhibitors (PPIs) are prescribed worldwide for the treatment of acid-peptic diseases.1 –3 They antagonize the enzyme H+/K+ adenosine triphosphatase in gastric cells, inhibiting acid secretion and raising gastric pH.3,4 Side effects related to PPIs are reported in only 1% to 3% of treated patients.1,5 Omeprazole, esomeprazole, and pantoprazole have a similar chemical structure, diffe ring from rabeprazole and lansoprazole.1,5 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Joana Sofia Pita, Jo ão Azevedo, Rosa-Anita Fernandes, Carlos Loureiro, Ana Todo Bom Tags: Letter Source Type: research

AllergyWatch
Oral immunotherapy (OIT) is a promising new treatment option for peanut allergy, despite disadvantages related to treatment withdrawal and reversibility of desensitization. Children recently diagnosed at preschool age might have clinical and immune profiles associated with an increased chance of treatment success. A randomized controlled trial of early OIT for infants and toddlers with newly diagnosed peanut allergy is reported. The study included 40 children, aged 9 to 36 months: 31 with clinical peanut allergy and 9 who were sensitized but never exposed. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: John J. Oppenheimer, Vivian Hernandez-Trujillio, Stanley M. Fineman Tags: From the Pages of allergyWatch Source Type: research

Inpatient β-lactam test-dose protocol and antimicrobial stewardship in patients with a history of penicillin allergy
Penicillin allergy is the most commonly reported drug allergy in hospitalized patients, resulting in increased second-line antibiotic use, nosocomial infections, and health care use. Given that most patients are not truly allergic, a safe strategy that empowers the admitting physician is needed. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Keith A. Sacco, Benjamin P. Cochran, Kevin Epps, Mark Parkulo, Alexei Gonzalez-Estrada Source Type: research

Immediate-hypersensitivity reactions to proton pump inhibitors - experience in a medical department.
PMID: 30465856 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Pita JS, Azevedo J, Fernandes RA, Loureiro C, Todo Bom A Tags: Ann Allergy Asthma Immunol Source Type: research

Asthma in the Melting Pot.
PMID: 30465857 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Louisias M, Wright L, Phipatanakul W Tags: Ann Allergy Asthma Immunol Source Type: research

Implementation of the NIAID Peanut Allergy Guidelines: Outcomes and Experience.
PMID: 30465858 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Pratt AL, Hemler JA Tags: Ann Allergy Asthma Immunol Source Type: research

Racial differences in Atopic Dermatitis.
PMID: 30465859 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Brunner PM, Guttman-Yassky E Tags: Ann Allergy Asthma Immunol Source Type: research

Inpatient Beta-lactam test-dose Protocol promotes Antimicrobial Stewardship in Patients with History of Penicillin Allergy.
CONCLUSION: The antibiotic choice in patients admitted to the hospital with a reported penicillin allergy can be improved by better evaluation of the allergy history and the use of a risk stratification guideline. PMID: 30465860 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Sacco KA, Cochran BP, Epps K, Parkulo M, Gonzalez-Estrada A Tags: Ann Allergy Asthma Immunol Source Type: research

The Glycerin Associated Pain (GAP) Study.
PMID: 30465861 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Coop CA, Barker K, Dickson S, Baker T, Waibel K Tags: Ann Allergy Asthma Immunol Source Type: research

AllergyWatch - Feb-19.
PMID: 30465862 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Oppenheimer JJ, Hernandez-Trujillio V, Fineman SM Tags: Ann Allergy Asthma Immunol Source Type: research

"Drug Allergy in children and adults: is it the double X chromosome?"
"Drug Allergy in children and adults: is it the double X chromosome?" Ann Allergy Asthma Immunol. 2018 Nov 19;: Authors: Norton A, Broyles AD PMID: 30465863 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Norton A, Broyles AD Tags: Ann Allergy Asthma Immunol Source Type: research

Inpatient Beta-lactam test-dose Protocol promotes Antimicrobial Stewardship in Patients with History of Penicillin Allergy
Penicillin allergy is the most commonly reported drug allergy in hospitalized patients, resulting in increased second-line antibiotic use, nosocomial infections, and healthcare utilization. Given that the vast majority of patients are not truly allergic, a safe strategy that empowers the admitting physician is needed. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Keith A. Sacco, Benjamin P. Cochran, Kevin Epps, Mark Parkulo, Alexei Gonzalez-Estrada Source Type: research

Asthma in the Melting Pot
America is becoming more diverse, with minority groups increasing at higher rates than whites. The health implications are vast, impacting all medical conditions. However, as asthma remains a persistent public health problem where the disease burden is higher in minorities and low income populations – the need to find solutions is crucial 1. These disparities or differences have been documented and defined to a significant degree in the literature, but what is lacking are solutions to tackle these differences. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Margee Louisias, Lakiea Wright, Wanda Phipatanakul Source Type: research

Implementation of the NIAID Peanut Allergy Guidelines: Outcomes and Experience
The publication of the Learning Early About Peanut Allergy (LEAP) study in 2015 represented a paradigm shift in the field of food allergy with the finding of an 81% reduction in the incidence of peanut allergy when early introduction of peanut was compared to strict avoidance in high risk infants.1 In 2017, the National Institute of Allergy and Infectious Disease (NIAID) provided official recommendations for early peanut introduction with the publication of the Addendum Guidelines to the 2010 Guidelines for Diagnosis and Management of Food Allergy in the United States. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Amanda L. Pratt, Jonathan A. Hemler Tags: Letters Source Type: research

The Glycerin Associated Pain (GAP) Study
Fifty percent glycerin is often used in allergen immunotherapy (AIT) extracts to preserve extract potency.1 However, glycerin is also an irritant and it is recommended to dilute glycerin to reduce pain and inflammation associated with immunotherapy.2, 3 The 2011 allergen immunotherapy practice parameter warns that “higher glycerin concentrations are associated with injection pain, which correlates with the total amount of glycerin injected.”4 To date, two studies evaluating the role of glycerin during allergen immunotherapy differed regarding their methods and conclusions. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Christopher A. Coop, Karen Barker, Scott Dickson, Troy Baker, Kirk Waibel Tags: Letters Source Type: research

Immediate-hypersensitivity reactions to proton pump inhibitors – experience in a medical department
Proton pump inhibitors (PPIs) are prescribed worldwide for the treatment of acid-peptic diseases1,2,3. They antagonize the enzyme H+/K+ ATPase in gastric cells, inhibiting acid secretion and raising gastric pH3,4. Side effects related to PPIs are reported in only 1-3% of treated patients1,5. Omeprazole, esomeprazole and pantoprazole have a similar chemical structure, differing from rabeprazole and lansoprazole1,5. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Joana Sofia Pita, Jo ão Azevedo, Rosa-Anita Fernandes, Carlos Loureiro, Ana Todo Bom Tags: Letters Source Type: research

AllergyWatch - Feb-19
From Allergy Watch Vol 20, July-Aug 2018 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: John J. Oppenheimer, Vivian Hernandez-Trujillio, Stanley M. Fineman Source Type: research

"Drug Allergy in children and adults: is it the double X chromosome?"
It is well established that autoimmune diseases, atopic conditions and asthma affect adult females more frequently than adult males. This discrepancy typically develops after childhood and affects females differently depending on their life cycle. As children, males have higher total and allergen specific IgE levels than females and are more likely to suffer from atopic disease and asthma than girls. However, as adults, this prevalence reverses and females are more likely to develop atopic conditions such as food allergies, atopic dermatitis, urticaria, angioedema and asthma. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Allison Norton, Ana Dioun Broyles Tags: Review Source Type: research

Racial differences in Atopic Dermatitis
Atopic dermatitis (AD), the most common chronic inflammatory skin disease,1 usually starts in early infancy, and can develop into a life-long therapeutic challenge, especially in its moderate-to-severe form.2 The etiology of this complex disease remains only partly understood, but it is most likely based on a complex interplay of genetic predisposition, skin barrier dysfunction, and environmental factors.3 AD is now understood to be an immune mediated disease with contributions of multiple inflammatory pathways, and particularly Type 2-associated inflammation. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Patrick M. Brunner, Emma Guttman-Yassky Tags: Review Source Type: research

Association of estrogen receptor α polymorphism rs1999805 with asthma
Women have higher rates of asthma and allergic disease as well as increased asthma severity compared with men.1 Premenstrual or perimenstrual worsening of asthma symptoms were reported in 17% of women enrolled in the severe asthma research program, with 52% of these women having severe asthma.2,3 Furthermore, use of birth control medications or hormone replacement therapy during perimenopause or postmenopause was also linked to worsening of asthma in some women.2,4 Mouse models of asthma found estrogen signaling through estrogen receptor (ER) α and not ERβ and increased allergic airway inflammation, mucous produ...
Source: Annals of Allergy, Asthma and Immunology - November 15, 2018 Category: Allergy & Immunology Authors: Melissa H. Bloodworth, Mark Rusznak, Lisa Bastarache, Janey Wang, Dawn C. Newcomb Tags: Letters Source Type: research

Estrogen receptor-alpha (ESR1) polymorphism rs1999805 associates with asthma.
PMID: 30448624 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 15, 2018 Category: Allergy & Immunology Authors: Bloodworth MH, Rusznak M, Bastarache L, Wang J, Newcomb DC Tags: Ann Allergy Asthma Immunol Source Type: research

Estrogen receptor-alpha (ESR1) polymorphism rs1999805 associates with asthma
As adults, women have higher rates of asthma and allergic disease as well as increased asthma severity compared to men.1 Pre or peri-menstrual worsening of asthma symptoms (PMA) were reported in 17% of women enrolled in the severe asthma research program, with 52% of these women with PMA having severe asthma.2, 3 Further, use of birth control medications or hormone replacement therapy during peri or post-menopause was also linked to worsening of asthma in some women.2, 4 Mouse models of asthma showed estrogen signaling through estrogen receptor-alpha (ER- α), and not ER-β, increased allergic airway inflammation,...
Source: Annals of Allergy, Asthma and Immunology - November 15, 2018 Category: Allergy & Immunology Authors: Melissa H. Bloodworth, Mark Rusznak, Lisa Bastarache, Janey Wang, Dawn C. Newcomb Tags: Letters Source Type: research

Exercise-induced anaphylaxis associated with the use of bee pollen
The use of alternative and complementary medicine, including herbal supplements, is widespread in the United States. Some supplements have been associated with allergic reactions, even anaphylaxis. One such over-the-counter (OTC) supplement is bee pollen. This product is derived from pollen loads collected by honeybees and held together via enzymes secreted in the saliva of the bees. It contains various pollens that can vary based on the path of the individual insect as well the geographical location and associated plant species. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 14, 2018 Category: Allergy & Immunology Authors: Kara B. McNamara, Lily Pien Tags: Letters Source Type: research

An ounce of caution
Superparamagnetic iron oxide nanoparticles are increasingly used alternatives to gadolinium-based magnetic resonance imaging (MRI) contrast agents in the diagnosis of osteomyelitis in diabetic patients with renal failure.1 Ferumoxytol is approved by the United States Food and Drug Administration and the European Medicines Agency for intravenous use for iron replacement therapy.1 –3 Ferumoxytol is composed of an iron–carbohydrate complex that minimizes dissociation and appearance of free iron into the serum. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 12, 2018 Category: Allergy & Immunology Authors: Alexander J. Heckman, Anjali Agarwal, Keith A. Sacco, Brett T. Hiroto, Pramod K. Guru Tags: Letters Source Type: research

The Effect of Delayed and Early Diagnosis in Siblings, and Importance of Newborn Screening for SCID.
PMID: 30439467 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 12, 2018 Category: Allergy & Immunology Authors: Krantz MS, Stone CA, Connelly JA, Norton AE, Khan YW Tags: Ann Allergy Asthma Immunol Source Type: research

An Ounce of Caution: Superparamagnetic Iron Oxide Nanoparticle Based MRI Contrast Associated Anaphylaxis.
PMID: 30439468 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 12, 2018 Category: Allergy & Immunology Authors: Heckman AJ, Agarwal A, Sacco KA, Hiroto BT, Guru PK Tags: Ann Allergy Asthma Immunol Source Type: research

Food OIT is Superior to Food Avoidance.
PMID: 30439469 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 12, 2018 Category: Allergy & Immunology Authors: Bird JA Tags: Ann Allergy Asthma Immunol Source Type: research

The Effect of Delayed and Early Diagnosis in Siblings, and Importance of Newborn Screening for SCID
Severe combined immunodeficiency (SCID) is a form of primary immunodeficiency that affects both cellular and humoral immunity, caused by genetic defects in lymphocyte development and function. There are over 20 known genes mutations that lead to SCID including defects that cause radiosensitivity due to impairment in DNA repair (1). Mutations in DCLREC1 resulting in absent or dysfunctional Artemis protein are the most common cause of SCID associated with increased radiosensitivity and were identified as the etiology of the unusually high incidence of T-B-NK+ SCID in Athabascan-speaking tribes, Apache and Navajo (2,3). (Sour...
Source: Annals of Allergy, Asthma and Immunology - November 12, 2018 Category: Allergy & Immunology Authors: Matthew S. Krantz, Cosby A. Stone, James A. Connelly, Allison E. Norton, Yasmin W. Khan Tags: Letters Source Type: research

An Ounce of Caution: Superparamagnetic Iron Oxide Nanoparticle Based MRI Contrast Associated Anaphylaxis
Superparamagnetic iron oxide nanoparticles (SPIONs) are increasingly utilized alternatives to gadolinium-based Magnetic Resonance Imaging (MRI) contrast agents in the diagnosis of osteomyelitis in diabetic patients with renal failure [1]. Ferumoxytol is approved by the United States Food and Drug Administration (FDA), the European Medicines Agency, for intravenous (IV) use for iron replacement therapy [1-3]. Ferumoxytol is composed of an iron-carbohydrate complex that minimizes dissociation and appearance of free iron into the serum. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 12, 2018 Category: Allergy & Immunology Authors: Alexander J. Heckman, Anjali Agarwal, Keith A. Sacco, Brett T. Hiroto, Pramod K. Guru Tags: Letters Source Type: research

Food OIT is Superior to Food Avoidance
Over the last decade much attention has focused on the possibility of using oral immunotherapy (OIT) as a therapeutic approach for treatment of IgE-mediated food allergies, a disease without a Food and Drug Administration (FDA)-approved disease-modifying therapy. Peanut allergy has been a particular concern because of its persistent nature and association with potentially life-threatening reactions. The OIT literature has been criticized for heterogeneity in trial design with disparities in identification of allergic individuals by double blind placebo controlled food challenges (DBPCFC), differences in desensitization app...
Source: Annals of Allergy, Asthma and Immunology - November 12, 2018 Category: Allergy & Immunology Authors: J. Andrew Bird Source Type: research

Food oral immunotherapy is superior to food avoidance-PRO
Over the last decade much attention has focused on the possibility of using oral immunotherapy (OIT) as a therapeutic approach for treatment of immunoglobulin (Ig) E-mediated food allergies, a disease without a Food and Drug Administration (FDA) –approved disease-modifying therapy. Peanut allergy has been a particular concern because of its persistent nature and association with potentially life-threatening reactions. The OIT literature has been criticized for heterogeneity in trial design with disparities in identification of allergic individuals by double blind placebo-controlled food challenges, differen...
Source: Annals of Allergy, Asthma and Immunology - November 12, 2018 Category: Allergy & Immunology Authors: J. Andrew Bird Tags: Pro/Con Debates Source Type: research

Review of 400 Consecutive Oral Food Challenges to Almond.
CONCLUSIONS: Among patients in our cohort, the probability of passing an almond OFC was 94%. Although higher almond sIgE level and SPT wheal size correlated with OFC failure, the pass rate remained>95% for patients with sIgE up to 10 kUA/L and SPT wheal size up to 5 mm. Among the patients who had a reaction to almond, anaphylaxis was uncommon. Our data support that performing outpatient OFCs to almond is safe for select patients. PMID: 30414467 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 7, 2018 Category: Allergy & Immunology Authors: Baker MG, Kattan J Tags: Ann Allergy Asthma Immunol Source Type: research

Immunology of the Ancestral Differences in Eosinophilic Esophagitis.
PMID: 30414468 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 7, 2018 Category: Allergy & Immunology Authors: Kottyan L, Spergel JM, Cianferoni A Tags: Ann Allergy Asthma Immunol Source Type: research

Review of 400 Consecutive Oral Food Challenges to Almond
Diagnosis of almond allergy is complicated by a high rate of false positive test results. Accurate diagnosis of almond allergy is critical as almond is a source of nutrition and milk products for children with other food allergies. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 7, 2018 Category: Allergy & Immunology Authors: Mary Grace Baker, Jacob Kattan Source Type: research

Immunology of the Ancestral Differences in Eosinophilic Esophagitis
Eosinophilic Esophagitis (EoE) is an allergen driven disease characterized by eosinophilic inflammation in the esophagus1. Like other atopic disorders such as atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), and asthma, EoE has complex etiology with genetic predisposition and environmental factors playing a major role in disease development2. The genetic predisposition has been suggested as an important factor by familial and twin studies. Additionally, numerous genetic risk loci have been now described linked to EoE risk confirming that inheritability is associated with genetic predisposition3. (Source: ...
Source: Annals of Allergy, Asthma and Immunology - November 7, 2018 Category: Allergy & Immunology Authors: Leah Kottyan, Jonathan M. Spergel, Antonella Cianferoni Source Type: research

Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies
Immunoglobulin E (IgE)-mediated food allergy is a growing problem with no curative therapy.1 Oral immunotherapy (OIT) has shown promise, but its utility is limited by reactions during treatment and a lack of sustained protection after therapy. Immunoglobulin E antibodies trigger hypersensitivity reactions to foods. Their effects, mediated by the high-affinity Immunoglobulin E receptor (Fc εRI) on mast cells and basophils, can be countered by IgG antibodies of shared specificity signaling via the inhibitory Fc receptor, FcγRIIb. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 4, 2018 Category: Allergy & Immunology Authors: Amanda J. Stranks, Samantha C. Minnicozzi, Samuel J. Miller, Oliver T. Burton, Stephanie L. Logsdon, Jonathan M. Spergel, Kari C. Nadeau, Jacqueline A. Pongracic, Dale T. Umetsu, Rima Rachid, Andrew J. MacGinnitie, Lynda C. Schneider, Hans C. Oettgen Tags: Letters Source Type: research

IgE blockade during food allergen ingestion enhances the induction of inhibitory IgG antibodies.
PMID: 30404033 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 4, 2018 Category: Allergy & Immunology Authors: Stranks AJ, Minnicozzi SC, Miller SJ, Burton OT, Logsdon SL, Spergel JM, Nadeau KC, Pongracic JA, Umetsu DT, Rachid R, MacGinnitie AJ, Schneider L, Oettgen HC Tags: Ann Allergy Asthma Immunol Source Type: research

IgE blockade during food allergen ingestion enhances the induction of inhibitory IgG antibodies
IgE-mediated food allergy is a growing problem with no curative therapy1. Oral immunotherapy (OIT) has shown promise, but its utility is limited by reactions during treatment and a lack of sustained protection following therapy. IgE antibodies trigger hypersensitivity reactions to foods. Their effects, mediated by Fc εRI on mast cells and basophils, can be countered by IgG antibodies of shared specificity signaling via the inhibitory Fc receptor, FcγRIIb2. OIT induces only modest reductions in specific IgE antibodies but stimulates dramatic increases in inhibitory IgG3, 4. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 4, 2018 Category: Allergy & Immunology Authors: Amanda J. Stranks, Samantha C. Minnicozzi, Samuel J. Miller, Oliver T. Burton, Stephanie L. Logsdon, Jonathan M. Spergel, Kari C. Nadeau, Jacqueline A. Pongracic, Dale T. Umetsu, Rima Rachid, Andrew J. MacGinnitie, Lynda Schneider, Hans C. Oettgen Tags: Letters Source Type: research

Educational outcomes of an anaphylaxis simulation activity among medical students and residents ¶
Failure to recognize anaphylaxis or delayed epinephrine auto-injector (EAI) administration may result in poor patient outcomes.   Clinical simulation is an educational method used for environment-controlled, team-based learning. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: S. Mawhirt, L. Fonacier, M. Aquino Tags: A001 Source Type: research

Higher starting dose protocols in coronary artery disease patients with aspirin hypersensitivity
Aspirin is a cornerstone of atherosclerosis therapy, but 1.5% of coronary artery disease (CAD) patients report aspirin allergy. Past protocols of challenge and/or desensitization for aspirin allergy excluded acute coronary syndrome (ACS) patients and/or started at low doses. Recent studies propose higher starting doses with fewer steps. The safety and efficacy of these newer protocols are not established, especially in the acute setting where the ability to tolerate aspirin is time-sensitive. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: E. Liang, C. Kim, S. Samant, J. Sheikh Tags: A002 Source Type: research

Socio-demographic differences in patients hospitalized for anaphylaxis in the united states
Anaphylactic shock is a life-threatening emergency that can lead to significant morbidity and mortality. Data from European studies have shown significant disparities in healthcare utilization for anaphylaxis, however there are limited studies describing the association between socioeconomic status and patient characteristics for hospitalizations related to anaphylaxis in the United States. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: S. Zafar, C. Nabors, S. Pal, S. Yandrapalli, A. Zafar Tags: A003 Source Type: research

Direct oral amoxicillin challenge without preliminary skin testing in patients with reported penicillin allergy
10% of hospitalized patients report penicillin allergy; studies indicate that ∼98% are not truly allergic. Unconfirmed penicillin allergy labels pose public health risks, and evaluation is recommended to improve antibiotic stewardship. While the most widely accepted protocol is penicillin skin testing (PST) followed by oral amoxicillin challenge, time constraints and resour ces may preclude this. Recent literature supports the safety and efficacy of direct oral amoxicillin challenge in low-risk individuals. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: N. Scanlon, M. Kuruvilla Tags: A004 Source Type: research

Improving emergency care for anaphylaxis: impact of a clinical pathway in a pediatric emergency department
Emergency Department (ED) management of anaphylaxis has not kept pace with advances in knowledge. Epinephrine use and utilization of guideline-based practice recommendations remains sub-optimal, particularly in children. We implemented a clinical pathway in our pediatric ED in August 2017 to improve care. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: J. Brown, J. Foti, S. Fenstermacher, K. Kazmier, E. Shephard, N. Deam, H. Clifton, L. Rutman, P. O'Hare Tags: A005 Source Type: research

Predictive decline in peanut skin test and rast among peanut-allergic children undergoing high-dose oral immunotherapy
Peanut immunotherapy remains a limited form of treatment for peanut allergic children. Limitations primarily stem from small study sizes, significant adverse events, unclear long-term immunological outcomes and the inability to reach tolerance. In our cohort of peanut anaphylaxis patients undergoing tolerance induction oral immunotherapy, we sought to determine the rate of decline in peanut skin prick testing (SPT) and RAST results following one year of high-dose, weekly peanut immunotherapy. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: I. Randhawa, T. Morphew, N. Marsteller Tags: A100 Source Type: research

Perception and practice of sublingual immunotherapy among practicing allergists in the us: 2018 follow-up survey.
Limited information regarding current trends of sublingual immunotherapy (SLIT) use in the United States and perception of SLIT relative to 2007 and 2013 is available, especially in light of recent FDA-approved SLIT options. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: A. Sivam, M. Tankersley Tags: A101 Source Type: research

Comparative study of βs-lactam de-labeling on the frequency of peri-operative vancomycin use
Vancomycin is the antibiotic of choice in β-lactam allergic adults undergoing surgical antibiotic prophylaxis. Because it is a suboptimal option, in 2015 a pre-operative drug allergy screening program began at the Montreal General Hospital (MGH). It de-labeled 94 % of patients evaluated, reducing vancomycin use to 3 %. To validate the prog ram effectiveness a prospective study comparing the Royal Victoria Hospital (RVH), which lacked de-labeling was undertaken.The aim of the study was to determine the effect of a de-labeling program on vancomycin use. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: Y. Moussa, J. Shuster, G. Matte, A. Sullivan, C. Mavridis, M. Ben-Shoshan, U. Pfeiffer, G. Baldini, R. Bondy, F. Carli, C. Tsoukas Tags: A102 Source Type: research

Age-related findings from the peanut allergy oral immunotherapy study of ar101 for desensitization (palisade) study
Oral immunotherapy (OIT) with AR101 is being developed for treatment of peanut allergy (PA). To better understand the promising phase 3 results, we sought to determine whether there were age-related treatment effects. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: A. Burks, T. Casale, K. Beyer, L. DuToit, S. Jones, J. Hourihane, W. Shreffler, A. Marcantonio, A. Vereda, R. Zawadzki, B. Vickery, D. Adelman Tags: A103 Source Type: research

Walnut and pecan cross-desensitization: epitope determination
Clinical trials using oral immunotherapy (OIT) for the treatment of walnut food allergy have shown promising results. In a randomized, double-blind, placebo-controlled, clinical trial participants with walnut and pecan food allergies underwent treatment with walnut OIT (n=12). Participants allergic to both walnut and pecan received only walnut oral immunotherapy. Participants receiving walnut oral immunotherapy passed food challenges against both walnut and pecan, suggesting possible cross-desensitization in individuals with pecan and walnut allergies. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: A. Sweeney, K. Nadeau Tags: A104 Source Type: research