From the Pages of AllergyWatch
For this edition of From Pages of AllergyWatch, I've selected articles from recent issues of Allergy Watch. The first article, with comments from Dr. Chow, presents data showing that house dust mite sublingual immunotherapy enhances antiviral resistance interferons. The next article, with comments from Dr. Hernandez-Trujillo, is an observational study examining the outcomes of oral food challenges. The last article, with comments from Dr. Lee, is a trial using an elemental formula for adults with eosinophilic esophagitis. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 21, 2024 Category: Allergy & Immunology Authors: Stanley Fineman, Timothy Chow, Vivian Hernandez-Trujillo, Gerald B. Lee Tags: Special Series Source Type: research

From the Pages of AllergyWatch
For this edition of From Pages of AllergyWatch, I've selected articles from recent issues of AllergyWatch. The first article, with comments from Dr. Lee, presents evidence that infants with older siblings have more mature gut microbiota and may be at reduced risk for developing food allergies. The next article, with comments from Dr. Joshi, reports data that children moving to low-poverty neighborhoods can result in reduced asthma symptoms. The third article, with comments from Dr. Knox, found that persistent disparities in adherence of peanut introduction continue despite published guidelines. (Source: Annals of Allergy, ...
Source: Annals of Allergy, Asthma and Immunology - March 20, 2024 Category: Allergy & Immunology Authors: Stanley M. Fineman, Gerald B. Lee, Shyam R. Joshi, Samantha M. Knox Tags: Special Series Source Type: research

Association between alopecia areata and allergic diseases: An All of Us database study
Several epidemiological studies have reported associations between alopecia areata (AA) and allergic diseases. This association may be linked to Type 2 inflammation contributing to AA pathophysiology, as suggested by a higher prevalence of atopic dermatitis, allergic rhinitis, allergic conjunctivitis, and asthma among AA individuals.1-5 Furthermore, epidemiologic evidence of AA patients experiencing seasonal relapses, comorbid atopic conditions, and elevated IgE levels may also indicate a shared immunological pathway with allergic diseases. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 19, 2024 Category: Allergy & Immunology Authors: Erika Tsutsui, Austin J. Piontkowski, Divija Sharma, Nicole Ramsey, Benjamin Ungar Tags: Letters Source Type: research

Clinical Characteristics and Management of Pediatric Egg-Induced Anaphylaxis: A Cross-Sectional Study
CONCLUSION: To our knowledge, this is the largest published cohort of pediatric egg-induced anaphylaxis. In this cohort, pre-hospital EAI use was very low. Additionally, we identified certain symptoms that distinguish egg-induced from other triggers of FIA. Taken together, high suspicion is crucial in identifying egg-induced anaphylaxis, given the younger patient demographic and frequent lack of prior FIA history.PMID:38499059 | DOI:10.1016/j.anai.2024.03.008 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 18, 2024 Category: Allergy & Immunology Authors: Connor Prosty Moniah Alyasin Sofianne Gabrielli Ann E Clarke Judy Morris Jocelyn Gravel Rodrick Lim Edmond S Chan Ran D Goldman Andrew O'Keefe Jennifer Gerdts Derek K Chu Julia Upton Elana Hochstadter Jocelyn Moisan Adam Bretholz Christine McCusker Xun Zh Source Type: research

Evidence for two clusters among non-eosinophilic asthmatics
CONCLUSION: Non eosinophilic asthma splits in two clusters distinguishing by disease onset, atopic status, smoking history, systemic and airway inflammation and disease control and quality of life.PMID:38499060 | DOI:10.1016/j.anai.2024.03.012 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 18, 2024 Category: Allergy & Immunology Authors: Halehsadat Nekoee Zahraei Florence Schleich Gilles Louis Sara Gerday Mare Sabbe Nicolas Bougard Fran çoise Guissard Virginie Paulus Monique Henket Benoit Petre Anne-Fran çoise Donneau Renaud Louis Source Type: research

Activated non-neuronal cholinergic system correlates with non-type 2 inflammation and exacerbations in severe asthma
CONCLUSION: This study indicated that the NNCS was significantly activated in SA, leading to elevated Ach and was associated with clinical features, non-T2 inflammation, and future exacerbations of asthma, highlighting the potential role of the NNCS in the pathogenesis of SA.PMID:38499061 | DOI:10.1016/j.anai.2024.03.009 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 18, 2024 Category: Allergy & Immunology Authors: Dan Huang Li Zhang Ying Liu Ji Wang Jie Zhang Katherine J Baines Gang Liu Alan Chen-Yu Hsu Fang Wang Zhihong Chen Brian G Oliver Min Xie Ling Qin Dan Liu Huajing Wan Fengming Luo Weimin Li Gang Wang Peter G Gibson Source Type: research

Clinical Characteristics and Management of Pediatric Egg-Induced Anaphylaxis: A Cross-Sectional Study
CONCLUSION: To our knowledge, this is the largest published cohort of pediatric egg-induced anaphylaxis. In this cohort, pre-hospital EAI use was very low. Additionally, we identified certain symptoms that distinguish egg-induced from other triggers of FIA. Taken together, high suspicion is crucial in identifying egg-induced anaphylaxis, given the younger patient demographic and frequent lack of prior FIA history.PMID:38499059 | DOI:10.1016/j.anai.2024.03.008 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 18, 2024 Category: Allergy & Immunology Authors: Connor Prosty Moniah Alyasin Sofianne Gabrielli Ann E Clarke Judy Morris Jocelyn Gravel Rodrick Lim Edmond S Chan Ran D Goldman Andrew O'Keefe Jennifer Gerdts Derek K Chu Julia Upton Elana Hochstadter Jocelyn Moisan Adam Bretholz Christine McCusker Xun Zh Source Type: research

Evidence for two clusters among non-eosinophilic asthmatics
CONCLUSION: Non eosinophilic asthma splits in two clusters distinguishing by disease onset, atopic status, smoking history, systemic and airway inflammation and disease control and quality of life.PMID:38499060 | DOI:10.1016/j.anai.2024.03.012 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 18, 2024 Category: Allergy & Immunology Authors: Halehsadat Nekoee Zahraei Florence Schleich Gilles Louis Sara Gerday Mare Sabbe Nicolas Bougard Fran çoise Guissard Virginie Paulus Monique Henket Benoit Petre Anne-Fran çoise Donneau Renaud Louis Source Type: research

Activated non-neuronal cholinergic system correlates with non-type 2 inflammation and exacerbations in severe asthma
CONCLUSION: This study indicated that the NNCS was significantly activated in SA, leading to elevated Ach and was associated with clinical features, non-T2 inflammation, and future exacerbations of asthma, highlighting the potential role of the NNCS in the pathogenesis of SA.PMID:38499061 | DOI:10.1016/j.anai.2024.03.009 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 18, 2024 Category: Allergy & Immunology Authors: Dan Huang Li Zhang Ying Liu Ji Wang Jie Zhang Katherine J Baines Gang Liu Alan Chen-Yu Hsu Fang Wang Zhihong Chen Brian G Oliver Min Xie Ling Qin Dan Liu Huajing Wan Fengming Luo Weimin Li Gang Wang Peter G Gibson Source Type: research

Clinical Characteristics and Management of Pediatric Egg-Induced Anaphylaxis: A Cross-Sectional Study
CONCLUSION: To our knowledge, this is the largest published cohort of pediatric egg-induced anaphylaxis. In this cohort, pre-hospital EAI use was very low. Additionally, we identified certain symptoms that distinguish egg-induced from other triggers of FIA. Taken together, high suspicion is crucial in identifying egg-induced anaphylaxis, given the younger patient demographic and frequent lack of prior FIA history.PMID:38499059 | DOI:10.1016/j.anai.2024.03.008 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 18, 2024 Category: Allergy & Immunology Authors: Connor Prosty Moniah Alyasin Sofianne Gabrielli Ann E Clarke Judy Morris Jocelyn Gravel Rodrick Lim Edmond S Chan Ran D Goldman Andrew O'Keefe Jennifer Gerdts Derek K Chu Julia Upton Elana Hochstadter Jocelyn Moisan Adam Bretholz Christine McCusker Xun Zh Source Type: research

Evidence for two clusters among non-eosinophilic asthmatics
CONCLUSION: Non eosinophilic asthma splits in two clusters distinguishing by disease onset, atopic status, smoking history, systemic and airway inflammation and disease control and quality of life.PMID:38499060 | DOI:10.1016/j.anai.2024.03.012 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 18, 2024 Category: Allergy & Immunology Authors: Halehsadat Nekoee Zahraei Florence Schleich Gilles Louis Sara Gerday Mare Sabbe Nicolas Bougard Fran çoise Guissard Virginie Paulus Monique Henket Benoit Petre Anne-Fran çoise Donneau Renaud Louis Source Type: research

Activated non-neuronal cholinergic system correlates with non-type 2 inflammation and exacerbations in severe asthma
CONCLUSION: This study indicated that the NNCS was significantly activated in SA, leading to elevated Ach and was associated with clinical features, non-T2 inflammation, and future exacerbations of asthma, highlighting the potential role of the NNCS in the pathogenesis of SA.PMID:38499061 | DOI:10.1016/j.anai.2024.03.009 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 18, 2024 Category: Allergy & Immunology Authors: Dan Huang Li Zhang Ying Liu Ji Wang Jie Zhang Katherine J Baines Gang Liu Alan Chen-Yu Hsu Fang Wang Zhihong Chen Brian G Oliver Min Xie Ling Qin Dan Liu Huajing Wan Fengming Luo Weimin Li Gang Wang Peter G Gibson Source Type: research

Advancing assessment of asthma control with a composite tool: the Asthma Impairment and Risk Questionnaire
CONCLUSION: Relative to other control tools and EO informed by GINA SCT and risk factors for poor asthma outcomes, AIRQ performs better in assessing both domains of current control and predicting exacerbation risk.PMID:38494113 | DOI:10.1016/j.anai.2024.03.011 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 17, 2024 Category: Allergy & Immunology Authors: Bradley E Chipps Robert S Zeiger David A Beuther Robert A Wise William McCann Joan Reibman Maureen George Ileen Gilbert James M Eudicone Karin S Coyne Gale Harding Kevin R Murphy Source Type: research

Gut microbiome in the first 1000 days and risk for childhood food allergy
CONCLUSION: The maternal and infant microbiomes throughout the first 1000 days of life influence FA risk through a number of proposed mechanisms. Further large, longitudinal cohort studies employing taxonomic, functional, and metabolomic analysis of the bacterial and viral microbiomes are needed to provide further insight on the host-microbe interactions underlying FA pathogenesis in childhood.PMID:38494114 | DOI:10.1016/j.anai.2024.03.010 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 17, 2024 Category: Allergy & Immunology Authors: Erin C Davis Cynthia Monaco Richard Insel Kirsi M J ärvinen Source Type: research

Bruton's tyrosine kinase inhibition for the treatment of allergic disorders
Ann Allergy Asthma Immunol. 2024 Mar 14:S1081-1206(24)00145-5. doi: 10.1016/j.anai.2024.03.002. Online ahead of print.ABSTRACTIgE signaling through its high-affinity receptor FcεRI is central to the pathogenesis of numerous allergic disorders. Oral inhibitors of Bruton's tyrosine kinase (BTKis), which are currently FDA-approved for the treatment of B cell malignancies, broadly inhibit the FcεRI pathway in human mast cells and basophils and therefore may be effective allergen-independent therapies for a variety of allergic diseases. The application of these drugs to the allergy space was previously limited by the low kina...
Source: Annals of Allergy, Asthma and Immunology - March 16, 2024 Category: Allergy & Immunology Authors: Erica V Lin Ragha V Suresh Melanie C Dispenza Source Type: research