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Hereditary angioedema with normal C1-Inhibitor: Clinical and genetic characterization of 15 Portuguese unrelated families
CONCLUSION: We described the first Portuguese series of patients with HAE-nC1-INH genetically characterized. Differences with others may contribute to improve current unmet needs and raise awareness of this rare disease. We highlight the identification of 3 new variants(additional molecular studies are ongoing) and the first report of erythema marginatum in HAE-n-C1INH.PMID:38342132 | DOI:10.1016/j.anai.2024.01.027 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 11, 2024 Category: Allergy & Immunology Authors: Eunice Dias de Castro Ana Lu ísa Pinhal Mariana Bragan ça Jo ão Parente Freixo Ant ónio Martinho Source Type: research

Intrinsic risk factors for alpha-gal syndrome in a case-control study, 2019-2020
CONCLUSION: This study suggests that intrinsic factors contribute to risk of developing AGS. Some traits are genetic, but common behaviors among households and family units likely also contribute. Identification of these risk factors can inform personal risk, aid healthcare providers in understanding susceptible populations, and contribute to ongoing understanding of AGS epidemiology.PMID:38341029 | DOI:10.1016/j.anai.2024.01.029 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 10, 2024 Category: Allergy & Immunology Authors: Marissa L Taylor Gilbert J Kersh Johanna S Salzer Emma S Jones Alison M Binder Paige A Armstrong Shailesh K Choudhary Grace K Commins Claire L Amelio Brad J Biggerstaff Charles B Beard Lyle R Petersen Scott P Commins Source Type: research

Incidence of drug-induced hypersensitivity syndrome associated with levetiracetam and clobazam is likely underreported
The FDA recently issued a statement requiring manufacturers of levetiracetam and clobazam to include warnings regarding drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) to patients and their caregivers.1 Levetiracetam, an anti-epileptic, is rarely associated with DiHS/DRESS, and clobazam, a benzodiazepine prescribed as an anxiolytic and anti-epileptic, has recently been linked to DiHS/DRESS.2-5 It is estimated that over 12 million prescriptions of levetiracetam and 750,000 prescriptions of clobazam were filled in 2022 in the United States. (Source: Annals of Allerg...
Source: Annals of Allergy, Asthma and Immunology - February 10, 2024 Category: Allergy & Immunology Authors: Nikhita R. Kichili, Alyssa Hansen, Dheeraj Kagithala, Ayezel Munoz Gonzalez, Michael Wilkerson Tags: Letter to Editor Source Type: research

Predominantly antibody deficiency and the association with celiac disease in Sweden: A nationwide case-control study
CONCLUSION: PAD was associated with an increased risk of CeD. A particularly strong association was seen in those with CVID, although this should be interpreted cautiously given the limited understanding of the mechanisms of histopathologic changes in these patients.PMID:38331244 | DOI:10.1016/j.anai.2024.01.019 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 8, 2024 Category: Allergy & Immunology Authors: Daniel V DiGiacomo Bjorn Roelstraete Benjamin Lebwohl Peter H R Green Lennart Hammarstr öm Jocelyn R Farmer Hamed Khalili Jonas F Ludvigsson Source Type: research

Hereditary angioedema with normal C1-inhibitor
(HAE-nC1-INH) is a rare genetic disease with similar phenotype to HAE-C1-INH but different genetic background. Currently, 6 subtypes are recognized, based on the underlying mutations. Several aspects need further clarification. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 8, 2024 Category: Allergy & Immunology Authors: Eunice Dias de Castro, Ana Lu ísa Pinhal, Mariana Bragança, João Parente Freixo, António Martinho Tags: Original Article Source Type: research