Neutrophil-to-lymphocyte ratio as a novel independent predictor of severe exacerbation in patients with asthma
Severe exacerbations are well-known complications of asthma that increase the total and asthma-related health care costs1 and decrease the quality of life of patients.2 Although some exacerbation predictors have been reported,3,4 it is difficult to predict and prevent severe exacerbations in a large percentage of patients affected by asthma. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 30, 2018 Category: Allergy & Immunology Authors: Takao Mochimaru, Soichiro Ueda, Yusuke Suzuki, Koichiro Asano, Koichi Fukunaga Tags: Letters Source Type: research

SERPING1 mutation in a rare hereditary angioedema with skin blisters.
PMID: 30508583 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 30, 2018 Category: Allergy & Immunology Authors: Serpa FS, Veronez CL, Campinhos FL, Moyses TR, Pesquero JB Tags: Ann Allergy Asthma Immunol Source Type: research

Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients.
PMID: 30508584 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 30, 2018 Category: Allergy & Immunology Authors: Brunner PM, Israel A, Leonard A, Pavel AB, Kim HJ, Zhang N, Czarnowicki T, Patel K, Murphrey M, Ramsey K, Rangel S, Zebda R, Soundararajan V, Zheng X, Estrada YD, Xu H, Krueger JG, Paller AS, Guttman-Yassky E Tags: Ann Allergy Asthma Immunol Source Type: research

Neutrophil to lymphocyte ratio is a novel independent predictor of severe exacerbation in asthma patients.
PMID: 30508585 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 30, 2018 Category: Allergy & Immunology Authors: Mochimaru T, Ueda S, Suzuki Y, Asano K, Fukunaga K Tags: Ann Allergy Asthma Immunol Source Type: research

Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. The pipeline of novel targeted treatments for AD is expanding, largely based on our growing knowledge of disease mechanisms, with new therapeutics particularly focused on immune modulation.1 Most of our understanding of AD is derived from profiling tissues and blood of longstanding AD in adults, due to the difficulty of obtaining samples from infants and young children. However, initiation of AD typically happens very early in life, and the disease is already chronically established in the majority of patients by 5yrs of age. (Source: Annals of Al...
Source: Annals of Allergy, Asthma and Immunology - November 30, 2018 Category: Allergy & Immunology Authors: Patrick M. Brunner, Ariel Israel, Alexandra Leonard, Ana B. Pavel, Hyun Je Kim, Ning Zhang, Tali Czarnowicki, Krishna Patel, Morgan Murphrey, Kara Ramsey, Stephanie Rangel, Rema Zebda, Vinaya Soundararajan, Xiuzhong Zheng, Yeriel D. Estrada, Hui Xu, James Source Type: research

SERPING1 mutation in a rare hereditary angioedema with skin blisters
Hereditary Angioedema (HAE) is a rare, autosomal dominant disease characterized clinically by recurrent episodes of edema that may affect the skin and internal organs. The pathophysiological background of HAE is primarily an increased vascular permeability reaction to a local overproduction of bradykinin1. The most frequent dermatological manifestation is angioedema, which may occur on any part of the body and erythema marginatum is sometimes seen as symptomatic of the onset of an attack. The formation of blisters, described by some authors2-5, is an infrequent cutaneous manifestation of HAE. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 30, 2018 Category: Allergy & Immunology Authors: Faradiba Sarquis Serpa, Camila Lopes Veronez, Fernanda Lug ão Campinhos, Therezinha Ribeiro Moyses, João Bosco Pesquero Tags: Letters Source Type: research

Neutrophil to lymphocyte ratio is a novel independent predictor of severe exacerbation in asthma patients
Severe exacerbations are well-known complications of asthma, which increase the total and asthma-related health care costs1 and decrease the quality of life of patients2. Although some exacerbation predictors have been reported3,4, it is difficult to predict and prevent severe exacerbations in a large percentage of patients affected by asthma. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 30, 2018 Category: Allergy & Immunology Authors: Takao Mochimaru, Soichiro Ueda, Yusuke Suzuki, Koichiro Asano, Koichi Fukunaga Tags: Letters Source Type: research

Erratum
In the Original Article, “Omalizumab chronic spontaneous urticaria: Efficacy, safety, predictors of treatment outcome, and time to response” (Ann Allergy Asthma Immunol. 2018;121:474-478), the title should have been set as “Omalizumab in chronic spontaneous urticaria: Efficacy, safety, predictors of treatment outcome, and time to response.” (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 29, 2018 Category: Allergy & Immunology Source Type: research

A new acronym for PPI-REE?
Eosinophilic esophagitis (EoE) is a complex allergic disease commonly associated with food-induced symptomatic esophageal dysfunction.1 This includes reflux, dysphagia, and dysmotility.2 Consensus guidelines have provided clinical information to guide EoE evaluation, including the use of proton pump inhibitors (PPIs), to distinguish gastroesophageal reflux disease from EoE, and observations that a unique subset of eosinophilic esophageal infiltration might be largely resolved using a PPI, also termed PPI-REE (PPI-responsive esophageal eosinophilia). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 29, 2018 Category: Allergy & Immunology Authors: Russell Hopp Tags: Correspondence Source Type: research

Challenges in allergy immunology practice
As our knowledge base continues to increase, many of the diseases we see and treat seem to have become more complex. This may come from a variety of factors, including better technology, better research, and better diagnostic techniques, among other factors. Not that long ago, asthma was classified more simply as either “intrinsic” or “extrinsic,” and rhinitis was either “allergic” or “nonallergic.” Now, with the vast improvements we enjoy in the practice of medicine, we have phenotypes and endotypes; we have biomarkers, treatment guidelines, practice parame-->ters, and mo...
Source: Annals of Allergy, Asthma and Immunology - November 29, 2018 Category: Allergy & Immunology Authors: Gailen D. Marshall Tags: Editorial Source Type: research

Information for Readers
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 29, 2018 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 29, 2018 Category: Allergy & Immunology Source Type: research

Information for Authors
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 29, 2018 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 29, 2018 Category: Allergy & Immunology Source Type: research

Author Index
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 29, 2018 Category: Allergy & Immunology Source Type: research

Antimicrobial resistance in atopic dermatitis
Atopic dermatitis (AD) results from a complex interplay of host genetic and environmental factors. A long-established association exists between AD and Staphylococcus aureus. In healthy individuals, this organism has a dichotomous relationship with the host, being a frequent component of the human microbiome, carried asymptomatically, and on occasion, an opportunistic pathogen capable of causing or influencing broad-ranging disease. In AD, high carriage rates of S aureus on affected skin are commonly observed, with recent meta-analysis evidence demonstrating colonization in approximately 70% of affected individuals. (Sourc...
Source: Annals of Allergy, Asthma and Immunology - November 29, 2018 Category: Allergy & Immunology Authors: C.P. Harkins, M.T.G. Holden, A.D. Irvine Tags: Perspective Source Type: research

Anti-microbial Resistance In Atopic Dermatitis: Need for an Urgent Rethink.
PMID: 30503409 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 29, 2018 Category: Allergy & Immunology Authors: Harkins CP, Holden MTG, Irvine AD Tags: Ann Allergy Asthma Immunol Source Type: research

Anti-microbial Resistance In Atopic Dermatitis: Need for an Urgent Rethink
Atopic dermatitis (AD) results from a complex interplay of host genetic and environmental factors. There is a long established association between AD and Staphylococcus aureus. In healthy individuals this organism has a dichotomous relationship with the host, being a frequent component of the human microbiome, carried asymptomatically, and on occasion, an opportunistic pathogen capable of causing or influencing a broad ranging disease. In AD, high carriage rates of S. aureus on affected skin is commonly observed, with recent meta-analysis evidence demonstrating colonisation in approximately 70% of affected individuals 1. (...
Source: Annals of Allergy, Asthma and Immunology - November 29, 2018 Category: Allergy & Immunology Authors: C.P. Harkins, M.T.G. Holden, A.D. Irvine Source Type: research

Measurement of exhaled nitric oxide in young children
Fractional exhaled nitric oxide (FeNO) is a direct marker of type 2 airway inflammation and aids in the diagnosis of asthma.1,2 FeNO is reproducible and easy to use in the clinic setting.3-5 The FeNO measurement technique is often easier for younger children to  master than spirometry6 and much less invasive than sputum induction or bronchoscopy.7,8 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 23, 2018 Category: Allergy & Immunology Authors: Kathleen Rickard, Margot MacDonald-Berko, Robert Anolik, Neal Jain, Craig La Force, Richard L. Wasserman Tags: Letter Source Type: research

Development of a Pediatric Asthma Predictive Index for Hospitalization.
PMID: 30476547 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 23, 2018 Category: Allergy & Immunology Authors: Jean T, Yang SJ, Crawford WW, Takahashi SH, Sheikh J Tags: Ann Allergy Asthma Immunol Source Type: research

Measurement of exhaled nitric oxide in young children with NIOX VERO.
PMID: 30476548 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 23, 2018 Category: Allergy & Immunology Authors: Rickard K, MacDonald-Berko M, Anolik R, Jain N, La Force C, Wasserman RL Tags: Ann Allergy Asthma Immunol Source Type: research

Development of a Pediatric Asthma Predictive Index for Hospitalization
Asthma is the third leading cause of hospitalization among children in the United States.1 Currently 6.2 million children in the U.S. have asthma.1 In 2014, the number of emergency department (ED) visits for asthma exacerbation in children less than 15 years old was approximately 820,000.2 Recently, the total estimated cost of asthma to society was $82 billion.3 There is currently no standard protocol for asthma admissions in the ED. This often leads to wide variation in management and disparities in care. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 23, 2018 Category: Allergy & Immunology Authors: Tiffany Jean, Su-Jau Yang, William W. Crawford, Scott H. Takahashi, Javed Sheikh Source Type: research

Measurement of exhaled nitric oxide in young children with NIOX VERO
Fractional exhaled nitric oxide (FeNO) is a direct marker of Type 2 (T2)-driven inflammation in the airways and aids in the diagnosis of asthma.1, 2 FeNO is reproducible and easy to use in the clinic setting.3 - 5 FeNO measurement technique is often easier for younger children to master than spirometry6 and much less invasive than sputum induction or bronchoscopy.7, 8 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 23, 2018 Category: Allergy & Immunology Authors: Kathleen Rickard, Margot MacDonald-Berko, Robert Anolik, Neal Jain, Craig La Force, Richard L. Wasserman Source Type: research

Where does worsening asthma end and an asthma exacerbation begin?
Asthma exacerbations serve as a marker of disease risk and necessity of asthma therapy. Frequency of exacerbation, in particular severe exacerbations that require emergency department visits or hospitalizations, is used as an indication of risk1 and a measure of response to asthma therapy.1 Exacerbations, in combination with symptoms and quality of life over time, are often noted as measures of asthma control. Prevention of future exacerbations is cited as an important reason for asthma controller therapy. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 20, 2018 Category: Allergy & Immunology Authors: Elissa M. Abrams, Allan B. Becker, Stanley J. Szefler Tags: Perspective Source Type: research

Cyclical hypersensitivity, anaphylaxis, and related hormonal reaction
A 16-year-old girl presented with recurring cyclical erythematous pruritic persistent rash that had vesicles at times, lip swelling, dizziness, tingling and burning on face and lips, hands tingling, and chest tightness for the past 2 years. The symptoms typically began 2 to 3 days before the onset of her menstrual cycle and continue into the cycle for 3 to 4 days before dissipating. However, because of the irregular nature of her cycles, which were treated with an oral estrogen-progestogen contraceptive pill, she sometimes noticed the onset of symptoms 1 or 2 days after the onset of her flow. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 20, 2018 Category: Allergy & Immunology Authors: William J. Lavery, Jonathan A. Bernstein Tags: CME Review Source Type: research

Cyclical Hypersensitivity, Anaphylaxis and Related Hormonal Reaction.
PMID: 30468931 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 20, 2018 Category: Allergy & Immunology Authors: Lavery WJ, Bernstein JA Tags: Ann Allergy Asthma Immunol Source Type: research

Title: Where does worsening asthma end and an asthma exacerbation begin?
PMID: 30468932 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 20, 2018 Category: Allergy & Immunology Authors: Abrams EM, Becker AB, Szefler SJ Tags: Ann Allergy Asthma Immunol Source Type: research

Cyclical Hypersensitivity, Anaphylaxis and Related Hormonal Reaction
Case Report (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 20, 2018 Category: Allergy & Immunology Authors: William J. Lavery, Jonathan A. Bernstein Tags: CME Reviews Source Type: research

Title: Where does worsening asthma end and an asthma exacerbation begin?
When does worsening asthma end, and an asthma exacerbation begin? (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 20, 2018 Category: Allergy & Immunology Authors: Elissa M. Abrams, Allan B. Becker, Stanley J. Szefler Tags: Perspective Source Type: research

Implementation of the NIAID Peanut Allergy Guidelines
The publication of the Learning Early About Peanut Allergy study in 2015 represented a paradigm shift in the field of food allergy with the finding of an 81% reduction in the incidence of peanut allergy when early introduction of peanut was compared with strict avoidance in high-risk infants.1 In 2017, the National Institute of Allergy and Infectious Disease (NIAID) provided official recommendations for early peanut introduction with the publication of the Addendum Guidelines to the 2010 Guidelines for Diagnosis and Management of Food Allergy in the United States. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Amanda L. Pratt, Jonathan A. Hemler Tags: Letters Source Type: research

Drug allergy in children and adults
This article reviews the latest science and epidemiologic studies related to drug allergy in children and adults to explore possible mechanisms related to female propensity for drug allergy. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Allison Eaddy Norton, Ana Dioun Broyles Tags: Review Source Type: research

Immediate-hypersensitivity reactions to proton pump inhibitors
Proton pump inhibitors (PPIs) are prescribed worldwide for the treatment of acid-peptic diseases.1 –3 They antagonize the enzyme H+/K+ adenosine triphosphatase in gastric cells, inhibiting acid secretion and raising gastric pH.3,4 Side effects related to PPIs are reported in only 1% to 3% of treated patients.1,5 Omeprazole, esomeprazole, and pantoprazole have a similar chemical structure, diffe ring from rabeprazole and lansoprazole.1,5 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Joana Sofia Pita, Jo ão Azevedo, Rosa-Anita Fernandes, Carlos Loureiro, Ana Todo Bom Tags: Letter Source Type: research

AllergyWatch
Oral immunotherapy (OIT) is a promising new treatment option for peanut allergy, despite disadvantages related to treatment withdrawal and reversibility of desensitization. Children recently diagnosed at preschool age might have clinical and immune profiles associated with an increased chance of treatment success. A randomized controlled trial of early OIT for infants and toddlers with newly diagnosed peanut allergy is reported. The study included 40 children, aged 9 to 36 months: 31 with clinical peanut allergy and 9 who were sensitized but never exposed. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: John J. Oppenheimer, Vivian Hernandez-Trujillio, Stanley M. Fineman Tags: From the Pages of allergyWatch Source Type: research

Inpatient β-lactam test-dose protocol and antimicrobial stewardship in patients with a history of penicillin allergy
Penicillin allergy is the most commonly reported drug allergy in hospitalized patients, resulting in increased second-line antibiotic use, nosocomial infections, and health care use. Given that most patients are not truly allergic, a safe strategy that empowers the admitting physician is needed. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Keith A. Sacco, Benjamin P. Cochran, Kevin Epps, Mark Parkulo, Alexei Gonzalez-Estrada Source Type: research

Immediate-hypersensitivity reactions to proton pump inhibitors - experience in a medical department.
PMID: 30465856 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Pita JS, Azevedo J, Fernandes RA, Loureiro C, Todo Bom A Tags: Ann Allergy Asthma Immunol Source Type: research

Asthma in the Melting Pot.
PMID: 30465857 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Louisias M, Wright L, Phipatanakul W Tags: Ann Allergy Asthma Immunol Source Type: research

Implementation of the NIAID Peanut Allergy Guidelines: Outcomes and Experience.
PMID: 30465858 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Pratt AL, Hemler JA Tags: Ann Allergy Asthma Immunol Source Type: research

Racial differences in Atopic Dermatitis.
PMID: 30465859 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Brunner PM, Guttman-Yassky E Tags: Ann Allergy Asthma Immunol Source Type: research

Inpatient Beta-lactam test-dose Protocol promotes Antimicrobial Stewardship in Patients with History of Penicillin Allergy.
CONCLUSION: The antibiotic choice in patients admitted to the hospital with a reported penicillin allergy can be improved by better evaluation of the allergy history and the use of a risk stratification guideline. PMID: 30465860 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Sacco KA, Cochran BP, Epps K, Parkulo M, Gonzalez-Estrada A Tags: Ann Allergy Asthma Immunol Source Type: research

The Glycerin Associated Pain (GAP) Study.
PMID: 30465861 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Coop CA, Barker K, Dickson S, Baker T, Waibel K Tags: Ann Allergy Asthma Immunol Source Type: research

AllergyWatch - Feb-19.
PMID: 30465862 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Oppenheimer JJ, Hernandez-Trujillio V, Fineman SM Tags: Ann Allergy Asthma Immunol Source Type: research

"Drug Allergy in children and adults: is it the double X chromosome?"
"Drug Allergy in children and adults: is it the double X chromosome?" Ann Allergy Asthma Immunol. 2018 Nov 19;: Authors: Norton A, Broyles AD PMID: 30465863 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Norton A, Broyles AD Tags: Ann Allergy Asthma Immunol Source Type: research

Inpatient Beta-lactam test-dose Protocol promotes Antimicrobial Stewardship in Patients with History of Penicillin Allergy
Penicillin allergy is the most commonly reported drug allergy in hospitalized patients, resulting in increased second-line antibiotic use, nosocomial infections, and healthcare utilization. Given that the vast majority of patients are not truly allergic, a safe strategy that empowers the admitting physician is needed. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Keith A. Sacco, Benjamin P. Cochran, Kevin Epps, Mark Parkulo, Alexei Gonzalez-Estrada Source Type: research

Asthma in the Melting Pot
America is becoming more diverse, with minority groups increasing at higher rates than whites. The health implications are vast, impacting all medical conditions. However, as asthma remains a persistent public health problem where the disease burden is higher in minorities and low income populations – the need to find solutions is crucial 1. These disparities or differences have been documented and defined to a significant degree in the literature, but what is lacking are solutions to tackle these differences. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Margee Louisias, Lakiea Wright, Wanda Phipatanakul Source Type: research

Implementation of the NIAID Peanut Allergy Guidelines: Outcomes and Experience
The publication of the Learning Early About Peanut Allergy (LEAP) study in 2015 represented a paradigm shift in the field of food allergy with the finding of an 81% reduction in the incidence of peanut allergy when early introduction of peanut was compared to strict avoidance in high risk infants.1 In 2017, the National Institute of Allergy and Infectious Disease (NIAID) provided official recommendations for early peanut introduction with the publication of the Addendum Guidelines to the 2010 Guidelines for Diagnosis and Management of Food Allergy in the United States. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Amanda L. Pratt, Jonathan A. Hemler Tags: Letters Source Type: research

The Glycerin Associated Pain (GAP) Study
Fifty percent glycerin is often used in allergen immunotherapy (AIT) extracts to preserve extract potency.1 However, glycerin is also an irritant and it is recommended to dilute glycerin to reduce pain and inflammation associated with immunotherapy.2, 3 The 2011 allergen immunotherapy practice parameter warns that “higher glycerin concentrations are associated with injection pain, which correlates with the total amount of glycerin injected.”4 To date, two studies evaluating the role of glycerin during allergen immunotherapy differed regarding their methods and conclusions. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Christopher A. Coop, Karen Barker, Scott Dickson, Troy Baker, Kirk Waibel Tags: Letters Source Type: research

Immediate-hypersensitivity reactions to proton pump inhibitors – experience in a medical department
Proton pump inhibitors (PPIs) are prescribed worldwide for the treatment of acid-peptic diseases1,2,3. They antagonize the enzyme H+/K+ ATPase in gastric cells, inhibiting acid secretion and raising gastric pH3,4. Side effects related to PPIs are reported in only 1-3% of treated patients1,5. Omeprazole, esomeprazole and pantoprazole have a similar chemical structure, differing from rabeprazole and lansoprazole1,5. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Joana Sofia Pita, Jo ão Azevedo, Rosa-Anita Fernandes, Carlos Loureiro, Ana Todo Bom Tags: Letters Source Type: research

AllergyWatch - Feb-19
From Allergy Watch Vol 20, July-Aug 2018 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: John J. Oppenheimer, Vivian Hernandez-Trujillio, Stanley M. Fineman Source Type: research

"Drug Allergy in children and adults: is it the double X chromosome?"
It is well established that autoimmune diseases, atopic conditions and asthma affect adult females more frequently than adult males. This discrepancy typically develops after childhood and affects females differently depending on their life cycle. As children, males have higher total and allergen specific IgE levels than females and are more likely to suffer from atopic disease and asthma than girls. However, as adults, this prevalence reverses and females are more likely to develop atopic conditions such as food allergies, atopic dermatitis, urticaria, angioedema and asthma. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Allison Norton, Ana Dioun Broyles Tags: Review Source Type: research

Racial differences in Atopic Dermatitis
Atopic dermatitis (AD), the most common chronic inflammatory skin disease,1 usually starts in early infancy, and can develop into a life-long therapeutic challenge, especially in its moderate-to-severe form.2 The etiology of this complex disease remains only partly understood, but it is most likely based on a complex interplay of genetic predisposition, skin barrier dysfunction, and environmental factors.3 AD is now understood to be an immune mediated disease with contributions of multiple inflammatory pathways, and particularly Type 2-associated inflammation. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Patrick M. Brunner, Emma Guttman-Yassky Tags: Review Source Type: research