Key policies to support asthma medication management for children
Appropriate use of and adherence to asthma medications are critical components of controlling pediatric asthma morbidity. Guideline based asthma therapy recommends use of short acting nebulizers or inhalers to provide quick symptom relief and daily use of long term controller therapies, such as inhaled corticosteroids, to prevent inflammation and exacerbations.1 However, children often lack access to controller and rescue therapies or have poor adherence to their therapies, leading to worse asthma control and health outcomes. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 25, 2019 Category: Allergy & Immunology Authors: Sandra E. Zaeh, Meredith C. McCormack, Michelle N. Eakin Tags: Perspective Source Type: research

Effects of Indoor Particulate Matter Exposure on Daily Asthma Control
Asthma is a chronic inflammatory airways disease that is initiated and maintained by a complex interaction between genes and the environment1. Since most people in Europe and the United States spend the majority of their time indoors it is likely that indoor environmental exposures are at least as important as those encountered outdoors2. Indoor particulate matter (PM) exposure can arise firstly through activities that involve combustion such as cooking and smoking, and secondly through inhalation of household dust, which contains a variety of aeroallergens such as the house dust mite (HDM) protein Der p1. (Source: Annals ...
Source: Annals of Allergy, Asthma and Immunology - July 25, 2019 Category: Allergy & Immunology Authors: Syed Hussain, Sarah Parker, Karen Edwards, Joanne Finch, Antoine Jeanjean, Roland Leigh, Sherif Gonem Source Type: research

Choosing the right biologic for severe asthma
In the past few years, we have seen the emergence of numerous biologics on the market for severe type 2 (T2) asthma. In addition to omalizumab (a monoclonal anti-immunoglobulin E [IgE] antibody), 3 anti-interleukin (IL) 5 agents are approved for eosinophilic asthma, and an anti-IL4Ra biologic recently received Food and Drug Administration approval for the indication of severe asthma. For patients with severe T2 asthma (approximately 5% of the asthma population), this translates to newer, targeted therapeutic options that have been shown to reduce asthma exacerbations and that generally have a favorable side effect profile....
Source: Annals of Allergy, Asthma and Immunology - July 24, 2019 Category: Allergy & Immunology Authors: Mauli Desai, John Oppenheimer Tags: Perspective Source Type: research

Choosing the right biologic for severe asthma: precision medicine through the lens of patient-centered decision making.
PMID: 31351166 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 24, 2019 Category: Allergy & Immunology Authors: Desai M, Oppenheimer J Tags: Ann Allergy Asthma Immunol Source Type: research

Choosing the right biologic for severe asthma: precision medicine through the lens of patient-centered decision making
In the past few years, we have seen the emergence of numerous biologics on the market for severe type 2 (T2) asthma. In addition to omalizumab (a monoclonal anti-IgE antibody), three anti-interleukin (IL) 5 agents are approved for eosinophilic asthma and an anti-IL4Ra biologic recently received FDA approval for the indication of severe asthma. For patients with severe T2 asthma (about 5% of the asthma population), this translates to newer, targeted therapeutic options that have been shown to reduce asthma exacerbations and that generally have a favorable side effect profile(1). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 24, 2019 Category: Allergy & Immunology Authors: Mauli Desai, John Oppenheimer Tags: Perspective Source Type: research

Aspirin desensitization or biologics for AERD?
PMID: 31349010 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 23, 2019 Category: Allergy & Immunology Authors: Steinke JW Tags: Ann Allergy Asthma Immunol Source Type: research

Autoimmunity in Common Variable Immunodeficiency.
CONCLUSION: Mechanisms producing these conditions are poorly understood but include cytokine and cellular inflammatory pathways, and loss of tolerance to self-antigens through the multiple signaling molecules and pathways common to tolerance and immune deficiency. PMID: 31349011 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 23, 2019 Category: Allergy & Immunology Authors: Agarwal S, Cunningham-Rundles C Tags: Ann Allergy Asthma Immunol Source Type: research

Autoimmunity in Common Variable Immunodeficiency
Common variable immunodeficiency (CVID) is a primary immunodeficiency that is clinically heterogeneous, characterized by both infectious and non-infectious complications. While the hallmark of disease presentation is commonly a history of recurrent sinopulmonary infections, autoimmunity and non-infectious inflammatory conditions are increasing associated with CVID. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 23, 2019 Category: Allergy & Immunology Authors: Shradha Agarwal, Charlotte Cunningham-Rundles Tags: Review Source Type: research

Aspirin desensitization or biologics for AERD?
Aspirin-exacerbated respiratory disease (AERD) is a syndrome characterized by asthma that is often severe with progressive airway remodeling, the presence of eosinophilic chronic sinusitis with nasal polyp (CRSwNP) formation, and intolerance to aspirin and other non-selective cyclooxygenase 1 (COX-1) inhibitors.1 The prevalence of AERD in the general population is 1% which increases to 7% amongst those with asthma. In the most severe cases, ingestion of aspirin can trigger systemic reactions and even death. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 23, 2019 Category: Allergy & Immunology Authors: John W. Steinke Tags: Perspective Source Type: research

Review Article: Treatment strategies for the yellow zone
To evaluate relevant studies and documents that address treatment strategies for acute loss of asthma control (yellow zone). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 19, 2019 Category: Allergy & Immunology Authors: August Generoso, Linh-An Tuong, John Oppenheimer Tags: Review Article Source Type: research

Treatment Strategies for the Yellow Zone.
PMID: 31330241 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 19, 2019 Category: Allergy & Immunology Authors: Generoso A, Tuong LA, Oppenheimer J Tags: Ann Allergy Asthma Immunol Source Type: research

Elevated YKL-40 serum levels in patients with chronic spontaneous urticaria.
PMID: 31330242 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 19, 2019 Category: Allergy & Immunology Authors: Zhou PM, Fu LX, Chen T, Wang L, Lu YH Tags: Ann Allergy Asthma Immunol Source Type: research

Elevated YKL-40 serum levels in patients with chronic spontaneous urticaria
Chronic spontaneous urticaria (CSU), a common vascular skin disease with high incidence (approximately 0.5% to 1%) and recurrent attacks, is one of the skin diseases that seriously affect the quality of patients ’ life1. Some CSU patients have resistance to treatment. About 45%-60% of patients could be effectively treated by antihistamines. Studies demonstrate that histamine and other vasoactive substances, released by mast cell degranulation, can ultimately lead to increase the permeability of human derm al microvascular endothelial cells (HDMECs)2, which is considered to be the central link in the pathogenesis of C...
Source: Annals of Allergy, Asthma and Immunology - July 19, 2019 Category: Allergy & Immunology Authors: Pei-mei Zhou, Li-xin Fu, Tao Chen, Lin Wang, Yong-hong Lu Tags: Letters Source Type: research

Treatment Strategies for the Yellow Zone
Asthma control changes over time and many factors contribute to this variability. Environmental exposures such as seasonal allergen fluctuations, second-hand tobacco exposure, and viral upper respiratory tract infections (RTI) are just a few of the known triggers of lability 1. In addition, host factors such as inhaler technique and co-morbid conditions including atopic diseases, obesity, and acid reflux can also contribute to this changeability. During times of lability, overzealous intervention can lead to overuse of oral corticosteroids (OCS) and healthcare visits, while delayed treatment can lead to severe exacerbation...
Source: Annals of Allergy, Asthma and Immunology - July 19, 2019 Category: Allergy & Immunology Authors: August Generoso, Linh-An Tuong, John Oppenheimer Tags: Review Source Type: research

Risk factors with epinephrine use
Oral food challenges (OFC) and immunotherapy (IT) are common allergy clinic procedures with inherent risk of an allergic reaction, including anaphylaxis. Although exceedingly rare, fatal and near-fatal anaphylactic reactions have occurred.1 –3 Providers must understand the potential risk factors for severe reactions when performing these procedures. Previous studies specifically reviewed risk factors for severe reactions during IT or OFCs individually.3–8 However, data are limited on all-cause allergic reactions in the allergy clin ic and associated predictive factors for epinephrine use in the clinic. (Source:...
Source: Annals of Allergy, Asthma and Immunology - July 17, 2019 Category: Allergy & Immunology Authors: Monica T. Kraft, Rebecca Scherzer, Kasey Strothman, Melissa Moore-Clingenpeel, Mitchell H. Grayson Tags: Letter Source Type: research

A real-world study evaluating adeQUacy of Existing Systemic Treatments for patients with moderate-to-severe Atopic Dermatitis (QUEST-AD): baseline treatment patterns and unmet needs assessment.
PMID: 31325566 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 17, 2019 Category: Allergy & Immunology Authors: Wei W, Ghorayeb E, Andria M, Walker V, Schnitzer J, Kennedy M, Chen Z, Belland A, White J, Silverberg JI Tags: Ann Allergy Asthma Immunol Source Type: research

Risk Factors with Epinephrine Use: 5-year review of in clinic pediatric allergic reactions.
PMID: 31325567 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 17, 2019 Category: Allergy & Immunology Authors: Kraft MT, Scherzer R, Strothman K, Moore-Clingenpeel M, Grayson MH Tags: Ann Allergy Asthma Immunol Source Type: research

Risk Factors with Epinephrine Use: 5-year review of in clinic pediatric allergic reactions
Oral food challenges (OFC) and immunotherapy (IT) are common allergy clinic procedures with inherent risk of an allergic reaction, including anaphylaxis. Although exceedingly rare, fatal and near-fatal anaphylactic reactions have occurred.1-3 It is important that providers understand the potential risk factors for severe reactions when performing these procedures. Previous studies specifically reviewed risk factors for severe reactions during IT or OFCs individually.3-8 However, data is limited on all-cause allergic reactions in the allergy clinic and associated predictive factors for epinephrine use in the clinic. (Source...
Source: Annals of Allergy, Asthma and Immunology - July 17, 2019 Category: Allergy & Immunology Authors: Monica T. Kraft, Rebecca Scherzer, Kasey Strothman, Melissa Moore-Clingenpeel, Mitchell H. Grayson Tags: Letters Source Type: research

A real-world study evaluating adeQUacy of Existing Systemic Treatments for patients with moderate-to-severe Atopic Dermatitis (QUEST-AD): baseline treatment patterns and unmet needs assessment
Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease associated with gene –environment interactions, immune dysregulation, and skin barrier dysfunction, and is characterized by pruritus, xerosis, and eczematous lesions.1 Evidence supports the systemic nature of AD;2 it is commonly associated with asthma and atopic/allergic conditions, with which it shares common pathoph ysiological pathways.3 AD occurs frequently in children; however, it also affects adults,4 and figures showed the 1-year prevalence to be 4.9%–10.2%. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 17, 2019 Category: Allergy & Immunology Authors: Wenhui Wei, Eric Ghorayeb, Michael Andria, Valery Walker, James Schnitzer, Martha Kennedy, Zhen Chen, Angela Belland, John White, Jonathan I. Silverberg Source Type: research

Two approaches for diagnosis of nonsteroidal anti-inflammatory drug hypersensitivity in children
The oral provocation test (OPT) with culprit drug is the gold standard in the diagnosis of nonsteroidal anti-inflammatory drug hypersensitivity (NSAID-H). Some authors have proposed that the total number of OPTs required to diagnose NSAID-H is much lower with acetyl salicylic acid (ASA) provocations, regardless of patients' reaction history, and less time consuming. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 16, 2019 Category: Allergy & Immunology Authors: Isil Eser Simsek, Mujde Tuba Cogurlu, Metin Aydogan Tags: Original Article Source Type: research

Two approaches for diagnosis of non-steroidal anti-inflammatory drug hypersensitivity in children.
PMID: 31323315 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 16, 2019 Category: Allergy & Immunology Authors: Simsek IE, Cogurlu MT, Aydogan M Tags: Ann Allergy Asthma Immunol Source Type: research

Two approaches for diagnosis of non-steroidal anti-inflammatory drug hypersensitivity in children
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in the treatment of fever and pain in children.1 NSAID hypersensitivity (NSAID-H) is one of the most common causes of drug-induced hypersensitivity reactions in child population.2, (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 16, 2019 Category: Allergy & Immunology Authors: Isil Eser Simsek, Mujde Tuba Cogurlu, Metin Aydogan Source Type: research

Detection of American Cockroach Allergens as Environmental Markers Using Rapid Competitive Lateral Flow Tests.
PMID: 31295553 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 8, 2019 Category: Allergy & Immunology Authors: Lee MF, Chen YH, Lin SJ, Liu HC, Lin TM Tags: Ann Allergy Asthma Immunol Source Type: research

A call for cost-effectiveness analysis for biologic therapies in chronic rhinosinusitis with nasal polyps.
PMID: 31295554 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 8, 2019 Category: Allergy & Immunology Authors: Codispoti CD, Mahadavinia M Tags: Ann Allergy Asthma Immunol Source Type: research

Detection of American Cockroach Allergens as Environmental Markers Using Rapid Competitive Lateral Flow Tests
It is known that sensitization to cockroach allergens is not only associated with the development of allergic diseases, but also with increasing severity and mortality of asthma. Additionally, the levels of cockroach allergens in settled household dust are associated with airway sensitization and asthma morbidity,1,2 making allergen avoidance as a crucial step in the management of allergies.3 However, patients are usually unaware of the degree of cockroach infestation in their homes. Previous surveys of house dust samples found that 20-62% of the homes tested had detectable levels of cockroach allergens, despite there bein...
Source: Annals of Allergy, Asthma and Immunology - July 8, 2019 Category: Allergy & Immunology Authors: Mey-Fann Lee, Yi-Hsing Chen, Shyh-Jye Lin, Hsin-Chun Liu, Tzu-Mei Lin Tags: Letters Source Type: research

A call for cost-effectiveness analysis for biologic therapies in chronic rhinosinusitis with nasal polyps
Chronic rhinosinusitis (CRS) is a chronic disease of the upper airways that is both common, as it affects more than 10 million Americans1, and economically onerous, as it is associated an annual loss of 60 paid work days missed per patient from both absenteeism and presenteeism2. CRS is associated with a significant decline in quality of life (QOL)3. The majority of CRS patients do not improve with current medical options and need to undergo repetitive surgeries. Not surprisingly, CRS is associated with a high financial burden on society with an estimated 60 billion dollars per year 4. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 8, 2019 Category: Allergy & Immunology Authors: Christopher D. Codispoti, Mahboobeh Mahadavinia Tags: CME Reviews Source Type: research

Precision medicine for lung diseases
Personalized medicine is not new. For centuries physicians have provided individualized care based on the nuanced clinical presentations of patients and the severity of their diseases. However, analytical advances over the past decade have sparked a hope that we may soon be able to deliver medical care with unprecedented resolution and effectiveness. To distinguish that new era of personalized medicine from the kind practiced by Galen in ancient Rome, a new term has been coined. Precision medicine describes a molecule-based approach to personalized medicine, one that can use precise biological measures (biomarker assays, g...
Source: Annals of Allergy, Asthma and Immunology - July 4, 2019 Category: Allergy & Immunology Authors: Thomas L. Croxton, Weiniu Gan, Patricia J. Noel, James P. Kiley Tags: Perspective Source Type: research

Anaphylaxis due to macrogol in a laxative solution with a positive basophil activation test.
, Bobadilla-González P PMID: 31279834 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 4, 2019 Category: Allergy & Immunology Authors: Giangrande N, García-Menaya JM, Marcos-Fernández M, Cámara-Hijón C, Bobadilla-González P Tags: Ann Allergy Asthma Immunol Source Type: research

Precision Medicine for Lung Diseases: A National Heart, Lung, and Blood Institute Perspective.
PMID: 31279835 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 4, 2019 Category: Allergy & Immunology Authors: Croxton T, Gan W, Noel P, Kiley J Tags: Ann Allergy Asthma Immunol Source Type: research

Precision Medicine for Lung Diseases: A National Heart, Lung, and Blood Institute Perspective
Personalized medicine is not new. For centuries physicians have provided individualized care based on the nuanced clinical presentations of patients and the severity of their diseases. However, analytical advances over the past decade have sparked a hope that we may soon be able to deliver medical care with unprecedented resolution and effectiveness. To distinguish that new era of personalized medicine from the kind practiced by Galen in ancient Rome, a new term has been coined. Precision medicine describes a molecule-based approach to personalized medicine, one which can utilize precise biological measures (biomarker assa...
Source: Annals of Allergy, Asthma and Immunology - July 4, 2019 Category: Allergy & Immunology Authors: Thomas Croxton, Weiniu Gan, Patricia Noel, James Kiley Tags: Perspective Source Type: research

Anaphylaxis due to macrogol in a laxative solution with a positive basophil activation test
Polyethylene glycol (otherwise known as macrogol or PEG) belongs to a family of synthetic nonionic hydrophilic polymers achieved as condensation products of glycols with ethylene oxide. Different types of macrogol exist, each with a specific molecular weight (from 200 to 20,000 g/mol) and length, which gives them specific pharmacological qualities (e.g., viscosity, density). As a consequence, PEG has wide applications as an excipient, solvent, dispersing and thickening agent in the food, cosmetic, medical, and pharmaceutical industries. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 4, 2019 Category: Allergy & Immunology Authors: Nicola Giangrande, Jes ús Miguel García-Menaya, Mariana Marcos-Fernández, Carmen Cámara-Hijón, Pedro Bobadilla-González Tags: Letters Source Type: research

Idiopathic postprandial diarrhea responsive to antihistamines
We report the clinical presentations of these patients along with laboratory and other test results listed in Table 1. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 3, 2019 Category: Allergy & Immunology Authors: Yasmin Hassoun, Margo Rockwell Stevenson, David I. Bernstein Tags: Letter Source Type: research

Immediate vs delayed cow's milk protein allergy in terms of tolerance at year 1
We conducted a trial to compare the rates of positive oral provocation tests (OPTs) and of clinical symptoms present from different systems (gut, skin, respiratory tract) in cases with a positive OPT in a group of immunoglobulin E (IgE) and in 1 of non-IgE cow's milk protein allergy (CMPA) at 1 year of age. Moreover, we tried to identify possible prognostic factors contributing to tolerance at 1 year of age OPT, such as the existence of multiple food allergies, a family history of atopy, the type of milk feeding (breastfeeding vs formula feeding), and the level of antibody concentration against cow's milk protein. (Source:...
Source: Annals of Allergy, Asthma and Immunology - July 3, 2019 Category: Allergy & Immunology Authors: Ioannis Xinias, Dimitrios Cassimos, Grigorios Trypsianis, Maria Nivatsi, Antigoni Mavroudi Tags: Letter Source Type: research

Immediate versus delayed cow's milk protein allergy in terms of tolerance at year one.
PMID: 31279074 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 3, 2019 Category: Allergy & Immunology Authors: Xinias I, Cassimos D, Trypsianis G, Nivatsi M, Mavroudi A Tags: Ann Allergy Asthma Immunol Source Type: research

Weed Pollen Season Trends In Relation To Atmospheric Co2 Changes In Indiana And Ohio.
PMID: 31279075 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 3, 2019 Category: Allergy & Immunology Authors: Vitalpur G, Ahmad HA, Slaven JE Tags: Ann Allergy Asthma Immunol Source Type: research

Idiopathic Post-Prandial Diarrhea Responsive to Anti-histamines.
PMID: 31279076 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 3, 2019 Category: Allergy & Immunology Authors: Hassoun Y, Stevenson MR, Bernstein DI Tags: Ann Allergy Asthma Immunol Source Type: research

Idiopathic Post-Prandial Diarrhea Responsive to Anti-histamines
We report herein the clinical presentations of these patients along with laboratory and other test results listed in Table 1. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 3, 2019 Category: Allergy & Immunology Authors: Yasmin Hassoun, Margo Rockwell Stevenson, David I. Bernstein Tags: Letters Source Type: research

Weed Pollen Season Trends In Relation To Atmospheric Co2 Changes In Indiana And Ohio
Allergic rhinitis (AR) and asthma both lead to significant morbidity and healthcare usage in the United States.1,2 Pollens contribute to increased AR symptoms and asthma exacerbations. Ragweed (Ambrosia spp) and other weed pollens have been shown to affect AR and asthma issues in the Midwestern US, especially in the late summer and early fall season. Knowledge about pollen season lengths and patterns can help with management of allergic rhinitis and asthma.3,4,5 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 3, 2019 Category: Allergy & Immunology Authors: Girish Vitalpur, Hassan A. Ahmad, James E. Slaven Tags: Letters Source Type: research

Immediate versus delayed cow ’s milk protein allergy in terms of tolerance at year one
We conducted a trial to compare the rates of positive oral provocation tests (OPTs) and of clinical symptoms present from different systems (gut, skin, respiratory tract) in cases with a positive OPT in a group of IgE and in one of non-IgE cow ’s milk protein allergy (CMPA) at 1 year of age. Moreover, we tried to identify possible prognostic factors contributing to tolerance at one year of age OPT, such as the existence of multiple food allergies, a family history of atopy, the type of milk feeding (breastfeeding vs formula feeding) and the level of antibody concentration against cow’s milk protein. (Source: An...
Source: Annals of Allergy, Asthma and Immunology - July 3, 2019 Category: Allergy & Immunology Authors: Ioannis Xinias, Dimitrios Cassimos, Grigorios Trypsianis, Maria Nivatsi, Antigoni Mavroudi Tags: Letters Source Type: research

Systemic reactions to subcutaneous immunotherapy
Systemic reactions are a known risk of subcutaneous immunotherapy (SCIT) for aeroallergens. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 2, 2019 Category: Allergy & Immunology Authors: S. Shahzad Mustafa, Theresa Bingemann, Holly Blue, Kelly Conn, Todd Hanley, Allison Ramsey Tags: Original Article Source Type: research

Asthma and viral infections
To synthesize available data related to the complex associations among viral infections, atopy, and asthma. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 2, 2019 Category: Allergy & Immunology Authors: Irene Mikhail, Mitchell H. Grayson Tags: Review Source Type: research

Systemic Reactions to Subcutaneous Immunotherapy (SCIT): Effects of Dosing and Aeroallergen Content.
PMID: 31276805 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 2, 2019 Category: Allergy & Immunology Authors: Mustafa SS, Bingemann T, Blue H, Conn K, Hanley T, Ramsey A Tags: Ann Allergy Asthma Immunol Source Type: research

Clinically Relevant Contact Allergens in the Modern Era.
PMID: 31276806 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 2, 2019 Category: Allergy & Immunology Authors: Milam EC, Cohen DE Tags: Ann Allergy Asthma Immunol Source Type: research

Asthma and viral infections: an intricate relationship.
PMID: 31276807 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 2, 2019 Category: Allergy & Immunology Authors: Mikhail I, Grayson MH Tags: Ann Allergy Asthma Immunol Source Type: research

Clinically Relevant Contact Allergens in the Modern Era
The field of contact dermatitis is constantly evolving, influenced by trends in industrial practices and consumer behaviors. The general population is exposed to hundreds of natural and synthetic chemicals each day. A single perfume, for example, may include up to 100 different chemicals. Many chemicals elicit irritant or allergic contact dermatoses (ACD) in susceptible hosts, which in turn may cause significant emotional, social, economic, and occupational impacts. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 2, 2019 Category: Allergy & Immunology Authors: Emily C. Milam, David E. Cohen Tags: Perspective Source Type: research

Asthma and viral infections: an intricate relationship
Asthma is the most common chronic medical condition in the pediatric population, affecting 5-10% of children and adolescents 1 and is characterized by chronic inflammation of the airways, excessive mucus production, and bronchial hyper-reactivity, and reversible airflow obstruction that leads to recurrent episodes of wheezing, dyspnea and cough. This review will discuss the strong link between asthma and viral infections. Viral infections trigger infant wheezing episodes, have been implicated in the inception of asthma, and are recognized as an important risk factors for asthma exacerbations (Figure 1). (Source: Annals of ...
Source: Annals of Allergy, Asthma and Immunology - July 2, 2019 Category: Allergy & Immunology Authors: Irene Mikhail, Mitchell H. Grayson Source Type: research

Systemic Reactions to Subcutaneous Immunotherapy (SCIT): Effects of Dosing and Aeroallergen Content
Subcutaneous allergen immunotherapy (SCIT) is effective for allergic rhinitis, allergic conjunctivitis, and allergic asthma1. Local reactions are the most common adverse effect associated with SCIT1, though systemic reactions to SCIT (SCITSR) are the most serious adverse effect1. The rate of systemic reactions to SCIT with a conventional dosing schedule is reported to be 0.1-0.2% per injection.1,2 It is generally accepted that the potential benefits of SCIT for select atopic conditions outweigh this risk of SCITSR. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 2, 2019 Category: Allergy & Immunology Authors: S Shahzad Mustafa, Theresa Bingemann, Holly Blue, Kelly Conn, Todd Hanley, Allison Ramsey Source Type: research

Drug allergy: Veni, vidi, vici-come, understand, and delabel, avoid, or desensitize.
PMID: 31255190 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 1, 2019 Category: Allergy & Immunology Authors: Castells M Tags: Ann Allergy Asthma Immunol Source Type: research

Drug Allergy.
PMID: 31255191 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 1, 2019 Category: Allergy & Immunology Authors: Dinakar C, Lang DM, Fineman SM Tags: Ann Allergy Asthma Immunol Source Type: research

A primer on cost-effectiveness in the allergy clinic
Evidence-based medicine in the era of personalized health care delivery is woven into every patient encounter, and technological advances continue to sculpt how care delivery will look in the near future.1 For the practicing allergist, balancing risks, benefits, and costs of rapidly developing advances in technology is a continuing challenge.2 –4 Resources in medicine are finite, and therefore the price of care matters.5,6 In fact, more than 30% of health care spending has been estimated to be wasteful (directed toward low-value care). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - June 29, 2019 Category: Allergy & Immunology Authors: Marcus Shaker, Matthew Greenhawt Tags: CME Review Source Type: research